Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy by Joshi Gaurav Santoshrao, Smriti Jamwal, Rakesh Kumar, Ekta Bisht, Bisen Harsh Krishnakumar, Shreya Katoch, R.K. Asrani

“…Future studies should focus on clinical trials to establish their efficacy and safety in humans, paving the way for new cancer therapies.…”
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Enhanced antitumor activity of combined hepatic arterial infusion chemotherapy with Lenvatinib and PD-1 inhibitors in unresectable hepatocellular carcinoma: a meta-analysis by Lingling Zhao, Cheng Xu, Jiewen Deng, Yang Ni

“…This meta-analysis aims to assess whether the integration of HAIC with lenvatinib and PD-1 inhibitors (referred to as the HAIC-L-P group) leads to better treatment effectiveness and security compared to lenvatinib and PD-1 inhibitors alone (L-P group) in uHCC.MethodsAn exhaustive search of the literature was conducted, including PubMed, the Cochrane Library, Embase, ClinicalTrials.gov, and Web of Science, from the start of each database until September 2024, to ensure a thorough and up-to-date compilation of relevant studies. …”
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Protocol publication rate and comparison between article, registry and protocol in RCTs by Sylvain Mathieu, Jean-Baptiste Bouillon-Minois, Laurent Renard Triché, Emmanuel Coudeyre, De Chazeron Ingrid, Finotto Thomas, Catherine Laporte, Xavier Moisset, Ludovic Samalin, Guillaume Villatte, Bruno Pereira, Methodology And Evidence Statistics for Transparency in medical Research and Outcome reporting (MAESTRO) working group

“…Abstract Background Increasing transparency in clinical research is crucial to avoid misleading conclusions. Registering clinical trials prior to participant enrolment is mandatory, and the publication of trial protocols could further enhance transparency. …”
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Cost–utility and budget impact analysis of tocilizumab for the treatment of refractory systemic juvenile idiopathic arthritis in Thailand by Nitichen Kittiratchakool, Disorn Kulpokin, Chonticha Chanjam, Soamarat Vilaiyuk, Sirirat Charuvanij, Gun Phongsamart, Parichat Khaosut, Manasita Tanya, Ratanavadee Nanagara, Sira Nantapaisarn, Pattara Leelahavarong

“…In contrast, tocilizumab showed obvious efficacy in clinical trials in improving treatment response and QoL. …”
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Efficacy and Safety of Allisartan Isoproxil/Amlodipine in Patients With Essential Hypertension Uncontrolled by Amlodipine: A Phase III, Multicenter, Double‐Blind, Parallel‐Group, R... by Hongjie Chi, Xin Zhang, Shumei Ma, Gang Pan, Xiaojuan Lian, Yan Chen, Haotian Pei, Zichen Liu, Xiangmin Lin

“…Trial Registration: ClinicalTrials.gov identifier: NCT06465264…”
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Efficacy of non-surgical mechanical debridement with and without adjunct antimicrobial photodynamic therapy in the treatment of peri-implantitis among patients undergoing chemother... by Asma Saleh Almeslet, Malak Mohammed ALOsaimi, Chitra Jhugroo, Abdullah Faraj Alshammari, Darshan Devang Divakar, Cristalle Soman

“…Hence further long-term follow-up clinical trials involving multiple sessions of aPDT after MD are needed.…”
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Meals, Education, and Gardens for In-School Adolescents (MEGA): study protocol for a cluster randomised trial of an integrated adolescent nutrition intervention in Dodoma, Tanzania by Wafaie W Fawzi, Dongqing Wang, Abbas Ismail, Leonard Kamanga Katalambula, Andrea R Modest, Tara Young, Mary Mwanyika-Sando, Amani Tinkasimile, Dominic Mosha, Augustine Malero, Said Vuai

“…Local dissemination meetings will be held with key stakeholders.Trial registration number NCT04788303.; ClinicalTrials.gov Identifier.…”
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Investigating the effect of using a home safety training application by caregivers on accident risk management in the elderly by Mahdie Dehnavi, Najmeh Valizadeh zare, Seyd Reza Mazlom, Samira Mohajer, Tahereh Sadeghi, Mohammad Namazinia, Danial Baghie

“…Methods: This randomized clinical trial was conducted in 2022 in Mashhad, Iran. …”
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Novel CAD/CAM-splint-based navigation protocol enhances intraoperative maxillary position control in orthognathic surgery: a case control study by Felix Schrader, Leonardo Saigo, Norbert Kübler, Majeed Rana, Max Wilkat

“…Trial registration Retrospectively registered with the German Clinical Trials Register (DRKS00034795).…”
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Evaluation of Biologics ACE2/Ang(1–7) Encapsulated in Plant Cells for FDA Approval: Safety and Toxicology Studies by Henry Daniell, Geetanjali Wakade, Smruti K. Nair, Rahul Singh, Steven A. Emanuel, Barry Brock, Kenneth B. Margulies

“…Vital biomarkers and organs were not adversely affected despite the 10-fold higher absorption in the tissues, demonstrating the safety for the first in-human clinical trials of ACE2/Ang(1–7). The NOAEL observed in the rats was 2.5–7.5-fold higher than that of the anticipated efficacious therapeutic dose in humans for the treatment of cardiopulmonary disorders, and it was 314-fold higher than the NOAEL for topical delivery via chewing gum. …”
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Improving apgar scores and reducing perineal injuries through midwife-led quality improvements: an observational study in Uganda by Johanna Blomgren, Michael B. Wells, Dinah Amongin, Kerstin Erlandsson, John Wanyama, Diana A. Afrifa, Helena Lindgren

“…Conclusion This study demonstrates that low 5-min Apgar scores and perineal injuries decreased during a midwife-led Quality Improvement intervention focusing on dynamic birth positions, intrapartum support, and perineal protection strategies. Clinical trial This study is registered on ClinicalTrials.gov as of 14th February 2022, under registration number NCT05237375.…”
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Lifetime quality of life and cost consequences of delays in endovascular treatment for acute ischaemic stroke: a cost-effectiveness analysis from a Singapore healthcare perspective by Mayank Goyal, Weiyi Ni, Deidre Anne De Silva, Yu Li Ng, Kelvin Tan, Wolfgang G Kunz

“…Clinical outcomes and cost data were derived from clinical trials, literature, expert opinion, electronic medical records and community-based surveys from Singapore. …”
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The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications by Monika Kamińska, Maria Jasiewicz, Magdalena Miernik-Skrzypczak, Aleksandra Spyra, Marta Malicka, Natalia Dąbrowska, Aleksandra Kozioł, Katarzyna Moczyróg

“…Pluripotent stem cells showed promise in islet transplantation, achieving stable glycemic control in clinical trials. In type 2 diabetes, stem cell therapy improved insulin sensitivity and reduced insulin dependency, with evidence of β-cell regeneration. …”
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48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse by Wen-xiong Xu, Qian Zhang, Xiang Zhu, Chao-shuang Lin, You-ming Chen, Hong Deng, Yong-yu Mei, Zhi-xin Zhao, Dong-ying Xie, Zhi-liang Gao, Chan Xie, Liang Peng

“…The study was submitted to ClinicalTrials.gov Protocol Registration and Results System with the assigned NCT ID NCT02883647.…”
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Protocol for the implementation evaluation of an integrated paediatric and primary care model: Strengthening Care for Children (SC4C) by Yvonne Zurynski, Susan Woolfenden, Peter D Hibbert, Harriet Hiscock, Raghu Lingam, Karen Wheeler, Michael Hodgins, Jade Burley, Rachel Pelly, Jane Le, Sonia Khano, Tammy Meyers Morris, Stephanie Germano

“…Results will be submitted for publication in peer-reviewed journals and presented at relevant conferences.Trial registration number Australia New Zealand Clinical Trials Registry 12620001299998 on 1 December 2020.…”
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Effects of hydrolyzed collagen supplementation for Skin Anti-Aging by Anna Gliwa, Marek Kurowski, Karolina Kuczapska, Monika Ryglewicz, Dariusz Fabian, Elbieta Leszczynska-Knaga, Natalia Jakubczyk, Weronika Rutkowska-Kawalec, Paweł Moczydłowski, Karolina Michhalczuk

“…In order to investigate the efficacy and effects of hydrolyzed collagen for the skin, we need both preclinical studies, availability assessments and controlled clinical trials on a wide range of patients. Overall, it can be concluded that as little as 12 weeks of hydrolyzed fish collagen supplementation improves the quality and appearance of skin in the aging population.Importantly, HC-containing formulations were found to be safe and well-tolerated. …”
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Effect of motivational interviewing to promote advance care planning among palliative care patients in ambulatory care setting: a randomized controlled trial by Helen Yue-Lai Chan, Doris Yin-Ping Leung, Po-Tin Lam, Polly Po-Shan Ko, Raymond Wai-Man Lam, Kin-Shan Chan

“…Trial registration ClinicalTrials.gov Identifier: NCT04162912 (Registered on 14/11//2019).…”
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Acute effect of endurance exercise on human milk insulin concentrations: a randomised cross-over study by Rebecca Lyng Holm, Mads Holmen, Md Abu Jafar Sujan, Md Abu Jafar Sujan, Guro F. Giskeødegård, Trine Moholdt, Trine Moholdt

“…Future research should determine the effect of regular exercise on insulin in human milk and potential impact for infant health outcomes.Clinical trial registrationClinicalTrials.gov, identifier NCT05042414.…”
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The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis by Peiye Zhu, Yunrui Jin, Jiya Sun, Xia Zhou

“…A meta-analysis was performed to assess the changes in levels of inflammation and oxidative stress in patients with T2DM.MethodsRelevant literatures before November 6, 2024 were screened through Web of Science,Embase,the Cochrane Library and other sources (ClinicalTrials, ProQuest Dissertations and Theses). The quality of the literature was evaluated according to the Cochrane Handbook of Systematic Reviews. …”
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Evaluating the Effectiveness of a Multimodal Psychotherapy Training Program for Medical Students in China: Protocol for a Randomized Controlled Trial by Tao Pei, Yinan Ding, Jinsong Tang, Yanhui Liao

“…Trial RegistrationClinicalTrials.gov NCT06258460; https://clinicaltrials.gov/ct2/show/NCT06258460 International Registered Report Identifier (IRRID)DERR1-10.2196/58037…”
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