Completion of a standardizable competency-based research training program improves understanding and preparedness for both new and experienced clinical research professionals by Lucy Palmer, Sandra E. Morones, Heidi T. Jacobe, Rhonda Oilepo

“…The Joint Task Force for Clinical Trial Competency created a competency framework for CRPs, which has demonstrated positive results from various institutions, but training programs have been limited in standardization, replicability, and dissemination. …”
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Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alon... by Zohreh Tehranchinia, Bita Saghi, Hoda Rahimi

“…This study was a prospective assessor- and analyst-blind, randomized split-face clinical trial which was performed on patients with bilateral malar epidermal melasma. …”
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Acute Lymphoblastic Leukemia following Lenalidomide Maintenance for Multiple Myeloma: Two Cases with Unexpected Presentation and Good Prognostic Features by Abdullah M. Khan, Jameel Muzaffar, Hermant Murthy, John R. Wingard, Jan S. Moreb

“…One patient was diagnosed on routine biopsy performed as part of requirements of the clinical trial. Both patients had B-cell ALL, without known poor risk cytogenetics, and were managed with standard induction therapies resulting in complete remission. …”
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The Effect of Anterior Capsule Polishing on Capsular Contraction and Lens Stability in Cataract Patients with High Myopia by Dandan Wang, Xiaoyu Yu, Zhangliang Li, Xixia Ding, Hengli Lian, Jianyang Mao, Yinying Zhao, Yun-E. Zhao

“…The study was registered at http://www.clinicaltrials.gov, and the clinical trial accession number is NCT 03142269.…”
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Gross motor abnormalities in relation to balance and weight indicators in children with spastic diplegia by Lamis Neyazy Elrakhawy, Khaled Ahmed Mamdouh, Hoda Abdel Azim Eltalawy, Radwa S. Abdulrahman

“…Trial registration The study registered in ClinicalTrial.gov in October 2024 (NCT06642922).…”
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The Efficacy of Functional and Traditional Exercise on the Body Composition and Determinants of Physical Fitness of Older Women: A Randomized Crossover Trial by Antônio Gomes de Resende-Neto, José Carlos Aragão-Santos, Bruna Caroline Oliveira-Andrade, Alan Bruno Silva Vasconcelos, Clodoaldo Antônio De Sá, Felipe José Aidar, Josimari Melo DeSantana, Eduardo Lusa Cadore, Marzo Edir Da Silva-Grigoletto

“…This is a randomized clinical trial in which participants performed two 12-week periods of different training methods, separated by eight weeks of washout. …”
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Evaluation of Monocular Treatment for Meibomian Gland Dysfunction with an Automated Thermodynamic System in Elderly Chinese Patients: A Contralateral Eye Study by Yinying Zhao, Jialu Xie, Junhua Li, Yana Fu, Xiaolei Lin, Shangrong Wang, Jiling Ma, Yune Zhao

“…This study was a prospective, examiner-masked, contralateral eye clinical trial. The eye perceived by the patient to be worse (test eye) received a 12-minute LipiFlow treatment, while the other eye served as control. …”
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Longitudinal Study on Low-Dose Aspirin versus Placebo Administration in Silent Brain Infarcts: The Silence Study by Ilaria Maestrini, Marta Altieri, Laura Di Clemente, Edoardo Vicenzini, Patrizia Pantano, Eytan Raz, Mauro Silvestrini, Leandro Provinciali, Isabella Paolino, Carmine Marini, Matteo Di Giuseppe, Tommasina Russo, Francesco Federico, Cristiana Coppola, Maria Pia Prontera, Domenico Maria Mezzapesa, Vincenzo Lucivero, Lucilla Parnetti, Paola Sarchielli, Maria Peducci, Domenico Inzitari, Giovanna Carlucci, Carlo Serrati, Carla Zat, Anna Cavallini, Alessandra Persico, Giuseppe Micieli, Stefano Bastianello, Vittorio Di Piero

“…Despite the study limitations, SBI seems to be a negative prognostic factor and ASA preventive treatment might improve SBI prognosis. EU Clinical trial is registered with EudraCT Number: 2005-000996-16; Sponsor Protocol Number: 694/30.06.04.…”
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Analysis of kinematic and kinetic changes in scoliosis following spinal manipulation by Yanyun Gou, Lin Meng, Shaoqing Chen, Zheng Jiang, Huangwei Lei

“…This study utilized a single-arm clinical trial design involving 35 patients aged 18 to 20 with idiopathic scoliosis (IS) and Cobb angles ranging from 10° to 30°. …”
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Misuse of Statistical Methods in 10 Leading Chinese Medical Journals in 1998 and 2008 by Shunquan Wu, Zhichao Jin, Xin Wei, Qingbin Gao, Jian Lu, Xiuqiang Ma, Cheng Wu, Qian He, Meijing Wu, Rui Wang, Jinfang Xu, Jia He

“…Many mistakes were found in the randomised controlled trial (56.3% in 1998; 67.9% in 2008), non- randomised clinical trial (57.3%; 58.6%), basic science study (72.9%; 65.5%), case study or case series study (48.4%; 47.2%), and cross-sectional study (57.1%; 44.2%). …”
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The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease by Edward C. Lauterbach, Leonardo F. Fontenelle, Antonio L. Teixeira

“…Additionally, PD-related gene transcription, animal model, and human neuroprotective clinical trial data were reviewed. Results indicate that, from a PD pathobiology perspective, the safest drugs (i.e., drugs least likely to promote cellular neurodegenerative mechanisms balanced against their likelihood of promoting neuroprotective mechanisms) include pramipexole, valproate, lithium, desipramine, escitalopram, and dextromethorphan. …”
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Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japane... by Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh

“…An 8-week, single-center, single-arm, open-label clinical trial was conducted. Eleven healthy, middle-aged Japanese men received two 125-mg NMN capsules once daily before breakfast. …”
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Physical literacy among chinese elementary school students: the mediating role of physical knowledge and physical competency by Li Mengyu, Wang Yuxing, Zan Ziqing, Liu Lizhu, You Lili

“…Physical competency explained 56.40% of the association between physical motivation and physical participation. Clinical trial number Not applicable…”
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Understanding Types of Stigma Experienced in Black Women Living With HIV in Baltimore, Maryland: A Mixed Methods Study by Tanya Mikhael, Kyra Jennifer Waligora Mendez, Chun‐An Sun, Joy Chepkorir, Hae‐Ra Han

“…Design Secondary analysis of quantitative and qualitative data from a recent clinical trial in Baltimore, Maryland. Methods Quantitative data were collected in the baseline survey, and qualitative data were gathered during 6‐month follow‐up focus group and individual interviews. …”
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Effectiveness of a holistic neuropsychological rehabilitation program using virtual reality by Liliana Mendes, Luís Paulo Reis, Fernando Barbosa

“…A total of 27 participants of both sexes with moderate or severe ABI participated in an investigation in a clinical trial-type design with pre-test and post-test. …”
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Evaluation of Urinary Tract Infection following Corticosteroid Therapy in Patients with Multiple Sclerosis Exacerbation by Aliyeh Bazi, Seyed Mohammad Baghbanian, Monireh Ghazaeian, Sahar Fallah, Narjes Hendoiee

“…This double-blind randomized clinical trial was conducted on 56 people with multiple sclerosis relapse who had undergone methylprednisolone for 5 days. …”
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Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy by Selwyn M. Prea, Elsa C. Chan, Gregory J. Dusting, Algis J. Vingrys, Bang V. Bui, Guei-Sheung Liu

“…Preclinical studies of gene transfer in a large animal model have provided impressive preliminary results with a number of transgenes. In addition, a clinical trial in patients suffering from advanced neovascular AMD has provided proof-of-concept for successful gene transfer. …”
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The Bipolar Depression Electrical Treatment Trial (BETTER): Design, Rationale, and Objectives of a Randomized, Sham-Controlled Trial and Data from the Pilot Study Phase by Bernardo de Sampaio Pereira Junior, Gabriel Tortella, Beny Lafer, Paula Nunes, Isabela Martins Benseñor, Paulo Andrade Lotufo, Rodrigo Machado-Vieira, André R. Brunoni

“…Conclusion. This upcoming clinical trial will address the efficacy of tDCS for BD on different degrees of refractoriness. …”
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Safety and Efficacy of Combined Yttrium 90 Resin Radioembolization with Aflibercept and FOLFIRI in a Patient with Metastatic Colorectal Cancer by Andre De Souza, Kevin Pelham Daly, James Yoo, Muhammad Wasif Saif

“…An ongoing randomized clinical trial aims to define the role of combined targeted therapy and chemotherapy with radioembolization with Y90.…”
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New therapies in pulmonary arterial hypertension: Recent insights by Giulia Guglielmi, Konstantinos Dimopoulos, S. John Wort

“…Finally, strategies that target the serotonin pathway, and other metabolic and hormonal pathways are described.This review includes both preclinical and clinical trial data that support efficacy, safety and the future potential of such therapies. …”
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