Long-Term Stability of Hydromorphone in Human Plasma Frozen at −20°C for Three Years Quantified by LC-MS/MS by Andreas Wehrfritz, Stefanie Schmidt, Harald Ihmsen, Jürgen Schüttler, Christian Jeleazcov

“…To evaluate the stability of the analgesic opioid hydromorphone, 44 human frozen plasma samples of a former clinical trial were reanalyzed after at least three years. …”
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Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease by Roger F. Butterworth, Ali Canbay

“…L-ornithine L-aspartate (LOLA) has hepatoprotective properties in patients with fatty liver of diverse etiology and results of a multicenter randomized clinical trial reveal that 12 weeks treatment with oral LOLA (6–9 g/d) results in a dose-related reduction in activities of liver enzymes and triglycerides together with significant improvements of liver/spleen CT ratios. …”
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Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris? by Mina Mirnezami, Hoda Rahimi

“…In this randomized double-blind clinical trial, a total of 118 patients with moderate or severe acne were randomly divided into two (case and control) groups. …”
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The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial by Gansheng Tan, Anna L Huguenard, Kara M Donovan, Phillip Demarest, Xiaoxuan Liu, Ziwei Li, Markus Adamek, Kory Lavine, Ananthv K Vellimana, Terrance T Kummer, Joshua W Osbun, Gregory J Zipfel, Peter Brunner, Eric C Leuthardt

“…Methods: In this randomized clinical trial, 24 SAH patients were assigned to either a taVNS treatment or a sham treatment group. …”
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TCR Gene Transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 Epitopes as Melanoma-Specific Immune Targets by Trudy Straetemans, Mandy van Brakel, Sabine van Steenbergen, Marieke Broertjes, Joost Drexhage, Joost Hegmans, Bart N. Lambrecht, Cor Lamers, Pierre van Der Bruggen, Pierre G. Coulie, Reno Debets

“…We intend to start testing these MAGE-specific TCRs in phase I clinical trial.…”
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Investigating The Effect of Transcutaneous Electrical Nerve Stimulation on The Severity of Restless Legs Syndrome in Hemodialysis Patients by Abolfazl Kalmishi, Ali Abedi, Katayoun Samadi, HamidReza Shoraka, Mostafa Rad

“…Materials and Methods: This clinical trial study was conducted on 60 patients undergoing hemodialysis treatment in the dialysis department of Vasei Sabzevar and Imam Khomeini Esfrain Hospitals, from December of 2022 to March 2023. …”
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Oral lactoferrin as a treatment of pediatrics’ anemia resulted from chronic kidney diseases: a randomized controlled trial by Sahar Kamal Hegazy, Mai Salah El-Din Koura, Mohamed Shokry Elharoun

“…This randomized and parallel clinical trial aimed to compare the effectiveness of oral lactoferrin with intravenous (IV) iron dextran in managing anemia resulted from CKD in pediatrics. …”
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The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood by Okko Savonius, Irmeli Roine, Saeed Alassiri, Taina Tervahartiala, Otto Helve, Josefina Fernández, Heikki Peltola, Timo Sorsa, Tuula Pelkonen

“…Clinical data and the diagnostic CSF samples from 245 children (median age eight months) with bacterial meningitis were obtained from a clinical trial in Latin America in 1996–2003. MMP-9 levels in the CSF were assessed by zymography, while MMP-8, MPO, and TIMP-1 concentrations were determined with immunofluorometric and enzyme-linked immunosorbent assays. …”
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Preoperative uterine artery embolisation before hysterectomy in women with giant uterine fibroid and HIV-associated nephropathy by Filip Szkodziak, Sławomir Woźniak, Łukasz Światłowski, Emilia Maleszyk, Piotr Szkodziak, Krzysztof Pyra, Viktor Berczi, Tomasz Paszkowski, Tomasz Jargiełło

“…Although the benefits of pre-operative UAE before planned myomectomy or hysterectomy in high surgical risk patients with large fibroids has yet to be confirmed in a well-designed clinical trial, this procedure seems to be a promising tool to reduce the risk of perioperative complications in such patients.…”
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Air Bubble Technique for Fundus Visualization during Vitrectomy in Aphakia by Mahmoud Mohamed Farouk, Takeshi Naito, Mohammed Elagouz, Hatem Ammar, Alahmady Hamad Alsmman, Engy Mohamed Mostafa

“…This trial is registered with Pan African Clinical Trial Registry PACTR201709002466296.…”
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Diagnosis of Sleep Apnea Hypopnea Syndrome Using Fusion of Micro-motion Signals from Millimeter-wave Radar and Pulse Wave Data by Xiang ZHAO, Wei WANG, Chenyang LI, Jian GUAN, Gang LI

“…Experimental results of a clinical trial dataset at Shanghai Jiaotong University School of Medicine Affiliated Sixth People’s Hospital demonstrated that the AHI estimated by the proposed approach correlates with the gold standard PSG with a coefficient of 0.93, indicating good consistency. …”
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Diagnostic accuracy of CCTA-derived versus angiography-derived quantitative flow ratio (CAREER) study: a prospective study protocol by Liang Zhang, Yang Chen, Cheng Li, Ming Li, Shaofeng Guan, Xinkai Qu, Tingwen Weng, Qian Gan, Zehang Li, Wenzheng Han, Xinrong Zhai, Lin Qi, Xifeng Chang, Shengxian Tu

“…The objective of this investigator-initiated, prospective, single-centre clinical trial is to evaluate the diagnostic performance of CT-QFR with respect to angiography-derived QFR, using FFR as the reference standard.Methods and analysis A total of 216 patients who have at least one lesion with a diameter stenosis of 30%–90% in an artery with ≥2.0 mm reference diameter will be enrolled in the study. …”
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Diabetic Retinopathy and BDNF: A Review on Its Molecular Basis and Clinical Applications by Mehrdad Afarid, Ehsan Namvar, Fatemeh Sanie-Jahromi

“…The most relevant in vitro and clinical trial studies were then extracted for final interpretation. …”
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DIFFERENT CERVICAL LAMINOPLASTY TECHNIQUES - UPDATE AND SYSTEMATIC REVIEW by FRANCISCO ALVES DE ARAÚJO JÚNIOR, JURANDIR MARCODES RIBAS FILHO, OSVALDO MALAFAIA, ALUÍZIO AUGUSTO ARANTES JÚNIOR, GUILHERME HENRIQUE WEILER CECCATO, PEDRO HELO DOS SANTOS NETO

“…In this phase, a literature review was carried out using the descriptor “cervical laminoplasty”, employing “clinical trial”, “meta-analysis”, “review,” and “systematic review” as filters. …”
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Tuberculosis vaccines and therapeutic drug: challenges and future directions by Yajing An, Ruizi Ni, Li Zhuang, Ling Yang, Zhaoyang Ye, Linsheng Li, Seppo Parkkila, Ashok Aspatwar, Wenping Gong

“…This review meticulously maps out the contemporary landscape of TB vaccine development, with a focus on antigen identification, clinical trial progress, and the obstacles and future trajectories in vaccine research. …”
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Biochemical Characterization of Early Osteoarthritis in the Ankle by Hagen Schmal, Gian M. Salzmann, Elia R. Langenmair, Ralf Henkelmann, Norbert P. Südkamp, Philipp Niemeyer

“…Methods. 49 patients with a mean age of 33±14 years undergoing an arthroscopy of the ankle with different stages of chronic OA were prospectively included in a clinical trial. Lavage fluids were analyzed by ELISA. …”
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Comparison of the Effect of Sertraline and Escitalopram on the Treatment of Major Depressive Disorder in Hemodialysis Patients: A Randomized Controlled Trial by Tahereh Sabaghian, Roya Vaziri-Harami, Seyed Alireza Ebadi, Minoo Heidari Almasi, Azadeh Ahmadi Koomleh, Amir Behnam Kharazmi, Ehsan Farhadi, Mahdiyeh Miri, Amir Ahmad Nassiri

“…Materials and Methods: In this single-blind randomized clinical trial, 100 patients with End-Stage Renal Disease (ESRD) undergoing hemodialysis with a Beck Depression Inventory (BDI) score greater than 15 who were not using medication for depression were included in the study. …”
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Subfoveal Choroidal Thickness after Panretinal Photocoagulation with Red and Green Laser in Bilateral Proliferative Diabetic Retinopathy Patients: Short Term Results by Ramak Roohipoor, Sina Dantism, Aliasghar Ahmadraji, Reza Karkhaneh, Mohammad Zarei, Fariba Ghasemi

“…Study Design. Randomized clinical trial. Methods. A total of 50 patients with bilateral proliferative diabetic retinopathy and no diabetic macular edema underwent PRP. …”
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Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat by Luciano L. Furlanetti, Máté D. Döbrössy, Iñigo A. Aranda, Volker A. Coenen

“…Deep brain stimulation (DBS) of the superolateral branch of the medial forebrain bundle (MFB) has provided rapid and dramatic reduction of depressive symptoms in a clinical trial. Early intracranial self-stimulation experiments of the MFB suggested detrimental side effects on the animals’ health; therefore, the current study looked at the viability of chronic and continuous MFB-DBS in rodents, with particular attention given to welfare issues and identification of stimulated pathways. …”
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Factors predicting secondary hypertension in young adults with hypertension: a retrospective study by Nicha Prasert, Worapaka Manosroi, Benya Hankamolsiri, Muslimah Wae-uma, Papot Choonklai

“…Individuals who do not have any of these predictors may have a lower likelihood of secondary hypertension; however, these markers should always be used in conjunction with a thorough clinical assessment and are not intended to serve as definitive criteria for diagnosis. Clinical trial number Not applicable.…”
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