Therapeutic landscape for inherited ocular diseases: current and emerging therapies by Hwei Wuen Chan, Jaslyn Oh, Bart Leroy

“…This review discusses the fundamentals underlying the mode of inheritance, natural history studies and clinical trial outcomes, as well as current and emerging therapies covering gene therapy strategies, cell-based therapies and bionic vision.…”
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Digestive bleeding in children by Ana Barbarita Navarro Sombert, Graciela Goire Herrera, Ledicel Nilo Gámez Fonts, Luis Antonio García Rodríguez

“…The most serious bleedings are secondary to esophageal varices and Meckel's diverticulum. A good clinical trial, supported by image and endoscopic tests, and standardized therapy, are the key elements for the reduction of mortality in these patients. …”
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EXPAREL® (Long-Acting Liposomal Bupivacaine) Use for Popliteal Nerve Block in Postoperative Pain Control after Ankle Fracture Fixation by Patrick Discepola, Mohamed Bouhara, Minho Kwon, Bilal A. Siddiqui, Trevor A. Whitwell, Swetha Y. Sanghvi, Keith D. Cook, Ross E. Moore, Anna Korban, Jean D. Eloy

“…These inconsistent results and the possibility of bimodal kinetics creating analgesic gaps as seen in two of our patients indicate that more studies with larger sample size are needed to better characterize these phenomena and determine if more consistent results can be obtained in a future clinical trial.…”
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The Efficacy of Implementing Labor Analgesia Education via the WeChat Public Platform—A Randomized Controlled Study by Lijun Ma, Yan Cheng, Hailian Liu, Wenjing Yang, Chen Yang

“…It has significant clinical value and promising prospects for promotion. Clinical Trial Registration: The study was registered with the Chinese Clinical Trial Registry (ChiCTR1900025231).…”
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Efficacy analysis of folic acid in chronic atrophic gastritis with Helicobacter pylori infection: a systematic review and meta-analysis by Hui Li, Jincheng Li, Mingyu Lai

“…Methods Using a systematic review method, consider randomized controlled trials (RCT), including clinical trial reports, unpublished clinical trial data, and conference papers. …”
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Association of Serum Adiponectin with Intima Media Thickness of Dorsalis Pedis Artery and Macroangiopathy in Type 2 Diabetes by Tao Chen, Mei Tu, Lihua Huang, Youping Zheng

“…Decrease of adiponectin as an independent risk factor for both macroangiopathy and D-IMT among Chinese patients with T2DM suggests that adiponectin might have clinical utility in the prediction of diabetic macroangiopathy. This clinical trial is registered in the “Chinese Clinical Trial Registry.” …”
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Combination therapy versus monotherapy: retrospective analysis of antibiotic treatment of enterococcal endocarditis by Razan Saman, Christopher P. Primus, Robert West, Simon J. Woldman, Jonathan A. T. Sandoe

“…Clinical trial number Not applicable.…”
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The antihypertensive efficacy of a quadruple single-pill combination in patients with resistant hypertension: study protocol for a randomized, open-label, crossover trial by Yuanyuan Yao, Xin Zhang, Runyu Ye, Shanshan Jia, Xiangyu Yang, Xiaoping Chen

“…Trial registration Chinese Clinical Trial Registry ChiCTR2400081878. Registered on March 14, 2024 ( http://www.chictr.org.cn ).…”
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Medical thoracoscopy combined with intrapleural injection of urokinase for treatment of pleural infection-a multicenter, prospective, randomized controlled study: study protocol by Kaige Wang, Linhui Yang, Panwen Tian, Fen Tan, Dan Liu, Weimin Li

“…Methods This study is a prospective, multicenter, randomized controlled clinical trial involving patients with pleural infections. …”
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Research Progress on Tumor Treatment Strategies Targeting TGF-β by Jian ZHANG, Binyue LYU, Xiao ZHAO

“…Currently, multiple drugs targeting this pathway are in clinical trial stage, which involve three aspects of TGF-β, namely, production, activation, and signal transduction. …”
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IMPACT-CABG Trial: Implantation of CD133+ Stem Cells in Patients Undergoing Coronary Bypass Surgery—Presentation of the First Treated Patient by Jessica Forcillo, Louis-Mathieu Stevens, Samer Mansour, Ignacio Prieto, Denis-Claude Roy, Nicolas Noiseux

“…The IMPACT-CABG study is the first Canadian randomized-controlled phase II clinical trial aiming to assess the effect of intramyocardial (IM) injections of CD133+-selected stem cells in patients referred for coronary artery bypass graft (CABG) with a “chronic” myocardial infarction and persistent left ventricular dysfunction. …”
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Association of delayed asthma diagnosis with asthma exacerbations in children by Chung-Il Wi, MD, Euijung Ryu, PhD, Katherine S. King, MS, Jung Hyun Kwon, MD, PhD, Joshua T. Bublitz, BS, Miguel Park, MD, Sergio E. Chiarella, MD, Jason D. Greenwood, MD, MS, Thanai Pongdee, MD, Lynnea Myers, PhD, Björn Nordlund, PhD, Sunghwan Sohn, PhD, Elham Sagheb, MS, Bhavani Singh Agnikula Kshatriya, MS, Dave Watson, PhD, Hongfang Liu, PhD, Beverley J. Sheares, MD, MS, Carla M. Davis, MD, Wade Schulz, MD, PhD, Young J. Juhn, MD, MPH

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Enhancing collaborative clinical reasoning among multidisciplinary healthcare teams in a neurosurgery ICU: insights from video-reflexive ethnography by Ching-Yi Lee, Ching-Hsin Lee, Sze-Yuen Yau, Hung-Yi Lai, Po-Jui Chen, Mi-Mi Chen

“…By enhancing CCR, healthcare teams can improve patient outcomes and ensure safer healthcare delivery. Clinical trial number Not required, as this is not a clinical trial and does not involve any healthcare interventions with human participants.…”
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An Objective Pain Score for Chronic Pain Clinic Patients by Agnes K. Pace, Melanio Bruceta, John Donovan, Sonia J. Vaida, Jill M. Eckert

“…This study was registered with ClinicalTrial.gov with National Clinical Trial Number NCT02882971.…”
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Dentoskeletal effects of aesthetic and conventional twin block appliances in the treatment of skeletal class II malocclusion: a randomized controlled trial by Mohamed Najati Alsilq, Mohamed Youssef

“…A two-arm parallel group randomized clinical trial was performed at the Department of Orthodontics, University of Damascus, Syria. …”
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Update on Chemotherapy in the Treatment of Urothelial Carcinoma by Carrie Costantini, Frederick Millard

“…Optimal second-line therapy remains undefined, and targeted agents are under investigation. Clinical trial participation should be encouraged in patients with urothelial carcinoma of the bladder to help improve treatment regimens and outcomes. …”
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Moderate Hypofractionated Post-Prostatectomy Radiotherapy (MYSTERY) Versus Conventionally Fractionated Post-Prostatectomy Radiotherapy (COPORT) for the Patients With Localized Pros... by Yiyin Liang MD, Weiwei Zhang MD, Xianzhi Zhao MD, Huojun Zhang MD, PhD

“…Methods and analysis This study is a prospective, single-center, open-label, randomized controlled clinical trial. Patients with localized prostate cancer will be randomly allocated to receive COPORT (66-74 Gy at 2 Gy per fraction) or MYSTERY (57.5-65 Gy at 2.5 Gy per fraction). …”
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Efficacy of contralateral acupuncture in women with migraine without aura: protocol for a randomised controlled trial by Ling Zhao, Qifu Li, Yanan Wang, Jialei Feng, Xinghe Zhang, Siwen Zhao, Chonghui Xing, Yongli Song, Xuanxiang Zeng, Meng Kong, Yunqiu Zheng, Taipin Guo

“…The results of this study will be published in a peer-reviewed journal and presented at conferences.Trial registration number Chinese Clinical Trial Registration Center (ChiCTR2100051479).…”
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Regenerative fibroblasts derived from autologous skin tissue for the treatment of Sjögren’s syndrome: a case report by Zhao-Xia Ma, Xing-Fei Wu, Li Cao, Cheng-Yan Jiao, Dai-Ping Ma, Yun-Hui Zhao, Zhi-Xing Yang, Min Hu, Min Hu

“…No adverse effects were associated with the use of rFib in the volunteer during the clinical trial.SummaryThe results of this clinical trial indicate that intravenous injections of autologous rFib are both safe and effective for treating SS. …”
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Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: seconda... by Helen Macpherson, Robin M Daly, Patricia M Livingston, Declan G Murphy, Patrick J Owen, Timo Rantalainen, Niamh L Mundell, Jeremy L Millar, Steve F Fraser, Jack Dalla Via, Stephen J Foulkes

“…Exercise training adherence below recommended guidelines does not support cognitive health in men treated with ADT for prostate cancer.Trial registration number Australian and New Zealand Clinical Trial Registry (ACTRN12614000317695, registered 25/03/2014) and acknowledged under the Therapeutic Goods Administration Clinical Trial Notification Scheme (CT-2015-CTN-03372-1 v1).…”
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