The Pain and Sleep Questionnaire Three-Item Index (PSQ-3): A Reliable and Valid Measure of The Impact of Pain on Sleep in Chronic Nonmalignant Pain of Various Etiologies by Lindsay E Ayearst, Zoltan Harsanyi, Kenneth J Michalko

“…Because pain-related sleep disturbance may serve as a marker for the assessment of responses to treatment for chronic pain, inclusion of a measure designed to assess the impact of pain on sleep in clinical trial protocols is important, if not necessary. …”
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A Retrospective Patient Chart Review and Survey in Patients with Cryopyrin-associated Periodic Syndromes Treated with Anakinra by Helen J. Lachmann, Renée J.G. Arnold, Marco Gattorno, Isabelle Koné-Paut, Alberto Ferreira, Jasmin Kümmerle-Deschner

“…According to patient recall, 12 of 21 patients (57.1%) discontinued anakinra to enter another clinical trial; of the 12, eight (38%) specifically discontinued anakinra only for that reason, and four patients cited entering a clinical trial as one of many reasons for discontinuing anakinra. …”
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Modulation of gut microbiota in targeted cancer therapy: insights on the EGFR/VEGF/KRAS pathways by Li Gong, Shixue Yang, Junli Huang, Yongsheng Li

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THE USE OF ARTIFICIAL INTELLIGENCE IN THE THERAPEUTIC MANAGEMENT OF PAPILLARY THYROID MICROCARCINOMA: A RANDOMIZED CONTROLLED TRIAL PROTOCOL by Ramona Elena Teiu, Tudor Florin Ursuleanu, Hlescu Cristian Stefan, Roxana Grigorovici, Andreea Roxana Luca, Maria Paula Comanescu, Alina Ionela Calin, Alexandru Grigorovici

“…I will validate this method of diagnosis and prognosis of papillary thyroid cancer, optimized by the artificial intelligence algorithm, by conducting a randomized, controlled clinical trial over a period of 12 months. Results I will validate the diagnostic method by using AI. …”
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Reassessing the Role for Lamivudine in Chronic Hepatitis B Infection: A Four-Year Cohort Analysis by Tahir Shaikh, Curtis Cooper

“…The data supporting the use of antiviral agents other than lamivudine in the management of patients with hepatitis B virus (HBV) infection are based on highly selected clinical trial populations that may not be representative of typical HBV-infected populations encountered in many clinics. …”
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Sedative Effect of Nasal Midazolam-Ketamine at Different Doses on 3-6-year-old Uncooperative Dental Patients by Masoud Fallahinejad Ghajari, Ghassem Ansari, Mostafa Mohaveri, Ahmad Eghbali Zarch, Sajjad Razavi

“…Objectives: This randomized clinical trial compares higher and lower-dose intranasal ketamine/midazolam cocktails in pediatric dentistry.  …”
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Efficacy and safety of Xiongzhitongluo granules in the treatment of acute ischemic stroke: study protocol for a randomized controlled trial by Yunmeng Chen, Jingjing Wei, Xiao Liang, Yue Liu, Lina Miao, Di Zhao, Yunfan Zhang, Hongxi Liu, Yunling Zhang

“…Written informed consent was obtained from all participants.Clinical trial registrationhttps://clinicaltrials.gov/, identifier, ChiCTR2200061859.…”
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Technologically-Treated Polyclonal Affinity-Purified Antibodies to the Tumor Necrosis Factor-α, Brain Specific S-100 Protein and Histamine in Treatment of Functional Dyspepsia: Res... by Yu. O. Shulpekova, I. V. Maev, V. B. Grinevich, I. B. Khlynov, Yu. G. Shvarts, V. T. Ivashkin

“…There were 29 adverse events (AEs) recorded in 25 patients including 16 cases in 13 (8.6 %) patients in Kolofort® group and 13 AEs in 12 (7.6 %) patients in placebo group.Conclusion: the clinical trial demonstrates the positive effect of Kolofort® in FD with a favorable safety profile.…”
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Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis by Ryoji Ichijima, Hisatomo Ikehara, Tomomi Sugita, Daisuke Yamaguchi, Yasuhiko Nagata, Kanako Ogura, Mitsuru Esaki, Yosuke Minoda, Hiroyuki Ono, Yuki Maeda, Shinsuke Kiriyama, Tetsuya Sumiyoshi, Yuichi Kanmura

“…ABSTRACT Aim This study aimed to compare the use of remimazolam and midazolam in upper gastrointestinal endoscopy in Japan as a sub‐analysis of data from an investigator‐initiated clinical trial of remimazolam. Methods and Results Patients in two groups were matched using propensity score matching. …”
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Żywienie a prewencja chorób układu krążenia by Grażyna Nowicka

“…Recent epidemiological and clinical trial data provide evidence of the great effectiveness of dietary interventions in cardiovascular disease prevention and treatment. …”
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Leadless pacemaker implantation in a patient with congenital azygos continuation of the inferior vena cava by Lanyan Guo, Minxia Zhang, Ying Zhao, Qun Yan, Xuyang Feng, Ling Tao

“…Finally, venous computed tomography (CT) angiography was conducted to testify such venous developmental abnormality. Clinical trial number Not applicable…”
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Poor Outcomes in Hepatic Amyloidosis: A Report of 2 Cases by Brandon Yim, Elizabeth Kertowidjojo, Yue Zhang, Pruthvi Patel

“…Currently, there is little literature describing treatment outcomes for biopsy-proven hepatic amyloidosis and current treatment guidelines recommend that patients enroll in a clinical trial due to insufficient evidence to suggest an optimal treatment regimen. …”
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Attitude towards genetic testing for breast cancer susceptibility genes and choice of prevention strategies in Chinese women with or without breast cancer by Xue Yu, Furong Kou, Yuntao Xie

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A Single-Center Retrospective Study of the Impact of Thyroid Cancer on the Malignant Risk of Contralateral TI-RADS 3 and 4 Nodules by Huan Liu, Jun Jin, Qiao Chen, Zhongmin Li

“…This study has been registered with the Chinese Clinical Trial Registry (clinical trial registration number: ChiCTR2000038611, registration time: September 26, 2020).…”
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The effects of lymphocele formation after living donor kidney transplantation on mid-term allograft function by Christian Kuhn, Bernd Jänigen, Laura Matuschik, Max J. Rieger, Daniel Sidler, Stefan Zschiedrich

“…They may reflect a disturbed microvasculature and warrant closer control of cardiovascular risk factors and allograft monitoring of affected patients. Clinical trial details Not applicable, the study is not a clinical trial.…”
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Ultrasound-Guided Thoracic Paravertebral Injection of Platelet-Rich Plasma for the Treatment of Thoracic Herpes Zoster-Related Pain: A Study Protocol by Liu Wang, Xinyu Lei, Zhixuan Lan, Ruilin He, Zongbin Jiang

“…Trial Registration This clinical trial is registered with the Chinese Clinical Trial Registry (ChiCTR) at https://www.chictr.org.cn/index.html (Registration Number: ChiCTR2400087248, Registration Date: 2024–07-23).…”
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Efficacy of Lazolex® Gel in the Treatment of Herpes Simplex Mucocutaneous Infections and the Prevention of Recurrences: A Pilot Study by Tina A. Kituashvili, Vakhtang G. Kvirkvelia, George G. Galdava, Nino G. Archvadze

“…A single-center, single-arm, open-label, phase II clinical trial was conducted with 30 patients divided into two groups: 15 patients with herpes simplex virus type 1 (HSV-1) infections and 15 with herpes simplex virus type 2 (HSV-2). …”
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Angiotensin receptor neprilysin inhibition versus individualized RAAS blockade: design and rationale of the PARALLAX trial by Rolf Wachter, Sanjiv J. Shah, Martin R. Cowie, Peter Szecsödy, Victor Shi, Ghionul Ibram, Ziqiang Zhao, Jianjian Gong, Sven Klebs, Burkert Pieske

“…We sought to compare the effect of ARNI to background‐medication‐based individualized comparators (BMICs) on N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), functional capacity [6 min walk distance (6MWD)], symptoms, and quality of life [Kansas City Cardiomyopathy Questionnaire (KCCQ)] in patients with HF and EF >40% in a randomized clinical trial. Methods PARALLAX is a prospective, randomized, controlled, double‐blind multicentre clinical trial in patients with chronic symptomatic HF with EF >40%, New York Heart Association (NYHA) class II–IV symptoms, elevated natriuretic peptides, and evidence of structural heart disease. …”
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Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

“…These data provide the rationale for the 2 ongoing studies evaluating CPX-351 vs 7+3 in non–MRC-AML and non–t-AML using MRD as the primary end point for ALFA-2101 phase 2 clinical trial and event-free survival for AMLSG 30-18 phase 3 clinical trial.…”
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Antibiotic Prophylaxis in Transarterial Therapy of Hepatocellular Carcinoma: A Meta-Analysis by Jun Wang, Xiao Dong He, You Cheng Zhang

“…Accordingly, this meta-analysis examined clinical trial evidence regarding the effects of prophylactic antibiotic therapy versus no prophylactic treatment with respect to infectious complications in patients undergoing transarterial therapy for HCC.…”
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