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Oncolytic virus OH2 extends survival in patients with PD-1 pretreated melanoma: phase Ia/Ib trial results and biomarker insights
Published 2025-02-01“…NCT04386967 is the clinical trial identifier.Results All 44 patients were enrolled. …”
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Effectiveness of a universal film intervention in reducing violence against children and increasing positive parenting among migrant and displaced caregivers from Myanmar: a commun...
Published 2025-02-01“…The trial was prospectively registered with Thai Clinical Trials Registry TCTR20230222005. Findings: Between February and June 2023, 2249 participants in 44 communities completed baseline assessments and were randomly assigned to intervention (n = 1116) and control (n = 1133). 2023 caregivers (n = 998 in intervention and n = 1025 in control) completed the four-week endline survey and 1909 caregivers (n = 961 in intervention and n = 948 in control) completed the four-month follow-up. …”
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2464
Does pregabalin offer potential as a first-line therapy for generalized anxiety disorder? A meta-analysis of efficacy, safety, and cost-effectiveness
Published 2025-02-01“…Efficacy and safety were evaluated using various scales and adverse events (AEs). Randomized clinical trials were included in the study. Four major databases were used for this study. …”
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Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design.
Published 2024-01-01“…The data and biosamples will allow examination of mechanistic hypotheses and biomarkers, thus providing insights into potential therapeutic interventions.<h4>Clinical trials.gov identifier</h4>Clinical Trial Registration: http://www.clinicaltrials.gov. …”
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Mental health disorder symptom changes among public safety personnel after emotional resilience skills training
Published 2025-04-01“…Trial registration: ClinicalTrials.gov, NCT05530642.…”
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HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals
Published 2024-10-01“…Trial registration: This trial was registered on ClinicalTrials.Gov on June 18, 2024. Registration: NCT06453616.…”
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2469
Sex differences in murine MASH induced by a fructose-palmitate-cholesterol-enriched diet
Published 2025-02-01“…The identification of intrinsic, within-sex, diet-dependent disparities underscores the critical need to include both male and female individuals in MAFLD/MASH studies and clinical trials. Impact and implications:: Despite the importance of metabolic dysfunction-associated steatohepatitis (MASH) in impairment of human health, the potential for and mechanisms of sex-dependent responses have yet to be well-studied, particularly with respect to the possible influence of high-fructose corn syrup additives to the diet, which has been linked to metabolic and hepatic disturbances. …”
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Immune monitoring of trabectedin therapy in refractory soft tissue sarcoma patients - the IMMUNYON study
Published 2025-02-01“…These findings support further research into immune monitoring for future clinical trials.…”
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GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study
Published 2025-02-01“…GWAS meta-analysis combined results from seven cohorts and clinical trials totalling 14,070 statin-treated individuals of European ancestry within the GIST consortium. …”
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Comparable outcomes after busulfan- or treosulfan-based conditioning for allo-HSCT in children with ALL: results of FORUM
Published 2025-02-01“…This trial was registered at www.ClinicalTrials.gov as #NCT01949129.…”
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Jet Injection of Naked mRNA Encoding the RBD of the SARS-CoV-2 Spike Protein Induces a High Level of a Specific Immune Response in Mice
Published 2025-01-01“…<b>Background:</b> Although mRNA vaccines encapsulated in lipid nanoparticles (LNPs) have demonstrated a safety profile with minimal serious adverse events in clinical trials, there is opportunity to further reduce mRNA reactogenicity. …”
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Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials
Published 2024-03-01“…We investigated the safety and immunogenicity of a heterologous prime-boost regimen involving a chimpanzee adenovirus 3 vectored Ebola vaccine [either monovalent (cAd3-EBOZ) or bivalent (cAd3-EBO)] prime followed by a recombinant modified vaccinia virus Ankara EBOV vaccine (MVA-EbolaZ) boost in two phase 1/1b randomized open-label clinical trials in healthy adults in the United States (US) and Uganda (UG). …”
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Exploring the association between tissue sodium content, heart failure subtypes, and symptom burden: insights from magnetic resonance imaging
Published 2025-01-01“…Trial registrationGerman Clinical Trials Register (DRKS), registration number (DRKS00015615).…”
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Characteristics of adherent and non-adherent patients with hypertension in a Norwegian cross-sectional study
Published 2025-02-01“…Adherence was significantly and negatively related to younger age, non-European ethnicity, and increasing number of prescribed antihypertensive pills, and positively to the type of prescribed medication, especially angiotensin receptor blocker (www.ClinicalTrials.gov identifier: NCT03209154).…”
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Hybrid versus vaccine immunity of mRNA-1273 among people living with HIV in East and Southern Africa: a prospective cohort analysis from the multicentre CoVPN 3008 (Ubuntu) studyRe...
Published 2025-02-01“…The ongoing Ubuntu study is registered on ClinicalTrials.gov (NCT05168813) and this work was conducted from December 2021 to March 2023. …”
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First-Line Chemo-Immunotherapy in SCLC: Outcomes of a Binational Real-World Study
Published 2025-01-01“…This retrospective study aims to evaluate the real-world effectiveness of chemo-immunotherapy in patients with ES-SCLC, focusing on subpopulations excluded from clinical trials. Methods: A retrospective binational multicenter study was conducted, involving consecutive patients with ES-SCLC from 10 British and 10 Swiss institutions. …”
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Factors Contributing to Retention in Care and Treatment Adherence Among People Living With HIV Returning to Care in South-Eastern Tanzania: A Qualitative Study
Published 2025-02-01“…Ndege1. 1, Agatha Ngulukila1. 1, Alex John Ntamatungiro1. 16. 67. 7, Vaileth Nyaenza3. 310. 1011. 11, Emmanuel Nyenza1. 1, Amina Nyuri1. 1, James Okuma4. 45. 5, Ally Olotu1. 1, Daniel H Paris4. 45. 5, Martin Rohacek1. 14. 45. 5, Leila Samson1. 1, Elizabeth Senkoro1. 1, George Sigalla1. 1, Joseph Singo1. 1, Jamali B Siru1. 1, Jenifa Tarimo1. 1, Albart R Malabe3. 310. 1011. 11, Juerg Utzinger4. 45. 5, Fiona Vanobberghen4. 45. 5, Maja Weisser1. 14. 45. 510. 10, John Wigay1. 1, Lulu Wilson1. 1 On behalf of the KIULARCO Study Group1Interventions and Clinical Trials Department, Ifakara Health Institute, Morogoro, Tanzania; 2School of Life Science and Bioengineering, The Nelson Mandela African Institute of Science and Technology, Tengeru, Arusha, Tanzania; 3Department of Health Services, Mzumbe University, Mbeya, Tanzania; 4Department of Secondary Education, Singida, Tanzania; 5Chronic Disease of Ifakara, St. …”
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Clinical impact of [18F]FDG-PET/CT in ARI0002h treatment, a CAR-T against BCMA for relapsed/refractory multiple myeloma
Published 2025-02-01“…This trial was registered at www.ClinicalTrials.gov as #NCT04309981; and EudraCT, 2019-001472-11.…”
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