ULACNet-301, OPTIMO protocol: optimizing HPV vaccination regimen for cancer prevention in children and adolescents living with HIV by Delia Pinto-Santini, Emilia M. Jalil, Giovana Teixeira Fernandes, Genevieve Hilaire, Lenka Kolevic, Robinson Cabello, Beatriz Grinsztejn, William Pape, Marie Marcelle Deschamps, Margaret G. House, Emma Brofsky, Vikrant V. Sahasrabuddhe, Sayan Dasgupta, Siavash Pasalar, Margaret M. Madeleine, Joseph Carter, Priya R. Prabhu, Denise Galloway, Ann Duerr

“…Trial registration ClinicalTrials.gov NCT04265950.…”
Get full text

The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity by Chiara Pesenti, Stefania Elena Navone, Laura Guarnaccia, Andrea Terrasi, Jole Costanza, Rosamaria Silipigni, Silvana Guarneri, Nicola Fusco, Laura Fontana, Marco Locatelli, Paolo Rampini, Rolando Campanella, Silvia Tabano, Monica Miozzo, Giovanni Marfia

“…Despite countless experimental researches for new therapeutic strategies and promising clinical trials, the prognosis remains extremely poor, with a mean survival of less than 14 months. …”
Get full text

Integrating Videoconferencing Therapist Guidance Into Stepped Care Internet-Delivered Cognitive Behavioral Therapy for Child and Adolescent Anxiety: Noninferiority Randomized Contr... by Sonja March, Susan H Spence, Larry Myers, Martelle Ford, Genevieve Smith, Caroline L Donovan

“…Trial RegistrationAustralian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12618001418268; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?…”
Get full text

Clinical benefits and risks of remote patient monitoring: an overview and assessment of methodological rigour of systematic reviews for selected patient groups by Constanze Wartenberg, Helen Elden, Malte Frerichs, Lennart L Jivegård, Kajsa Magnusson, Georgios Mourtzinis, Ola Nyström, Kajsa Quitz, Helen Sjöland, Therese Svanberg, Helena Vallo Hult

“…Methods A literature search for systematic reviews of clinical trials on remote patient monitoring in the selected patient groups was conducted by two information specialists, followed by assessment of relevance by a team of clinical and methodological experts in Region Västra Götaland, Sweden. …”
Get full text

Increased risk for alcohol- and other substance-exposed pregnancies among women who smoke tobacco: A secondary analysis of a primary care-based intervention by Thomas F. Northrup, Angela L. Stotts, Stephen M. Fischer, Kirk L. von Sternberg, Mary M. Velasquez

“…Primary care providers should screen for alcohol and tobacco co-use and provide brief intervention and/or treatment referral. CLINICAL TRIAL REGISTRATION The study was registered on the official website of ClinicalTrials.gov IDENTIFIER ID NCT01032772…”
Get full text

Validating a clinically based MS-MLPA threshold through comparison with Sanger sequencing in glioblastoma patients by Halka Lhotska, Karolina Janeckova, Hana Cechova, Jaromir Macoun, Tatiana Aghova, Libuse Lizcova, Karla Svobodova, Lucie Hodanova, Dora Konecna, Jiri Soukup, Filip Kramar, David Netuka, Zuzana Zemanova

Get full text

WATER versus WATER II 5‐year update: Comparing Aquablation therapy for benign prostatic hyperplasia in 30–80‐cm3 and 80–150‐cm3 prostates by Mohamad Baker Berjaoui, David‐Dan Nguyen, Saud Almousa, Karim Daher, Neil Barber, Mo Bidair, Peter Gilling, Paul Anderson, Kevin C. Zorn, Gopal Badlani, Mitch Humphreys, Steven Kaplan, Ronald P. Kaufman Jr, Dean Elterman, Mihir Desai, Claus Roehrborn, Naeem Bhojani

“…In parallel, WATER II (W‐II; NCT03123250), a prospective, multicentre, single‐arm international clinical trial, explores Aquablation outcomes in prostates ranging from 80 to 150 cm3. …”
Get full text

The Effects of MyChoices and LYNX Mobile Apps on HIV Testing and Pre-Exposure Prophylaxis Use by Young US Sexual Minority Men: Results From a National Randomized Controlled Trial by Katie B Biello, Kenneth H Mayer, Hyman Scott, Pablo K Valente, Jonathan Hill-Rorie, Susan Buchbinder, Lucinda Ackah-Toffey, Patrick S Sullivan, Lisa Hightow-Weidman, Albert Y Liu

“…Trial RegistrationClinicalTrials.gov NCT03965221; https://clinicaltrials.gov/study/NCT03965221…”
Get full text

Path model explaining the association between fear of falling and health-related quality of life in (pre-)frail older adults by Tjard Sattler, Sophie Gottschalk, Hans-Helmut König, Tobias Braun, Gisela Büchele, Michael Denkinger, Tim Fleiner, Corinna Nerz, Kilian Rapp, Martina Schäufele, Christian Werner, Judith Dams

“…Trial registration German Clinical Trials Register, ID: DRKS00024638, https://drks.de/search/en/trial/DRKS00024638 , date of registration: March 11th 2021.…”
Get full text

Modulation of brain activity in brain-injured patients with a disorder of consciousness in intensive care with repeated 10-Hz transcranial alternating current stimulation (tACS): a... by David Williamson, Francis Bernard, Stefanie Blain-Moraes, Caroline Arbour, Virginie Williams, Louis de Beaumont, Catherine Duclos, Béatrice P De Koninck, Daphnee Brazeau, Amelie A Deshaies, Marie-Michele Briand, Charlotte Maschke

“…The trial’s results will be published on a public trial registry database (ClinicalTrials.gov).Trial registration number NCT05833568.…”
Get full text

Safety and efficacy of filgotinib in patients with rheumatoid arthritis: final results of the DARWIN 3 long-term extension study by Arthur Kavanaugh, Paul Emery, René Westhovens, Mark C Genovese, Kevin L Winthrop, Rieke Alten, Dick de Vries, Lorenzo Dagna, Patrick Verschueren, Maria Greenwald, Regina Cseuz, Robin Besuyen, Vikas Modgill, Ly Huong Le

“…Objectives DARWIN 3 (ClinicalTrials.gov: NCT02065700) assessed the safety and efficacy of filgotinib in a long-term extension (LTE) of two phase II randomised controlled rheumatoid arthritis (RA) trials.Methods Eligible patients completing the 24-week DARWIN 1 (filgotinib plus methotrexate) and DARWIN 2 (filgotinib monotherapy) trials could enrol. …”
Get full text

Exploring the Feasibility of a 5-Week mHealth Intervention to Enhance Physical Activity and an Active, Healthy Lifestyle in Community-Dwelling Older Adults: Mixed Methods Study by Kim Daniels, Sharona Vonck, Jolien Robijns, Kirsten Quadflieg, Jochen Bergs, Annemie Spooren, Dominique Hansen, Bruno Bonnechère

“…Trial RegistrationClinicalTrials.gov NCT05650515; https://clinicaltrials.gov/study/NCT05650515…”
Get full text

Human versus Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings (HumAn-1): protocol for a randomised controlled trial by Éimhín Ansbro, Jing Luo, Chung-Chou H Chang, Kaushik Ramaiya, Bruce L Rollman, Sylvia Kehlenbrink, Sae-Rom Chae, Abigail Foulds, Claire Josey, Christina Lalama, Margaret L Prust, Bedowra Zabeen, Graham Ogle

“…Findings will also be shared at local, regional and international scientific meetings.Trial registration number ClinicalTrials.gov: NCT05614089.…”
Get full text

Patient Voices: Multimethod Study on the Feasibility of Implementing Electronic Patient-Reported Outcome Measures in a Comprehensive Cancer Center by Cinzia Brunelli, Sara Alfieri, Emanuela Zito, Marco Spelta, Laura Arba, Linda Lombi, Luana Caselli, Augusto Caraceni, Claudia Borreani, Anna Roli, Rosalba Miceli, Gabriele Tine', Ernesto Zecca, Marco Platania, Giuseppe Procopio, Nicola Nicolai, Luigi Battaglia, Laura Lozza, Morena Shkodra, Giacomo Massa, Daniele Loiacono, Giovanni Apolone

“…Trial RegistrationClinicalTrials.gov NCT03968718; https://clinicaltrials.gov/study/NCT03968718…”
Get full text

Do preoperative interventions affect patient satisfaction or expectation fulfilment following total hip arthroplasty? A systematic review by April-Rose Matt, Joanne L. Kemp, Andrea B. Mosler, Lucy Salmon, Diogo Almeida Gomes, Alysha De Livera, Erica Hateley, Adam L. Semciw

“…Methods: MEDLINE, EMBASE, Cochrane Register of Clinical Trials, CINAHL and Sports Discus were searched from inception to May 2023. …”
Get full text

Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by reducing CCL2-mediated macrophage infiltration in sensory ganglia and sciatic nerve by Yuanyuan Li, Ruoyao Xu, Muyan Chen, Kaige Zheng, Huimin Nie, Chengyu Yin, Boyu Liu, Yan Tai, Junying Du, Jie Wang, Jianqiao Fang, Boyi Liu

“…Conventional medications lack effectiveness on PIPN. Clinical trials identified beneficial effects of acupuncture on PIPN among patients receiving chemotherapy. …”
Get full text

Comprehensive coronary CT angiography in people living with HIV: a systematic review and meta-analysis by Binh T Nguyen, Edward Hulten, Venkatesh L Murthy, Tarin Phillips, Gregory M Blake, Jonathan A Aun, Lisa M Conte, Ritika Gadodia, Aakash Tuli, Sara L Robinson, Travis E Harrell

“…This systematic review and meta-analysis summarise and estimate pooled effect sizes for observational studies among PLWH using comprehensive coronary CT angiography (CTA).Design Preferred Reporting Items for Systematic Review and Meta-analysis reporting guidelines were used.Data sources PubMed, Embase, Web of Science, CINAHL, Cochrane Clinical Trials and EBM were searched from inception to 23 February 2024.Eligibility criteria We included studies evaluating coronary atherosclerosis in adult PLWH with controls and CTA results for plaque prevalence, extent, severity and high-degree stenosis.Data extraction and synthesis Two independent reviewers used standardised methods to screen for relevance by title, abstract and full-text review. …”
Get full text

Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects by Massimo Mammucari, Enrica Maggiori, Domenico Russo, Chiara Giorgio, Gianpaolo Ronconi, Paola E Ferrara, Flora Canzona, Luciano Antonaci, Bartolomeo Violo, Renato Vellucci, Domenico Rocco Mediati, Alberto Migliore, Umberto Massafra, Barbara Bifarini, Fabio Gori, Massimo di Carlo, Stefano Brauneis, Teresa Paolucci, Piergiovanni Rocchi, Anna Cuguttu, Raffaele Di Marzo, Alessandro Bomprezzi, Stefania Santini, Manuela Giardini, Anna Rosa Catizzone, Fiammetta Troili, Dario Dorato, Alessandra Gallo, Costanza Guglielmo, Silvia Natoli

“…Despite the lack of randomized clinical trials in some fields of application, a general consensus is also reached in nonpharmacological mechanism of action, the technique execution modalities, the scientific rationale to apply it in some indications, and the usefulness of the informed consent. …”
Get full text

Clinical Study of Sentinel Lymph Node Detection to Evaluate Pelvic Lymph Node Metastasis to Determine the Prognosis of Patients with Early Cervical Cancer by Peipei Li, Shuai Feng, Guodong Zhou, Lu Zhang, Xiugui Sheng, Dapeng Li

“…In our study, we believe that SLN biopsy is feasible when the tumor is ≦ 4 cm. Large scale clinical trials are required in China expand the sample size and validate the results of this study.…”
Get full text

The modern options of chronic hepatitis C antiviral therapy with daclatasvir: results of named patient program by V. T. Ivashkin, M. V. Mayevskaya, D. T. Abdurakhmanov, I. G. Bakulin, N. I. Geyvandova, M. L. Zubkin, S. N. Kizhlo, A. V. Kuznetsova, I. B. Latysheva, N. A. Mamonova, V. G. Morozov, O. I. Sagalova, Ye. V. Esaulenko, Ye. O. Lyusina

“…Before official registration of interferon-free treatment modes in 2015 experience of the application was limited to clinical trials or treatment within early approach programs. …”
Get full text