Mouthwash with Active Oxygen (blue®m) Reduces Postoperative Inflammation and Pain by Bruna Marca Mattei, Soraia A. W. Imanishi, Grasieli de Oliveira Ramos, Paloma Santos de Campos, Suyany Gabriely Weiss, Tatiana Miranda Deliberador

“…It is suggested that blue®m mouthwash positively influences tissue healing reducing pain and the postsurgical inflammatory process; however, randomized clinical trials should be done to prove this clinical observation.…”
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Discovery of novel PRMT1 inhibitors: a combined approach using AI classification model and traditional virtual screening by Jungan Zhang, Yixin Ren, Yixin Ren, Yun Teng, Han Wu, Jingsu Xue, Lulu Chen, Xiaoyue Song, Yan Li, Ying Zhou, Zongran Pang, Zongran Pang, Hao Wang, Hao Wang, Hao Wang

“…Although extensive research has been conducted on PRMT1, the reported inhibitors have not successfully passed clinical trials. In this study, deep learning was employed to analyze the characteristics of existing PRMTs inhibitors and to construct a classification model for PRMT1 inhibitors. …”
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Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury by Mariusz Sieminski, Michalina Reimus, Maria Kałas, Ewelina Stępniewska

“…This review summarizes data from in vitro studies, animal models, and clinical trials that focus on the usage of melatonin in TBI.…”
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Steroid-Refractory Acute GVHD: Predictors and Outcomes by Jason R. Westin, Rima M. Saliba, Marcos De Lima, Amin Alousi, Chitra Hosing, Muzaffar H. Qazilbash, Issa F. Khouri, Elizabeth J. Shpall, Paolo Anderlini, Gabriela Rondon, Borje S. Andersson, Richard Champlin, Daniel R. Couriel

“…Patients who fail to respond to steroids by day 14 should be considered for clinical trials. Severity of aGVHD, hyperacute GVHD, and sex mismatch could be integrated into prognostic scoring systems which may allow for pretreatment identification of patients unlikely to benefit from standard therapy with corticosteroids.…”
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Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects by Yelei Guo, Yao Wang, Weidong Han

“…Recent studies have highlighted the successes of chimeric antigen receptor-modified T- (CART-) cell-based therapy for B-cell malignancies, and early phase clinical trials have been launched in recent years. The few published clinical studies of CART cells in solid tumors have addressed safety and feasibility, but the clinical outcome data are limited. …”
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Stem Cell Tracking Technologies for Neurological Regenerative Medicine Purposes by Yongtao Zheng, Jiongwei Huang, Tongming Zhu, Ronggang Li, Zhifu Wang, Fukai Ma, Jianhong Zhu

“…The growing field of stem cell therapy is moving toward clinical trials in a variety of applications, particularly for neurological diseases. …”
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Gene Therapy for Parkinson's Disease by Rachel Denyer, Michael R. Douglas

“…This paper summarises the theoretical approaches to gene therapy for Parkinson's disease and the findings of clinical trials in this rapidly changing field.…”
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Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems by Matteo Perra, Ines Castangia, Matteo Aroffu, Federica Fulgheri, Rita Abi-Rached, Maria Letizia Manca, Hernán Cortés, María Luisa Del Prado-Audelo, Carla Nomura-Contreras, Alejandra Romero-Montero, Dietrich Büsselberg, Gerardo Leyva-Gómez, Javad Sharifi-Rad, Daniela Calina

“…Despite their potential, early clinical trials faced challenges due to severe side effects, prompting advancements in delivery systems such as antibody-maytansinoid conjugates (AMCs). …”
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Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects by Yufei Wang, Guangliang Li, Hanying Wang, Quan Qi, Xian Wang, Haiqi Lu

“…Nectin-4-targeted approaches, such as ADCs, oncolytic viruses, photothermal therapy and immunotherapy, have shown promising results in early-phase clinical trials. These therapies offer novel strategies for delivering targeted treatments to Nectin-4-expressing cancer cells, enhancing treatment efficacy and minimizing off-target effects. …”
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Artificial intelligence-based video monitoring of movement disorders in the elderly: a review on current and future landscapes by Kye Won Park, Maryam S Mirian, Martin J McKeown

“…The AI-based video monitoring systems offer improved efficiency and objectivity in remote patient monitoring, enabling real-time analysis of data, more uniform outcomes and augmented support for clinical trials. However, challenges, such as video quality, privacy compliance and noisy training labels, during development need to be addressed. …”
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Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold by J. M. Keppel Hesselink, Tineke de Boer, Renger F. Witkamp

“…However, it is less known that 6 clinical trials in a total of nearly 4000 people were performed and published last century, specifically studying PEA as a therapy for influenza and the common cold. …”
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The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia by Majd A. Al-Hamaly, Evelyn Winter, Jessica S. Blackburn

“…Mitocans have shown promise in T-ALL both in vitro and in vivo, with some currently in early-phase clinical trials. However, due to challenges in studying LSCs in T-ALL, our understanding of how mitochondrial function influences self-renewal remains limited. …”
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Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab by Taylor Pindi Sala, Jean-Marie Michot, Renaud Snanoudj, Marion Dollat, Emmanuel Estève, Bernadette Marie, Yacine Taoufik, Jean-François Delfraissy, Thierry Lazure, Olivier Lambotte

“…This new case of successful use of rituximab in HSP promotes more investigations of this treatment in clinical trials.…”
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Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges by Lipska Katarzyna, Gumieniczek Anna, Filip Agata A.

“…As a consequence, some pre-clinical and clinical trials were carried out to estimate anticancer effectiveness of VPA, in monotherapy and in new drug combinations, while other SCFAs were tested in pre-clinical studies. …”
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HIV-Related Immune Activation and Inflammation: Current Understanding and Strategies by Tingxia Lv, Wei Cao, Taisheng Li

“…To date, several clinical interventions or treatment candidates undergoing clinical trials have been proposed to combat this systemic immune activation/inflammation. …”
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Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies by Marie-Noëlle Giraud, Anne Géraldine Guex, Hendrik T. Tevaearai

“…The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells. …”
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Toxicological Review of Anticancer Plants Used in Traditional Medicine in Morocco by Soufiane Drioua, Abha Cherkani-Hassani, Otman El-Guourrami, Mouna Ameggouz, Ahmed Zahidi, Abdelhakim Bouyahaya, Sayyed Ibrahim Shah, Yaser Mohammed Al-Worafi, Long Chiau Ming, Hanane Benzaied, Anass Doukkali

“…Further research, including preclinical and clinical trials, should be conducted to investigate the potential therapeutic benefits of these plants. …”
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A Case of Non-Small Cell Lung Cancer with Possible “Disease Flare” on Nivolumab Treatment by Shotaro Chubachi, Hiroyuki Yasuda, Hidehiro Irie, Koichi Fukunaga, Katsuhiko Naoki, Kenzo Soejima, Tomoko Betsuyaku

“…Background. Recent clinical trials proven the clinically significant efficacy and tolerability of nivolumab, a programmed death 1 (PD-1) inhibitor, in previously treated patients with non-small cell lung cancer (NSCLC). …”
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Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma by Fabio Morandi, Francesco Frassoni, Mirco Ponzoni, Chiara Brignole

“…Indeed, several immunotherapeutic clinical trials have been performed and some of them also resulted beneficial. …”
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Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers? by M. W. Saif, B. Fallon, K. N. Syrigos

“…Recent developments in the understanding of the pathogenesis of ACC have led to multiple clinical trials involving targeted agents in the management of ACC. …”
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