The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes by M. C. Thomas, K. A. Jandeleit-Dahm, C. Tikellis

“…This review will examine these direct and indirect actions of PPAR agonists in the diabetic kidney and explore recent findings of clinical trials of PPAR agonists in patients with diabetes.…”
Get full text

Weighted Wilcoxon-Type Rank Test for Interval Censored Data by Ching-fu Shen, Jin-long Huang, Chin-san Lee

“…Interval censored (IC) failure time data are often observed in medical follow-up studies and clinical trials where subjects can only be followed periodically, and the failure time can only be known to lie in an interval. …”
Get full text

Histone Deacetylases Inhibitors in the Treatment of Retinal Degenerative Diseases: Overview and Perspectives by Hua Zhang, Xufeng Dai, Yan Qi, Ying He, Wei Du, Ji-jing Pang

“…Several HDACis have been approved for clinical trials to treat cancer. Studies have shown that HDACis have neuroprotective effects in nervous system damage. …”
Get full text

New Strategies in the Treatment of Ta-T1 Transitional Cell Carcinoma (TCC) of the Bladder by Maurizio A. Brausi

“…Furthermore, new chemotherapeutic drugs for intravesical use are being investigated in various clinical trials, with gemcitabine showing particularly promising results. …”
Get full text

Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease by Qingdong Guan, Jiguo Zhang

“…In this review, we will discuss the recent advances of novel biologics in clinics and clinical trials, and novel proinflammatory and anti-inflammatory cytokines found in IBD with focusing on IL-12 family and IL-1 family members as well as their relevance to the potential therapy of IBD.…”
Get full text

Clinical Outcomes of Specific Immunotherapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis by Jiang Chen, Guo Xiao-Zhong, Xing-Shun Qi

“…To evaluate the clinical outcomes of PC-specific immunotherapy, we performed a systematic review and meta-analysis of the relevant published clinical trials. The effects of specific immunotherapy were compared with those of nonspecific immunotherapy and the meta-analysis was executed with results regarding the overall survival (OS), immune responses data, and serum cancer markers data. …”
Get full text

Comprehensive review of myocardial injury after noncardiac surgery: prevention, intervention, and long-term management strategies by Moiud Mohyeldin, Sarah J. Norman, Ayzia Carney, Courtney Odza

“…We discuss the role of aspirin, statins, anticoagulation, and Dual Antiplatelet Therapy (DAPT) within the context of MINS, drawing on evidence from notable clinical trials as well as observational studies. Despite advancements in understanding and managing MINS, the condition continues to be associated with high mortality and major adverse cardiovascular events (MACE), underscoring the need for ongoing research and development of more effective management protocols.…”
Get full text

Systematic review and meta-analysis of the effect of zinc on wound healing by Nazanin Zand, Elena Arribas Lopez, Omorogieva Ojo, Tony Kochhar

“…The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and included data from four electronic data bases. Five clinical trials met the inclusion criteria. The meta-analysis suggested that zinc treatment may be associated with improvements in ulcers healing at the final endpoint MD: 1.41 (95% CI 1.04, 1.92, p = 0.03). …”
Get full text

Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease by Ai-Ling Lin, Angela R. Laird, Peter T. Fox, Jia-Hong Gao

“…Further developments of these techniques and the establishment of promising neuroimaging biomarkers will enhance our ability to diagnose aMCI and AD in their early stages and improve the assessment of therapeutic efficacy in these diseases in future clinical trials.…”
Get full text

Hypertension in the Elderly by Blas Gil-Extremera, Pedro Cía-Gómez

“…Methods. we analysed some significant clinical trials in order to present the relevant findings on those hypertensive population. …”
Get full text

Systematic scoping review of the concept of 'genetic identity' and its relevance for germline modification. by Floor M Goekoop, Carla G van El, Guy A M Widdershoven, Nadza Dzinalija, Martina C Cornel, Natalie Evans

“…EU legislation prohibits clinical trials that modify germ line 'genetic identity'. …”
Get full text

“Lost in translation?” Animal research in the era of precision medicine by Hamideh Frühwein, Norbert W. Paul

“…Abstract Preclinical animal research has long been a cornerstone in evaluating the efficacy, toxicity, and safety of potential drug treatments before they proceed to human clinical trials. However, given the intricate nature of human physiology and the complexities of diseases such as cancer, this paper critically examines the role of animal experimentation in translational research, both from epistemological and ethical viewpoints. …”
Get full text

Penile Rehabilitation Therapy with PDE-V Inhibitors Following Radical Prostatectomy: Proceed with Caution by M. Eric Brewer, Edward D. Kim

“…Despite the current enthusiasm of penile rehabilitation therapy, current scientific evidence with clinical trials is still limited.…”
Get full text

Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes by Kazuya Kusama, Kodai Oka, Yumi Yashiro, Kanoko Yoshida, Hiroaki Miyaoka, Kazuhiro Tamura

“…Further studies, including clinical trials, are required to validate the clinical potential of cordycepin.…”
Get full text

Antioxidants in Kidney Diseases: The Impact of Bardoxolone Methyl by Jorge Rojas-Rivera, Alberto Ortiz, Jesus Egido

“…We now review the biological bases of oxidative stress and its role in kidney diseases, with focus on diabetic nephropathy, as well as the role of the Keap1-Nrf2 pathway and recent clinical trials targeting this pathway with bardoxolone methyl.…”
Get full text

The Informed Consent in Allergology from a Scientific, Technological and Social Perspective by Marisela Luisa Pérez Pacaréu, Yanet Morejón del Rosario, Gloria Arlenys Suárez Rodríguez, Aleima Rodríguez Carbajal

“…This paper reviews the application of the informed consent within the specialty of allergology in procedures (skin tests), therapeutic interventions (immunotherapy) and research (clinical trials) from a scientific, technological and social perspective, based on the advances achieved in Cuba in recent years to obtain better allergenic extracts for testing, high-quality vaccines and new drugs to benefit the allergic patient. …”
Get full text

Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention? by Fredric J. Pashkow

“…The recognition of the critical importance of oxidative stress has led to the enthusiastic use of antioxidants in the treatment and prevention of heart disease, but the results of prospective, randomized clinical trials have been overall disappointing. Can this contradiction be explained and what are its implications for the discovery/development of future antioxidant therapeutics?…”
Get full text

Multiple Culprit Coronary Artery Thrombosis in a Patient with Coronary Ectasia by Bruno da Silva Matte, Gustavo Neves de Araujo, Felipe Homem Valle, Ana Maria Rocha Krepsky

“…Although routine aspiration thrombectomy in STEMI was not proven to be beneficial in randomized clinical trials, it was of great value in this case. We also discuss the relation between coronary ectasia, chronic inflammatory status, and increased platelet activity which may have caused plaque disruption in another already vulnerable vessel.…”
Get full text

Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities by Aiman B. Awan, Maryiam Jama Ali Osman, Omar M. Khan

“…We also discussed the recent update on small-molecule inhibitors and PROTACs and their progress in preclinical and clinical trials.…”
Get full text

Endoscopic Ultrasound-Guided Intratumoural Therapy for Pancreatic Cancer by Brian M Yan, Jacques Van Dam

“…The therapeutic modalities discussed are currently under development and will hopefully reach clinical practice if benefit is demonstrated through clinical trials. EUS FNI may be an exciting new technique for the delivery of desperately needed novel therapies for pancreatic cancer.…”
Get full text