PD-1 Blockade in Advanced Melanoma in Patients with Hepatitis C and/or HIV by Diwakar Davar, Melissa Wilson, Chelsea Pruckner, John M. Kirkwood

“…We argue for the further investigation of checkpoint inhibition in cancer patients with underlying chronic viral infections in the context of carefully designed clinical trials.…”
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Endoscopic Dilation with Bougies versus Balloon Dilation in Esophageal Benign Strictures: Systematic Review and Meta-Analysis by Iatagan R. Josino, Antônio C. Madruga-Neto, Igor B. Ribeiro, Hugo G. Guedes, Vitor O. Brunaldi, Diogo T. H. de Moura, Wanderley M. Bernardo, Eduardo G. H. de Moura

“…We included 5 randomized clinical trials (RCTs), totalizing 461 patients. Among them, 151 were treated with bougie dilation and 225 underwent balloon dilation. …”
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The Role of Lactobacillus reuteri DSMZ17648 for Helicobacter pylori eradication therapy (Review of literature and advisory council resolution, February 28, 2018) by V. T. Ivashkin, O. P. Alekseyeva, A. Yu. Baranovsky, Ye. K. Baranskaya, Ye. V. Beloborodova, T. A. Kolesov, N. V. Korochanskaya, K. . Lang, T. L. Lapina, I. V. Mayev, M. V. Mokshina, D. L. Nepomnyashchy, Ye. V. Onuchina, R. G. Sayfutdinov, T. H. Sviridova, V. I. Simanenkov, A. V. Tkachev, A. S. Trukhmanov, L. P. Faizova, I. B. Khlynov, O. B. Khlynova, A. A. Sheptulin

“…Potential of PylopassTM combination to various H. pylori eradication therapy modes is a subject offutnet multicenter randomized clinical trials for assessment of optimal combination to antibiotic drugs, treatment duration and adverse effect rates. …”
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Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy by Amaury Herbet, Marie Hautière, Frédéric Jean-Alphonse, Delphine Vivier, Christophe Leboeuf, Narciso Costa, Aloïse Mabondzo, Guilhem Bousquet, Franck Denat, Eric Reiter, Didier Boquet

“…Conclusions xiRB49-MMAE is a promising drug candidate for clinical trials in ETB + tumors. RB49 could be used as a diagnostic tool for patient stratification.…”
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How Many Diseases Are Colorectal Cancer? by A. Greystoke, S. A. Mullamitha

“…This disease heterogeneity leads to challenges in the design of clinical trials to assess novel therapies in the treatment of “colorectal cancer.”…”
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Pioglitazone versus Rosiglitazone: Effects on Lipids, Lipoproteins, and Apolipoproteins in Head-to-Head Randomized Clinical Studies by Mark A. Deeg, Meng H. Tan

“…In this review, we will focus on the randomized clinical trials that directly compared the lipid effects of the thiazolidinedione class of PPAR𝛾 agonists, pioglitazone and rosiglitazone, head-to-head either as monotherapy or in combination with other lipid-altering or glucose-lowering agents…”
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Stem Cell Therapy for Treatment of Stress Urinary Incontinence: The Current Status and Challenges by Shukui Zhou, Kaile Zhang, Anthony Atala, Oula Khoury, Sean V. Murphy, Weixin Zhao, Qiang Fu

“…In this paper, we review recent publications and clinical trials investigating the applications of several stem cell types as potential treatments for SUI and the underlying challenges of such therapy.…”
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Phase II study with sorafenib plus radiotherapy for advanced HCC with portal and/or hepatic vein tumor thrombosis by Yirui Zhai, Liming Wang, Hong Zhao, Fan Wu, Lingxia Xin, Feng Ye, Wei Sun, Yan Song, Lijuan Niu, Huiying Zeng, Jingbo Wang, Yuan Tang, Yongwen Song, Yueping Liu, Hui Fang, Ningning Lu, Hao Jing, Shunan Qi, Wenwen Zhang, Shulian Wang, Ye-Xiong Li, Jianxiong Wu, Bo Chen

“…This phase II trial shows that concurrent sorafenib and radiotherapy is effective and well-tolerated in the treatment of advanced HCC with portal vein or hepatic vein tumor thrombosis. Clinical trials registration: This study is registered at ClinicalTrials.gov (NCT03535259).…”
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Safety profile of sacituzumab govitecan in patients with breast cancer: A systematic review and meta-analysis by Maria Inez Dacoregio, Isabella Michelon, Caio Ernesto do Rego Castro, Francisco Cezar Aquino de Moraes, Guilherme Rossato de Almeida, Lis Victória Ravani, Maysa Vilbert, Ricardo Lima Barros Costa

“…Methods: We comprehensively searched PubMed, Embase, and Cochrane databases, and ASCO and ESMO websites for clinical trials (CTs) assessing the safety of SG in BC patients. …”
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Automatic tool for the reconciliation of serious adverse events for pharmacovigilance: design and implementation of Reconciliaid by Sara Contu, Renaud Schiappa, Yann Chateau, Emmanuel Chamorey

“…Background: Reporting serious adverse events (SAEs) is crucial to reduce or avoid toxicities that can lead to major consequences for patient’s health due to treatments tested in clinical trials. Its exhaustiveness is often inadequate, and we observe discrepancies between data published by pharmacovigilance organizations and clinical databases. …”
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Screening for Atrial Fibrillation by Digital Health Technology in Older People in Homecare Settings: A Feasibility Trial by Edvard Liljedahl Sandberg, Sigrun Halvorsen, Trygve Berge, Jostein Grimsmo, Dan Atar, Bjørnar Leangen Grenne, Jarle Jortveit

“…Users of homecare services are often excluded from clinical trials due to advanced age, multimorbidity, and frailty. …”
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A Reduction in ADAM17 Expression Is Involved in the Protective Effect of the PPAR-α Activator Fenofibrate on Pressure Overload-Induced Cardiac Hypertrophy by Si-Yu Zeng, Hui-Qin Lu, Qiu-Jiang Yan, Jian Zou

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Influence of nutritional status on rehabilitation efficacy of patients after stroke—a scoping review by Huan Chen, Caihong Fu, Weihao Fang, Zhenyao Wang, Dawei Zhang, Hu Zhang

“…The selection was restricted to randomized controlled clinical trials, irrespective of language or publication date. …”
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Alloreactivity of Allogeneic Mesenchymal Stem/Stromal Cells and Other Cellular Therapies: A Concise Review by Kiran Shah, Nirali Shah, Fatameh Ghassemi, Carolyn Ly, Teena George, Carla Lutz, Huseyin Sumer

“…In the current pandemic, clinical trials have begun in many parts of the world to treat severe cases of COVID with MSCs. …”
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The work of return to work. Challenges of returning to work when you have chronic pain: a meta-ethnography by Martin Underwood, Mary Grant, Kate Seers, Robert Froud, Joanne O-Beirne-Elliman

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Awardee Summary of 2023 Taiwan Oncology Society Clinical Research Award Recipient: Persistent Endeavors on Research of Digestive Cancers for Three Decades by Kun-Huei Yeh

“…Our team has made persistent endeavors in translational research and clinical trials of digestive cancers for almost three decades. …”
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Efficacy and safety of pharmacological treatments in inclusion body myositis: a systematic review by Pedro M Machado, Eduardo José Ferreira Santos, Nicholas Yapp, Pedro Sousa, Bayram Farisogullari, Hermaleigh Townsley

“…The search strategy was run on Cochrane Neuromuscular Disease Group Specialized Register, CENTRAL, MEDLINE and EMBASE, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform. …”
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Role of Signaling Transduction Pathways in Development of Castration-Resistant Prostate Cancer by Takahiro Inoue, Osamu Ogawa

“…Great advances in our understanding of the biological and molecular mechanisms of prostate cancer progression have resulted in many clinical trials of numerous targeted therapies. In this paper, we review mechanisms of CRPC development, with particular focus on recent advances in the understanding of specific intracellular signaling pathways participating in the proliferation of CRPC cells.…”
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Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside Roadmap by Manuel Mazo, Miriam Araña, Beatriz Pelacho, Felipe Prosper

“…In this review, we will focus on their use in the therapy of myocardial infarction, looking at their characteristics, in vitro and in vivo mechanisms of action, as well as clinical trials.…”
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Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens? by E. Pontali, M. Raviglione

“…In June 2024, WHO released ‘Key updates to the treatment of drug-resistant tuberculosis: rapid communication’, after the preliminary publication of results from two clinical trials: ‘BEAT-Tuberculosis’ and ‘endTB’. All proposed regimens include clofazimine (Cfz). …”
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