The Pathology of T Cells in Systemic Lupus Erythematosus by Anselm Mak, Nien Yee Kow

“…Lastly, while currently available outcomes of clinical trials evaluating therapeutic agents which manipulate the T cells such as calcineurin inhibitors indicate that they are at least as efficacious and safe as conventional immunosuppressants in treating lupus glomerulonephritis, larger clinical trials are undoubtedly required to validate these as-yet favourable findings.…”
Get full text

The methods of treatment of atrial fibrillation in patients with valvular heart disease by O.M. Grytsay, Y.V. Skybchyk, I.Y. Mokryk, E.V. Zhytyns’kiy, V.О. Kuts, О.J. Zharinov, B.M. Todurov

“…The article also presents the results of clinical trials in valvular atrial fibrillation, after surgical and complex treatment. …”
Get full text

Prostate-Specific Membrane Antigen-Based Therapeutics by Naveed H. Akhtar, Orrin Pail, Ankeeta Saran, Lauren Tyrell, Scott T. Tagawa

“…Anti-PSMA monoclonal antibody-drug conjugates have also been developed with completed and ongoing early-phase clinical trials. As PSMA is a selective antigen that is highly overexpressed in prostate cancer, anti-PSMA-based immunotherapy has also been studied and utilized in clinical trials.…”
Get full text

Ketogenic diets and Alzheimer’s disease by Klaus W. Lange, Katharina M. Lange, Ewelina Makulska-Gertruda, Yukiko Nakamura, Andreas Reissmann, Shigehiko Kanaya, Joachim Hauser

“…The present review provides a synopsis of preclinical studies and clinical trials assessing the efficacy of ketogenic diets in the treatment of AD. …”
Get full text

Novel Antiplatelet Agent Use for Acute Coronary Syndrome in the Emergency Department: A Review by M. Curial, E. Nath, E. Lang

“…To critically review clinical trials using ticagrelor and prasugrel in the treatment of ACS and inform practitioners of their potential utility in treating ACS in the ED. …”
Get full text

Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis? by Agnese Gugliandolo, Placido Bramanti, Emanuela Mazzon

“…In this review, we focused on the studies involving ALS rodent models and clinical trials in order to understand the potential beneficial effects of MSC transplantation. …”
Get full text

Reduced tracheal stenosing effect of nintedanib in a patient with scarred posttraumatic tracheal stenosis and airflow limitation - a case report by Stefanie Klampfleitner, Andreas Fertl, Ositha Prinz, Martin Doerfler-Schalm, Dieter Munker, Markus O. Henke

“…Further exploration of this potential in additional clinical trials would be valuable.…”
Get full text

A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke by Cesar Reis, Michael Wilkinson, Haley Reis, Onat Akyol, Vadim Gospodarev, Camila Araujo, Sheng Chen, John H. Zhang

“…This review explores the pathophysiology of NSCs on ischemic stroke, stem cell therapy studies and their effects on neurogenesis, the most recent clinical trials, and techniques to track and monitor the progress of endogenous and exogenous stem cells.…”
Get full text

Visceral adipose tissue area and proportion provide distinct reflections of cardiometabolic outcomes in weight loss; pooled analysis of MRI-assessed CENTRAL and DIRECT PLUS dietary... by Hadar Klein, Hila Zelicha, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Alon Kaplan, Yoash Chassidim, Yftach Gepner, Matthias Blüher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Ilan Shelef, Lu Qi, Jun Li, Frank B. Hu, Meir J. Stampfer, Iris Shai

“…Trial registration CENTRAL (Clinical-trials-identifier: NCT01530724); DIRECT PLUS (Clinical-trials-identifier: NCT03020186).…”
Get full text

An individual community member’s perspective on HIV cure-related research by Thomas J. Villa

Get full text

Poly-ADP ribose polymerase (PARP) inhibitor regimens for platinum-sensitive ovarian cancer in randomized, double-blind, phase III controlled trials: protocol for a systematic revie... by Xiaolian Peng, Jie Liu

“…IntroductionClinical trials have shown that PARP inhibitors are effective in treating patients with platinum-sensitive ovarian cancer. …”
Get full text

Safety profile of EZH2 inhibitors for cancer: a systematic review and meta-analysis by Zhou Zhao, Xiufeng Chen, Huayang Pang, Yan Shi, Hao Sun

“…Objective To evaluate the safety profiles of EZH2-targeted inhibitors in cancer treatment, focusing on treatment-related adverse events (TRAEs) across various clinical trials. Methods We conducted a systematic review and meta-analysis using data from clinical trials involving EZH2 inhibitors reported up to May 31, 2024. …”
Get full text

Treatment of Heart Failure with Sodium-glucose Cotransporter Type 2 Inhibitors by Riber Fabián Donoso Noroña, Nairovys Gómez Martínez, Adisnay Rodríguez Plasencia

“…Ten clinical trials were identified that met the inclusion criteria. …”
Get full text

Novel Approaches for Concurrent Irradiation in Locally Advanced Cervical Cancer: Platinum Combinations, Non-Platinum-Containing Regimens, and Molecular Targeted Agents by Giannis Mountzios, Aspasia Soultati, Dimitrios Pectasides, Meletios A. Dimopoulos, Christos A. Papadimitriou

“…More recently, molecular agents targeting critical pathways in cervical malignant transformation are being assessed in early clinical trials in combination with external-beam irradiation. …”
Get full text

Human-based complex in vitro models: their promise and potential for rare disease therapeutics by Surat Parvatam, Francesca Pistollato, Lindsay J. Marshall, Fabia Furtmann, Devashree Jahagirdar, Mohua Chakraborty Choudhury, Sujata Mohanty, Harshita Mittal, Saveetha Meganathan, Rakesh Mishra

“…We also discuss how these systems are being used in clinical trials to develop efficacy models for rare diseases. …”
Get full text

Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases by Jie Zheng, George Davey Smith, Tom R Gaunt, Maria K Sobczyk

“…Objective To scope the potential for (semi)-automated triangulation of Mendelian randomisation (MR) and randomised controlled trials (RCTs) evidence since the two methods have distinct assumptions that make comparisons between their results invaluable.Methods We mined ClinicalTrials.Gov, PubMed and EpigraphDB databases and carried out a series of 26 manual literature comparisons among 54 MR and 77 RCT publications.Results We found that only 13% of completed RCTs identified in ClinicalTrials.Gov submitted their results to the database. …”
Get full text

Short-Term Relapse Quantitation as a Fully Surrogate Endpoint for Long-Term Sustained Progression of Disability in RRMS Patients Treated with Natalizumab by Y. C. Wang, A. Sandrock, J. R. Richert, L. Meyerson, X. Miao

“…Time to sustained worsening in the expanded disability status scale as the standard for evaluating the accumulation of disability has been used as a measure of clinical efficacy in many relapsing-remitting multiple sclerosis (RRMS) clinical trials. However, this measurement usually requires a large sample and long-term study to demonstrate the treatment effect. …”
Get full text

Recanalization Therapies in Acute Ischemic Stroke: Pharmacological Agents, Devices, and Combinations by Vijay K. Sharma, Hock Luen Teoh, Lily Y. H. Wong, Jie Su, Benjamin K. C. Ong, Bernard P. L. Chan

“…Mechanical devices and approaches can achieve higher rates of recanalization but their safety and efficacy still need to be established in larger clinical trials. The field of acute revascularization is rapidly evolving, and various combinations of pharmacologic agents, mechanical devices, and novel microbubble/ultrasound technologies are being tested in multiple clinical trials.…”
Get full text

Current Status of Treatment of Spinal and Bulbar Muscular Atrophy by Fumiaki Tanaka, Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Hiroaki Adachi, Gen Sobue

“…Since ligand-induced nuclear translocation of mutant AR has been shown to be a critical step in motor neuron degeneration in SBMA, androgen deprivation therapies using leuprorelin and dutasteride have been developed and translated into clinical trials. Although the results of these trials are inconclusive, renewed clinical trials with more sophisticated design might prove the effectiveness of hormonal intervention in the near future. …”
Get full text

Long-Term Safety of Ixekizumab Treatment in Patients with Psoriasis, Psoriatic Arthritis, or Axial Spondyloarthritis: a Post Hoc Analysis of Cerebro-Cardiovascular Events by Mark Lebwohl, Atul Deodhar, Sergio Schwartzman, Carlo Salvarani, Meghan Feely McDonald, Natalia Bello, Elsie L. Grace, Elsa Inman, Andris Kronbergs, Marcus Ngantcha, Proton Rahman, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb, Andrew Blauvelt

“…Trial Registration The supplementary Table S1 provides a comprehensive list of clinical trials and their registration numbers.…”
Get full text