A comprehensive overview of selective and novel fibroblast growth factor receptor inhibitors as a potential anticancer modality by Jain Nem Kumar, Tailang Mukul, Thangavel Neelaveni, Makeen Hafiz A., Albratty Mohammed, Najmi Asim, Alhazmi Hassan Ahmad, Zoghebi Khalid, Alagusundaram Muthumanickam, Jain Hemant Kumar, Chandrasekaran Balakumar

“…Several FGFR inhibitors have been developed for addressing these genetically altered FGFR-harboring malignancies, and some have performed well in clinical trials. In contrast, others are still being investigated in different phases of clinical trials. …”
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Curcumin as a Therapeutic Agent in Dementia: A Mini Systematic Review of Human Studies by Natascia Brondino, Simona Re, Annalisa Boldrini, Antonella Cuccomarino, Niccolò Lanati, Francesco Barale, Pierluigi Politi

“…In the present systematic review we aimed to evaluate the state-of-the-art of clinical trials of curcumin in AD. We retrieved three published studies, while there are several ongoing clinical trials. …”
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Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease by Kyeong-Ah Kwak, Seung-Pyo Lee, Jin-Young Yang, Young-Seok Park

“…We also briefly summarize related clinical trials. Finally, future perspectives are discussed with regard to their clinical applications.…”
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Hyponatremia and Congestive Heart Failure: A Marker of Increased Mortality and a Target for Therapy by Adam Romanovsky, Sean Bagshaw, Mitchell H. Rosner

“…Continued clinical trials with these agents are needed to determine their specific role in the treatment of both chronic and decompensated heart failure.…”
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A survey of obstetric ultrasound uses and priorities for artificial intelligence-assisted obstetric ultrasound in low- and middle-income countries by Amy Sarah Ginsburg, Zylee Liddy, Eren Alkan, Kayla Matcheck, Susanne May

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Polatuzumab vedotin combined with bendamustine and rituximab for relapsed/refractory diffuse large B-cell lymphoma: A systematic review protocol. by Mohammadreza Eslami, Mahdi Mehrabi, Mehrdad Payandeh, Fakhredin Saba

“…A comprehensive search will be conducted across databases such as Medline/PubMed, Cochrane Library, Web of Science, Scopus, EMBASE, ProQuest, EU Clinical Trials Register, WHO International Clinical Trials Registry Platform (ICTRP), and ClinicalTrials.gov from the January 2000 to April 2024. …”
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TZDs and Bone: A Review of the Recent Clinical Evidence by Ann V. Schwartz

“…Increased fracture risk in women, but not men, was reported for both TZDs, based on analyses of adverse event reports from clinical trials. In short-term clinical trials in women, both TZDs caused more rapid bone loss. …”
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Statistical Inference of the Class of Nonparametric Tests for the Panel Count and Current Status Data from the Perspective of the Saddlepoint Approximation by Abd El-Raheem M. Abd El-Raheem, Mona Hosny, Ehab F. Abd-Elfattah

“…Equal allocation of both treatments is a largely prevalent approach in clinical trials to eliminate experimental bias and increase power. …”
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Optimizing non-invasive vagus nerve stimulation for treatment in stroke by Sheharyar S. Baig, Samantha Dorney, Mudasar Aziz, Simon M. Bell, Ali N. Ali, Li Su, Jessica N. Redgrave, Arshad Majid

“…In this review, we detail the ongoing studies of transcutaneous vagus nerve stimulation in stroke through systematic searches of registered clinical trials. We summarize the upcoming clinical trials of transcutaneous vagus nerve stimulation in stroke, highlighting their indications, parameter settings, scope, and limitations. …”
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Medicinal products used for the treatment and prophylaxis of COVID-19 by A. Vaitkevičius

“…Data on newly initiated clinical trials on medicinal products for the treatment and prevention of COVID-19 are also provided. …”
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Progress in Managing Heart Failure: an in-depth Review of Sacubitril/Valsartan Combination Therapy by Neeraj Hiremath, Jayasheela S. Hiremath, Sanatkumar B. Nyamagoud, Agadi Hiremath Viswanatha Swamy

“…Numerous significant clinical trials have investigated the drug’s safety and efficacy in treating individuals with heart failure and a failing systemic right ventricle. …”
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Cytokine Reduction in the Treatment of Joint Conditions by J. D. Sipe, J. Martel-Pelletier, I. G. Otterness, J.-P. Pelletier

“…Pharmacologic regulation of IL-1 and TNFα remain primary targets for treatment of arthritis, and results of early clinical trials are promising. However, the results of long-term clinical trials will be required to support the value of anti-cytokine therapy in treatment of arthritis.…”
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A Photothermal Modelling Approach for Micro-LED Arrays in Wireless Optogenetics by Yanping Ji, Chuanzhen Liu, Jiawei Li, Wensi Wang, Mengyi Zheng

“…However, as optogenetics moves towards clinical trials, combinatorial photostimulation based on arrays of LED light sources has emerged. …”
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An expert perspective on diversity-oriented standards for assessing sex and gender in clinical research by Hannah R. Hambruch, Nora M. Laskowski, Robert-Paul Juster, Georg Halbeisen, Georgios Paslakis

“…Experts rated the importance and practicality of assessing these concepts in clinical trials and evaluated terms for suitability and comprehension. …”
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Immunotherapeutic Approaches in Triple-Negative Breast Cancer: State of the Art and Future Perspectives by Karima Oualla, Loay Kassem, Lamiae Nouiakh, Lamiae Amaadour, Zineb Benbrahim, Samia Arifi, Nawfel Mellas

“…Recently, immunotherapy is being extensively explored in TNBC and clinical trials have shown promising results. In this article, we tried to explain the rationale and mechanisms of targeting the immune system in TNBC, to report the results from recent clinical trials that put immunotherapy as a new standard of care in TNBC in addition to ongoing trials and future directions in the next decade.…”
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Benefits from Long-Term Treatment in Irritable Bowel Syndrome by Stefano Evangelista

“…Long-term treatment should be reserved to diagnosed IBS patients with recurrent symptoms. Clinical trials with stabilized therapies and new active treatments showed an improvement of the symptoms over placebo that is often time-dependent but with high relapse rates (around 40%–50% when stopping treatment). …”
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Hypoxia-Inducible Factor-1 as a Therapeutic Target in Endometrial Cancer Management by Laura M. S. Seeber, Ronald P. Zweemer, René H. M. Verheijen, Paul J. van Diest

“…Further work is needed to identify selective HIF-1 inhibitors and to translate these into clinical trials.…”
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Retroperitoneal Lymph Node Dissection as Primary Treatment for Metastatic Seminoma by Brian Hu, Siamak Daneshmand

“…To better determine if RPLND can be recommended as a primary treatment option, two prospective clinical trials (SEMS and PRIMETEST) are underway. This review will examine the literature, discuss the benefits/limitations of RPLND, and compare the methodologies of the two ongoing clinical trials.…”
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The Critical Management of Spinal Cord Injury: A Narrative Review by Emilio Moreno-González, Antonio Ibarra

“…New neuroprotective agents currently in clinical trials show promising results and should be further studied to determine their role in acute SCI management.…”
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Peroxisome proliferator–activated receptor delta and liver diseases by Tomoo Yamazaki, Edward E. Cable, Bernd Schnabl

“…This review provides an overview of PPAR-delta’s function and biology in the liver, examines its kinetics and therapeutic potential across different liver diseases, and discusses the current status of clinical trials involving its agonists.…”
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