A case of de novo neuroendocrine prostate cancer presented with elevated level of serum CEA carrying BRCA2 mutation: case report and literature review by Weizhe Han, Nihati Rexiati, Fang Yu, Yongzhi Wang, Yueli Tian, Jianyuan Wu, Gang Wang, Tao Liu, Zhonghua Yang

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Perspectives on which health settings geriatricians should staff: a qualitative study of patients, care providers and health administrators by Eric Kai-Chung Wong, Andrea C. Tricco, Wanrudee Isaranuwatchai, David M. J. Naimark, Sharon E. Straus, Joanna E. M. Sale

“…The main barriers to implementing the geriatrician-led CGA related to lack of resources. Clinical trial number Not applicable.…”
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Psychosocial well-being index and sick leave in the workplace: a structural equation modeling of Wittyfit data by Rémi Colin-Chevalier, Bruno Pereira, Samuel Dewavrin, Thomas Cornet, Julien Steven Baker, Frédéric Dutheil

“…This new indicator could be used to analyze the association between psychosocial well-being and other health outcomes.Clinical trial registrationClinicaltrials.gov, identifier NCT02596737.…”
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TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor developed for the treatment of MTAP-deleted cancers by Kimberly J. Briggs, Kevin M. Cottrell, Matthew R. Tonini, Alice Tsai, Minjie Zhang, Douglas A. Whittington, Wenhai Zhang, Steven A. Lombardo, Satoshi Yoda, Erik W. Wilker, Samuel R. Meier, Yi Yu, Teng Teng, Alan Huang, John P. Maxwell

“…TNG908 is being tested clinically in patients with MTAP-deleted tumors, including glioblastoma, in a Phase I/II clinical trial (NCT05275478).…”
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Canadian Thoracic Society Recommendations for Management of Chronic Obstructive Pulmonary Disease – 2007 Update by Denis E O’Donnell, Shawn Aaron, Jean Bourbeau, Paul Hernandez, Darcy D Marciniuk, Meyer Balter, Gordon Ford, Andre Gervais, Roger Goldstein, Rick Hodder, Alan Kaplan, Sean Keenan, Yves Lacasse, Francois Maltais, Jeremy Road, Graeme Rocker, Don Sin, Tasmin Sinuff, Nha Voduc

“…The results of the largest randomized clinical trial ever undertaken in COPD have recently been published, enabling the Panel to make evidence-based recommendations on the role of modern pharmacotherapy. …”
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Effects of melatonin supplementation on oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: a double-blind, randomized controlled trial by Sara Sadeghi, Amirahmad Nassiri, Monir Sadat Hakemi, Fatemeh Hosseini, Fatemeh Pourrezagholie, Fatemeh Naeini, Aylar Nadiri Niri, Hossein Imani, Hamed Mohammadi

“…Given the lack of robust evidence, this double-blind clinical trial sought to investigate the effects of melatonin supplementation on oxidative stress and inflammatory markers in diabetic CKD patients. …”
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ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk by Fredrik Ildstad, Hanne Ellekjær, Torgeir Wethal, Stian Lydersen, Hild Fjærtoft, Bent Indredavik

“…Since there is a generally lower stroke risk after TIA during the last years, the benefit of these clinical risk scores and their role in TIA management seems limited. Clinical Trial Registration. This trial is registered with NCT02038725 (retrospectively registered, January 16, 2014).…”
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An empowerment programme to improve diet quality during pregnancy – the Power 4 a Healthy Pregnancy cluster randomised controlled trial by Renske M. van Lonkhuijzen, Jeanne H. M. de Vries, Elske Brouwer-Brolsma, Susanne Cremers, Janine P. M. Faessen, Edith J. M. Feskens, Annemarie Wagemakers

“…Trial registration International Clinical Trial Registry Platform NL-OMON23191, date of registration: 19/05/2021.…”
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Effects of royal jelly consumption on clinical outcomes in patients with ischemic stroke: A triple-blind randomized controlled trial by Elham Karimi, Arman Arab, Fariborz Khorvash, Maryam Kazemi, Reza Amani

“…Therefore, we conducted a randomized, triple-blind, placebo-controlled clinical trial to evaluate the role of RJ supplementation on clinical and biochemical outcomes in patients recovering from ischemic stroke. …”
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Two Transcutaneous Stimulation Techniques in Shoulder Pain: Transcutaneous Pulsed Radiofrequency (TPRF) versus Transcutaneous Electrical Nerve Stimulation (TENS): A Comparative Pil... by Mu-Lien Lin, Hung-Wei Chiu, Zao-Ming Shih, Po-Ying Lee, Pei-Zhi Li, Chin-Hong Guo, Yuan-Jie Luo, Shen-Chieh Lin, Kwan-Yu Lin, Yu-Ming Hsu, Angela Pang, Weiwu Pang

“…A prospective, randomized, and double-blind clinical trial. Setting. Academic pain service of a city hospital. …”
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Association between sleep during pregnancy and birth outcomes: a prospective cohort study by Libing Huang, Huanjun Chen, Fuhui Yao, Zhonghan Sun, Shijiao Yan, Yuwei Lai, Chuanzhu Lv, Xiong-Fei Pan, Rixing Wang, Xingyue Song

“…In order to reduce risk of adverse birth outcomes, sleep problems in pregnant women should be strengthened during pregnancy care. Clinical trial number Not applicable.…”
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Assessing caregiver stress and resource needs in pediatric cancer care by Shaimaa Mohamed Amin, Mahmoud Abdelwahab Khedr, Azza Medhat Aziz Mansy, Ahmed Hashem El-Monshed, Mohamed Gamal Noaman Malek, Ayman Mohamed El-Ashry

“…Future research should explore sustainable strategies to further reduce caregiver burden. Clinical trial number Not applicable.…”
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Various endurance training intensities improve GFR and Up-regulate AQP2/GSK3β in lithium-induced nephropathic rats by Shadan Saberi, Mohammad Amin Rajizadeh, Mohammad Khaksari, Azadeh Saber, Mohammad Akhbari, Soheil Aminizadeh, Forouzan Rafie

“…These findings suggest that tailored exercise regimens could be beneficial for patients undergoing long-term lithium therapy to prevent renal damage. Clinical trial number Not applicable. Graphical Abstract…”
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Risk factors for growth retardation in children with juvenile idiopathic arthritis: a case-control study by Ying Zhang, Liping Song, Weihu Ma, Ye Wang, Peipei Wang, Xiaolin Zhang, Zhe Zhang, Yuan Zhang, Qianhui Yu, Yang Yu, Lin Zhang

“…While each of these factors demonstrates moderate predictive value individually, their combined consideration significantly improves predictive accuracy. Clinical trial number Not applicable.…”
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High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT) by Yuxuan Ding, Yong Feng, Yangfan Ye, Jiayi Shen, Chang Guo, Xia He, Liangjun Zhu, Lijun Wang

“…Plasma cytokines IL-10, IL-17, and INF-α increased after treatment with both drugs.DiscussionIn summary, this is the first clinical trial demonstrating the safety and immunogenic activity of combined high and low dose radiotherapy with ICIs in MSS colorectal cancer liver metastases (CRLMs). …”
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Effects of home-based virtual reality upper extremity rehabilitation in persons with chronic stroke: a randomized controlled trial by Hiroyuki Ase, Kaoru Honaga, Mami Tani, Tomokazu Takakura, Futoshi Wada, Yuhei Murakami, Reina Isayama, Akira Tanuma, Toshiyuki Fujiwara

“…Trial registration: This study was registered in the University Hospital Medical Information Network (UMIN) Clinical Trial Registry in Japan (Unique Identifier: UMIN000038469) on November 1, 2019; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?…”
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Impact of functional re-education and environmental adaptation in cancer patients with respiratory pathology: Study protocol. by Eduardo Jose Fernandez-Rodriguez, Maria Isabel Rihuete-Galve, Alberto Garcia-Martin, Celia Sanchez-Gomez, Fausto Jose Barbero-Iglesias, Roberto Mendez-Sanchez, Ana Silvia Puente-Gonzalez, Susana Saez-Gutierrez, Emilio Fonseca-Sanchez, Juan Jesus Cruz-Hernandez

“…<h4>Trial registration</h4>ClinicalTrials.gov; ID: NCT06035263. Registered on: September 19, 2023. https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?…”
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Comparing the effects of Mycozin and Clotrimazole 1% creams on vaginal candidiasis: a triple-blinded randomized controlled trial by Khadije Hajizadeh, Zahra Alivand, Vahideh Rahmani, Leila Mehrannia, Sanam Nami, Behrooz Shokouhi, Mojgan Mirghafourvand

“…This equivalent, triple-blinded, randomized clinical trial was conducted on 126 patients who complained of vaginal itching referred to Al-Zahra Teaching Hospital, Tabriz, Iran between September 2023 and May 2024. …”
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Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized... by Azizeh Farshbaf-Khalili, Alireza Ostadrahimi, Mojgan Mirghafourvand, Khatereh Ataei-Almanghadim, Sara Dousti, Amir Mehdi Iranshahi

“…The alleviation of anxiety in the vitamin E group was more than in the placebo group. Clinical Trial Registration. The trial was registered at the Iranian Registry of Clinical Trials (https://irct.ir/IRCT20131009014957N6).…”
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Effect of enhanced recovery after surgery on older patients undergoing transvaginal pelvic floor reconstruction surgery: a randomised controlled trial by Xuezhu Huang, Sisi Deng, Xiaofeng Lei, Shentao Lu, Ling Dai, Chunyan She

“…Trial registration This study was retrospectively registered with the Chinese Clinical Trial Registry (registration number: ChiCTR2400084608). …”
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