Acceptability of a dapivirine levonorgestrel vaginal ring in two Phase 1 trials (MTN-030/IPM 041 and MTN-044/IPM 053/CCN019): Implications for multipurpose prevention technology de... by Barbara A Friedland, Holly Gundacker, Sharon L Achilles, Beatrice A Chen, Craig Hoesley, Barbra A Richardson, Clifton W Kelly, Jeanna Piper, Sherri Johnson, Brid Devlin, John Steytler, Kyle Kleinbeck, Bindi Dangi, Chantél Friend, Mei Song, Barbara Mensch, Ariane van der Straten, Cindy Jacobson, Craig W Hendrix, Jill Brown, Diana Blithe, Sharon L Hiller, MTN-030/IPM 041 and MTN-044/IPM 053/CCN019 Protocol Teams for the Microbicide Trials Network and the Contraceptive Clinical Trials Network

“…Trial registration: Clinical Trial Registration: MTN-030/IPM 041: ClinicalTrials.gov NCT02855346; MTN-044/IPM 053/CCN019: ClinicalTrials.gov NCT03467347.…”
Get full text

Differential effects of clary sage (Salvia sclarea L.) oil and linalyl acetate on depression levels in diabetic foot ulcer patients with T2DM: a randomized blinded controlled trial by Ji Won Son, Purum Kang, Sun Seek Min, Geun Hee Seol, Geun Hee Seol

“…These findings suggest that adjunct therapy in DFU patients should be individualized according to the degree of depression.Clinical trial registrationhttp://cris.nih.go.kr/, identifier KCT0009722.…”
Get full text

Ezetimibe Improves Rosuvastatin Effects on Inflammation and Vascular Endothelial Function in Acute Coronary Syndrome Patients Undergoing PCI by Changqing Sun, Wuyang Zheng, Ling Liang, Zuheng Liu, Wenchao Sun, Rong Tang

“…This trial is registered with https://clinicaltrials.gov/ct2/show/ChiCTR-IPR-17012219 (Chinese Clinical Trial Registry, http://www.chictr.org.cn on 02/08/2017).…”
Get full text

The Efficacy of Functional and Traditional Exercise on the Body Composition and Determinants of Physical Fitness of Older Women: A Randomized Crossover Trial by Antônio Gomes de Resende-Neto, José Carlos Aragão-Santos, Bruna Caroline Oliveira-Andrade, Alan Bruno Silva Vasconcelos, Clodoaldo Antônio De Sá, Felipe José Aidar, Josimari Melo DeSantana, Eduardo Lusa Cadore, Marzo Edir Da Silva-Grigoletto

“…This is a randomized clinical trial in which participants performed two 12-week periods of different training methods, separated by eight weeks of washout. …”
Get full text

The influence of prosthetic treatments and implant-supported prostheses on posterior mandibular ridge atrophy: a retrospective cohort study by Alwin Sokolowski, Sandra Huber, Behrouz Arefnia, Anke Pichler, Martin Lorenzoni, Armin Sokolowski

“…Long-term stability is possible with fixed partial prostheses, RPDs are less favorable in the absence of a distal support and bar-retained overdentures on four or more implants exhibited the lowest bone atrophy in fully edentulous mandibles. Clinical trial number Not applicable – retrospective analysis.…”
Get full text

Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma by Jiannan Lin, Shuwen Lu, Xiaoyu Zhao

“…However, further research is needed to explore their therapeutic potential and the mechanisms underlying their effects. Clinical trial number Not applicable.…”
Get full text

Safety and accuracy of digitally supported primary and secondary urgent care telephone triage in England: an observational study using routine data by Vanashree Sexton, Catherine Grimley, Jeremy Dale, Helen Atherton, Gary Abel

“…Service and clinician characteristics associated with potential under-triage need further investigation to inform ways of improving the safety and effectiveness of urgent care telephone triage. Clinical trial number Not applicable.…”
Get full text

Comparison of scores for predictability of corticosteroid failure in patients with acute severe ulcerative colitis by Knežević Milica A., Janjić Nebojša M., Lečić Vuk B., Todorović Nemanja B., Damjanov Dimitrije D.

“…Material and Methods: A retrospective clinical trial included 30 patients with ASUC. They were divided into a group with complete response to intravenous CS therapy and one without. …”
Get full text

“It's a good idea, but…”: a qualitative evaluation of the GoldiCare intervention in Norwegian home care services by Heike Fischer, Fredrik Klæboe Lohne, Fredrik Klæboe Lohne, Marius Steiro Fimland, Skender Elez Redzovic

“…Trial registrationThis clinical trial was registered on 08/05/2022 under NCT05 487027.…”
Get full text

A systematic review of outcomes reported in studies to optimise the medication use of patients at hospital discharge by Joke Wuyts, Veerle Foulon, Samuel Sebastian Allemann, Fabienne Boeni

“…Methods We systematically reviewed quantitative and qualitative literature using Embase, PubMed, CINAHL and the EU Clinical Trial Register databases. Studies investigating the optimisation of medication use following hospital discharge were eligible. …”
Get full text

Protocol of a parallel group Randomized Control Trial (RCT) for Mobile-assisted Medication Adherence Support (Ma-MAS) intervention among Tuberculosis patients. by Zekariyas Sahile, Lua Perimal-Lewis, Paul Arbon, Anthony John Maeder

“…<h4>Trial registration</h4>The trial is registered in the Pan-Africa Clinical Trials Registry with trial number PACTR202002831201865.…”
Get full text

Short-Term Observation of Ultrasonic Cyclocoagulation in Chinese Patients with End-Stage Refractory Glaucoma: A Retrospective Study by Dongpeng Hu, Shu Tu, Chengguo Zuo, Jian Ge

“…The study was registered with Chinese Clinical Trial Registry (http://www.chictr.org.cn; Registration number: ChiCTR-OOC-17014028).…”
Get full text

Association between elevated cystatin C levels and obstructive sleep apnea hypopnea syndrome: a systematic review and updated meta-analysis by Nianying Fu, Xiaotao Tan, Jie He

“…Furthermore, cystatin C levels could serve as a valuable clinical indicator for evaluating treatment effectiveness and severity of OSAHS. Clinical trial number Not applicable.…”
Get full text

Exploring the Variability in Acute Glycemic Responses to Exercise in Type 2 Diabetes by Tasuku Terada, Alanna Friesen, Baljot S. Chahal, Gordon J. Bell, Linda J. McCargar, Normand G. Boulé

“…This trial is registered with ClinicalTrial.gov NCT01144078.…”
Get full text

IMRAS-Immunization with radiation-attenuated Plasmodium falciparum sporozoites by mosquito bite: Cellular immunity to sporozoites, CSP, AMA1, TRAP and CelTOS. by Martha Sedegah, Michael R Hollingdale, Harini Ganeshan, Maria Belmonte, Jun Huang, Arnel Belmonte, Sandra Inoue, Rachel Velasco, Bradley Hickey, Nimfa Teneza-Mora, Joanne Lumsden, Sharina Reyes, Jo Glenna Banania, Anatalio Reyes, Ivelese Guzman, Thomas L Richie, Judith E Epstein, Eileen Villasante

“…<h4>Trial registration</h4>ClinicalTrials.gov NCT01994525.…”
Get full text

Effects of community family doctors-led intervention for self-management and medication adherence in type 2 diabetes mellitus patients: study protocol of a cluster randomised contr... by Yue Chen, Biqi Ren, Ningsheng Wang, Shuang Lei, Shuzhi Lin, Lianye Liu, Yufang Xiang, Bianling Feng

“…The findings will be published in peer-reviewed journals and presented at scientific conferences.Trial registration number Chinese Clinical Trial Registry, ChiCTR2100051685.…”
Get full text

Dynamic changes in peripheral blood lymphocyte trajectory predict the clinical outcomes of sepsis by Dongkai Li, Jiahui Zhang, Wei Cheng, Guoyu Zhao, Xianli Lei, Yawen Xie, Na Cui, Hao Wang

“…Incorporating longitudinal trajectory modeling and lymphocyte subsets may improve prognostic risk assessment and guide the selection of immunotherapies tailored to specific immune phenotypes in sepsis patients.Clinical trial registrationhttps://www.chictr.org.cn/showproj.aspx?…”
Get full text

Effects of photobiomodulation therapy in patients with chronic non-specific low back pain: protocol for a randomised placebo-controlled trial by Lucíola da Cunha Menezes Costa, Shaiane Silva Tomazoni, Leonardo Oliveira Pena Costa, Layana de Souza Guimarães, Amanda Costa Araujo, Dafne Port Nascimento, Flávia Cordeiro de Medeiros, Marina Athayde Avanzi

“…Therefore, the objective of this clinical trial is to evaluate the effects of PBMT in patients with chronic non-specific LBP in the short, medium and long term.Methods and analyses This is a prospectively registered, two-arm randomised placebo-controlled trial with blinded patients, assessors and treatment providers. …”
Get full text

Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies by Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Prasenjit Bhowmik, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

“…Furthermore, developments in biomarker discoveries and neuroimaging techniques are improving our ability to monitor inflammatory responses, allowing for more accurate and personalized treatment regimens. Preclinical and clinical trial data demonstrate the therapeutic potential of these tailored techniques. …”
Get full text

Clinical Dental Midline Shift Is Not a Predictor of the Side of Shorter Hemimandible: A Cone Beam Computed Tomography Diagnostic Study by Lígia Pereira da Silva, Alicia López-Solache, Urbano Santana-Penín, José López-Cedrún, María Jesus Mora, Pablo Varela-Centelles, Antonio González-Mosquera, Almudena Rodríguez-Fernández, Urbano Santana Mora

“…Tomographic images were acquired using the i-CAT^® Imaging System; mandibular/maxillary measurements were obtained with the Planmeca Romexis^® software v.6.This is an ancillary study of a clinical trial (NCT02144233) that included chronic pain (TMD diagnosis; DC/TMD criteria), fully dentate, and stable normo-occlusion participants. …”
Get full text