Safety and tolerability of intramuscular sotrovimab administered at different injection sites: results from the Phase 1 COSMIC study by Jennifer Moore, Alicia Aylott, Wen-Hung Chen, Jerzy Daniluk, Ian A. Hawes, Sergio Parra, Prosenjit Sarkar, Yasmin Sanchez-Pearson, Megan Turner, Amanda Peppercorn, Andrew Skingsley

“…To our knowledge, these are the first data to show that a >2 mL mAb injection into each deltoid muscle is well tolerated.Trial registration ClinicalTrials.gov identifier, NCT05280717…”
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Effect of Artificial Intelligence Helpfulness and Uncertainty on Cognitive Interactions with Pharmacists: Randomized Controlled Trial by Chuan-Ching Tsai, Jin Yong Kim, Qiyuan Chen, Brigid Rowell, X Jessie Yang, Raed Kontar, Megan Whitaker, Corey Lester

“…Trial RegistrationClinicalTrials.gov NCT06795477; https://clinicaltrials.gov/study/NCT06795477…”
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Does the transition from face-to-face to face-to-screen improve oral health literacy? A non-inferiority randomized controlled trial by Negar Ebrahimi, Katayoun Sargeran, Reza Yazdani, Ahmad Reza Shamshiri

“…Trial registration The trial protocol was registered in the Iranian Registry of Clinical Trials (IRCT) on 08–02-2022, (IRCT20220106053643N1|| http://www.irct.ir/ ).…”
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Comparison of Healthcare Encounters and Drug Persistence in Patients With Pulmonary Arterial Hypertension Receiving Oral Selexipag, Inhaled Iloprost, or Parenteral Treprostinil: A... by Ci Song, Peter Kunovszki, Amélie Beaudet

“…**Background:** Agents targeting the prostacyclin (PGI~2~) pathway are important in managing pulmonary arterial hypertension (PAH). No head-to-head clinical trials have compared outcomes between the 3 different PGI~2~-pathway drugs most commonly available in countries with advanced healthcare: oral selexipag, inhaled iloprost, and parenteral (subcutaneous or intravenous) treprostinil. …”
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Efficacy and safety of pembrolizumab in patients with advanced endometrial cancer: a systematic review and meta-analysis by Biqiong Pan, Xiaojun Lai, Jiefang Lu, Xiaoyan Bao, Zengke Fan, Jie Sun

“…ObjectiveThis meta-analysis evaluated pembrolizumab monotherapy and combination therapy’s efficacy and safety in recurrent or advanced endometrial cancer (EC).MethodsWe utilized PubMed, Embase, Cochrane Library, and Web of Science databases to identify clinical trials that were used to search literature from July 2013 to July 2023 to evaluate the efficacy and safety of pembrolizumab in patients with advanced EC. …”
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Real-World Clinical Outcomes and Treatment Patterns Among Black and Non-Black Patients With Prostate Cancer Initiated on Apalutamide in a Urology Setting by Benjamin H. Lowentritt, Carmine Rossi, Erik Muser, Frederic Kinkead, Bronwyn Moore, Patrick Lefebvre, Dominic Pilon, Shawn Du

“…**Discussion:** While clinical trials have demonstrated the efficacy and safety of apalutamide, there is limited real-world data describing treatment persistence and clinical outcomes among patients with mCSPC and nmCRPC who initiated apalutamide. …”
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Aberrant heterochromatin silences immune response genes in chronic lymphocytic leukemia by Olivia M. Depies, Qianqian Guo, Yuan Gao, Sutapa Sinha, Zhenqing Ye, Weiguo Han, Kari G. Rabe, Mingma S. Hoel, Heather C. Darby, Chuanhe Yu, Esteban Braggio, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Zhiquan Wang

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Neuromuscular monitoring and incidence of postoperative residual neuromuscular blockade: a prospective observational study by Alessandra Piersanti, Rossella Garra, Fabio Sbaraglia, Miryam Del Vicario, Rosa Lamacchia, Marco Rossi

“…Trial registration The study was registered at ClinicalTrials.gov ( NCT06193213 , date of registration: 05/01/2024).…”
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Efficacy and safety of upadacitinib in the treatment of moderate-to-severe atopic dermatitis: A systematic review. by Dan-Jie Zhao, Xia Li, Hai-Xia Lin, Hong Zheng, Di Zhou, Peng Tang

“…<h4>Methods</h4>PubMed, Medline, Embase, Web of Science, Clinical Trials Website, and Cochrane Library databases were searched from the time of establishment until January 6, 2024, to compile a list of all randomized controlled trials (RCTs) including upadacitinib in the treatment of moderate-to-severe AD. …”
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QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration by Jayshree Advani, Puja A. Mehta, Andrew R. Hamel, Sudeep Mehrotra, Christina Kiel, Tobias Strunz, Ximena Corso-Díaz, Madeline Kwicklis, Freekje van Asten, Rinki Ratnapriya, Emily Y. Chew, Dena G. Hernandez, Sandra R. Montezuma, Deborah A. Ferrington, Bernhard H. F. Weber, Ayellet V. Segrè, Anand Swaroop

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Complete metabolic response as early predictor of long-term efficacy after adoptive T cell therapy using tumor-infiltrating lymphocytes by Rikke Andersen, Troels Holz Borch, Eva Ellebaek, Inge Marie Svane, Helle Westergren Hendel, Kasper Madsen

“…In this study the predictive value of early metabolic response after TIL therapy is explored.Materials and methods: 60 patients treated with TIL therapy in 4 different clinical trials and with available [18F]2-fluoro-2-deoxy-d-glucose positron emission tomography-CT (FDG-PET/CT) scans at baseline and at least one follow-up scan 6–8 weeks and/or 12–16 weeks post-TIL infusion were included.Results: Obtaining complete metabolic response (CMR) was associated with significantly superior median overall survival (mOS) compared with not obtaining CMR (p&lt;0.0001). …”
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Protocol of a randomised trial of teriparatide followed by zoledronic acid to reduce fracture risk in adults with osteogenesis imperfecta by Jennifer Walsh, Catriona Keerie, Stuart H Ralston, Christopher J Weir, Muhammad K Javaid, WAYNE LAM, Bente L Langdahl, Jannie D Hald, Patricia Osborne

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The Role of Cardiac Resynchronization Therapy in Heart Failure: A Narrative Review by Olivier Uwishema, Ece Karabulut, Dalal Sheikhah, Burhan Kantawala, Misgana Gallo, Fatima Soufan, Magda Wojtara

“…This manuscript conducted a comparative analysis various hallmark clinical trials conducted in lieu of CRT, across many years (2002, 2003, 2004, 2005, 2017, 2018, 2020). …”
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Modular-based psychotherapy (MoBa) versus cognitive–behavioural therapy (CBT) for patients with depression, comorbidities and a history of childhood maltreatment: study protocol fo... by Elisabeth Schramm, Martin Hautzinger, Carolin Jenkner, Moritz Elsaesser, Sabine Herpertz, Hannah Piosczyk

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Comparison of Corneal Epitheliotrophic Factors of Undiluted Autologous Platelet-Rich Plasma and Autologous Serum Eye Drops for Dry Eye Disease by Passara Jongkhajornpong, Kaevalin Lekhanont, Sasivimol Rattanasiri, Prapaporn Pisitkun, Ammarin Thakkinstian

“…Trial registration ClinicalTrials.gov identifier, NCT04683796.…”
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Efficacy of Intravenous Versus Oral Administration of Levocarnitine in Maintenance Hemodialysis Patients: A Randomized Controlled Trial Investigating Therapeutic Approaches to Rena... by Sadia Rehman, Muhammad Farhan, Santosh Kumar, Muhammad Raza Sarfraz, Asma Naveed, Muhammad Tassaduq Khan, Hiya Huq

“…Trial Registration ClinicalTrials.gov: NCT05817799.…”
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Secondary prevention of preeclampsia by Muhammad Ilham Aldika Akbar, Muhammad Ilham Aldika Akbar, Roudhona Rosaudyn, Khanisyah Erza Gumilar, Khanisyah Erza Gumilar, Renuka Shanmugalingam, Gustaaf Dekker, Gustaaf Dekker

“…Proton pump inhibitors (PPIs) have shown potential in lowering soluble FMS-like tyrosine kinase-1 (sFlt-1) levels and enhancing endothelial function, but clinical trials have been inconsistent. Metformin, primarily used for improving insulin sensitivity, has potential advantages in decreasing PE incidence due to its anti-inflammatory and vascular properties, particularly in morbidly obese women. …”
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Safety Assessment of Glucose-Lowering Drugs and Importance of Structured Education during Ramadan: A Systematic Review and Meta-Analysis by Rashmi Shiju, Ayesha Akhil, Smitha Thankachan, Jaakko Tuomilehto, Monira Al Arouj, Abdullah Bennakhi

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Brief intervention to reduce fatigue impact in patients with inflammatory arthritis: design and outcomes of a single-arm feasibility study by Paul Ewings, Emma Dures, Sarah Hewlett, Joanna Thorn, Mwidimi Ndosi, Siobhan Creanor, Jo Adams, Lance M McCracken, Joe Lomax, Susan Bridgewater, Bryan Abbott, Alice Berry, Marie Urban

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Comparison of the safety of remimazolam and propofol during general anesthesia in elderly patients: systematic review and meta-analysis by Xianchun Liu, Longyi Zhang, Li Zhao, Xuelei Zhou, Wei Mao, Linlin Chen, Hongyu Zhu, Ying Xie, Linji Li

“…BackgroundRemimazolam is a novel sedative drug approved for procedural sedation and general anesthesia. Clinical trials have already explored its use in elderly patients for general anesthesia. …”
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