Comparing Prednisone and Methotrexate to Off-label Biologic Infliximab for Management of Ocular Uveitis: A Cost-minimization Analysis by William V. Padula, Miguel Cordero-Coma, Taygan Yilmaz, William V. Padula, Michéal J. Gallagher, Jonathan D. Campbell

“…As compared to prednisone, methotrexate was associated with increased costs and QALYs and was found to be a good value. Clinical trials of infliximab in the uveitis population are needed to reduce the uncertain estimates of inflixmab treatment success and the drug’s cost-effectiveness.…”
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Does the Harvesting Site Influence the Osteogenic Potential of Mesenchymal Stem Cells? by Van Thi Nguyen, Irene Tessaro, Antonio Marmotti, Camilla Sirtori, Giuseppe M. Peretti, Laura Mangiavini

“…The project number L1033 is registered with ClinicalTrials.gov NCT03369457.…”
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Endovascular versus Surgical Lower Extremity Revascularization among Patients with Chronic Kidney Disease by Qingzheng Chen, Jialin Han, Gomathy Parvathinathan, Elsie Ross, Margaret R. Stedman, Tara I. Chang

“…Multiple factors must be considered when counseling patients with CKD, who have a high burden of comorbid conditions. Clinical trials should include more patients with kidney disease, who are often otherwise excluded from participation, to better understand the most effective treatment strategies for this vulnerable patient population.…”
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Hospitalization outcomes in people living with HIV on Dolutegravir-based regimen in Mwanza, Tanzania: a comparative cohort by Godfrey A. Kisigo, Eric Barongo, Benson Issarow, Cody Cichowitz, Bahati Wajanga, Samuel Kalluvya, Robert N. Peck

“…Conclusion In conclusion, the mortality rate of hospitalized PLWH in Africa remains high in the DTG era. Clinical trials are urgently needed to test novel interventions for improving survival in this high-risk group. …”
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Cosmetic Appeal, HRQoL, and Effectiveness of Simple and Pseudotesticular Techniques of Orchidectomy in Prostate Cancer by Ijeoma N. C. Chibuzo, Augustine O. Takure, Olayiwola B. Shittu, Linus I. Okeke

“…This study is registered with the ClinicalTrials.gov of the National Institute of Health U.S. …”
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Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review by Natasha Cox, Christian D. Mallen, Ian C. Scott

“…These showed moderate- to high-quality evidence from clinical trials in more contemporary time-periods (mainly 1990s/2000s for synthetic DMARDs and post-2000 for biological/targeted synthetic DMARDs) that, in patients with active RA, short-term glucocorticoids and synthetic, biologic, and targeted synthetic DMARDs have efficacy at reducing pain intensity relative to placebo. …”
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Integrated Management of Cardiovascular–Renal–Hepatic–Metabolic Syndrome: Expanding Roles of SGLT2is, GLP-1RAs, and GIP/GLP-1RAs by Nikolaos Theodorakis, Maria Nikolaou

“…By synthesizing evidence from landmark clinical trials, we highlight the paradigm-shifting potential of these therapies. …”
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Components of cognitive–behavioural therapy for mitigating core symptoms in attention-deficit hyperactivity disorder: a systematic review and network meta-analysis by Sayo Hamatani, Kazuki Matsumoto, Yoshihiko Kunisato, Yoshifumi Mizuno

“…We searched MEDLINE (via PubMed), Embase, PsycINFO, ClinicalTrials.gov and Cochrane Library for literature published up to 31 March 2022. …”
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NS5A replication complex inhibitor daclatasvir in the basis of chronic hepatitis C interferon-free therapy by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…The drug is not registered in Russia yet, its approval in combination to asunaprevir is expected soon.Conclusion. Clinical trials have demonstrated that combination of daclatasvir with other medications possessing direct antiviral action, in particular with asunaprevir, and with pegilated interferon and ribavirin significantly increases treatment response rate at different categories of patients with chronic HCV-infection; that allows to reduce treatment duration of these patientsgroups. …”
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Variation in clinical and patient‐reported outcomes among complex heart failure with preserved ejection fraction phenotypes by Kelsey M. Flint, Sanjiv J. Shah, Eldrin F. Lewis, David P. Kao

“…These differences may inform the design of targeted clinical trials focusing on improvement in outcomes most relevant for specific HFpEF phenotypes.…”
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Ventilator-Associated Pneumonia After Cardiac Arrest and Prevention Strategies: A Narrative Review by Harinivaas Shanmugavel Geetha, Yi Xiang Teo, Sharmitha Ravichandran, Amos Lal

“…The controversy surrounding prophylactic antibiotics persists, but promising new strategies have been proposed; however, they are still awaiting well-designed clinical trials.…”
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PROMETHEUS: Long-Term Exacerbation and Mortality Benefits of Implementing Single-Inhaler Triple Therapy in the US COPD Population by Gerard Criner, Fernando Martinez, Hitesh Gandhi, Norbert Feigler, Bruce Pyenson, Matthew Emery, Umang Gupta, Muthiah Vaduganathan

“…**Discussion:** Widespread SITT adoption may be impeded by competitive pressures from generic treatments and nonadherence, and efficacy observed in clinical trials may not occur in real-world populations. …”
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TAD-SIE: sample size estimation for clinical randomized controlled trials using a Trend-Adaptive Design with a Synthetic-Intervention-Based Estimator by Sayeri Lala, Niraj K. Jha

“…Abstract Background Phase-3 clinical trials provide the highest level of evidence on drug safety and effectiveness needed for market approval by implementing large randomized controlled trials (RCTs). …”
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Effectiveness of interventions on healthcare professionals’ understanding and use of conscience: a systematic review protocol by Alex Clark, Megan Kennedy, Christina Lamb, Edith Pituskin, Ken Kirkwood, Yolanda Babenko-Mould

“…The objective of this review is to critically analyse the scholarly evidence available to ascertain the effectiveness of interventions that support healthcare professionals to understand and use their conscience in care practice.Methods and analyses At least two reviewers will systematically review 10 interdisciplinary, scholarly databases to examine qualitative, quantitative and mixed-methods studies including clinical trials pertaining to interventions related to conscience for healthcare professionals. …”
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Efficacy of preoperative pulmonary rehabilitation in lung cancer patients: a systematic review and meta-analysis of randomized controlled trials by Yalun Guo, Mengdie Pan, Meidi Xiong, Miao Liu, Na Zhu, Haoxu Dong, Chunhua Zhang

“…Therefore, an updated meta-analysis is needed to integrate the latest published randomized controlled clinical trials (RCT). This updated analysis was performed to identify the clinical effects of preoperative pulmonary rehabilitation on physical rehabilitation (lung function, activity endurance, and dyspnea), psychological rehabilitation, quality of life, length of hospital stay, and postoperative pulmonary complications in patients with lung cancer. …”
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A comparative longitudinal study between bilateral and unilateral totally extraperitoneal repair among patients with unilateral inguinal hernia at a tertiary care hospital in easte... by Bikash Kumar Sah, Jatin Goel, Vijay Pratap Sah, Bhawani Khanal, Abhijeet Kumar, Rakesh Kumar Gupta

“…Trial registration: ClinicalTrials.gov, identifier NCT06380621.…”
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Evaluation of the Outcomes of Coronectomy Procedure versus Surgical Extraction of Lower Third Molars Which Have a High Risk for Inferior Alveolar Nerve Injury: A Systematic Review by Nedal Abu-Mostafa, Lulwah M. AlRejaie, Fahad A. Almutairi, Ruba A. Alajaji, Maram M. Alkodair, Nourah A. Alzahem

“…A total of 97 articles were identified, and seven studies were finally included for conducting qualitative analysis: 3 randomized clinical trials and 4 clinical controlled trials. Cochrane Collaboration’s tool was used for assessing risk of bias. …”
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Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression by Hwa Young Ahn, Hwan Hee Kim, Ji-Yeon Hwang, Changhun Park, Bo Youn Cho, Young Joo Park

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Fostering active choice to empower behavioral change to reduce cardiovascular risk: A web-based randomized controlled trial. by Lorraine L Landais, Judith G M Jelsma, Olga C Damman, Evert A L M Verhagen, Danielle R M Timmermans

“…<h4>Trial registration</h4>ClinicalTrials.gov: NCT05142280. Prospectively registered.…”
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Cost-Utility Analysis of Add-on Cannabidiol vs Usual Care Alone for the Treatment of Seizures in Patients With Treatment-Resistant Lennox-Gastaut Syndrome or Dravet Syndrome in the... by Jamshaed Siddiqui, Sally Bowditch

“…Population characteristics, clinical inputs, and utility values were sourced from CBD clinical trials and quality-of-life studies. Drug acquisition, disease management, adverse events, and societal costs from published literature were included. …”
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