Cohort profile: the Halland osteoarthritis (HALLOA) cohort–from knee pain to osteoarthritis: a longitudinal observational study in Sweden by Ann Bremander, Maria L E Andersson, S Bergman, Katarina Aili, Emma Haglund

“…It is also important to study the development of chronic pain in OA, to get tools to identify individuals at risk and to be able to offer them treatment.Trial registration number ClinicalTrials.gov (NCT04928170).…”
Get full text

An Assessment of Usual Salt Intake among Older Normotensive Adults in Atonsu, a Suburb of Kumasi in the Ashanti Region of Ghana by Rufai Safianu, Jacob Plange-Rhule

“…Experimental and epidemiological studies as well as studies involving clinical trials show the existence of adverse effect of salt consumption on the blood pressure of adults. …”
Get full text

Therapeutic potential of phytocompounds of Bacopa monnieri (L.) Wettst (literature review) by O.O. Nikitina, D.S. Tsyba

“…The extract was not toxic to humans. Numerous clinical trials show the effectiveness of the use of extracts in the treatment of anhedonia, depression, Alzheimer's disease, Parkinson's disease, dementia and hyperactivity. …”
Get full text

Bimatoprost Intracameral Implant (Durysta®): A New Era in Glaucoma Management Through Sustained-Release Innovation by Vagiakis I, Papadopoulou EP, Amaxilati E, Tsiropoulos GN, Konstas AG, Panos GD

“…This review evaluates its pharmacology, efficacy, and safety, using data from pivotal clinical trials and recent real-world studies. The implant achieves IOP reductions comparable to topical prostaglandin analogs, with benefits for patient adherence and fewer common side effects. …”
Get full text

Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma: a single-institution study, systemic review and meta-analysis by Bin Wang, Xing-zhu Wen, Wei Zhang, Ming Qiu

“…Trial registration The clinical study was retrospectively registered to UMIN clinical trials registry (the registry number: UMIN000033835).…”
Get full text

Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity, and Biological Imaging by Charini Maladeniya, Taniya Darshani, Sameera R. Samarakoon, Frank R. Fronczek, W. M. C. Sameera, Inoka C. Perera, Theshini Perera

“…Platinum-based compounds are actively used in clinical trials as anticancer agents. In this study, two novel platinum complexes, (C1 = [PtCl2(N(SO2quin)dpa)], C2 = [PtCl2(N(SO2azobenz)dpa)]) containing quinoline and azobenzene appended dipicolylamine sulfonamide ligands were synthesized in good yield. …”
Get full text

Species Differences in the Biotransformation of Aflatoxin B1: Primary Determinants of Relative Carcinogenic Potency in Different Animal Species by David L. Eaton, David E. Williams, Roger A. Coulombe

“…John Groopman has played a leading role in every step of the way—from initial laboratory studies on specific AFB1 metabolites to the application of molecular biomarkers in epidemiological studies associating dietary AFB1 exposure with liver cancer, and the design and conduct of chemoprevention clinical trials to reduce cancer risk from unavoidable aflatoxin exposures by alteration of specific AFB1 biotransformation pathways. …”
Get full text

Effects of a Distributed Form of Constraint-Induced Movement Therapy for Clinical Application: The Keys Treatment Protocol by Sarah dos Anjos, Mary Bowman, David Morris

“…These findings support its feasibility and potential for outpatient stroke rehabilitation (ClinicalTrials.gov Registration: NCT05311384).…”
Get full text

Dual Role of Bacteria in Carcinoma: Stimulation and Inhibition by Suad A Al-Hilu, Wisam H Al-Shujairi

“…Finally, we provide past and ongoing clinical trials that include bacteria targeting tumors.…”
Get full text

Can a low-threshold check-up motivate older adults to schedule a dental visit? Study protocol for a randomized controlled trial by Aster De Vleeschauwer, Louise Poppe, Roos Colman, Barbara Janssens

“…Trial registration ClinicalTrials.gov NCT06341959. Registered on 25 April 2024.…”
Get full text

Neuromyelitis optica spectrum disorder: epidemiology, pathogenesis, diagnosis, treatment, and prognosis by J. Čemerkaitė, I. Kaukėnaitė, R. Liutkevičienė

“…Recent results of randomised clinical trials with monoclonal anti- bodies such as inebilizumab, satralizumab, tocilizumab, and eculizumab have proved their efficacy and safety in maintenance treatment of NMOSD. …”
Get full text

Abnormal Esophageal Scintigraphy Associates With a Distinct Clinical Phenotype in Patients With Systemic Sclerosis by Antonio D. Salas, Lisa R. Yanek, Laura K. Hummers, Ami A. Shah, Zsuzsanna H. McMahan

“…University of California Los Angeles Scleroderma Clinical Trials Consortium Gastrointestinal Tract (GIT) 2.0 scores measured GI symptoms, Medsger scores measured physician‐assessed SSc disease severity, and the Composite Autonomic Symptom Score 31 survey evaluated dysautonomia symptoms. …”
Get full text

Electronic patient-reported outcome measures using mobile health technology in rheumatology: A scoping review. by Jaclyn Shelton, Sierra Casey, Nathan Puhl, Jeanette Buckingham, Elaine Yacyshyn

“…A total of 39 (56%) studies directly evaluated the feasibility of ePROMs in clinical practice, 19 (27%) were clinical trials that used ePROMs as study endpoints, 9 (13%) were focus groups or surveys on smartphone application development, and 3 (4%) did not fit into one defined category.…”
Get full text

Promising Therapeutic Functions of Bone Marrow Mesenchymal Stem Cells Derived-Exosome in Asthma by Jia-Ying Yuan, Xiang-Yun Wang, Zhi-Ying Tong, Yu-Chao Dong, Jia-Yi Zhao, Yi Zhang, Yan Shang

“…However, BMMSC-Exo still lacked more clinical trials for evaluating the effects on asthma, and the technology of extraction and purification still needs to be improved for wide use. …”
Get full text

LoVE4MUM Mobile App to Prevent Postpartum Depression: Protocol for a Pilot Randomized Controlled Trial by Siti Sabrina Kamarudin, Idayu Badilla Idris, Shalisah Sharip, Norfazilah Ahmad

“…Trial RegistrationClinicalTrials.gov NCT06366035; https://clinicaltrials.gov/study/NCT06366035 International Registered Report Identifier (IRRID)PRR1-10.2196/63564…”
Get full text

Use of Machine Learning to Predict Individual Postprandial Glycemic Responses to Food Among Individuals With Type 2 Diabetes in India: Protocol for a Prospective Cohort Study by Niteesh K Choudhry, Shweta Priyadarshini, Jaganath Swamy, Mridul Mehta

“…Trial RegistrationClinical Trials Registry-India CTRI/2022/02/040619; https://tinyurl.com/mrywf6bf International Registered Report Identifier (IRRID)DERR1-10.2196/59308…”
Get full text

Effectiveness of cognitive–behavioural therapy: a protocol for an overview of systematic reviews and meta-analyses by Sarah E Lamb, Shona Kirtley, Beth Fordham, Thavapriya Sugavanam, Sally Hopewell, Karla Hemming, Jeremy Howick, Roshan das Nair, Julia Hamer-Hunt

Get full text

Economic Evaluation of Boceprevir for the Treatment of Patients with Genotype 1 Chronic Hepatitis C Virus Infection in Hungary by Raymond Odhiambo, Jagpreet Chhatwal, Shannon Allen Ferrante, Antoine El Khoury, Elamin Elbasha

“…**Background:** Recent international, randomized, placebo-controlled clinical trials (SPRINT-2; RESPOND-2) demonstrated that the triple combination of peginterferon (PEG), ribavirin (RBV) and boceprevir (BOC) was more efficacious than the standard dual therapy of PEG and RBV in treatment of patients chronically infected with genotype 1 hepatitis C virus (HCV) infection. …”
Get full text

Proseal laryngeal mask airway and endotracheal intubation in lower abdominal gynecological surgeries for perioperative gastric volume assessment and assessing postoperative recover... by Ranjay Mahaseth, Bhavna Gupta, Gaurav Jain, Anupama Bahadur, Deepak Singla, Debendra K. Tripathy

“…Methods: The study commenced after obtaining approval from Institutional Ethical Committee (IEC number-AIIMS/IEC/22/251 Date: 27/05/2022) and after registration in Clinical Trials Registry - India (CTRI) (CTRI/2022/07/044102 Registered on: 18/07/2022) and was conducted from August 2022 to August 2023. …”
Get full text

Therapeutic strategies for fungating and ulcerating breast cancers: A systematic review and narrative synthesis by Valentina Zagardo, Mandara Harikar, Gianluca Ferini

Get full text