Gene Editing in Pluripotent Stem Cells and Their Derived Organoids by Hang Zhou, Yun Wang, Li-Ping Liu, Yu-Mei Li, Yun-Wen Zheng

“…Current preclinical and clinical trials have demonstrated initial safety and efficacy of PSC gene editing; however, for better application in clinical settings, additional investigation is warranted.…”
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Development of Delivery Systems Enhances the Potency of Cell-Based HIV-1 Therapeutic Vaccine Candidates by Amin Hadi, Abbas Rastgoo, Maryam Eskandarian, Nooshin Haghighipour, Azam Bolhassani

“…Among different vaccination strategies, cell-based vaccines could achieve in clinical trials. Cell viability and low nucleic acid expression are the problems related to dendritic cells (DCs) and mesenchymal stem cells (MSCs), which are transfected with plasmid DNA. …”
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The Effect of Transobturator Tape Surgery on Female Sexual Functions: A Systematic Review by Engin Yildirim, Nuriye Buyukkayaci Duman, Umit Gorkem, Ozgur Kan

“…Results: A total of 24 clinical trials were evaluated. The most frequently administered scales were the female sexual function index and The Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire -12. …”
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Immunotherapies to Nano-Immunotherapies: Advances in Immune Targeting in Bladder Cancer by Beatriz Ramos, Dakota Rogers

“…Immune checkpoint inhibitors such as nivolumab, pembrolizumab, avelumab, and atezolizumab have shown promising results in clinical trials and have been approved for metastatic and high-risk bladder cancer. …”
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Identification of unmet palliative care needs of nursing home residents: A scoping review protocol. by Patrice Crowley, Mohamad M Saab, Nicola Cornally, Isabel Ronan, Sabin Tabirca, David Murphy

“…A search of grey literature will also be conducted in databases such as CareSearch, Trip, GuidelineCentral, ClinicalTrials.gov, and the National Institute for Health and Care and Excellence website. …”
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Bibliometrics of NIHR HTA monographs and their related journal articles by Norman Waugh, Pamela Royle

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Corpus callosotomy for treatment of pediatric epilepsy: two clinical cases and a literature review by R. Matonytė, S. Ročka, J. Grikinienė

“…The paper describes two pediatric patients treated in Vilnius University Hospital Santara Clinics, Department of Pediatric Neurology and Neurosurgery, who underwent a corpus callosotomy, and compares the outcome of these clinical cases with the results of recent clinical trials. …”
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A Prospective Comparative Study between Implantable Phakic Intraocular Contact Lens and Implantable Collamer Lens in Treatment of Myopia in Adults by Mahmoud Rateb, Ahmed A.M. Gad, Dalia Tohamy, Mohamed Nagy Elmohamady

“…The study was registered in clinical trials and the registration number is NCT04624035. …”
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How Cognitive Reserve should Influence Rehabilitation Choices using Virtual Reality in Parkinson’s Disease by Letizia Pezzi, Andrea Di Matteo, Roberta Insabella, Sara Mastrogiacomo, Carlo Baldari, Victor Machado Reiss, Teresa Paolucci

“…PubMed, Cochrane Library, Scopus, and Web of Sciences databases were analysed to identify randomized clinical trials (RCT) and randomized pilot trials that addressed the rehabilitation of motor symptoms in subjects with PD using VR. …”
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Effect of different regional anaesthesia techniques on postoperative analgesia following percutaneous nephrolithotomy: A systematic review and network meta-analysis by Kun Long, Chengfu Zhou, Jingqiu Liang, Xixi Tang, Zhijian Li, Qi Chen

“…Methods: We searched PubMed, ScienceDirect, ClinicalTrials.gov, MEDLINE, Web of Science, Ovid and EMBASE to identify all relevant randomised controlled trials published up to January 2024. …”
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Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors. by Shirley D Wenker, María Isabel Farias, Victoria Gradaschi, Corina Garcia, Juan Beauquis, María Celeste Leal, Carina Ferrari, Xianmin Zeng, Fernando J Pitossi

“…Even though successful transplantation of dopamine-producing cells into the striatum exhibits favourable effects in animal models and clinical trials; transplanted cell survival is low. Since every transplant elicits an inflammatory response which can affect cell survival and differentiation, we aimed to study in vivo and in vitro the impact of the pro-inflammatory environment on human dopaminergic precursors. …”
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Reconstruction by Pancreaticogastrostomy versus Pancreaticojejunostomy following Pancreaticoduodenectomy: A Meta-Analysis of Randomized Controlled Trials by YinFeng Shen, WenYin Jin

“…Published data of randomized clinical trials (RCTs) comparing the clinically relevant outcomes of PG versus PJ after PD were analyzed. …”
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Exploiting question-answer framework with multi-GRU to detect adverse drug reaction on social media by Jiao-huang Luo, Ai-hua Yang

“…The dilemma arises from the inherent impossibility of conducting a comprehensive evaluation of a drug before its market release, constrained by the limitations in scale and duration of clinical trials. Therefore, the post-marketing detection of ADRs in a timely and accurate manner becomes imperative. …”
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From Molecule to Patient Rehabilitation: The Impact of Transcranial Direct Current Stimulation and Magnetic Stimulation on Stroke—A Narrative Review by Anca Badoiu, Smaranda Ioana Mitran, Bogdan Catalin, Tudor Adrian Balseanu, Aurel Popa-Wagner, Florin Liviu Gherghina, Carmen Valeria Albu, Raluca Elena Sandu

“…Thus, no response or even worsening effects were obtained under certain circumstances both in animal stroke model studies and in clinical trials. Overall, weighing up risks and benefits, the new transcranial electrical and magnetic stimulation techniques can represent effective tools with which to improve the patients’ recovery after stroke, with minimal to no adverse effects. …”
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Anti-Inflammatory and Antimicrobial Effects of Herbal Formulation Called Apo-Taat Using Extended-Spectrum ß-Lactamase-Producing Escherichia coli Isolates by Thanakan Kitnithiprapha, Sumalee Panthong, Intouch Sakpakdeejaroen, Sumalee Kondo

“…Furthermore, safety and clinical trials should be conducted in the future.…”
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Efficacy and tolerance of second-generation antipsychotics in anorexia nervosa: A systematic scoping review. by Solène Thorey, Corinne Blanchet, Sélim Benjamin Guessoum, Marie Rose Moro, Maude Ludot, Emilie Carretier

“…<h4>Introduction</h4>Second-generation antipsychotics (SGAs) are frequently prescribed for the treatment of resistant anorexia nervosa. However, few clinical trials have been conducted so far and no pharmacological treatment has yet been approved by the Food and Drug Administration. …”
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Neonatal Surgery Intensive Care Unit: Hacettepe University Experience by Umit Ayse Tandircioglu, Hasan Tolga Celik, Sule Yigit, Murat Yurdakok

“…The protocol was registered with Clinical Trials.gov identifier NCT04734002. RESULTS: The total number of newborns admitted to the neonatal intensive care unit was 5442. …”
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Association of CVAI, LAP and SMI with risk of haematological toxicity after immunochemotherapy in patients with DLBCL: a retrospective study by Caifeng Liao, Hurong Lai, Yansong Tu, Ling He, Chuyang Lin, Huaijun Tu, Jian Li

“…Trial registration: This is a retrospective study, and no registration on ClinicalTrials.gov.…”
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Multicenter randomized double-blind placebo-controlled crossover study of the effect of prolonged noisy galvanic vestibular stimulation on posture or gait in vestibulopathy. by Chisato Fujimoto, Takuya Kawahara, Yayoi S Kikkawa, Makoto Kinoshita, Teru Kamogashira, Mineko Oka, Tsukasa Uranaka, Naoya Egami, Kentaro Ichijo, Kayoko Kabaya, Sachiyo Katsumi, Ikumi Takashima, Yoshiharu Yamamoto, Masato Yagi, Tatsuya Yamasoba, Shinichi Iwasaki

“…<h4>Materials and methods</h4>This trial was registered in the Japan Pharmaceutical Information Center Clinical Trials Information registry (jRCT1080224083). …”
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Phytoconstituent analysis, bioactivity, and safety evaluation of various colors of Chrysanthemum morifolium flower extracts for cosmetic application by Angsana Neatpatiparn, Varaporn Buraphacheep Junyaprasert, Krit Thirapanmethee, Veerawat Teeranachaideekul

“…However, further studies, including human clinical trials, are needed to confirm these biological activities and safety profiles.…”
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