PD-L1 Expression and CD8+ T Cell Infiltration Predict a Favorable Prognosis in Advanced Gastric Cancer by Yangyang Wang, Chunchao Zhu, Wei Song, Jun Li, Gang Zhao, Hui Cao

“…Programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors have exhibited remarkable activity in clinical trials and were approved by the FDA for clinical therapy in several types of tumors. …”
Get full text

Submucosal Injection Solution for Endoscopic Resection in Gastrointestinal Tract: A Traditional and Network Meta-Analysis by Zhang Yu Huai, Wei Feng Xian, Luo Chang Jiang, Wang Xi Chen

“…PubMed, Cochrane Library, Embase, and clinical trials register center were searched with terms of “endoscopic resection” and “submucosal injection solution” to identify relevant randomized controlled trials (RCTs). …”
Get full text

Protective Effect of Melatonin on Acute Pancreatitis by Jolanta Jaworek, Joanna Szklarczyk, Andrzej K. Jaworek, Katarzyna Nawrot-Porąbka, Anna Leja-Szpak, Joanna Bonior, Michalina Kot

“…The beneficial effects of melatonin shown in experimental studies suggest that melatonin ought to be employed in the clinical trials as a supportive therapy in acute pancreatitis and could be used in people at high risk for acute pancreatitis to prevent the development of pancreatic inflammation.…”
Get full text

Metabolomic profile and its association with the diagnosis of prostate cancer: a systematic review by Angela Patricia Salinas Pita, Mildrey Mosquera Escudero, Eliecer Jiménez-Charris, Herney Andrés García-Perdomo

“…Methods We conducted a search strategy in MEDLINE (OVID), EMBASE, LILACS, and the Cochrane Central Register of Controlled Trials (CENTRAL) from 2008 to the present. We included Clinical trials and analytical and descriptive observational studies that reported metabolite results and metabolite profiles in serum, tissue, urine, and seminal fluid. …”
Get full text

How Much Time Should Be Waited and What Are the Main Findings to Evaluate the Hepatocellular Carcinoma Response to Regorafenib? A Real-Life Experience by Gustavo Hideki Kawanami, Leopoldo Katsuda, Thiara Barcelos Rocha, Fabio da Silva Yamashiro, Leonardo Pelafsky, Xingshun Qi, Fernando Gomes Romeiro

“…The knowledge of the main adverse events described in the pilot clinical trials can avoid unnecessary withdrawal of regorafenib. …”
Get full text

Research Progress on the Structure and Function, Immune Escape Mechanism, Antiviral Drug Development Methods, and Clinical Use of SARS-CoV-2 M^pro by Jiayi Ren, Zhengfu Zhang, Yi Xia, Daqun Zhao, Dingqin Li, Shujun Zhang

“…This review summarizes the recent research progress on the novel coronavirus’s main proteases, including the pivotal role of M^pro in the virus’s life cycle, the structure and catalytic mechanism of M^pro, the self-maturation mechanism of M^pro, the role of M^pro in virus immune escape, the current methods of developing antiviral drugs targeting M^pro, and the key drugs that have successfully entered clinical trials. The aim is to provide researchers involved in the development of antiviral drugs targeting M^pro with systematic and comprehensive information.…”
Get full text

Prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum—the study protocol by Irina Chmelova, Irina Chmelova, Dalibor Pastucha, Dalibor Pastucha, Tomas Hudecek, Zdenek Guran, Zdenek Guran, Sona Ciecotkova, Lubomír Martínek, Jana Zubikova, Alena Matlova, Jakub Dolezel, Dana Salounova, Jakub Chmelo

“…The study is registered at ClinicalTrials.gov, ID: NCT05646043.ConclusionThe results of this study can serve as a foundation for larger, multicentre, controlled studies in the future.…”
Get full text

Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated by Michele Ammendola, Rosario Sacco, Giuseppe Sammarco, Giuseppe Donato, Valeria Zuccalà, Roberto Romano, Maria Luposella, Rosa Patruno, Carlo Vallicelli, Giorgio Maria Verdecchia, Davide Cavaliere, Severino Montemurro, Girolamo Ranieri

“…In this pilot study, we suggest that MCPT and c-KitR-EC play a role in gastric cancer angiogenesis, so we think that several c-KitR or tryptase inhibitors such as gabexate mesilate and nafamostat mesilate might be evaluated in clinical trials as a new antiangiogenetic approach.…”
Get full text

Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat by Tamara Zenz, Robert Jenke, Denys Oliinyk, Sandra Noske, René Thieme, Tim Kahl, Ines Gockel, Florian Meier-Rosar, Achim Aigner, Thomas RH Büch

“…Introduction: Histone deacetylase inhibitors (HDACi) have shown promising preclinical activity in gastric cancer cells; unfortunately, however, these could not be confirmed in clinical trials. This highlights the need for the identification of underlying reasons, which may also provide the basis for possible combination therapies. …”
Get full text

The SGLT-2 Inhibitors and their Role in the Treatment of Heart Failure - A Review of Literature by Silvia Ciraolo, Agnieszka Kulczycka-Rowicka, Joanna Wojda, Katarzyna Lesiczka-Fedoryj, Anna Walczak, Zuzanna Kościuszko, Adam Sobiński, Matylda Czerwonka, Katarzyna Kurza, Julianna Podolec

“… • Research materials and methods: A comprehensive literature review was conducted, analyzing clinical trials, guideline documents, and mechanistic studies on SGLT2 inhibitors. …”
Get full text

Impact of Moderate to Severe Renal Impairment on Mortality and Appropriate Shocks in Patients with Implantable Cardioverter Defibrillators by Venkata M. Alla, Kishlay Anand, Mandeep Hundal, Aimin Chen, Showri Karnam, Tom Hee, Claire Hunter, Aryan N. Mooss, Dennis Esterbrooks, Syed M. Mohiuddin

“…Due to underrepresentation of patients with chronic kidney disease (CKD) in large Implantable-Cardioverter Defibrillator (ICD) clinical trials, the impact of ICD remains uncertain in this population. …”
Get full text

The rise of weekly insulins: addressing the challenges of type 2 diabetes care in Brazil by André Gustavo Daher Vianna, Daniely Freitas Alves, Taís Silveira Assmann, Rosângela Roginski Réa

“…Currently, two once-weekly insulin treatments, insulin icodec and efsitora alfa, have shown promise in clinical trials, demonstrating efficacy and safety profiles similar or better than those of daily insulin therapies. …”
Get full text

Intracranial germ cell tumors: advancement in genomic diagnostics and the need for novel therapeutics by Kee Kiat Yeo, Kee Kiat Yeo, Joanna Gell, Joanna Gell, Joanna Gell, Girish Dhall, Girish Dhall, Ching Lau, Ching Lau, Ching Lau

“…In this review, we will discuss the potential novel therapeutics and the clinical trials that are currently under development.…”
Get full text

Foodborne Event Detection Based on Social Media Mining: A Systematic Review by Silvano Salaris, Honoria Ocagli, Alessandra Casamento, Corrado Lanera, Dario Gregori

“…A comprehensive search was conducted across PubMed, EMBASE, CINAHL, Arxiv, Scopus, and Web of Science databases, excluding clinical trials, case reports, and reviews. Two independent reviewers screened studies using Covidence, with a third resolving conflicts. …”
Get full text

Role of artificial intelligence in imaging and endoscopy for the diagnosis, monitoring and prognostication of inflammatory bowel disease: a scoping review protocol by Mallory Chavannes, Bram Verstockt, Mariangela Allocca, David T Rubin, Kerri Novak, Lynn Kysh, Noa Krugliak Cleveland, Michael Todd Dolinger, Tom S Robbins, Shintaro Sagami

“…We will include both observational studies and clinical trials. Study characteristics will be extracted using a data extraction form. …”
Get full text

Recent Advances and Perspectives on the Use of Mineralocorticoid Receptor Antagonists for the Treatment of Hypertension and Chronic Kidney Disease: A Review by Kisho Miyasako, Yujiro Maeoka, Takao Masaki

“…Here, we discuss recent findings and the roles of MRAs in the management of hypertension and CKD, with a focus on the evidence obtained from fundamental research and major clinical trials.…”
Get full text

Therapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent Studies by Aekkhaluck Intharuksa, Warunya Arunotayanun, Mingkwan Na Takuathung, Yaowatat Boongla, Siripat Chaichit, Suthiwat Khamnuan, Anchalee Prasansuklab

“…However, further studies, including in vivo and clinical trials, are essential to evaluate the safety, optimal dosages, and long-term effectiveness of herbal treatments for patients under chronic PM exposure.…”
Get full text

Homoharringtonine: mechanisms, clinical applications and research progress by Wen Wang, Lan He, Lan He, Ting Lin, Ting Lin, Ting Lin, Fulan Xiang, Yibin Wu, Fangliang Zhou, Fangliang Zhou, Fangliang Zhou, Yingchun He, Yingchun He, Yingchun He

“…Additionally, HHT exhibits multiple biological activities, including immunomodulation, antiviral effects, and anti-fibrotic properties, with recent studies also revealing its potential neuroprotective functions. In clinical trials, Homoharringtonine has demonstrated promising efficacy in the treatment of hematological malignancies, particularly in various types such as acute myeloid leukemia and chronic myeloid leukemia. …”
Get full text

The Canadian Registry for Pulmonary Fibrosis: Design and Rationale of a National Pulmonary Fibrosis Registry by Christopher J. Ryerson, Benjamin Tan, Charlene D. Fell, Hélène Manganas, Shane Shapera, Shikha Mittoo, Mohsen Sadatsafavi, Teresa To, Andrea Gershon, Jolene H. Fisher, Kerri A. Johannson, Nathan Hambly, Nasreen Khalil, Theodore K. Marras, Julie Morisset, Pearce G. Wilcox, Andrew J. Halayko, Mohammad Adil Khan, Martin Kolb

“…As the largest and most comprehensive cohort of Canadian ILD patients, CARE-PF establishes a network for future clinical research and early phase clinical trials and provides a platform for translational and basic science research.…”
Get full text

An Overview of Innovative Techniques to Improve Cervical Cancer Screening by Esther R. Nijhuis, Nathalie Reesink-Peters, G. Bea A. Wisman, Hans W. Nijman, Jelmer van Zanden, Haukeline Volders, Harry Hollema, Albert J. H. Suurmeijer, Ed Schuuring, Ate G. J. van der Zee

“…In our opinion the results of large clinical trials should be awaited before proceeding to implement HPV DNA detection. …”
Get full text