Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review by José Luis Estela-Zape, Mayra Liliana Pizarro-Loaiza, Gabriel Arteaga, Santiago Castaño, Leonardo Fierro

“…However, further research is needed to clarify the underlying molecular mechanisms and validate these compounds through preclinical and clinical trials.…”
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Liposarcomas of the hypopharynx: a systematic review of the literature by Andrea Corvino, Giuseppe Riva, Matteo Sensini, Massimiliano Garzaro, Giancarlo Pecorari

“…The inclusion criteria were: clinical trials, cohort studies, case-control studies, case reports and case series on hypopharyngeal liposarcomas. …”
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Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia by David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó

“…There is not much research in clinical trials regarding mGluR2/3 PAMs. However, several lines of evidence from animal models have indicated the efficiency of mGluR2/3 PAMs. …”
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The risks of adverse events with mirtazapine for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis by Caroline Barkholt Kamp, Johanne Juul Petersen, Pascal Faltermeier, Sophie Juul, Christina Dam Bjerregaard Sillassen, Faiza Siddiqui, Rebecca Kjaer Andersen, Joanna Moncrieff, Mark Abie Horowitz, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud, Janus Christian Jakobsen

“…Methods We searched relevant sources from inception to 7 March 2024 for randomised clinical trials comparing mirtazapine versus placebo in adults with major depressive disorder. …”
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The safety and efficacy of cannabinoids for the treatment of mental health and substance use disorders: protocol for a systematic review and meta-analysis by Jack Wilson, Andrew Langcake, Zachary Bryant, Tom P. Freeman, Janni Leung, Gary C. K. Chan, Amir Englund, Myfanwy Graham, Emily Stockings

“…Electronic databases (Ovid MEDLINE, PsychINFO, Cochrane Central Register of Controlled Clinical Trials, Cochrane Database of Systematic Reviews, and Embase) were searched from 1980 to 24 May 2023. …”
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Implementation of the STEPPS program for the treatment of self-harm behaviors in Catalonia’s prisons: barriers and facilitators by Rosa Lorente-Català, Irene Jaén, Xavier Buscà-Huertas, Berta Framis, Azucena García-Palacios

“…Trial registration NCT06297460 (ClinicalTrials.gov, retrospectively registered).…”
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Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials by Baocheng Xie, Houlong Luo, Yusheng Zhang, Qinghui Wang, Chenhui Zhou, Daohua Xu

“…A systematic literature search was performed in the SinoMed, PubMed, Embase, ClinicalTrials.gov, and Cochrane Controlled Trials Register databases from building database to January 2018. …”
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Evaluating the effectiveness of a mental health literacy module - A randomized controlled trial among school teachers by Vidya Prabhu, Lena Ashok, Veena Ganesh Kamath, Amitha Puranik, Sebastian Padickaparambil, Nikitha Sibil Rebello, Praveen Arhanthabailu, Varalakshmi Chandrasekaran

“…Conclusion: The present study found that the intervention module was effective in enhancing the MHL of teachers across all the domains, which may facilitate early intervention among adolescents at the school level.The trial has been registered with the Clinical Trials Registry of India prospectively. (CTRI/2017/11/010633)…”
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The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study by Xiangqian Huang, Xiaoming Zhang, Jiahao Song, Duo Lan, Mengqi Wang, Xunming Ji, Da Zhou, Ran Meng

“…Abstract Background and purpose Although Ginkgo biloba extract (GBE) has been shown to be effective in treating acute ischemic stroke (AIS) in several clinical trials, concerns regarding adverse events, such as bleeding, have been raised. …”
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Adverse Effects of Carbetocin versus Oxytocin in the Prevention of Postpartum Haemorrhage after Caesarean Section: A Randomized Controlled Trial by D. Mannaerts, L. Van der Veeken, H. Coppejans, Y. Jacquemyn

“…The study was registered in the International Journal of Clinical Trials (ISRCTN 95504420, 2/2017).…”
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Contemplating the Bibliometric Data Onto Sepsis and Gut Microbiome: Mapping Trends, Collaborations, and Global Contributions by Zhang Li, Wang Yi, Li Ping, Li Xiang, Yu Xiangyou

“…The prominence of the United States in the field underscores the need for welldesigned clinical trials and prospective cohort studies to advance therapeutic strategies. …”
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Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial by Blake J. Lawrence, Natalie Gasson, Andrew R. Johnson, Leon Booth, Andrea M. Loftus

“…The trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR: 12614001039673). While controlling for moderator variables, Generalized Linear Mixed Models (GLMMs) showed that when compared to the control group, the intervention groups demonstrated variable statistically significant improvements across executive function, attention/working memory, memory, language, activities of daily living (ADL), and quality of life (QOL; Hedge’s g range = 0.01 to 1.75). …”
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Antisecretory factor in severe traumatic brain injury (AFISTBI): protocol for an exploratory randomized placebo-controlled trial by Linus Réen, David Cederberg, Niklas Marklund, Edward Visse, Peter Siesjö

“…Trial registration ClinicalTrials.gov NCT04117672. Registered on September 17, 2017. …”
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The Combination of Ketorolac with Local Anesthesia for Pain Control in Day Care Retinal Detachment Surgery: A Randomized Controlled Trial by Xiaohong Chen, Bingqian Liu, Xiaoling Liang, Jiaqing Li, Tao Li, Yonghao Li, Xiling Yu, Cancan Lyu, Xiujuan Zhao, Silvia Tanumiharjo, Chenjin Jin, Lin Lu

“…This trial is registered with ClinicalTrials.gov NCT02729285.…”
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Tannins for food preservation and human health: A review of current knowledge by Yesim Ozogul, Yilmaz Ucar, Eskindir Endalew Tadesse, Nikheel Rathod, Piotr Kulawik, Monica Trif, Tuba Esatbeyoglu, Fatih Ozogul

“…This review presents structure and classification of tannins, their extraction techniques, potential properties of tannins as a preservative agent and possible health benefits of tannins with clinical trials.…”
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Effectiveness of the Electromagnetic Shock Wave Therapy in the Treatment of Cellulite by Débora Apª O. Modena, Caroline Nogueira da Silva, Talita C. P. Delinocente, Tatiane Bianca de Araújo, Tania Maria de Carvalho, Clovis Grecco, Renata Gomes Moreira, Gisele Campos, José Ricardo de Souza, Renata Michelini Guidi

“…This trial is registered with ClinicalTrials: NCT03275259.…”
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Spinal Cord Stimulation for Refractory Angina Pectoris: Current Status and Future Perspectives, a Narrative Review by Roberto Gazzeri, Jacopo Mosca, Felice Occhigrossi, Marco Mercieri, Marcelo Galarza, Matteo Luigi Giuseppe Leoni

“…Innovations in neurostimulation, including closed-loop systems and personalized treatment strategies have the potential to further optimize outcomes. Rigorous clinical trials are needed to consolidate the role of SCS as a cornerstone therapy for the management of RAP.…”
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The role of glucagon-like peptide-1 receptor (GLP-1R) agonists in enhancing endothelial function: a potential avenue for improving heart failure with preserved ejection fraction (H... by Darshan Hullon, Ghasaq K. Subeh, Yelizaveta Volkova, Karolina Janiec, Adam Trach, Ruslan Mnevets

“…GLP-1R agonists, including semaglutide and liraglutide, have demonstrated significant cardioprotective effects, such as improving vascular endothelial function, reducing inflammation, and preventing atherosclerosis. Clinical trials, such as the STEP-HFpEF trial, have shown positive results in reducing symptoms and physical restrictions in HFpEF patients. …”
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ErbB- and MUC1-targeted CAR-T cell immunotherapy of oral squamous cell carcinoma by Saffron E. Summers, Saffron E. Summers, Vehid Salih, Andrew D. Foey

“…Currently, there are few clinical trials investigating the use of CAR-T cells in HNSCC/OSCC; however, results from trials investigating similar solid tumours, such as breast cancer, can be adopted to help evaluate the use of CAR-T in this cancer. …”
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A high-fat meal significantly impacts the bioavailability and biphasic absorption of cannabidiol (CBD) from a CBD-rich extract in men and women by Bo Anne Daniëlla Frederique Saals, Tessa Helena De Bie, Eral Osmanoglou, Ties van de Laar, Adriaan Willem Tuin, Anne Claire Benedikte van Orten-Luiten, Renger Frederik Witkamp

“…This trial was registered on October 19, 2020, with ClinicalTrials.gov under the identifier NCT04589455. The registration title is: Determination of Pharmacokinetics and Food-effect of CBD from a Hemp Extract in Healthy Human Volunteers.…”
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