Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis by Wan-fu Lin, Mao-feng Zhong, Yu-ren Zhang, Huan Wang, He-tong Zhao, Bin-bin Cheng, Chang-quan Ling

“…Five electronic databases were searched for clinical trials focusing on the role of PLR in the prognosis of HCC. …”
Get full text

Applying Focal Therapy to Lesions Detected via Magnetic Resonance Imaging: Delivering Cancer Ablation Beyond the Visibility Phenomenon by Clement Orczyk, Teresa Marsden, Francesco Giganti, Joseph M. Norris, Santosh Waigankar, Louise Dickinson, Shonit Punwani, Alex Kirkham, Alex Freeman, Aiman Haider, Caroline M. Moore, Arnauld Villers, Clare Allen, Mark Emberton

“…Focal therapy (FT) is a promising approach with a low side-effect profile for treating magnetic resonance imaging (MRI)-visible PC within a limited framework of guideline recommendations or clinical trials. On the basis of accumulated clinical and research experience, we present a systematic approach to FT indications for ablation of visible targets that includes imaging findings, margin delineation, and energy selection. …”
Get full text

Performance of Size 1 I-Gel Compared with Size 1 ProSeal Laryngeal Mask in Anesthetized Infants and Neonates by Gulay Erdogan Kayhan, Zekine Begec, Mukadder Sanli, Ender Gedik, Mahmut Durmus

“…This trial is registered with: ClinicalTrials.gov NCT01704118.…”
Get full text

Efficacy and Tolerability of Intravenous Ferric Carboxymaltose in Patients with Iron Deficiency at a Hospital Outpatient Clinic: A Retrospective Cohort Study of Real-World Clinical... by António Robalo Nunes, Ana Palricas Costa, Sara Lemos Rocha, Ana Garcia de Oliveira

“…Although its use has been extensively studied in clinical trials, real-world evidence regarding FCM treatment is scarce. …”
Get full text

Exosomes in neuron-glia communication: A review on neurodegeneration by Naeimeh Akbari-Gharalari, Sina Khodakarimi, Farshad Nezhadshahmohammad, Mohammad Karimipour, Abbas Ebrahimi-Kalan, Jiagian Wu

“…Furthermore, an exploration of the Clinicaltrials.gov database was undertaken to identify clinical trials related to cellular signaling, utilizing analogous terminology. …”
Get full text

Three-dimensional dynamics of mesothelin-targeted CAR.CIK lymphocytes against ovarian cancer peritoneal carcinomatosis by Federica Galvagno, Valeria Leuci, Annamaria Massa, Chiara Donini, Ramona Rotolo, Sonia Capellero, Alessia Proment, Letizia Vitali, Andrea Maria Lombardi, Valentina Tuninetti, Lorenzo D’Ambrosio, Alessandra Merlini, Elisa Vigna, Giorgio Valabrega, Luca Primo, Alberto Puliafito, Dario Sangiolo

“…Abstract Intraperitoneal cellular immunotherapy with CAR-redirected lymphocytes is an intriguing approach to target peritoneal carcinomatosis (PC) from ovarian cancer (OC), which is currently evaluated in clinical trials. PC displays a composite structure with floating tumor cells within ascites and solid-like masses invading the peritoneum. …”
Get full text

Classifications of haemodialysis vascular access stenosis: a scoping review by Petr Waldauf, Michael Corr, Stephen O’neill, Katerina Lawrie, Jan Malik, Libor Janousek, Stepan Maly, Jaroslav Chlupac

“…This review aims to present a comprehensive summary and propose further methodological approaches.Design A systematic review of the literature, evaluating classifications for dialysis-related VA stenosis.Data sources Web of Science, Scopus, PubMed, Google Scholar and the ClinicalTrials.gov registry were searched from inception to 7 December 2024.Eligibility criteria All articles containing classifications regarding dialysis VA were eligible, with no restrictions on the study type or language of the full text.Data extraction and synthesis Two independent researchers performed the search and initial screening. …”
Get full text

The Effect of SP/NK1R on the Expression and Activity of Catalase and Superoxide Dismutase in Glioblastoma Cancer Cells by Faranak Korfi, Hossein Javid, Reza Assaran Darban, Seyed Isaac Hashemy

“…Therefore, this drug might be introduced as a potential candidate for controlling glioblastoma cancer in animal models and clinical trials.…”
Get full text

Lecanemab’s Path Forward: Navigating the Future of Alzheimer’s Treatment in Europe Amidst the EMA's Rejection by Alessandro Martorana, Chiara Giuseppina Bonomi, Martina Gaia Di Donna, Caterina Motta

“…The EMA’s refusal underscores the need to address doubts surrounding the real-world effectiveness and safety of such treatments, especially concerning amyloid-related imaging abnormalities (ARIAs), a common side effect observed in clinical trials. The recent approval of lecanemab by the UK's Medicines and Healthcare products Regulatory Agency, despite the National Institute for Health and Care Excellence’s rejection on cost-effectiveness grounds, further fuels the debate on the feasibility of anti-amyloid therapies. …”
Get full text

Liquid biopsy approaches to capture tumor evolution and clinical outcomes during cancer immunotherapy by Susan Scott, Mark Sausen, Valsamo Anagnostou, Jennifer Jackson, Vincent Lam, Joseph C Murray, Lavanya Sivapalan, Jenna Vanliere Canzoniero, Blair Landon, Benjamin P. Levy

“…The clinical translation of liquid biopsies is propelled by the increasing number of ctDNA-directed interventional clinical trials in the immuno-oncology space, signifying a critical step towards implementation of liquid biopsies in precision immuno-oncology.…”
Get full text

Chimerism in Myeloid Malignancies following Stem Cell Transplantation Using FluBu4 with and without Busulfan Pharmacokinetics versus BuCy by Shatha Farhan, Michael Bazydlo, Klodiana Neme, Nancy Mikulandric, Edward Peres, Nalini Janakiraman

“…This will need to be examined in larger retrospective multicenter studies and prospective clinical trials.…”
Get full text

INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW by Auria Ekanti Pratiwi, Oki Suwarsa, Achadiyani, Nur Atik

“…Hence, further research and evaluation in clinical trials are needed.…”
Get full text

Safety and Efficacy of Two Trabecular Micro-Bypass Stents as the Sole Procedure in Japanese Patients with Medically Uncontrolled Primary Open-Angle Glaucoma: A Pilot Case Series by Daisuke Shiba, Shingo Hosoda, Saori Yaguchi, Naoki Ozeki, Kenya Yuki, Kazuo Tsubota

“…Implantation of two trabecular micro-bypass stents as the sole procedure in Japanese POAG patients effectively reduced IOP and exhibited a favorable safety profile. Clinical Trials Registration number is UMIN000004002.…”
Get full text

Controversial Roles of Regenerating Family Proteins in Tissue Repair and Tumor Development by Luting Yu, Qingyun Wu, Shenglong Jiang, Jia Liu, Junli Liu, Guoguang Chen

“…Successively, short peptides derived from Reg3δ and Reg3α have been employed in clinical trials, showing favorable therapeutic effects in patients with type I and type II diabetes. …”
Get full text

Effectiveness of breathing exercises on urinary symptoms, muscle activity, and strength in women with multiple sclerosis and urinary incontinence—a study protocol for a randomized... by Atieh Nazem, Shabnam ShahAli, Mehdi Dadgoo, Holakoo Mohsenifar, Ismail Ebrahimi Takamjani, Laleh Abadi Marand

“…Trial registration The trial was registered in the Iranian Registry of Clinical Trials with code IRCT20180916041051N3 and was approved on 23 May 2024. …”
Get full text

Real-World Characterization of Toxicities and Medication Management in Recipients of CAR T-Cell Therapy for Relapsed or Refractory Large B-Cell Lymphoma in Nova Scotia, Canada by Jenna Shaw, Mahmoud Elsawy, Rachel Nielsen, Amye Michelle Harrigan, Tara T. DiCostanzo, Laura V. Minard

“…Patients who received CAR T-cell therapy in NS, Canada, experienced comparable toxicities and efficacy to those reported in pivotal clinical trials and other real-world experiences.…”
Get full text

Is Vitamin D Deficiency the Cause or the Effect of Systemic Lupus Erythematosus: Evidence from Bidirectional Mendelian Randomization Analysis by Yang Ding, Shengyi Yang, Shasha Fan, Yi Tang, Yan Teng, Xiaohua Tao, Wei Lu

“…Future studies, including random controlled clinical trials, should evaluate the association and mechanisms between serum VD levels and SLE.…”
Get full text

PARP Inhibitors in the Treatment of Ovarian Cancer by Andrzej Paweł Zuzak, Magdalena Cieślik-Porębska, Krzysztof Kułak, Jagoda Niewiadomska

“…These inhibitors have been validated in multiple clinical trials, underscoring their robustness and effectiveness. …”
Get full text

Nonpharmacological Modulation of Chronic Inflammation in Parkinson’s Disease: Role of Diet Interventions by Stefania Kalampokini, Anouck Becker, Klaus Fassbender, Epameinondas Lyros, Marcus M. Unger

“…Future research should focus on planning larger clinical trials with dietary interventions in PD in order to obtain hard evidence for the hypothesized beneficial effects.…”
Get full text

Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People by Bing Han, Qin Li, Ningjian Wang, Yi Chen, Chunfang Zhu, Yingchao Chen, Fangzhen Xia, Zhen Cang, Meng Lu, Ying Meng, Chi Chen, Yingli Lu

“…However, further clinical trials are needed to confirm this association.…”
Get full text