Pembrolizumab for the Treatment of Locally Advanced Cutaneous Squamous Cell Carcinoma: Patient Selection and Special Considerations by Stewart M, Geiger JL

“…Pembrolizumab, approved by the FDA in 2020 for recurrent or metastatic cSCC not amenable to curative surgery or radiation, has shown promising results in clinical trials. Immunotherapy is also being explored in neoadjuvant settings, with ongoing trials evaluating its potential to improve outcomes for high-risk patients with recurrent or metastatic disease. …”
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Is there a risk of esketamine misuse in clinical practice? by Carlos Roncero, Milton Merizalde-Torres, Néstor Szerman, Marta Torrens, Pablo Vega, Pilar Andres-Olivera, Francisco Javier Álvarez

“…In 2019, intranasal esketamine gained approval as a promising therapy for those individuals grappling with treatment-resistant depression. Both clinical trials and real-world studies have underscored its efficacy in alleviating and remitting depressive symptoms, with sustained benefits observed for nearly 4.5 years. …”
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Analysis of restoration in atrophic scar by intradermal autologous dermal tissue: a pilot study by Sudhir Singh, Adarsh L. Singh, Deepika Singh

“…It is important to continue conducting research and clinical trials to establish the benefits and limitations of autologous dermal tissue transplantation for depressed scars. …”
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Minimally invasive lateral, posterior, and posterolateral sacroiliac joint fusion for low back pain: a systematic review and meta-analysis by Kai Xu, Ya-Ling Li, Song-Hua Xiao, Yong-Wei Pan

“…Methods The PubMed, Web of Science, Embase, Cochrane Library, and ClinicalTrials.gov databases were comprehensively searched for studies up to 31 August 2024. …”
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Aaron Temkin BECK: After Cricitical Thinking to A Creative Psychotherapy Theory] by Mehmet DÝNÇ

“…Numerous controlled clinical trials have now demonstrated that cognitive therapy is effective in a variety of psychiatric conditions including depression, bulimia nervosa, hypochondriasis, social phobia, obsessive-compulsive disorder, substance abuse, body dysmorphic disorder, and post-traumatic stress disorder. …”
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Semaglutide Protects against 6-OHDA Toxicity by Enhancing Autophagy and Inhibiting Oxidative Stress by Dong-xing Liu, Chen-sheng Zhao, Xiao-na Wei, Yi-peng Ma, Jian-kun Wu

“…In addition, there are some clinical trials to study the neuroprotective effect of GLP-1 analog on PD patients. …”
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Survival Analysis of Diabetic Colorectal Cancer Patients on Metformin by Alex Brandon Wong, Ravi Patnaik, Li Ling Chaw, Shir Kiong Lu, Long Chiau Ming, Wen Han Chooi, Ya Chee Lim

“…However, the association between cancer progression and metformin use requires further investigation, and high-powered clinical trials are needed to support these findings. …”
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Comprehensive evaluation of pure and hybrid collaborative filtering in drug repurposing by Clémence Réda, Jill-Jênn Vie, Olaf Wolkenhauer

“…The outcomes of past clinical trials can be used to predict novel drug-disease associations by leveraging drug- and disease-related similarities. …”
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Antimicrobial proteins from oyster hemolymph improve the efficacy of conventional antibiotics. by Kate Summer, Qi Guo, Lei Liu, Bronwyn Barkla, Sarah Giles, Kirsten Benkendorff

“…Effective HPE concentrations are comparable to AMPPs currently approved for use or in clinical trials pipelines. Proteomics analysis of HPE identified a number of proteins including abundant known AMPPs. …”
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Aaron Temkin BECK: After Cricitical Thinking to A Creative Psychotherapy Theory by Mehmet DİNÇ

“…Numerous controlled clinical trials have now demonstrated that cognitive therapy is effective in a variety of psychiatric conditions including depression, bulimia nervosa, hypochondriasis, social phobia, obsessive-compulsive disorder, substance abuse, body dysmorphic disorder, and post-traumatic stress disorder. …”
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Comparison of Gastric Emptying Time after the Ingestion of Whisky with Isocalorically Adjusted Glucose Solution by Tadashi Okabe, Hideo Terashima, Atsuhiro Sakamoto

“…This study is registered with the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN000034443).…”
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Phytocannabinoids: a new frontier in Alzheimer’s disease management by Jagadeesh S. Rao

“…At present, numerous FDA-controlled clinical trials are being conducted to assess the beneficial impacts of THC and CBD in the treatment of cognitive and neuropsychiatric symptoms associated with AD. …”
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Diagnostic pathways for breast cancer in 10 International Cancer Benchmarking Partnership (ICBP) jurisdictions: an international comparative cohort study based on questionnaire and... by David Weller, Usha Menon, Alina Zalounina Falborg, Henry Jensen, Andriana Barisic, Anne Kari Knudsen, David H Brewster, Victoria Cairnduff, Eva Grunfeld, Elizabeth Harland, Mats Lambe, Rebecca-Jane Law, Yulan Lin, Martin Malmberg, Donna Turner, Richard D Neal, Victoria White, Samantha Harrison, Peter Vedsted, Una MacLeod, Conan Donnelly, Anna Gavin, Jon Emery, Oliver Bucher, Jatinderpal Kalsi, Chantelle Anandan, Evangelia Ourania Fourkala, Therese Kearney, Marie-Louise Essink-Bot, Sigrun Saur Almberg, Breann Hawryluk, Jacqueline Kelly, Jackie Boylan, Jan Willem Coebergh, David Brewster, Stefan Bergström, Victoria Hammersley, Rebecca Bergin, Alina Zalounina Falborg, Andriana Barisi, Kerry Moore, Maria Rejmyr Davis

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Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe. by Joe D Piper, Clever Mazhanga, Marian Mwapaura, Gloria Mapako, Idah Mapurisa, Tsitsi Mashedze, Eunice Munyama, Maria Kuona, Thombizodwa Mashiri, Kundai Sibanda, Dzidzai Matemavi, Monica Tichagwa, Soneni Nyoni, Asinje Saidi, Manasa Mangwende, Dzivaidzo Chidhanguro, Eddington Mpofu, Joice Tome, Gabriel Mbewe, Batsirai Mutasa, Bernard Chasekwa, Handrea Njovo, Chandiwana Nyachowe, Mary Muchekeza, Kuda Mutasa, Virginia Sauramba, Ceri Evans, Melissa J Gladstone, Jonathan C Wells, Elizabeth Allen, Melanie Smuk, Jean H Humphrey, Lisa F Langhaug, Naume V Tavengwa, Robert Ntozini, Andrew J Prendergast

“…<h4>Trial registration</h4>ClinicalTrials.gov The SHINE follow-up study was registered with the Pan-African Clinical Trials Registry (PACTR202201828512110). …”
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Blood-based prognostic scores and early dynamics under immunotherapy to select patients with metastatic solid tumors for continuing immune check-point inhibition: a prospective lon... by Javier García-Corbacho, Alberto Indacochea, Iván Victoria, Débora Moreno, Laura Angelats, Azucena E. González Navarro, Laura Mezquita, Fara Brasó-Maristany, Patricia Galván, Begoña Mellado, Nuria Viñolas, Tamara Sauri, Miquel Nogué, Barbara Adamo, Joan Maurel, Estela Pineda, Lydia Gaba, Oscar Reig, Neus Basté, Esther Sanfeliu, Manel Juan, Aleix Prat, Francesco Schettini

“…Methods Overall 173 adult patients with metastatic solid tumors candidates to ICI in clinical trials at our Institution were prospectively recruited. …”
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Assessment of Bowel Preparation Using Low-Volume Sulphate-Based Preparations in Comparison with Macrogols: A Multicenter, Randomized, Comparative Clinical Study of the 3rd Phase by E. D. Fedorov, V. V. Veselov, S. V. Kashin, E. V. Tikhomirova, A. V. Veselov, D. V. Zavyalov, A. Kornowski, T. E. Gorskaya, M. Volteau, T. Ponchon

“…This study is registered with the ClinicalTrials.gov Registry of Clinical Trials, No. NCT02321462.Conflict of interest: this study was sponsored by Ipsen Pharma.Acknowledgements: the authors express their sincere gratitude to all the patients who participated in the study, as well as to specialists having provided medical care for the patients, researchers and employees of the participant research centres. …”
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From Bench to Bedside to Bug: An Update of Clinically Relevant Advances in the Care of Persons with Helicobacter pylori Associated Diseases by N Chiba, ABR Thomson, P Sinclair

“…The role of H pylori eradication in persons with uninvestigated dyspepsia remains controversial. New clinical trials of H pylori treatment show symptom relief and improvement in the quality of life of persons with functional dyspepsia, especially in those with ulcer-like or reflux-like dyspepsia. …”
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The role of informal caregivers in suicide prevention for men– findings from a psychological autopsy study by Laura Hofmann, Anna-Lena Springer, Birgit Wagner

“…Trial registration German Clinical Trials Register, DRKS00030758, Registered on 11.11.2022.…”
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Bio-Tribocorrosion of Titanium Dental Implants and Its Toxicological Implications: A Scoping Review by Sumit Gaur, Rupali Agnihotri, Sacharia Albin

“…However, further validation of the role of bio-tribocorrosion on the durability of the Ti dental implants and Ti toxicity is warranted through clinical trials.…”
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Role of nutritional factors at the irritable bowel syndrome by Yu. O. Shulpekova, A. V. Sedova

“…Efficacy of functional food products containing bacteria of probiotic strain Bifidobacterium animalis sp. lactis DN-173 010 for treatment of IBS symptoms is demonstrated in clinical trials. At detection of symptoms link to intake of specific products it is necessary to exclude food allergy and enzymopathies (e.g. lactase deficiency), which should be defined as independent diseases under the «mask» of irritable bowel syndrome.Conclusion. …”
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