Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation by Yi Shen, Changli Lu, Ruoting Men, Jianping Liu, Tinghong Ye, Li Yang

“…This study was registered at ClinicalTrials.gov (identifier: NCT02994537).…”
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Two Approaches to Cognitive Evaluation: Assessing the Strengths and Limitations of GPCOG and ACE-III by Magdalena Mąka, Dominik Sikora, Piotr Oleksy, Adam Zając, Karol Zieliński, Łukasz Papież, Ewa Góralczyk, Jakub Kamiński, Bartosz Buczkowski, Dagmara Wochnik

“…Materials and Methods : A review of 37 peer-reviewed studies, including clinical trials and validation research, was conducted using databases like PubMed and Google Scholar. …”
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Sulodexide Protects Renal Tubular Epithelial Cells from Oxidative Stress-Induced Injury via Upregulating Klotho Expression at an Early Stage of Diabetic Kidney Disease by Yu Ning Liu, Jingwei Zhou, Tingting Li, Jing Wu, Shu Hua Xie, Hua-feng Liu, Zhangsuo Liu, Tae Sun Park, Yaoxian Wang, Wei Jing Liu

“…The hypoalbuminuric effect of sulodexide (SDX) on diabetic kidney disease (DKD) was suggested by some clinical trials but was denied by the Collaborative Study Group. …”
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Canadian Expert Panel Recommendations on the Management of CNS Symptoms Related to Efavirenz by M John Gill, Anita Rachlis, Sharon Walmsley, Mark Halman, The Efavirenz Consensus Working Group

“…In routine practice, the discontinuation rate of efavirenz due to adverse effects appears higher than that described in clinical trials. To minimize early treatment interruption and maximize the benefit of long term viral suppression that can be achieved with efavirenz therapy, health care providers and patients have identified that there is a need for information, education about and practical tools for the management of efavirenz-related side effects. …”
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The Effect of Hyperbaric Oxygen Therapy on Functional Impairments Caused by Ischemic Stroke by Emily R. Rosario, Stephanie E. Kaplan, Sepehr Khonsari, Garrett Vazquez, Niyant Solanki, Melanie Lane, Hiriam Brownell, Sheila S. Rosenberg

“…While research suggests a benefit of hyperbaric oxygen therapy (HBOT) for neurologic injury, controlled clinical trials have not been able to clearly define the benefits. …”
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Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection by Romain Vial, Christine Zandotti, Sophie Alain, Alexandre Decourt, Noémie Jourde-Chiche, Raj Purgus, Charleric Bornet, Laurent Daniel, Valérie Moal, Tristan Legris

“…These findings need to be confirmed in clinical trials.…”
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A network-based analysis anticipates time to recovery from major depression revealing a plasticity by context interplay by Claudia Delli Colli, Aurelia Viglione, Silvia Poggini, Francesca Cirulli, Flavia Chiarotti, Alessandro Giuliani, Igor Branchi

“…We conducted a secondary analysis in two randomized clinical trials, STAR*D and CO-MED. Symptom severity was assessed using the Quick Inventory of Depressive Symptomatology while the context was measured at enrollment with the Quality-of-Life Enjoyment and Satisfaction Questionnaire. …”
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Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review by Adil Farooq Wali, Jayachithra Ramakrishna Pillai, Sirajunisa Talath, Pooja Shivappa, Sathvik Belagodu Sridhar, Mohamed El-Tanani, Imran Rashid Rangraze, Omnia Ibrahim Mohamed, Nowar Nizar Al Ani

“…Future research directions include refining these delivery approaches, further elucidating molecular mechanisms, and conducting clinical trials to validate findings. These efforts could significantly advance the role of phytocompounds in breast cancer management.…”
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The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts by Giuseppe Maiolino, Giacomo Rossitto, Paola Caielli, Valeria Bisogni, Gian Paolo Rossi, Lorenzo A. Calò

“…Finally, the results of randomized clinical trials employing antioxidants completed up to date, despite demonstrating no benefits in healthy populations, suggest a benefit in high-risk patients. …”
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The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances to Double-Lumen Endotracheal Intubation: A Prospective, Randomized, Double-Blind, and Placebo-Controlled Tria... by Tanyong Pipanmekaporn, Yodying Punjasawadwong, Somrat Charuluxananan, Worawut Lapisatepun, Pavena Bunburaphong

“…This trial is registered with ClinicalTrials.gov NCT01289769.…”
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Textural analysis and artificial intelligence as decision support tools in the diagnosis of multiple sclerosis – a systematic review by Filip Orzan, Ştefania D. Iancu, Laura Dioşan, Zoltán Bálint

“…Future research should prioritize clinical trials to establish the real-world applicability of AI-driven decision support tools. …”
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The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review by Xue Zhao, Qing Han, Yujia Liu, Chenglin Sun, Xiaokun Gang, Guixia Wang

“…We performed systematic review, searching MEDLINE, EMASE, ClinicalTrials.gov, the Cochrane Library, and Web of Science from inception to March 2016. …”
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Palmitoylethanolamide, a Natural Retinoprotectant: Its Putative Relevance for the Treatment of Glaucoma and Diabetic Retinopathy by Jan M. Keppel Hesselink, Ciro Costagliola, Josiane Fakhry, David J. Kopsky

“…PEA has been evaluated for glaucoma, diabetic retinopathy, and uveitis, pathological states based on chronic inflammation, respiratory disorders, and various pain syndromes in a number of clinical trials since the 70s of 20th century. PEA is available as a food supplement (PeaPure) and as diet food for medical purposes in Italy (Normast, PeaVera, and Visimast). …”
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Employing the Oncolytic Vesicular Stomatitis Virus in Cancer Virotherapy: Resistance and Clinical Considerations by Alaa A. Abdelmageed, Stephen Dewhurst, Maureen C. Ferran

“…Several VSV-based phase I/II clinical trials show promise; however, addressing resistance and developing novel strategies to enhance therapeutic efficacy are essential for realizing the full potential of VSV oncolytic virotherapy. …”
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CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production by Emily E. O’Driscoll, Sakshi Arora, Jonathan F. Lang, Beverly L. Davidson, Ophir Shalem

“…Food and Drug Administration-approved AAV-mediated gene therapies already on the market and numerous more in clinical trials. However, manufacturing rAAV vectors is an expensive, timely, and labor-intensive process that limits the commercial use of AAV-mediated gene therapies. …”
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The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease by Zhenzhen Lu, Yifei Zhong, Wangyi Liu, Ling Xiang, Yueyi Deng

“…We will summarize the progress of Chinese herbal medicine (CHM) in the treatment of DKD from two aspects. In clinical trials, the Chinese herbal formulas were efficacy and safety confirmed by the randomized controlled trials. …”
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Extensive Use of Interventional Therapies Improves Survival in Unresectable or Recurrent Intrahepatic Cholangiocarcinoma by Ricarda Seidensticker, Max Seidensticker, Kathleen Doegen, Konrad Mohnike, Kerstin Schütte, Patrick Stübs, Erika Kettner, Maciej Pech, Holger Amthauer, Jens Ricke

“…This trial is registered with German Clinical Trials Registry (Deutsche Register Klinischer Studien), DRKS-ID: DRKS00006237.…”
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Preliminary Evidence for Feasibility, Use, and Acceptability of Individualized Texting for Adherence Building for Antiretroviral Adherence and Substance Use Assessment among HIV-In... by David J. Moore, Jessica L. Montoya, Kaitlin Blackstone, Alexandra Rooney, Ben Gouaux, Shereen Georges, Colin A. Depp, J. Hampton Atkinson, The TMARC Group

“…This trial is registered with ClinicalTrials.gov NCT01317277.…”
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The comparison of biodistribution of glutathione PEGylated nanoliposomal doxorubicin formulations prepared by pre‐insertion and post‐insertion methods for brain delivery in normal... by Amin Mehrabian, Saba Dadpour, Mohammad Mashreghi, Javad Zarqi, Anis Askarizadeh, Ali Badiee, Leila Arabi, Seyedeh Alia Moosavian, Mahmoud Reza Jaafari

“…Here, the 5% pre‐inserted PEG2000‐GSH PEGylated liposomal doxorubicin was conducted according to 2B3‐101 being tested in clinical trials. In addition, PEGylated nanoliposomal doxorubicin connected to the spacer‐GSH targeting ligand (GSGGCE) and the PEG3400 was conducted using post‐insertion method. …”
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Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes by Prasad Sherekar, Sanvidhan G. Suke, Archana Dhok, Srikant Malegaonkar, Shrikrishna A. Dhale

“…The preclinical findings open the doors to clinical trials for operational and regenerative nanoformulations, which eventually create a positive change in medical practice. …”
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