CRISPR-Cas9 in basic and translational aspects of cancer therapy by Maryam Samareh Salavatipour, Zahra Poursalehi, Negin Hosseini Rouzbahani, Sohaib Mohammadyar, Mohammad Vasei

“…Clinicaltrials.gov, a resource that provides access to information on clinical trials, was also searched in this review. Results: We have defined the basics of this technology and then mentioned some clinical and preclinical studies using this technology in the treatment of a variety of solid tumors as well as hematologic neoplasms. …”
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Regenerative Medicine for Neurological Disorders by Dong-Hyuk Park, David J. Eve, Yong-Gu Chung, Paul R. Sanberg

“…Finally, the National Institutes of Health guidelines for human stem cell research, clinical trials of commercialized stem cells without larger animal testing, and prohibition of medical tourism were big controversial issues that led to heated discussion.…”
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Development and application of a clinical core data set for deep brain stimulation in Parkinson’s disease, dystonia or tremor: from data collection to data exchange and data sharin... by Anna-Lena Hofmann, Jonas Widmann, Lilly Brandstetter, Udo Selig, Fabian Haug, Julian Haug, Rüdiger Pryss, Jasper Mecklenburg, Andrea Kreichgauer, Philipp Capetian, Christian J. Hartmann, Christian Niklas, Petra Ritter, Patricia Krause, Alfons Schnitzler, Jens Volkmann, Andrea A. Kühn, Peter Heuschmann, Kirsten Haas

“…Trial registration number ClinicalTrials.gov (DRKS-ID: DRKS00031878).…”
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Physical and cognitive-based training in healthy older adults: Evidence from a systematic review and meta-analysis by Fatemeh Adelirad, Zeinab Javadivala, Iman Dianat, Aysan Amrahi Tabieh, Vijay Kumar Chattu

“…Methods: For this systematic review and meta-analysis, randomized clinical trials (RCTs) published between 2000 and 6 February 2023 were extracted from several electronic databases, including, ProQuest, PubMed, Scopus, Embase, and Web of Science. …”
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<i>In Vitro</i> and <i>In Vivo</i> Interventions Reveal the Health Benefits of Levan-Type Exopolysaccharide Produced by a Fish Gut Isolate <i>Lactobacillus reuteri</i> FW2 by Waqar Ahmad, Anam Nasir, Satya Prakash, Azam Hayat, Mujaddad ur Rehman, Shazia Khaliq, Kalsoom Akhtar, Munir Ahmad Anwar, Nayla Munawar

“…It also signifies the need for a further detailed investigation based on clinical trials to include levan in dietary supplements for improved health and well-being.…”
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Integrated treatment of depression and moderate to severe alcohol use disorder in women shows promise in routine alcohol use disorder care – a pilot study by Anna Persson, Anna Persson, Daniel Wallhed Finn, Alice Broberg, Amanda Westerberg, Åsa Magnusson, Åsa Magnusson, Olof Molander

“…Negative effects were reported in terms of increased adverse emotional experiences.DiscussionThe investigated integrated treatment for co-occurring depression and alcohol use disorder continues to show promise. Randomized clinical trials are needed to evaluate its effectiveness.…”
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Association between Metformin Use and Cancer Stage at Diagnosis among Elderly Medicare Beneficiaries with Preexisting Type 2 Diabetes Mellitus and Incident Prostate Cancer by Amit D. Raval, Malcolm D. Mattes, Suresh Madhavan, Xiaoyun Pan, Wenhui Wei, Usha Sambamoorthi

“…This is the first epidemiological study to support the role of metformin in reducing the risk of advanced prostate cancer. Randomized clinical trials are needed to confirm the causal link between metformin use and prostate cancer diagnosis stage.…”
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Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment by Mohamed E. Awad, Khaled A. Hussein, Inas Helwa, Mohamed F. Abdelsamid, Alexandra Aguilar-Perez, Ibrahim Mohsen, Monte Hunter, Mark W. Hamrick, Carlos M. Isales, Mohammed Elsalanty, William D. Hill, Sadanand Fulzele

“…The aim of this study is to review all the published clinical trials on autologous bone marrow mesenchymal stem cells (BM-MSCs) in the repair of cartilage lesions of the knee. …”
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Exploring the Pharmacological Potential of Carrageenan Disaccharides as Antitumor Agents: An In Silico Approach by Ohana Leticia Tavares Silva, Monique Gabriela das Chagas Faustino Alves, Hugo Alexandre Oliveira Rocha

“…These findings offer new insights into the pharmacological properties and mechanisms of action of carrageenan-derived disaccharides, highlighting their potential for further exploration in clinical trials and experimental studies.…”
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Exploring TNFR1: from discovery to targeted therapy development by Yingying Li, Ruiwei Ye, Haorui Dai, Jiayi Lin, Yue Cheng, Yonghong Zhou, Yiming Lu

“…This review emphasizes the emerging field of targeted therapies aimed at selectively modulating TNFR1 activity, identifying promising therapeutic strategies that exploit TNFR1 as a drug target through an evaluation of current clinical trials and preclinical studies. In conclusion, this study contributes novel insights into the biological functions of TNFR1 and presents potential therapeutic strategies for clinical application, thereby having substantial scientific and clinical significance.…”
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Therapies for Mitochondrial Disorders by Kayli Sousa Smyth, Anne Mulvihill

“…Obstacles towards discovering effective therapies include the rarity of MTDS, its pathogenic complexity and lack of clinical trials. Despite the lack of current curative therapies for MTDS, emerging therapies promise exciting and clinically meaningful therapies in the future.…”
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Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA): A Targeted Antioxidant Strategy to Counter Oxidative Stress in Retinopathy by Marco Zeppieri, Caterina Gagliano, Fabiana D’Esposito, Mutali Musa, Irene Gattazzo, Maria Sole Zanella, Federico Bernardo Rossi, Alessandro Galan, Silvia Babighian

“…Several studies have shown that a higher intake of omega-3 fatty acids is associated with a lower risk of developing diabetic retinopathy and age-related macular degeneration (AMD). Reviewing clinical trials and observational studies that support the protective role of omega-3s in retinal disorders is essential. …”
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Is Thymoglobulin or Rituximab the Cause of This Serum Sickness? A Case Report of Serum Sickness Dilemma and Literature Review by Amarpreet Sandhu, Antonia Harford, Pooja Singh, Eduardo Alas

“…There are not any evidence-based guidelines or published clinical trials to help guide therapy for antibody-induced serum sickness; however, we successfully treated our case with three doses of Methylprednisone 500 mg intravenously. …”
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Oral Administration of Lactobacillus plantarum 299v Reduces Cortisol Levels in Human Saliva during Examination Induced Stress: A Randomized, Double-Blind Controlled Trial by Hannah Andersson, Cecilia Tullberg, Siv Ahrné, Kristina Hamberg, Irini Lazou Ahrén, Göran Molin, Mikael Sonesson, Åsa Håkansson

“…The registration number of the study is NCT02974894, and the study is registered at ClinicalTrials.gov.…”
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Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review by Aya Khouchlaa, Aicha El Baaboua, Hamza El Moudden, Fatima Lakhdar, Saad Bakrim, Naoual El Menyiy, Omar Belmehdi, Hicham Harhar, Nasreddine El Omari, Abdelaali Balahbib, Moon Nyeo Park, Gokhan Zengin, Bonglee Kim, Abdelhakim Bouyahya

“…Nevertheless, pharmacokinetic validation and toxicological examinations are required to detect any possible toxicity for future clinical trials.…”
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Disease-Specific Target Gene Expression Profiling of Molecular Imaging Probes: Database Development and Clinical Validation by Lawrence Wing-Chi Chan, Connie Hiu-Ching Ngo, Fengfeng Wang, Moss Y. Zhao, Mengying Zhao, Helen Ka-Wai Law, Sze Chuen Cesar Wong, Benjamin Yat-Ming Yung

“…Validated with the in vitro study, the expression profiles of disease-associated targets can indicate the eligibility of patients for clinical trials of the treatment probe. A Web search tool of the DIPP database is available at http://www.polyu.edu.hk/bmi/dipp/ .…”
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Current AAV-mediated gene therapy in sensorineural hearing loss by Jieyu Qi, Xiaolong Fu, Liyan Zhang, Fangzhi Tan, Nianci Li, Qiuhan Sun, Xiaojie Hu, Zuhong He, Ming Xia, Renjie Chai

“…It is currently possible to regenerate hair cells to treat sensorineural hearing loss by FX-322, a small molecule drug in clinical trials. With the development of genetic engineering technology, gene therapy has brought a promising treatment strategy for many previously intractable diseases. …”
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Dentin-derived alveolar bone graft for alveolar augmentation: A systematic review by Dedy Agoes Mahendra, Kavanila Bilbalqish, Alexander Patera Nugraha, Arief Cahyanto, Kaushik Sengupta, Kamal Hanna, Asti Meizarini, Ninuk Hariyani

“…The review included both randomized controlled trials (RCT), pilot studies, clinical trials, and retrospective studies reporting on dentin-derived ABG use for alveolar augmentation. …”
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First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin by Soichiro Sue, Nobumi Suzuki, Wataru Shibata, Tomohiko Sasaki, Hiroaki Yamada, Hiroaki Kaneko, Toshihide Tamura, Tomohiro Ishii, Masaaki Kondo, Shin Maeda

“…This study was registered in the UMIN Clinical Trials Registry as UMIN000016335.…”
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Direct-Acting Oral Anticoagulants in the Management of Cerebral Venous Sinus Thrombosis—Where Do We Stand? by Nikhil Vojjala, Supriya Peshin, Lakshmi Prasanna Vaishnavi Kattamuri, Rabia Iqbal, Adit Dharia, Jayalekshmi Jayakumar, Rafi Iftekhar, Shagun Singh, Mamtha Balla, Claudia S. Villa Celi, Ramya Ramachandran, Rishab Prabhu, Sumeet K. Yadav, Geetha Krishnamoorthy, Vijendra Singh, Karan Seegobin

“…Ongoing multicentric clinical trials are currently reviewing the role of these agents in both short-term as well as long-term. …”
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