Bone Loss Prevention of Bisphosphonates in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis by Yan Hu, Xiaoting Chen, Xiaojing Chen, Shuang Zhang, Tianyan Jiang, Jing Chang, Yanhong Gao

“…Eleven randomized clinical trials were included in the meta-analysis. The data indicated that the percentage change in the increased BMD in the bisphosphonates groups was superior to that of the control groups at the lumbar spine and total hip. …”
Get full text

Multiplex Tests for Respiratory Tract Infections: The Direct Utility of the FilmArray Respiratory Panel in Emergency Department by Siyuan Yang, Hui Li, Yunxia Tang, Fengting Yu, Chengjie Ma, Huimin Zhang, Lin Pang, Hongxin Zhao, Linghang Wang

“…The FilmArray Respiratory Panel with multiplex targets for respiratory pathogens has been widely used and verified in clinical trials in special test settings. However, it is necessary to evaluate the panel’s performance at the point of care directly, in nonspecific test settings. …”
Get full text

Shedding Light on the Prognostic and Predictive Value of Circulating Tumor DNA for Management of Patients with Early-Stage Colon Cancer by Rami Yanes MD, Turcin Saridogan MD, PhD, Vikram Gorantla MD, Abigail Overacre PhD, Ronan W. Hsieh MD, James Celebrezze MD, Tara Magge MD, Meghana Singhi MD, Anwaar Saeed MD, Amer H. Zureikat MD, Arvind N. Dasari MD, Ibrahim Halil Sahin MD

“…Currently, randomized clinical trials are enrolling to better define this role. …”
Get full text

Dietary Fatty Acids and Predementia Syndromes by Vincenzo Solfrizzi, Vincenza Frisardi, Cristiano Capurso, Alessia D' Introno, Anna M. Colacicco, Gianluigi Vendemiale, Antonio Capurso, Francesco Panza

“…However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms in non–Vapolipoprotein E (APOE) ε4 carriers, and on cognitive symptoms only in very mild Alzheimer's disease (AD) subgroups, MCI patients, and cognitively unimpaired non-APOE ε4 carriers. …”
Get full text

Targeting Herpetic Keratitis by Gene Therapy by Hossein Mostafa Elbadawy, Marine Gailledrat, Carole Desseaux, Diego Ponzin, Stefano Ferrari

“…By November 2012, approximately 28 clinical trials were approved to assess novel gene therapy agents. …”
Get full text

Synergistic Effects of SDS and H2O2 Combinations on Tracheal Scaffold Development: An In Vitro Study Using Goat Trachea by Dhihintia Jiwangga, Ferdiansyah Mahyudin, Gondo Mastutik, Estya Nadya Meitavany, null Juliana, Priangga Adi Wiratama

“…In the development of tissue-engineered tracheal scaffolds, in vitro studies play a crucial role in allowing researchers to evaluate the efficacy and safety of scaffold designs and fabrication techniques before progressing to in vivo or clinical trials. This research involved the decellularization of goat trachea using SDS, H2O2, and their combinations. …”
Get full text

Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results by M. Pracht, J. Edeline, L. Lenoir, M. Latournerie, H. Mesbah, O. Audrain, Y. Rolland, B. Clément, J. L. Raoul, E. Garin, E. Boucher

“…Treating lobar hepatocellular carcinoma with ipsilateral portal vein thrombosis with yttrium-90 glass-microsphere radioembolization is safe and efficacious. Further clinical trials are warranted to confirm these results and to compare 90Y-microS with sorafenib, taking into account not only survival but also the possibility of secondary surgery for putative curative intention after downstaging.…”
Get full text

Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases by Lei Tian, Ruixiang Zhao, Xinyi Xu, Zhiwei Zhou, Xiaofang Xu, Dongmei Luo, Zhiqiang Zhou, Yu Liu, Ariel Kushmaro, Robert S. Marks, András Dinnyés, Qun Sun

“…The present study provides an overview of the preventive and therapeutic effects of L. plantarum on diabetes, obesity, non-alcoholic fatty liver disease, kidney stone disease, and cardiovascular diseases in animal models and human clinical trials. Ingesting L. plantarum demonstrated its ability to reduce inflammatory and oxidative stress levels by regulating the production of cytokines and short-chain fatty acids (SCFAs), the activity of antioxidant enzymes, and the balance of intestinal microbial communities to alleviate the symptoms of chronic metabolic diseases. …”
Get full text

Nanomédicaments pour le traitement de maladies graves et recherches duales by Couvreur, Patrick

“…Depending on the country and therapeutic indications, between 40 to 60 nanomedicines are currently on the market, with over a hundred in clinical trials. This review aims to describe and discuss the characteristics and functionalities of the different generations of nanocarriers, from their inception to the present day, discussing the prospects they offer for the production of therapeutic proteins, for facilitating gene editing (CRISPR/Cas9), and for enabling immune checkpoint blockade in oncology. …”
Get full text

Therapeutic Options for the Management of the Cardiorenal Syndrome by Katerina Koniari, Marinos Nikolaou, Ioannis Paraskevaidis, John Parissis

“…That leads to an increasing concern about novel options, such as the use of vasopressin antagonists, adenosine A1 receptor antagonists, and renal-protective dopamine. Initial clinical trials have shown quite encouraging results in some heart failure subpopulations but have failed to demonstrate a clear beneficial role of these agents. …”
Get full text

HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia by Oscar Peralta-Zaragoza, Jessica Deas, Claudia Gómez-Cerón, Wendy Argelia García-Suastegui, Geny del Socorro Fierros-Zárate, Nadia Judith Jacobo-Herrera

“…Therefore, in this paper, we discuss the main diagnostic methods, management strategies, and followup of HPV-associated cervical lesions and review clinical trials applying gene therapy strategies against the development of cervical cancer.…”
Get full text

Research advances in Pimpinella thellungiana: Nutrients, bioactive compounds, and functional properties benefitting livestock by Shuxian Zhang, Minglu Yang, Tao Xu, Qiongxian Yan, Allan Degen, Xiaoling Zhou

“…Wolff (P. thellungiana), a medicinal herb, has been reported to relieve growth retardation and overexertion in ethnopharmacological clinical trials. This paper summarizes and classifies a total of 106 bioactive compounds that were isolated and identified from P. thellungiana, including flavonoids, simple phenylpropanoids, coumarins, volatile compounds, and simple polyphenols, and discusses its pharmaceutical benefits, including its growth-promoting, antioxidant, anti-inflammatory, anti-atherosclerotic, and hepatoprotective properties. …”
Get full text

Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders by Emmanuel Ortega-Robles, Benito de Celis Alonso, Jessica Cantillo-Negrete, Ruben I. Carino-Escobar, Oscar Arias-Carrión

“…Furthermore, MRI provides objective metrics for tracking disease progression and assessing therapeutic efficacy, making it an indispensable tool in clinical trials. Despite these advances, the absence of standardized protocols limits their integration into routine clinical practice. …”
Get full text

COVID-19 vaccination: challenges in the pediatric population by Alice Nicoleta Azoicai, Ingrith Miron, Ancuta Lupu, Monica Mihaela Alexoae, Iuliana Magdalena Starcea, Mirabela Alecsa, Vasile Valeriu Lupu, Ciprian Danielescu, Alin Horatiu Nedelcu, Delia Lidia Salaru, Felicia Dragan, Ileana Ioniuc

“…An analysis of recent published studies reveals that the majority of clinical trials have reported a sustained immune response following COVID-19 vaccination in children across various age groups worldwide. …”
Get full text

Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients by Pauline Duffuler, Khushwant S. Bhullar, Jianping Wu

“…Moreover, additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.…”
Get full text

Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications by Poojitha Rajasekar, Christina L. O’Neill, Lydia Eeles, Alan W. Stitt, Reinhold J. Medina

“…Extensive evidence from various human clinical trials has clearly established that a period of poor glycemic control early in the disease process carries negative consequences, such as an increase in the development and progression of vascular complications that becomes evident many years later. …”
Get full text

Effectiveness and adverse effects of immersive technologies used for rehabilitation of patients with non-specific neck pain: a systematic review by Joanna S. Kostka, Agnieszka Zawadzka-Fabijan, Dariusz Działa, Bogumiła Bruc, Magdalena Pruszyńska, Gabriela Figas, Rory J. O'Connor, Antti Malmivaara, Jolanta E. Kujawa

“…Methods: A systematic literature search of randomized controlled trials was conducted using Medline (PubMed), Embase (Ovid), Scopus, Cochrane Database of Systematic Reviews, WHO, Pedro, and ClinicalTrials.gov. Risk of bias was assessed with Cochrane Risk of Bias tool. …”
Get full text

Applications of cell penetrating peptide-based drug delivery system in immunotherapy by Jing-Jing Du, Ru-Yan Zhang, Shangchi Jiang, Shanshan Xiao, Yiting Liu, Yongheng Niu, Wen-Xiang Zhao, Dongyuan Wang, Dongyuan Wang, XianShi Ma

“…Then, we concluded the recent progress of their clinical trials for different diseases. Finally, we discussed the challenges and opportunities CPPs met to translate into clinical applications. …”
Get full text

The Role of Platelet Concentrates and Growth Factors in Facial Rejuvenation: A Systematic Review with Case Series by Giuseppina Malcangi, Angelo Michele Inchingolo, Alessio Danilo Inchingolo, Laura Ferrante, Giulia Latini, Irma Trilli, Paola Nardelli, Marialuisa Longo, Andrea Palermo, Francesco Inchingolo, Gianna Dipalma

“…<i>Materials and Methods</i>: A comprehensive literature search was performed on PubMed, Web of Science, and Scopus, focusing on human clinical trials published between February 2019 and February 2024 related to PRP and facial esthetics. …”
Get full text

Adjunctive Therapies to Cerclage for the Prevention of Preterm Birth: A Systematic Review by Emily A. DeFranco, Amy Miyoshi Valent, Tondra Newman, Jodi Regan, Jessica Smith, Louis J. Muglia

“…None of the 12 were prospective randomized clinical trials. No comparative studies were identified addressing the issues of antibiotics, bedrest, or pessary as adjunctive treatments to cerclage. …”
Get full text