Belzutifan for the treatment of renal cell carcinoma by Xiancheng Wu, David Lazris, Risa Wong, Scott S. Tykodi

“…Belzutifan has demonstrated activity in clinical trials as a front- and later-line therapy, and in combination with tyrosine kinase inhibitors. …”
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Gut Microbiome in Obsessive Compulsive Disorder: Potential of Probiotics as an Adjuvant Therapy by Grace Yong-En Kong, Vengadesh Letchumanan, Loh Teng-Hern Tan, Jodi Woan-Fei Law

“…In vivo animal studies showed that probiotics can potentially improve OCD symptoms. Nevertheless, clinical trials are required to determine the efficacy of probiotics as an adjuvant therapy to alleviate OCD symptoms. …”
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The Discovery of Novel Experimental Therapies for Inflammatory Arthritis by Charles J. Malemud

“…A few of them have even entered the first phase of human clinical trials.…”
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L-Ornithine L-Aspartate for the Treatment of Sarcopenia in Chronic Liver Disease: The Taming of a Vicious Cycle by Roger F. Butterworth

“…Thus, a vicious cycle occurs whereby hyperammonemia causes severe muscle damage and sarcopenia that, in turn, limits the capacity of muscle to remove excess blood-borne ammonia and the cycle continues. Randomized clinical trials and meta-analyses confirm that L-ornithine L-aspartate (LOLA) is an effective ammonia-lowering agent currently employed for the treatment of hepatic encephalopathy (HE) that stimulates both urea synthesis by residual hepatocytes and muscle glutamine synthesis together with putative hepatoprotective actions. …”
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The Dynamicity of the Oxytocin Receptor in the Brain May Trigger Sensory Deficits in Autism Spectrum Disorder by Claudia Camerino

“…The neurohormone oxytocin (Oxt) is involved in the etiology of ASD, and there are several ongoing clinical trials regarding Oxt administration in ASD patients. …”
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Long-Term Use of Ruxolitinib in an AML Patient with Posttransplant Steroid Refractory GVHD by Philip T. Sobash, Achuta K. Guddati, Vamsi Kota

“…The long-term use of ruxolitinib has not been explicitly studied outside the context in the treatment of multiple myeloma. With current clinical trials underway for the use of ruxolitinib in srGVHD, there are still no current guidelines or protocols for long-term clinical use. …”
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Pneumocystis carinii Pneumonia in HIV — Investigate or Just Treat? by Steven Kesten

“…This strategy has not been tested in controlled clinical trials although decision analysis models have attempted to evaluated it, it's liekly reasonable to choose empirical antimicrobial therapy in specific clinical settings such as: (a) typical radiographic picture in a person with dyspnea and/or nonproductive cough. presence of HIV and a CD4 count of less than 200 cells/mm3:(b) previous PCP, typical appearance and the patient is known to tolerate standard anti-PCP medications: and (c) high clinical suspicion in a patient who refuses bronchoscopy yet desires treatment or where bronchoscopy cannot he performed. …”
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Contemporary Evaluation and Management of the Diabetic Foot by Bauer E. Sumpio

“…While these, increasingly expensive, therapies have shown promising results in clinical trials, the results have yet to be translated into widespread clinical practice leaving a huge scope for further research in this field.…”
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Stem Cell Applications in Tendon Disorders: A Clinical Perspective by Mark Young

“…Even though cellular therapies offer some potential in treating tendon disorders, there have been few published clinical trials to determine the ideal cell source, the number of cells to administer, or the optimal bioscaffold for clinical use.…”
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CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance by Kayode Komolafe, Maricica Pacurari

“…Furthermore, encouraging preclinical data has necessitated the progression of a few of these drugs into clinical trials in order to make the most effective use of interventions in the development of viable targeted therapeutics. …”
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The Genus <i>Chiliadenus</i>: A Comprehensive Review of Taxonomic Aspects, Traditional Uses, Phytochemistry and Pharmacological Activities by Lucinda Villaescusa Castillo, Francisco Zaragozá García, Cristina Zaragozá Arnáez

“…However, the lack of comparative studies among <i>Chiliadenus</i> species and the scarcity of in vivo studies and clinical trials hinder the full realization of its therapeutic potential. …”
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Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties by Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai

“…Such targetable agents, including RFB4(dsFv)-PE38 (BL22), IL13-PE38QQR, and Tf-CRM107, are being tested in clinical trials. Several agents using unique technology such as a cleavable adapter or immunoliposomes with antibodies are also in the preclinical stage. …”
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Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease by Caihua Wang, Chunpeng Zhu, Liming Shao, Jun Ye, Yimin Shen, Yuezhong Ren

“…During the past decade, stimulation of bile acid receptors with their agonists has been extensively explored for the treatment of NAFLD in both animal models and clinical trials. Early evidence has suggested the potential of bile acid receptor agonists in NAFLD management, but their long-term safety and effectiveness need further clarification.…”
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Perspectives for Clinical Translation of Adipose Stromal/Stem Cells by Mimmi Patrikoski, Bettina Mannerström, Susanna Miettinen

“…Moreover, the current status of clinical trials applying ASCs and the patent landscape in the field of ASC research are presented. …”
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Usefulness of Therapeutic Laser for Pain Management in Orthodontic Treatment by Karen Daniela Villavicencio Córdova, Katherim Anahí Cortez Campaña, Pamela Jeanneth Salinas Villacis

“…Of the total selected, 13 were bibliographic review articles, 20 clinical trials and 1 case report. It was determined that the recommended wavelength for a favorable and relieving result to exist, in the areas of pain where the laser is applied, is 810 nm (nanometers) and that the laser sessions can be applied daily or intermittently. with a maximum irradiation of 10 seconds in each area of pain. …”
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Exercise Induced Adipokine Changes and the Metabolic Syndrome by Saeid Golbidi, Ismail Laher

“…In this paper we briefly describe the pathophysiologic role of four important adipokines (adiponectin, leptin, TNF-α, and IL-6) in the metabolic syndrome and review some of the clinical trials that monitored these adipokines as a clinical outcome before and after exercise.…”
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The mRNA-1647 vaccine: A promising step toward the prevention of cytomegalovirus infection (CMV) by Adewunmi Akingbola, Abiodun Adegbesan, Olajumoke Adewole, Kolade Adegoke, Akpevwe Emmanuella Benson, Paul Ayomide Jombo, Sandra Uchechukwu Eboson, Victor Oluwasola, Ademola Aiyenuro

“…We have reviewed results from Phase 1 and 2 clinical trials of the mRNA-1647 vaccine, demonstrating robust immune responses in both seronegative and seropositive participants. …”
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Targeting the Heart of Mycobacterium: Advances in Anti-Tubercular Agents Disrupting Cell Wall Biosynthesis by Ahmad Diab, Henry Dickerson, Othman Al Musaimi

“…Beyond these, six promising molecules currently in Phase II clinical trials are designed to target arabinan synthesis pathways, sutezolid, TBA 7371, OPC-167832, SQ109, and both benzothiazinone derivatives BTZ043 and PBTZ169, highlighting advancements in the development of cell wall-targeting therapies.…”
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Beneficial Effects of Dietary Nitrate on Endothelial Function and Blood Pressure Levels by Jenifer d’El-Rei, Ana Rosa Cunha, Michelle Trindade, Mario Fritsch Neves

“…The increased levels of nitrite by nitrate intake seem to have beneficial effects in many of the physiological and clinical settings. Several clinical trials are being conducted to determine the broad therapeutic potential of increasing the bioavailability of nitrite in human health and disease, including studies related to vascular aging. …”
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Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy by Ronaldo J. F. C. do Amaral, Henrique V. Almeida, Daniel J. Kelly, Fergal J. O’Brien, Cathal J. Kearney

“…We conclude with a perspective for future clinical trials using IFP stem cells.…”
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