African animal trypanocide resistance: A systematic review and meta-analysis by Keneth Iceland, Kasozi, Ewan, Thomas MacLeod, Susan, Christina Welburn

“…ISM (SMD = −0.41, 95% CI: −0.96, 0.14; I2 = 5%, P = 0.38) showed multiple cross-resistance. Clinical studies also showed evidence of multi-drug resistance on DA and ISM (RR = 1.01, 95% CI: 0.71–1.43; I2 = 46%, P = 0.16). …”
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Characterisation of Chemical Constitutes and Spermatogenic Activity of Ushir (Vetiveria Zizanioides Linn) versus Ikshu (Saccharum Officinarum Linn) in Male Wistar Rats: A Research... by Akshay Sudhir Pargaonkar, Jaymala Jadhav, Bhagyashree Ratan Jibkate, Minakshi Urkude

“…Standardisation of Ayurvedic medicines at the pharmaceutical and analytical levels is important for proceeding with preclinical or clinical studies. The outcomes of animal research have helped consider the drug’s benefits and drawbacks. …”
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Approaches for difficult-to-induce-seizures electroconvulsive therapy cases (DEC): a Japanese expert consensus by Yoshiteru Takekita, Taro Suwa, Kazuyuki Yasuda, Hirotsugu Kawashima, Wataru Omori, Naoki Kurimoto, Takashi Tsuboi, Takamasa Noda, Nobuatsu Aoki, Ken Wada, Ken Inada, Minoru Takebayash, Expert Consensus Development Working Group, Electroconvulsive Therapy Committee, Japanese Society of General Hospital Psychiatry

“…These recommendations should be further evaluated in future clinical studies.…”
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Multimodal data-based longitudinal prognostic model for predicting atrial fibrillation recurrence after catheter ablation in patients with patent foramen ovale and paroxysmal atria... by Shoupeng Duan, Xujun Li, Jun Wang, Yuhong Wang, Tianyou Xu, Fuding Guo, Yijun Wang, Lingpeng Song, Zeyan Li, Xiaomeng Yang, Xiaoyu Shi, Hengyang Liu, Liping Zhou, Yueyi Wang, Hong Jiang, Lilei Yu

“…Abstract Background Clinical studies on atrial fibrillation (AF) recurrence after catheter ablation in patients diagnosed with patent foramen ovale (PFO) and paroxysmal AF (PAF) are scarce. …”
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Brief Report: Clinical Characteristics and Outcomes of Patients With Thoracic SMARCA4-Deficient Undifferentiated Tumors by Alissa J. Cooper, MD, Andrea Arfe, PhD, Biagio Ricciuti, MD, Andréanne Gagné, MD, PhD, Lynette M. Sholl, MD, Alessandro Di Federico, MD, Mark M. Awad, MD, PhD, Mihaela Aldea, MD, PhD, Maria Rosa Ghigna, MD, Miruna Grecea, MD, Phoebe Clark, MS, Jamie E. Chaft, MD, Mark G. Kris, MD, Gregory J. Riely, MD, Charles M. Rudin, MD, PhD, Ibiayi Dagogo-Jack, MD, Mari Mino-Kenudson, MD, Lingzhi Hong, MD, PhD, Neda Kalhor, MD, Natalie Vokes, MD, Anita Bowman, MS, Soo-Ryum Yang, MD, Natasha Rekhtman, MD, PhD, Adam J. Schoenfeld, MD

“…A few patients had remarkable response to regimens including immunotherapy. Prospective clinical studies are urgently needed to identify better therapeutic approaches to treat this aggressive malignancy, and this analysis may serve as a benchmark for future clinical trial design.…”
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Fatigue in living kidney donors compared to a German general population sample: an exploratory study by Dilek Akkus, Adrian Westenberger, Gunilla Einecke, Gunilla Einecke, Wilfried Gwinner, Uwe Tegtbur, Mariel Nöhre, Martina de Zwaan

“…BackgroundClinical studies have not conclusively clarified whether fatigue scores in living kidney donors after donation are fundamentally different from general population samples. …”
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Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…The median onset time for AEs related to upadacitinib was 41.00 days (interquartile range [IQR] 10–141.5 days), with the majority occurring within 3 months of treatment initiation (n = 269, 66.09%), particularly in the first month (n = 171, 42.01%).ConclusionOur findings affirm clinical observations and reveal potential new AE signals for upadacitinib, underscoring the need for prospective clinical studies to verify these results and clarify their clinical relevance. …”
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Detection of genetic determinants of potentially oncogenic representatives of the intestinal microbiota as biomarkers of colorectal cancer by Viktoriya N. Shumilova, Artemij E. Goncharov, Daniil V. Azarov, Stanislav I. Sitkin, Elgudzha L. Latariya, Batyrbek I. Aslanov, Mikhail A. Bobrakov, Rustem E. Topuzov

“…Non-invasive diagnostic methods based on the determination of hidden blood in the stool (fecal immunochemical test, guaiac test), which have been proven to be effective in clinical studies, are used for CRC screening. However, a significant disadvantage of the available non-invasive diagnostic methods is the low sensitivity in detecting the oncological process at the early stages. …”
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HKA angle exceeding 5 degrees is strongly associated with lateral patellar translation beyond 2 mm: surgical recommendations for avoiding adverse effects on the patellofemoral join... by Zheng Jiang, Nan Zhen, Yanjie Mao, Axiang He, Han Guo, Weiming Lin, Diwen Tang, Yang Qu, Tsung-Yuan Tsai, Wanjun Liu

“…Avoiding overcorrection of the HKA angle beyond 5 degrees of valgus reduces lateral patellar translation, which may help prevent AKP. Additional clinical studies are necessary to validate these biomechanical findings and clarify their impacts on patient outcomes.…”
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Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level by Giusy Rita Maria La Rosa, Alejandro Ismael Lorenzo-Pouso, Vito Carlo Alberto Caponio, Mariangela Valentina Puci, Mariangela Valentina Puci

“…Strict inclusion criteria were applied to identify observational and experimental clinical studies on AP in IBDs patients. The bias risk was assessed using the Joanna Briggs Institute critical appraisal tools and a biases' report selected from the Oxford Centre for Evidence Based Medicine Catalogue of Bias. …”
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Effect of trace elements and nutrients on 21 autoimmune diseases: a Mendelian randomization study by Ming-Jie Jia, Hua-Fang Yin, Ying-Chao Liang, Feng Jiang, Hui-Lin Li, Hui-Lin Li

“…BackgroundNumerous clinical studies have observed a close relationship between serum trace elements, nutrients, and autoimmune diseases. …”
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Effects of Calliandra and Sesbania on Daily Milk Production in Dairy Cows on Commercial Smallholder Farms in Kenya by D. N. Makau, J. A. VanLeeuwen, G. K. Gitau, S. L. McKenna, C. Walton, J. Muraya, J. J. Wichtel

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Nanobubble Ozone Stored in Hyaluronic Acid-Decorated Liposome Solutions: Inactivating Antibiotic-Resistant Bacteria and Genotoxicity, Sub-Acute and Sub-Chronic Toxicity Tests by Erkan Alkan P, Karabiyik T

“…In the following process, it would be appropriate to support the product through clinical studies.Keywords: nanobubble liposomes, ozone, NOHAL, antibacterial agents, genotoxicity, sub-acute toxicity, sub-chronic toxicity…”
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The “Chopsticks” Method: A Technique for Capsular Retraction During Hip Arthroscopy Utilizing Switching Sticks by Alec E. Winzenried MD, Kyle R. Wagner MD, Lucas McLean MD, Andrea M. Spiker MD

“…Numerous cadaveric and clinical studies have shown the importance of capsular closure in optimizing post-operative outcomes and, similarly, the importance of decreasing iatrogenic injury to the capsule intraoperatively. …”
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Moxibustion for Herpes Zoster and Postherpetic Neuralgia: A Meta-Analysis by Yuanen Huang, Jingping Wu, Hongbin Cheng, Yanling Liu

“…However, due to the obvious publication bias, the interpretation of the results should be cautious, and more rigorous randomized controlled clinical studies should be included to further confirm the results in the future.…”
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Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne: A Scoping Review of Current Results by Sutema IAMP, Latarissa IR, Widowati IGAR, Sartika CR, Ciptasari NWE, Lestari K

“…Inclusion criteria are RCTs and clinical studies from 2009 to 2024 examining probiotics for acne treatment. …”
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Evaluation of the Performance of an Ocular Surface Modulator Containing ST-Lysyal Versus Hyaluronic Acid Eyedrops in Patients with Dry Eye Disease: A Pilot Study by Stefano Barabino, Andrea Rosa, Sara Marini, Carlo Domenico Bianchi, Maurizio Rolando

“…Trial Registration The study was registered in the ISRCTN registry for Clinical Studies with no. 13587929.…”
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Potential of right ventricular function assessment with echocardiography in transcatheter aortic valve replacement: by Yoshihisa Morita, Taro Kariya, Michael Dougherty, Andrew Peters, Nicholas Ruggiero

“…Also, increasing use of sedation rather than general anesthesia for transfemoral approach transcatheter aortic valve replacement (TAVR) reduces the need for intraoperative transesophageal echocardiography (TEE). Recent clinical studies have demonstrated the importance of 3-dimensional (3D) echocardiography and a longitudinal strain for RV function assessment. …”
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TROPION-Breast04: a randomized phase III study of neoadjuvant datopotamab deruxtecan (Dato-DXd) plus durvalumab followed by adjuvant durvalumab versus standard of care in patients... by Heather L. McArthur, Sara M. Tolaney, Rebecca Dent, Peter Schmid, Jamil Asselah, Qiang Liu, Jane Lowe Meisel, Naoki Niikura, Yeon Hee Park, Gustavo Werutsky, Giampaolo Bianchini, Jay C. Andersen, Robert Kozarski, Nana Rokutanda, Barbara Pistilli, Sibylle Loibl

“…Datopotamab deruxtecan (Dato-DXd), a TROP2-directed antibody-drug conjugate consisting of a humanized IgG1 monoclonal antibody attached via a plasma-stable cleavable linker to a topoisomerase-I inhibitor payload, has shown efficacy alone or in combination with durvalumab, a selective, high-affinity anti-programmed cell death ligand 1 antibody, in early-phase clinical studies. Objectives: The primary objective of TROPION-Breast04 is to evaluate the efficacy and safety of neoadjuvant Dato-DXd plus durvalumab followed by adjuvant durvalumab with or without chemotherapy versus standard of care in patients with previously untreated early-stage TNBC or HR-low/HER2− breast cancer. …”
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Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024 by Lian Y, Zhang H, Xing W, Li S, Lai X, Jia S, Shang J, Liu H

“…Future research trajectories are likely to encompass investigations into the relationship between HF and pyroptosis, as well as clinical studies on pharmaceuticals targeting the NLRP3 inflammasome as a therapeutic approach for HF.Conclusion: This investigation provides a comprehensive bibliometric analysis and synopsis of NLRP3 inflammable-related studies in HF. …”
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