Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review by Sarah Ezquerra, Amparo Zuleta, Rodrigo Arancibia, José Estay, Francisco Aulestia, Flavio Carrion

“…Still, further research and clinical studies with controlled and consistent results are needed to see the real therapeutic efficacy of MSC spheroids.…”
Get full text

Rhegmatogenous retinal detachment: current treatment approaches by A.V. Doga, D.O. Shkvorchenko, L.A. Kryl, M.R. Taevere, D.A. Buryakov

“…This paper discusses routine and promising surgical techniques for RRD, compare these techniques, and reviews novel technologies and randomized clinical studies that will sign ificantly improve surgical outcomes.…”
Get full text

Normothermic Crystalloid Polarizing Cardioplegia Improves Systolic and Diastolic Function in a Porcine Model of Cardiopulmonary Bypass by David Santer, Stefan Heber, Anne-Margarethe Kramer, Judith Radloff, Katharina Heissl, Attila Kiss, David J. Chambers, Seth Hallström, Bruno K. Podesser

“…These results suggest beneficial effects for polarizing cardioplegia; clinical studies are required to confirm these effects.…”
Get full text

The clinical pattern of intentional injuries at a primary Saudi Arabian trauma center by Bader Hamza Shirah, Hamza Asaad Shirah, Ibrahim Abdulaziz Zabeery, Osama Abdulqader Sogair, Ahmed Medawi Alahmari, Wael Awad Alhaidari, Maher Hamdan Alamri, Waal Nafa Aljabri

“…The clinical pattern is similar in most aspects to international reports but differs in certain features due to the specific religious and conservative characteristics of the community. Nationwide clinical studies are strongly recommended.…”
Get full text

Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis by He Cao, Zhi Cao, Yue Han, Jing Shan

“…Future experimental validation and clinical studies are necessary to confirm the safety and efficacy of this proposed vaccine in managing uveitis and preserving vision.…”
Get full text

ZSH‐2208: A novel retinoid with potent anti‐tumour effects on ESCC stem cells via RARγ–TNFAIP3 axis by Ruoxue Chen, Xuan Huang, Jiayun Hou, Junjie Ni, Wenrui Zhao, Quanlin Li, Heng Jiao, Xin Cao

“…Methods Our previous study has reported WYC‐209, which is capable of inducing apoptosis of CSCs in melanoma and hepatoma, but is ineffective against ESCC. Additionally, clinical studies in ESCC still lack drug candidates that effectively target CSCs. …”
Get full text

Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adults by Farwa Ali, Jeremy A. Syrjanen, Dan J. Figdore, Walter K. Kremers, Michelle M. Mielke, Clifford R. Jack, David S. Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, B. Gwen Windham, Leland R. Barnard, Ronald C. Petersen, Alicia Algeciras-Schimnich

“…A sample of 2641 Mayo Clinic Study of Aging participants with measurements of plasma biomarkers and gait parameters was analyzed in this cross-sectional study. …”
Get full text

Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization Analysis by Renjie Gu, Liangqiong Chen, Minhui Hua, Huangtai Miao, Yongwei Qin

“…Clinical relevance: The findings of this study hold potential clinical significance in guiding early management strategies for GERD, reducing the incidence of TMD, and optimizing healthcare resource allocation, thereby improving patient quality of life. Further clinical studies are warranted to validate these findings and explore underlying mechanisms.…”
Get full text

Enhanced detection of circulating tumor cells using a MUC1 promoter-driven recombinant adenovirus by Cheng Wang, Huihui Gu, Jia Cai, Chuandong Zhu, Qin Zheng, Hanfeng Xu, Lixue Wang, Yuan Wan

“…CTC Model Samples were employed to determine detection rates, and clinical samples from breast cancer patients were analyzed to preliminarily evaluate the efficacy of CTC detection in a clinical context.ResultsIn preclinical and clinical studies, rAdF35-MUC1 exhibited a significantly high detection efficiency for breast cancer cells, outperforming the existing hTERT-dependent adenovirus (rAdF35-hTERT), especially in detecting CTCs at low quantities. …”
Get full text

Patient-centered outcomes for gastrointestinal cancer care: a scoping review protocol by Natalie G Coburn, Frances C Wright, Alyson L Mahar, Lesley Gotlib Conn, Julie Hallet, Amy T Hsu, Paul D James, Joanna Yang, Tori Barabash, Luckshi Rajendran, Claire Ludwig, Ekaterina Kosyachkova, Julie Deleemans

“…To foster informed and value-driven treatment choices, evidence-based information on outcomes relevant to patients is needed. Traditionally, clinical studies have largely focused on a few concrete and easily measurable outcomes such as survival, disease progression and immediate treatment toxicities. …”
Get full text

Asthma-associated prostate enlargement and bladder smooth muscle hypercontractility: unveiling a potential link to LUTS by Peibin Cen, Ming Chen, Xin Qiu, Wenbin Guo, Hongyu Lan, Xingyu Zhou, Ming Lei, Guohua Zeng, Qingfeng Yu

“…Abstract Background In male patients, benign prostate hyperplasia (BPH) and overactive bladder (OAB) secondary to BPH are the primary causes of Lower Urinary Tract Symptoms (LUTS). Recent clinical studies have reported an increased risk of LUTS, particularly severe LUTS conditions, in male asthmatic patients. …”
Get full text

Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…Divergence of approaches and findings between preclinical studies and clinical trials highlights the need for evaluating the design of future clinical studies with particular emphasis on radiation dose and fractionation, immune biomarkers and selecting appropriate end points for combination radiation/immune modulator trials, recognizing that direct effect on the tumor and potential abscopal effect may well be different. …”
Get full text

Bacteroides Fragilis Exacerbates T2D Vascular Calcification by Secreting Extracellular Vesicles to Induce M2 Macrophages by Cong Chen, Zhengfeng Liang, Yuqi He, Yan Gao, Shuhui Ouyang, Lili Wang, Jianghua Liu, Jingsong Cao

“…Concurrently, Mef2d activated by the EV targets and upregulates the expression of pro‐calcification factor Serpine1, thereby exacerbating T2D VC. Clinical studies have shown that Serpine1 is significantly elevated in the peripheral blood of patients with T2D VC and is closely associated with T2D VC. …”
Get full text

Acupuncture treatment of restless legs syndrome: a randomized clinical controlled study protocol based on PET-CT and fMRI by Lin Tang, Na Zhao, Xiaolin Gao, Jinjin Li, Xintong Yu, Ruilong Liang, Chen Xie, Lutong Li, Qianqian Wang, Wenjia Yang

“…RLS seriously affects the quality of life. Clinical studies have confirmed that acupuncture can alleviate the clinical symptoms of RLS. …”
Get full text

Local application of sodium thiosulfate as an otoprotectant for cisplatin-exposed patients – A narrative literature review to explore the potential benefit for children with cancer... by Nienke Streefkerk, Amirhossein Masroor, James I. Geller, Martine van Grotel, Marc Ansari, Eric Bouffet, Archie Bleyer, Brice Fresnau, Michael Sullivan, Alwin D.R. Huitema, Alexander E. Hoetink, Per Kogner, Rudolf Maibach, Allison F. O’Neill, Vassilios Papadakis, Kaukab M. Rajput, Gareth J. Veal, Penelope R. Brock, Annelot J.M. Meijer, Marry M. van den Heuvel-Eibrink

“…Findings: From 256 studies, ten studies met the inclusion criteria, including seven preclinical studies, and three clinical studies. Four studies (two preclinical, two clinical) which included pharmacokinetic data, showed that locally administered STS was associated with low systemic serum STS levels. …”
Get full text

Evaluating Stable Chronic Obstructive Pulmonary Disease by Ultrasound by Togay Evrin, Semih Korkut, Leyla Ozturk Sonmez, Lukasz Szarpak, Burak Katipoglu, Jacek Smereka, Ramazan Guven, Evrim Eylem Akpinar

“…The use of US in COPD patients could help to support clinical decision, but further clinical studies are necessary to confirm those findings.…”
Get full text

Effect of Multiradiance Low-Level Laser Therapy and Topical Silver Sulfadiazine on Healing Characteristics of Dermal Wounds in Marine Toads (Rhinella marina) by Kate E. Archibald, Tara Harrison, Brigid Troan, Dustin Smith, Larry J. Minter

“…Current recommendations for wound management in amphibians are based primarily on clinical experience and on extrapolation from other taxa, whereas controlled clinical studies are lacking. Low-level laser therapy, also termed photobiomodulation, has gained popularity in veterinary medicine and may represent a valuable adjunct therapy for wound care in amphibians, though dosing and safety evaluations have not been previously reported. …”
Get full text

Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta‐analysis by Tieci Yi, Min Li, Fangfang Fan, Lin Qiu, Zhi Wang, Haoyu Weng, Xiaoke Shang, Changdong Zhang, Wei Ma, Yan Zhang, Yong Huo

“…Methods and results We used the MEDLINE, Cochrane Library, Embase, and PubMed databases to identify clinical studies (published to 4 August 2021) that evaluated the effect of ISD on HF. …”
Get full text

Early health technology assessment of tongue swab for non-sputum based pulmonary tuberculosis diagnosis in ThailandResearch in context by Langming Mou, Teerawat Wiwatpanit, Apiwat Piriyapol, Puwadol Chawengkul, Janjira Thaipadungpanit, Puttarin Kulchaitanaroaj, Yot Teerawattananon, Yi Wang

“…The TPP outlines three target levels to guide innovators in designing effective clinical studies. Findings: The landscape review identified the clinical workflow and reimbursement process of all PTB diagnostic tests in Thailand. …”
Get full text

Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma by Junchen Liu, Junchen Liu, Kun Dai, Kun Dai, Muhammad Auwal Saliu, Muhammad Auwal Saliu, Mansur Dabai Salisu, Mansur Dabai Salisu, Jiangyu Gan, Lukman Olalekan Afolabi, Dehong Yan, Guizhong Zhang, Maoxuan Liu, Maoxuan Liu, Xiaochun Wan, Xiaochun Wan

“…Chimeric antigen receptor T-cell (CAR-T) therapies have shown promise in glioblastoma clinical studies, but responses remain inconsistent due to heterogeneous tumor antigen expression and immune evasion post-treatment. …”
Get full text