Impact of coronary bifurcation angle on the pathogenesis of atherosclerosis and clinical outcome of coronary bifurcation intervention-A scoping review. by Yoshinobu Murasato, Kyohei Meno, Takahiro Mori, Katsuhiko Tanenaka

“…Previous bench and clinical studies have evaluated the impact of the BA between the proximal main vessel and the side branch (Angle A) and the BA between the distal main vessel and the side branch (Angle B) on the clinical outcomes of bifurcation stenting. …”
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Clinical efficacy studies of the vaccine against feline panleukopenia, calicivirus infection and viral rhinotracheitis Carnifel PCH in kittens by T. S. Galkina, A. A. Komarova, A. M. Kiselev

“…The product was developed and tested for its quality in accordance with the requirements of the Russian Federation law. Clinical studies were conducted using 8–12 week-old kittens from different litters born from seronegative, non-vaccinated cats and kept in the household, in a veterinary hospital and animal shelters. …”
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Impact of glycolysis inhibitor (2-DG) and oxidation and phosphorylation uncoupler (2,4-DNP) on brain metabolites by O. B. Shevelev, M. P. Moshkin

“…Since the activity of many enzymes is under the control of adenosine triphosphate (ATP) or cofactors, such as nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH), energy deficiency can cause metabolic changes in brain tissue. Some clinical studies using proton nuclear magnetic resonance spectroscopy (1H NMR spectroscopy) revealed metabolic changes in brain tissue in patients with neurodegenerative diseases. …”
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Research status of east Asian traditional medicine treatment for chronic cough: A scoping review. by Boram Lee, Chan-Young Kwon, Ye Ji Kim, Jae Hyun Kim, Kwan-Il Kim, Beom-Joon Lee, Jun-Hwan Lee

“…<h4>Methods</h4>Based on Arksey and O'Malley's scoping review methodological framework, a total of six English, Chinese, Korean, and Japanese electronic databases were searched on August 2022. Any clinical studies on EATM targeting chronic cough patients (regardless of their cause) were included.…”
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«Management of a pharmaceutical organization» – practical communicative lectures in English by Alexandra A. Efimova, Anastasia I. Liashko, Evgenia A. Tsitlionok

“…The conditions of the modern pharmaceutical market determine a number of additional requirements to the list of professional competencies of pharmaceutical employees who must be fluent in key aspects of management, search for new active substances, pharmaceutical development, preclinical and clinical studies, registration, as well as marketing and post-marketing research. …”
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Therapeutic potential of phytocompounds of Bacopa monnieri (L.) Wettst (literature review) by O.O. Nikitina, D.S. Tsyba

“…Numerous clinical trials show the effectiveness of the use of extracts in the treatment of anhedonia, depression, Alzheimer's disease, Parkinson's disease, dementia and hyperactivity. An analysis of clinical studies in Ukraine shows that drugs based on B. monnieri can be used in the complex treatment of cognitive impairment associated with dyscirculatory encephalopathy in adults and perinatal CNS damage in children. …”
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Virtual Screening, Toxicity Evaluation and Pharmacokinetics of Erythrina Alkaloids as Acetylcholinesterase Inhibitor Candidates from Natural Products by Permana A, Akili AWR, Hardianto A, Latip JB, Sulaeman AP, Herlina T

“…These results warrant further investigation in preclinical and clinical studies to validate its therapeutic potential and safety for Alzheimer’s disease treatment.Keywords: Erythrina alkaloid, pharmacokinetics, In silico, acetylcholinesterase inhibitors, virtual screening…”
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Patient experiences of an ankle fracture and the most important factors in their recovery: a qualitative interview study by Rebecca Samantha Kearney, Rebecca McKeown, David R Ellard, Zi Heng Liew

“…The results of this study will enable an increased understanding of the factors of relevance to individuals with ankle fracture, allowing collection of appropriate outcomes in clinical studies for this condition. Ultimately these results will help formulate appropriate patient-centred rehabilitation plans for these patients.Trial registration number ISRCTN15537280; Pre-results…”
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Additive Effects of Glutathione in Improving Antibiotic Efficacy in HIV–<i>M.tb</i> Co-Infection in the Central Nervous System: A Systematic Review by Leena Nabipur, Michael Mouawad, Vishwanath Venketaraman

“…Animal models demonstrated reduced bacterial burden in the lungs, liver, and spleen with GSH supplementation, along with enhanced granuloma stability. Clinical studies highlighted increased TH1 cytokine production, reduced inflammatory markers, and improved CD4+ T cell counts in HIV–<i>M.tb</i> co-infected patients. …”
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Diagnostic Imaging for Distal Extremity Injuries in Direct Access Physical Therapy: An Observational Study by Michael S Crowell, John S Mason, Jamie B Morris, Max K Dummar, Paul A Kuwik

“… # Hypothesis/Purpose To describe the utilization of diagnostic imaging in foot/ankle and wrist/hand injuries by physical therapists in a direct-access sports physical therapy clinic. # Study Design Retrospective cohort study. # Methods The Agfa Impax Client 6 image viewing software (IMPAX) was searched from 2014 to 2018 for patients with diagnostic imaging ordered for foot/ankle and wrist/hand injuries. …”
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Prognostic Value of TRPM7 Expression and Factor XIIIa-Expressing Tumor-Associated Macrophages in Gastric Cancer by Muhammet Calik, Ilknur Calik, Gokhan Artas, Ibrahim Hanifi Ozercan

“…However, there are no comprehensive clinical studies about the effect of TRPM7 expression on gastric cancer (GC) prognosis. …”
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Methyl Gallate Attenuates Doxorubicin-Induced Cardiotoxicity in Rats by Suppressing Oxidative Stress by Akheruz Zaman Ahmed, Shakta Mani Satyam, Prakashchandra Shetty, Melanie Rose D’Souza

“…Our study opens the perspective to clinical studies for consideration of methyl gallate as a potential chemoprotectant nutraceutical in the combination chemotherapy with doxorubicin to limit its cardiotoxicity.…”
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Effects of Elevated Ambient Temperature on Reproductive Outcomes and Offspring Growth Depend on Exposure Time by Huda Yahia Hamid, Md Zuki Abu Bakar Zakaria, Goh Yong Meng, Abd. Wahid Haron, Noordin Mohamed Mustapha

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Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates. by Athos Silva De Oliveira, Leroy Versteeg, Neima Briggs, Rakesh Adhikari, Maria Jose Villar, JeAnna R Redd, Peter Hotez, Maria Elena Bottazzi, Jeroen Pollet

“…This study explores the development of mRNA vaccine candidates based on Na-GST-1, building on the success of recombinant Na-GST-1 (rNa-GST-1) protein, currently assessed as a subunit vaccine candidate, which has shown promise in preclinical and clinical studies.<h4>Methodology/findings</h4>By leveraging the flexible design of RNA vaccines and protein intracellular trafficking signal sequences, we developed three variants of Na-GST-1 as native (cytosolic), secretory, and plasma membrane-anchored (PM) antigens. …”
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Studying the impact of chitosan salicylaldehyde/schiff base/CuFe2O4 in PC3 cells via theoretical studies and inhibition of PI3K/AKT/mTOR signalling by Ghada H. Elsayed, Asmaa M. Fahim

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Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis by Yong-chao Qiao, Jian Shen, Lan He, Xue-zhi Hong, Fang Tian, Yan-hong Pan, Ling Liang, Xiao-xi Zhang, Hai-lu Zhao

“…We performed a comprehensive search up to July 2016 for all clinical studies about the changes of Treg, IL-6, IL-10, IL-17, TGF-β, and TNF-α in T2DM patients versus healthy controls. …”
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Efficacy of a new treatment algorithm for capsulitis of the fingers in rock climbers by Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Christoph Lutter, Christoph Lutter, Hans-Christoph Lang, Mario Perl, Othmar Moser, Michael Simon

“…BackgroundAlthough finger joint capsulitis has been described among the most frequent injuries in climbers, no clinical studies on treatment strategies and outcomes are available.Study designProspective case series study.MethodsBetween 2015 and 2018 we prospectively treated 50 patients (38 male, 12 female) with a total number of 69 independent finger joint capsulitis according to a clinic specific treatment regimen and evaluated the outcome retrospectively. …”
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Evaluation of Five Ready-to-Use Bases for the Topical Administration of Propranolol Hydrochloride to Treat Infantile Hemangioma by Chiara Lacassia, Annalisa Cutrignelli, Flavia Maria la Forgia, Sergio Fontana, Antonio Lopalco, Nunzio Denora, Angela Assunta Lopedota

“…<b>Background/Objectives</b>: Since 2008, following clinical studies conducted on children that revealed the ability of the β-adrenergic antagonist propranolol to inhibit capillary growth in infantile hemangiomas (IHs), its oral administration has become the first-line treatment for IHs. …”
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Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies by Sahar Balkhi, Giorgia Bilato, Andrea De Lerma Barbaro, Paola Orecchia, Alessandro Poggi, Lorenzo Mortara

“…Preclinical and clinical studies highlight reduced toxicity and enhanced anti-tumor efficacy, overcoming TME-driven immune suppression. …”
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The dipeptide carnosine alleviates acute pancreatitis in an experimental model by Heresh Rezaei, Saeed Heidari, Mohammad Mehdi Ommati, Babak Taheri, Forouzan Khodaei, Mohammad Ali Dehghani, Ayeh Rowhanirad, Azadeh Veisi-Goshtasb, Zahra Honarpishefard, Negar Azarpira, Hossein Niknahad, Reza Heidari

“…Further research is needed to confirm these protective effects in clinical studies and assess carnosine safety in AP.…”
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