Mixed-methods process evaluation of a proactive approach to healthcare in Parkinson’s disease—ParkProReakt: a protocol of a hybrid efficacy-implementation study by Xinyu Huang, Max Geraedts, Elke Kalbe, Carsten Eggers, David José Pedrosa, Ann-Kristin Folkerts, Marcin Grzegorzek, Marlena van Munster, Johanne Stümpel, Natalie Altschuck, Ingmar Wellach, Hannes Boebinger, Anna Pedrosa, Kati Niemand, Dirk Becker, Nicole Pohlschmidt, Isabel Doblinger, Kristina Schmidt, Daniel Wolferts, Marius Nisslmueller, Gennet Beer, Mohammad Osman Ashraf, Florian Eberhardt, Rebecca Wichartz, Birgit Samans, Volker Gross, Keywan Sohrabi, Linda Kerkemeyer, Uemran Seven, Paulina Olgemoeller, Artur Piet, Mona Irsfeld, Marlena van Munster

“…Results will be communicated to the funding body and disseminated through scientific publications.Trial registration This study was registered with the German Registry for Clinical Studies (DRKS)—number: DRKS00031092.…”
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Isolation and Characterization of <i>Lactobacillus gasseri</i> Strains from Women for Potential Vaginal Health Applications by Eui-Chun Chung, Jong Seo Lee, Hye Ji Lim, Seok-Jin Kim, Youn-Jee Chung, Kum-Joo Shin

“…These findings indicate that BELG74 could be a promising probiotic for improving vaginal health, with further clinical studies needed to confirm these benefits.…”
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ST Elevation Myocardial Infarction in Patients with COVID-19: Case Series by Sofia Lakhdar, Chandan Buttar, Laura Guzman Perez, Nso Nso, Mahmoud Nassar, Giovina Collura

“…Patients with COVID-19 also encounter cardiovascular conditions that potentially increase their risk for mortality. Few clinical studies reveal the development of ST segment elevation myocardial infarction (STEMI) in patients with COVID-19. …”
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Histopathological investigation of the effect of coenzyme q10 on intestinal mucosa and tight junction proteins in experimental colitis model by Saadet Ozen Akarca Dizakar, Murside Ayse Demirel

“…However, it is thought that more detailed and various experimental and clinical studies supported by advanced molecular techniques are needed on the protective effects of CoQ10 against ulcerative colitis patients.…”
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Monitoring Everyday Upper Extremity Function in Patients with Complex Regional Pain Syndrome: A Secondary, Retrospective Analysis from ncRNAPain by Gudrun-Karin Kindl, Ann-Kristin Reinhold, Fabiola Escolano-Lozano, Johannes Degenbeck, Frank Birklein, Heike L. Rittner, Karolin Teichmüller

“…Developing QuickDASH versions for CRPS patients could reduce the load of questions in clinical studies. It would be prudent to consider the unexpected age dependency of the DASH in future studies. …”
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Healing potentiality of blood clot, S-PRF and A-PRF as scaffold in treatment of non-vital mature single rooted teeth with chronic peri-apical periodontitis following regenerative e... by Omnia Badawy Darwish, Said Mohamed Abdel Aziz, Hany Samy Sadek

“…There is a need for future randomized clinical studies to consolidate procedures in this field with more prolonged evaluation periods. …”
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Development and Application of Physiologically-Based Pharmacokinetic Model to Predict Systemic and Organ Exposure of Colorectal Cancer Drugs by Sara Peribañez-Dominguez, Zinnia Parra-Guillen, Iñaki F. Troconiz

“…Results: The data from 51 clinical studies were extracted and combined in one single dataset. …”
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Options of dyslipidemia treatment at non-alcoholic fatty liver disease by M. V. Mayevskaya, M. A. Morozova

“…Specification of efficacy and safety of application of the drug requires more large-scale clinical studies. Omega-3-PUFAs is one more option in the lipid metabolism disorders treatment in this group of patients. …”
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Construction of a potentially functional long noncoding RNA-microRNA-mRNA network in diabetic cardiomyopathy by Qiwen Cao, Zhihui Dong, Yangbo Xi, Jiana Zhong, Jianzhong Huang, Qunfeng Yang

“…Further experimental validation and clinical studies are warranted to translate these findings into clinical applications.…”
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Mechanical analysis of 3D printed dental restorations manufactured using different resins and validation with FEM analysis by Buse Cebi Gul, Fatih Demirci, Nagehan Baki, Erkan Bahce, Mutlu Özcan

“…The wear and fracture resistance of resin-based materials should be supported by clinical studies.…”
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Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges by Man Wang, Fei Yu, Yuan Zhang

“…Owing to gaps between preclinical and clinical studies, nano-immunotherapy faces multiple challenges, including the biosafety of nanomaterials and clinical trial design. …”
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Clinicopathological and prognostic significance of the microcystic elongated and fragmented pattern in endometrial cancer: a systematic review and meta-analysis by Yan Zhang, Peng Jia, Baofeng Duan

“…Consequently, this research aimed to clarify the prognostic implications of the MELF pattern for individuals diagnosed with endometrial carcinoma.Design Systematic review and meta-analysis of observational clinical studies.Data sources An extensive review of the literature was conducted using reputable databases such as PubMed, Embase, Web of Science and the Cochrane Library, covering the period from January 2003 to October 2023. …”
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Involvement of transposable elements in Alzheimer’s disease pathogenesis by R. N. Mustafin, E. K. Khusnutdinova

“…Experimental and clinical studies have shown pathological activation of retroelements in Alzheimer’s disease. …”
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Pranayama (yogic breathing practices) in Parkinson’s disease: protocol for a scoping review of literature by Sarika Chaturvedi, Dhiraj Agarwal, Prajwal Rao, Shalesh Rohatgi

“…Previous systematic reviews and meta-analyses have not detailed the pranayama practices used in clinical studies, and there is no clarity on the pranayama practices that would be most beneficial for Parkinson’s disease. …”
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Efficacy of vaccines based on chimeric or multiepitope antigens for protection against visceral leishmaniasis: A systematic review. by Karine Ferreira Lopes, Mariana Lourenço Freire, Silvane Maria Fonseca Murta, Edward Oliveira

“…The review included original studies that reported parasite load or positivity rates in animals immunized with these vaccines and subsequently challenged or exposed to L. infantum infection in preclinical and clinical studies. Key information was extracted, tabulated, and analyzed, with the risk of bias being assessed using the SYRCLE Risk Tool.…”
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Evidence of Negative Effects of Defect Size and Older Patient Age by Quantitative CT-Based 3D Image Analysis in Ultraporous Beta-Tricalcium Phosphate Grafted Extremity Bone Defects... by Timothy A. Damron, Kenneth A. Mann

“…Ultraporous beta tricalcium phosphate (TCP) is a popular synthetic compound used in this situation. Prior clinical studies based on plain X-ray analysis suggest incorporation of TCP is incomplete, even when combined with bone marrow (BMA). …”
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Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review by Siddharth Shah, Hadeel M. Mansour, Brandon Lucke-Wold

“…Data are presented chronologically as clinical studies were published. Therapeutic strategies based on stem cells have drawn a lot of interest as possible HD therapies. …”
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Rhus Verniciflua Stokes Inhibits PD-1 Expression and Induces Anticancer Effects by Enhancing T Cell Function by Seoyoung Kim PhD, Young-Kwan Lee PhD, Wang-Jun Lee MD, PhD, Hyoun Jong Moon MD, PhD, Sanghun Lee KMD, PhD

“…Background: Over the last decade, the anticancer effects of Rhus verniciflua Stokes (RVS) have been reported in various preclinical or clinical studies. However, the effects of RVS on immuno-oncology, especially on the functional properties of T cells and their phenotypes, remain unclear. …”
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Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review. by Claudia Eberle, Michaela F Kirchner, Raphaela Herden, Stefanie Stichling

“…We selected n = 45 epidemiological as well as clinical studies and n = 21 experimental studies. In brief, pre-conceptional paternal risk factors, such as obesity, own birth weight, high-fat and low-protein diet, undernutrition, diabetes mellitus, hyperglycaemia, advanced age, smoking as well as environmental chemical exposure affect clearly metabolic and cardiovascular health of their offspring later in life.…”
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Effect of the hour-1 bundle on clinical outcomes in patients with sepsis and septic shock: A protocol for systematic review and meta-analysis. by Shukun Hong, Hongye Wang, Xiaoguang Fan, Jian Liu, Lujun Qiao

“…The following electronic databases will be searched: PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science. All clinical studies comparing the impact of the hour-1 bundle and non-hour-1 bundle on clinical outcomes in patients with sepsis and septic shock will be included. …”
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