Ultra-processed food consumption and the risk of incident chronic kidney disease: a systematic review and meta-analysis of cohort studies by Bingjie Xiao, Jinxian Huang, Linyi Chen, Yujie Lin, Jianghong Luo, Huifen Chen, Lizhe Fu, Fang Tang, Wenwei Ouyang, Yifan Wu

“…Thus, more standardized clinical studies and further exploration of the mechanisms are needed in the future.…”
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Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes by Flavia Bruna, David Contador, Paulette Conget, Benjamín Erranz, Claudia L. Sossa, Martha L. Arango-Rodríguez

“…Preclinical and clinical studies have shown that a therapeutic effect results from mesenchymal stromal cells (MSCs) transplant. …”
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Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications by Eleftheria Papachristoforou, Vaia Lambadiari, Eirini Maratou, Konstantinos Makrilakis

“…Regarding DM specifically, previous experimental and clinical studies have pointed to the fact that oxidative stress probably plays a major role in the pathogenesis and development of diabetic complications. …”
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Nutritional Evaluation of Pediatric Patients with Sickle Cell Disease Treated with Hydroxyurea by Belkis Lázara Rodríguez Jorge, Lucía Morejón Díaz, Yoandra León Rayas, María Santa Cruz

“…<strong>Background:</strong> clinical studies in patients with sickle cell disease have shown that the use of hydroxyurea is associated with a reduction in acute and chronic complications, including those related to the nutritional status of these patients. …”
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Delving into the therapeutic prospects of desmostachya bipinnata (L.) in the context of polycystic ovary syndrome (PCOS): A comprehensive review by Sarthak Mishra, Payal Mittal

“…Despite these findings, additional clinical studies are required to validate its efficacy. …”
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Bibliometric and Altmetric Analysis of the 100 Most Cited Articles on Piriformis Syndrome by Burak Tayyip Dede, Muhammed Oguz, Fatih Bagcier, Ebru Aytekin

“…The country that produced the most articles was the United States, and the most cited author was Fishman. Clinical studies accounted for the majority of the top 100 articles (n=44). …”
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Is there a role for acromioclavicular (AC) joint capsular repair and reconstruction in high-grade AC separations? A systematic review by Al-Achraf Khoriati, Tony Antonios, Zien Alabdin Fozo, Aliya Choudhury, Magnus Arnander, Eyiyemi Pearse, Duncan Tennent

“…Methods: This is a systematic review of biomechanical and clinical studies that describe AC reconstructive or reparative techniques. …”
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In vitro Evaluation of Titanium Exfoliation during Simulated Surgical Insertion of Dental Implants by Tanisha Mishra, Bhavna Jha Kukreja, Ruchi Patel, Mahesh Ghadage, Pranita Dalave, Shivani Kumari, Naina Pattnaik, Manish S. Jadhav

“…This exfoliation could potentially impact peri-implant tissue health and osseointegration. Further clinical studies are necessary to assess the long-term effects of titanium particle exfoliation on implant success.…”
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Hypokalemic paralysis in an adolescent following dexamethasone and B12 injection: A case report and literature review by Keivan Sahebi, Hassan Foroozand, Mohammad Bahmei, Raziee Taghizadeh, Samane Zare, Soroor Inaloo

“…However, this hypothesis is based on a few cases, and further pathophysiological and clinical studies are needed to clarify whether B12 supplementation exacerbates hypokalemia induced by glucocorticoids or if the observation is coincidental or context-specific. …”
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Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury by Susan Bengs, Alexia Rossi, Martina Haberecker, Nidaa Mikail, Alexander Meisel, Achi Haider, Muriel Grämer, Angela Portmann, Atanas Todorov, Christof Schönenberger, Caroline E. Gebhard, Gabriela M. Kuster, Vera Regitz-Zagrosek, Catherine Gebhard

“…Abstract Previous work indicates that SARS-CoV-2 virus entry proteins angiotensin-converting enzyme 2 (ACE-2) and the cell surface transmembrane protease serine 2 (TMPRSS-2) are regulated by sex hormones. However, clinical studies addressing this association have yielded conflicting results. …”
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The effects of SN Ps in the regions of positioning RNA polymerase II on the TBP/promoter affinity in the genes of human circadian clock by O. A. Podkolodnaya, D. A. Rasskazov, N. L. Podkolodnyy, N. N. Podkolodnaya, V. V. Suslov, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko

“…These predictions are important for identification of candidate SNP markers of various pathologies associated with the dysfunction of circadian clock genes for further testing them in experimental and clinical studies, as well as for verification of mathematical models of the circadian oscillator.…”
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Does HbA1c Level Have Clinical Implications in Diabetic Patients Undergoing Coronary Artery Bypass Grafting? A Systematic Review and Meta-Analysis by Jia Zheng, Jing Cheng, Tong Wang, Qian Zhang, Xinhua Xiao

“…However, further clinical studies with larger sample sizes and longer follow-up period are urgently warranted.…”
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Pharmacological regression of atherosclerotic plaque in patients with type 2 diabetes by Loredana Bucciarelli, Daniele Andreini, Giulio Stefanini, Roberta Maria Fiorina, Marco Francone, Federica Catapano, Maria Elena Lunati, Edoardo Conte, Davide Marchetti, Paolo Fiorina

“…In this review, we are revisiting the existence of atherosclerosis regression in preclinical and clinical studies, with a focus on the latest mechanistic insights and on the newest pharmacological agents, particularly in patients with diabetes. …”
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Photodynamic Antimicrobial Chemotherapy for Root Canal System Asepsis: A Narrative Literature Review by P. Diogo, T. Gonçalves, P. Palma, J. M. Santos

“…The level of evidence available in clinical studies to answer this question is low and at high risk of bias.…”
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Management of Oro-Antral Communication: A Systemic Review of Diagnostic and Therapeutic Strategies by Gianna Dipalma, Angelo Michele Inchingolo, Irma Trilli, Laura Ferrante, Angela Di Noia, Elisabetta de Ruvo, Francesco Inchingolo, Antonio Mancini, Stefan Cocis, Andrea Palermo, Alessio Danilo Inchingolo

“…Using targeted keywords, articles in English published within the last 10 years were analyzed from databases such as PubMed, WoS and Scopus, selecting only clinical studies on human patients. After thorough screening, 20 publications were included in the qualitative analysis, among 734 initially identified. …”
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The perfect molecule for hormonal contraception: Estetrol benefits. A review by Elena A. Gorbunova, Inna A. Apolikhina

“…The article highlights promising results from clinical studies that confirm the efficacy of E4-based COCs, showing high levels of patient satisfaction. …”
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Enhanced Proliferation of Porcine Bone Marrow Mesenchymal Stem Cells Induced by Extracellular Calcium is Associated with the Activation of the Calcium-Sensing Receptor and ERK Sign... by Jingjing Ye, Wei Ai, Fenglin Zhang, Xiaotong Zhu, Gang Shu, Lina Wang, Ping Gao, Qianyun Xi, YongLiang Zhang, Qingyan Jiang, Songbo Wang

“…In conclusion, our findings provided evidence that the enhanced pBMSCs proliferation in response to Ca2+o was associated with the activation of CaSR and ERK1/2 signaling pathway, which may be useful for the application of pBMSCs in future clinical studies aimed at tissue regeneration and repair.…”
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Opicapone, a Novel Catechol-O-methyl Transferase Inhibitor, for Treatment of Parkinson's Disease "Off" Episodes by Amnon A. Berger, Ariel Winnick, Jonathan Izygon, Binil M. Jacob, Jessica S. Kaye, Rachel J. Kaye, Elisa E. Neuchat, Adam M. Kaye, Edward S. Alpaugh, Elyse M. Cornett, Andrew H. Han, Alan D. Kaye

“…By inhibiting COMT, opicapone slows levodopa metabolism and increases its availability. Several clinical studies demonstrated significant improvement in treatment efficacy and reduction in duration of "off episodes." …”
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Quality of commercialized dry extracts of blood orange juice in Brazilian compounding pharmacies: Dry extracts of blood orange juice by Lídia Cristina Merlin de Meneses, Maria Izabel Lamego Neta, Jhenifer Luisa Miniuki, Ingrid Vicente Farias, Larissa Benvenutti, Otto Mauricio Santos Gerlach, Flávio H. Reginatto, Angela Malheiros, José Roberto Santin, Tania Mari Bellé Bresolin

“…Abstract The juice of blood oranges, especially those of the Citrus sinensis variety Moro, cultivated in the region of Sicily (Italy), is an increasingly popular drink due to its beneficial health properties, such as its ability to reduce abdominal fat, related to its anthocyanin constituents, especially cyanidin-3-O-glycoside (C3G), as demonstrated in pre-clinical and clinical studies. However, the dry extract of C. sinensis juice currently available at compounding pharmacies in Brazil includes samples from various countries, some of which may not have adequate climatic conditions for the production of anthocyanins. …”
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Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review by Maroua Jalouli, Md Ataur Rahman, Partha Biswas, Hasanur Rahman, Abdel Halim Harrath, In-Seon Lee, In-Seon Lee, Sojin Kang, Jinwon Choi, Moon Nyeo Park, Bonglee Kim, Bonglee Kim

“…Epidemiological and clinical studies highlight the potential of polyphenol-rich diets to decrease the risk and alleviate symptoms of neurodegenerative disorders and neuroinflammation. …”
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