Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy by Rebecca F. Slykerman, Naomi Davies, Klara Vlckova, Kenneth J. O'Riordan, Shalome A. Bassett, James Dekker, Harriët Schellekens, Niall P. Hyland, Gerard Clarke, Elaine Patterson

“…In this review, we consider how these decisions can be supported in light of information accrued from a range of clinical studies across healthy, at‐risk and pathological study populations, where specific strains have been evaluated in the context of gastrointestinal physiology, brain function and behaviour. …”
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GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study by Emma F. Magavern, Harshal Deshmukh, Geraldine Asselin, Elizabeth Theusch, Stella Trompet, Xiaohui Li, Raymond Noordam, Y.-D. Ida Chen, Teresa E. Seeman, Kent D. Taylor, Wendy S. Post, Jean-Claude Tardif, Dirk S. Paul, Emelia J. Benjamin, Nancy L. Heard-Costa, Ramachandran S. Vasan, Jerome I. Rotter, Ronald M. Krauss, J.Wouter Jukema, Paul M. Ridker, Patricia B. Munroe, Mark J. Caulfield, Daniel I. Chasman, Marie-Pierre Dubé, Graham A. Hitman, Helen R. Warren

“…Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. …”
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Assessment of point-of-care quantitative serum canine pancreatic lipase testing for diagnosing acute pancreatitis in dogs by Pin-Chen Liu, Pin-Chen Liu, Kendy Tzu-yun Teng, Kendy Tzu-yun Teng, Tsia-Lu Lin, Chi-Hsuan Sung, Tsun-Li Cheng, Chi-Chung Chou, Chi-Chung Chou

“…Recently, a commercial point-of-care testing method (Vcheck CPL) that offers quantitative measurement of CPL has emerged. However, clinical studies on its value (or utility) are limited. …”
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Economic Spectrofluorometric Bioanalysis of Empagliflozin in Rats’ Plasma by Bassam Ayoub, Noha El Zahar, Haidy Michel, Mariam Tadros

“…Moreover, with the suitable modifications, the described novel extraction of empagliflozin could be adopted to human plasma samples and future clinical studies. Moreover, development of new simple cost-effective methods is necessary to give the researchers a set of “varieties” that they can use according to the laboratory limitations, especially in the developing countries in addition of being a greener method due to the lower consumption of toxic solvents and lower waste production.…”
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Safety of Levodopa-Carbidopa Intestinal Gel Treatment in Patients with Advanced Parkinson’s Disease Receiving ≥2000 mg Daily Dose of Levodopa by Cindy Zadikoff, Werner Poewe, James T. Boyd, Lars Bergmann, Horia Ijacu, Pavnit Kukreja, Weining Z. Robieson, Janet Benesh, Angelo Antonini

“…Data were collected from several prospective, phase III clinical studies and an observational registry. The phase III program (N = 412) included four multicenter studies: a 12-week, randomized, double-blind study and three open-label studies extending ≥12 months. …”
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PARP inhibitors as therapy for small cell lung carcinoma: A systematic review and meta-analysis of clinical trials by Samuel Pratama, Lowilius Wiyono, Martien Silviandy Setiawan, Brigitta Cindy Lauren

“…Further and larger clinical studies are needed to validate the efficacy and safety of PARPi therapy for SCLC patients.…”
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HBV Core Promoter Inhibition by Tubulin Polymerization Inhibitor (SRI-32007) by Raj Kalkeri, Junzhong Peng, Chunsheng Huang, Zhaohui Cai, Roger G. Ptak, Mark J. Suto

“…To identify potential new antiviral molecules, a select group of compounds previously evaluated in clinical studies were tested against 12 different viruses. …”
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Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity by Florence Vallelian, Marc Pfefferlé, Irina L Dubach, Raphael M Buzzi, Elena Dürst, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Larissa Imhof, Sandra Koernig, Didier Le Roy, Thierry Roger, Rok Humar, Dominik J Schaer

“…However, preclinical and clinical studies faced dose-limiting toxicities mediated by necroinflammatory liver disease. …”
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Research status of traditional & complementary medicine systems across the world by Vedvati Bhapkar, Vallari Nisargand, Pawankumar Godatwar, Supriya Bhalerao

“…Maximum COVID-19 related clinical studies were registered for TCM (n = 335), followed by Ayurveda (n = 112). …”
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Clinically meaningful improvements after gene therapy for aromatic L-amino acid decarboxylase deficiency (AADCd) in the Peabody Developmental Motor Scale, Second Edition (PDMS-2) a... by Wuh-Liang Hwu, Hui-Min Lee, John Devin Peipert, Rongrong Zhang, Christian Werner, J. Rafael Sierra, Thomas O’Connell, Jonathan J. Woolley, Marjorie Crowell, Antonia Wang, Ioannis Tomazos

“…Methods Data from N = 30 patients from three single-arm clinical studies of eladocagene exuparvovec were analyzed. …”
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Effect of maternal cigarette smoking and alcohol consumption during pregnancy on birth weight and cardiometabolic risk factors in infants, children and adolescents: a systematic re... by Eunice Bolanle Turawa, Tammy Charlene Hartel, André Oelofse, Juléy Janice Abigail De Smidt

“…Therefore, this review aims to provide a summary of the most recent evidence on birth outcomes and cardiometabolic risk in children associated with alcohol and/or tobacco exposure in utero.Methods and analysis PubMed, Scopus and Web of Science will be searched to identify published articles from 1 January 2001. Clinical studies that investigate the association between maternal cigarette smoking or alcohol consumption and birth weight and cardiometabolic risk factors in infants, children and adolescents will be included. …”
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Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment by Hanan Seddiek, Mira Hanna, Amany Elsayed Mohamed Hamoud, Marawan Abd Elbaset, Ahmed M. A. Akabawy, Mohamed Zakaria Kotb, Mohamed Mansour Khalifa

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Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel by Anil Pareek, Nitin Chandurkar, Vivek Raut, Kumar Naidu

“…It can be further developed in clinical studies for the unmet medical needs in management of CVDs and overcome the pharmacogenomic limitations of Clopidogrel.Trial registration number Clinical Trial Registry-India URL: http://ctri.nic.in. …”
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The Effect of Submucosal Injection of Plasma-Rich Platelets on Blood Inflammatory Markers for Patients with Bimaxillary Protrusion Undergoing Orthodontic Treatment by Trefa Mohammed Ali Mahmood, Omar Fawzi Chawshli

“…This trial is registered with U1111-1221-8829 by Sri Lanka Clinical Trial Registry, SLCTR/2018/040, and No. 64 on 6th August 2018 at the local clinical studies database, College of Dentistry.…”
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History of Pain Research and Management in Canada by Harold Merskey

“…Their work continues while a variety of basic and clinical studies are advancing knowledge of fundamental mechanisms, including work by Henry and by Sawynok on purines; by Salter and by Coderre on spinal cord mechanisms and plasticity; by Katz on postoperative pain; by several workers on children's pain; and by Bushnell and others in Montreal on cerebral imaging. …”
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Unlocking the Healing Potential: A Comprehensive Review of Ecology and Biology of Medical‐Grade Honey in Wound Management and Tissue Regeneration by Parmis Barazesh, Helia Hajihassani, Fatemeh Motalebi, Seyedeh Mobina Hosseini Neiresi, Romina Hajihassani, Ahmad Reza Mehrabian

“…The review focuses on how honey's botanical origins affect its medical properties and wound‐healing capabilities. Finally, clinical studies on honey's effectiveness in wound healing were reviewed compared to traditional treatments. …”
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Role of antimicrobial photodynamic therapy for the management of peri‑implant diseases among habitual nicotinic product users: A systematic review by Abdulrahman M. AlMubarak

“…Using Boolean operators, the following keywords were searched in different combinations: antimicrobial photodynamic therapy; crestal bone loss; peri‑implant diseases; probing depth; nicotine; and smoking. Original clinical studies were included. Letters to the Editor, Case-reports, case-series, commentaries, reviews and perspectives/expert opinions were excluded. …”
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High Doses of Halotolerant Gut-Indigenous Lactobacillus plantarum Reduce Cultivable Lactobacilli in Newborn Calves without Increasing Its Species Abundance by Alexander Rodriguez-Palacios, Henry R. Staempfli, J. Scott Weese

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Use of iStent as a Standalone Operation in Patients with Open-Angle Glaucoma by Yu-Yen Chen, Yun-Ju Lai, Yung-Feng Yen, Li-Ying Huang

“…We searched various databases between January 1, 2000, and September 30, 2019, and included only peer-reviewed, prospective, or retrospective clinical studies in our analyses. Details regarding the IOP and the number of medications at baseline and end point were recorded from each study. …”
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A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar. by James A Watson, Thomas Lamb, Jane Holmes, David A Warrell, Khin Thida Thwin, Zaw Lynn Aung, Min Zaw Oo, Myat Thet Nwe, Frank Smithuis, Elizabeth A Ashley

“…For most antivenoms there is little information from clinical studies to infer the relationship between dose and efficacy or dose and toxicity. …”
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