Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism by Jiefeng Huang, Wuyan Lu, Shenli Zhao, Zixin Cai, Linxiao Li, Zihao Hu, Yu Jiang, Jinyi Deng, Yiming Tang, Chenzhang Shi, Chen Wang, Guangpeng Liu, Shuaijun Li

“…Despite the widespread occurrence of fibrotic diseases, effective therapies are lacking. Recent clinical studies have demonstrated a positive correlation between serum homocysteine (Hcy) levels and the severity of systemic sclerosis. …”
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Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy by Hicham Wahnou, Riad El Kebbaj, Bertrand Liagre, Vincent Sol, Youness Limami, Raphaël Emmanuel Duval

“…Furthermore, we examine the preclinical and clinical studies that have demonstrated the efficacy of CNPs in treating different types of tumors, including breast, colorectal, and pancreatic cancers. …”
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Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis by Navjot Kaur, Nusrat Shafiq, Harish Negi, Avaneesh Pandey, Srinivas Reddy, Harpreet Kaur, Neelima Chadha, Samir Malhotra

“…A number of experimental and clinical studies have been conducted to explore therapeutic potential of Terminalia arjuna in cardiovascular ailments specially in patients of coronary heart disease. …”
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Cellular therapies in rheumatic and musculoskeletal diseases by Pedro Franco-Fuquen, Juana Figueroa-Aguirre, David A. Martínez, Eider F. Moreno-Cortes, Juan E. Garcia-Robledo, Fabio Vargas-Cely, Daniela A. Castro-Martínez, Mustafa Almaini, Januario E. Castro

“…Preliminary data from patients with RMDs, particularly those with lupus erythematosus and dermatomyositis, suggest that CAR T-cells targeting CD19 can induce rapid and sustained depletion of circulating B cells, leading to complete clinical and serological responses in cases that were previously unresponsive to conventional therapies.This review will provide an overview of the current state of preclinical and clinical studies on the use of CAR T-cells and other cellular therapies for RMDs. …”
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Old and Recent Advances in Life Cycle, Pathogenesis, Diagnosis, Prevention, and Treatment of Malaria Including Perspectives in Ethiopia by Dejen Nureye, Solomon Assefa

“…However, three types of vaccines and a lot of novel compounds are under perclinical and clinical studies that are triggered by the occurrence of resistance among commonly used drugs and insecticides. …”
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How to Deal with Pulpitis: An Overview of New Approaches by Jakub Fiegler-Rudol, Wojciech Niemczyk, Katarzyna Janik, Anna Zawilska, Małgorzata Kępa, Marta Tanasiewicz

“…In vitro, animal, and clinical studies focusing on innovative regenerative endodontic techniques were analyzed. …”
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Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities by Piero Ruscitti, Paola Di Benedetto, Onorina Berardicurti, Vasiliki Liakouli, Francesco Carubbi, Paola Cipriani, Roberto Giacomelli

“…Interestingly, different preclinical and clinical studies have suggested that biologic agents commonly used to treat RA patients may be effective in improving CVD. …”
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The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A “Me Too” or “the Special One” Antidiabetic Class? by Ricardo Godinho, Cristina Mega, Edite Teixeira-de-Lemos, Eugénia Carvalho, Frederico Teixeira, Rosa Fernandes, Flávio Reis

“…Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) increase glucagon-like peptide-1 (GLP-1) availability and correct the “incretin defect” seen in T2DM patients. Clinical studies have shown good glycaemic control with minimal risk of hypoglycaemia or any other adverse effects, despite the reports of pancreatitis, whose association remains to be proved. …”
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Review of Metabolic Surgery for Type 2 Diabetes in Patients with a BMI < 35 kg/m2 by Hideharu Shimizu, Poochong Timratana, Philip R. Schauer, Tomasz Rogula

“…To evaluate current status of metabolic surgery, we reviewed the available clinical studies which described surgical treatment for T2DM with mean BMI  <  35 kg/m2. 18 studies with 477 patients were identified. 30% of the patients was insulin users. …”
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Pigmented Maize (Zea mays L.) Contains Anthocyanins with Potential Therapeutic Action Against Oxidative Stress - A Review by Jesús Miguel Magaña Cerino, Héctor Arturo Peniche Pavía, Axel Tiessen, Carmen Magdalena Gurrola Díaz

“…Given the importance of the biological properties of maize anthocyanins, it is necessary to understand the current knowledge and propose further research or clinical studies which allows us to better elucidate the biological mechanism of maize anthocyanins derivatives of several varieties and processes of cooking and combination with other ingredients to enhance their nutritional and health benefits.…”
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INTRAOPERATIVE PHOTODYNAMIC THERAPY FOR METASTATIC PERITONEAL TUMORS by E. A. Suleimanov, V. M. Khomyakov, L. G. Serova, L. I. Moskvicheva, E. V. Filonenko, A. D. Kaprin

“…Benefits, opportunities and possibilities of application of intraoperative photodynamic therapy (IOPDT) for secondary peritoneal tumors are described in details, the results of a number of domestic and foreign clinical studies are shown, the successful application of intraoperative photodynamic therapy in clinical oncology, which allows reducing the risk of secondary tumor lesions of the peritoneum significantly, is demonstrated. …”
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Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial by Fahimeh Pakravan, Afsaneh Yegdaneh, Somayeh Taymouri, Shiva Rahimi, Negin Ghahremani

“…Nonetheless, further clinical studies are required to shed more light on this topic. …”
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Black rice (Oryza sativa L.) and its anthocyanins: mechanisms, food applications, and clinical insights for postprandial glycemic and lipid regulation by Thavaree Thilavech, Tanyawan Suantawee, Charoonsri Chusak, Phim On Suklaew, Sirichai Adisakwattana

“…Utilizing black rice flour and its anthocyanin-rich extracts in food products enhances health benefits by suppressing starch digestibility and increasing phytochemical content and antioxidant capacity. Clinical studies support the potential of black rice and its food derivatives to effectively manage postprandial glycemic and lipidemic responses while increasing plasma antioxidant capacity. …”
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Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors by Gianna Dipalma, Angelo Michele Inchingolo, Valeria Colonna, Pierluigi Marotti, Claudio Carone, Laura Ferrante, Francesco Inchingolo, Andrea Palermo, Alessio Danilo Inchingolo

“…Only English-language clinical studies involving human subjects were included. …”
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DPP-4 Inhibitors as Treatments for Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis by Qixian Wang, Min Long, Hua Qu, Rufei Shen, Rui Zhang, Jing Xu, Xin Xiong, Hui Wang, Hongting Zheng

“…Objective. Several clinical studies have reported the application of dipeptidyl peptidase-4 (DPP-4) inhibitors as treatments for type 1 diabetes mellitus (T1DM). …”
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Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions by Fereshteh Asgharzadeh, Fereshteh Asgharzadeh, Mahsa Attarian, Majid Khazaei, Majid Khazaei, Abdulridha Mohammed Al-Asady, Abdulridha Mohammed Al-Asady, Abdulridha Mohammed Al-Asady, Saeide Mansoori, Hamideh Naimi, Moein Eskandari, Azar Khorrami, Seyedeh Elnaz Nazari, Akram Aminian, Marjaneh Farazastanian, Elaheh Eshtad, Amir Avan, Amir Avan, Mikhail Ryzhikov, Malihe Hasanzadeh, Seyed Mahdi Hassanian, Seyed Mahdi Hassanian

“…Jujube-treated group.DiscussionThe results collectively indicate that Z. jujube is a safe and potent natural product with anti-inflammatory and anti-fibrotic properties, highlighting its potential as a novel candidate for clinical studies targeting UA in patients.…”
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Confirmatory Factor Analysis of the Motor Unified Parkinson’s Disease Rating Scale by Stefanie D. Vassar, Yvette M. Bordelon, Ron D. Hays, Natalie Diaz, Rebecca Rausch, Cherry Mao, Barbara G. Vickrey

“…This supports motor UPDRS containing multiple subscales that can be analyzed separately and provide information distinct from the total score that may be useful in clinical studies.…”
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Phantom-based investigation of block sequential regularised expectation maximisation (BSREM) reconstruction for zirconium-89 PET-CT for varied count levels by Lara M. Bonney, Matthew D. Walker, Daniel R. McGowan

“…Conclusion Where BSREM reconstruction is used for Zr-89 images, careful attention must be paid to the choice of weighting factor, especially for quantitative clinical studies. The effect of varying beta on several measures of image quality was characterised for the case of a phantom, with the results indicating that the value of beta for optimal Zr-89 quantitation is lower than what is generally used for optimal visualisation. …”
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A Robust Metatranscriptomic Technology for Population-Scale Studies of Diet, Gut Microbiome, and Human Health by Andrew Hatch, James Horne, Ryan Toma, Brittany L. Twibell, Kalie M. Somerville, Benjamin Pelle, Kinga P. Canfield, Matvey Genkin, Guruduth Banavar, Ally Perlina, Helen Messier, Niels Klitgord, Momchilo Vuyisich

“…Stool metatranscriptomic analysis offers a comprehensive functional view of the gut microbiome, but despite its usefulness, it has rarely been used in clinical studies due to its complexity, cost, and bioinformatic challenges. …”
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Osteoarthritis synovium as a nidus for monosodium urate crystal deposition inducing severe gout studied by label‐free stimulated Raman scattering combined with synovial organoids by Ziyi Chen, Wenjuan Wang, Yaxin Chen, Minbiao Ji, Yinghui Hua

“…Osteoarthritis (OA), the most prevalent type of arthritis, is a progressive degenerative joint disease. Previous clinical studies have reported that gout frequently affects OA joints; however, the underlying mechanism remains unidentified. …”
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