Epigenetic Drug Interventions in Breast Cancer: A Narrative Review of Current Research and Future Directions by Sarah Bibi Mungly, Evelyn Priya Peter, Ling-Wei Hii, Chun-Wai Mai, Felicia Fei-Lei Chung

“…With renewed interest in epigenetic-modifying pharmaceutical agents, namely DNA methyltransferase inhibitors (DNMTi), histone deacetylase inhibitors (HDACi), bromodomain and extra-terminal inhibitors (BETi), and enhancer of zeste homolog 2 inhibitors (EZH2i), there have been extensive preclinical and clinical studies to evaluate the safety and efficacy of these agents as potential treatments for breast cancer. …”
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A potential innovative surrogate marker for hypoxic injury: Shehata marker of angiogenesis by Shehata A. Mohamed

“…As tumor-associated angiogenesis is the most prominently and clinically studied, this model constitutes the significant base for the notions of this work. …”
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Clinical Accuracy of Instrument-Read SARS-CoV-2 Antigen Rapid Diagnostic Tests (Ag-IRRDTs) by Ali Umit Keskin, Pinar Ciragil, Aynur Eren Topkaya

“…We used PRISMA Checklist and searched databases (PubMed, Web of Science Core Collection and FIND) for publications evaluating the accuracy of SARS-CoV-2 Ag-IRRDTs as of 30 September 2021, and included 40 independent clinical studies resulting in 48 Ag-IRRDT datasets with 137,770 samples. …”
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Biomechanical comparison of the efficacy of Cfr-PEEK and titanium systems in the fixation following sagittal split advancement osteotomy: a biomechanical study by Esengul Sen, Damla Torul

“…However, future experimental and clinical studies that include larger samples and different designs need to be done.…”
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An Insight into Potential Pharmacotherapeutic Agents for Painful Diabetic Neuropathy by Zunaira Qureshi, Murtaza Najabat Ali, Minahil Khalid

“…Unfortunately, there is no internationally recommended drug that directly hinders the pathological mechanisms that result in painful diabetic neuropathy. Clinical studies have shown that anticonvulsant and antidepressant therapies have proven fruitful in management of pain associated with PDN. …”
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Plants Used in Antivenom Therapy in Rural Kenya: Ethnobotany and Future Perspectives by Timothy Omara

“…In a continued effort to identify some antiophidic East African botanical species, this study generated ethnobotanical information on antivenom plants reported in Kenya, with a view to identify potential species which could be subjected to in vitro and clinical studies for possible development into antivenoms. …”
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Probiotics to Prevent the Need for, and Augment the Use of, Antibiotics by Gregor Reid

“…Improvements in clinical studies, manufacturing and regulatory standards must coincide with this progress to ensure that physicians and consumers have reliable, proven products for safe and efficacious use.…”
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hsa_circWDR37_016 Regulates Hypoxia-Induced Proliferation of Pulmonary Arterial Smooth Muscle Cells by Shan-Shan Li, Shuang Liang, Yao Long, Xu Chen, Xin Jin

“…Pulmonary arterial hypertension (PAH) is characterized by abnormal remodeling of pulmonary vessel walls caused by excessive pulmonary arterial smooth muscle cell (PASMC) proliferation. Our previous clinical studies have demonstrated the importance of the downregulated circRNA in PAH. …”
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Targeting HER2 in Nuclear Medicine for Imaging and Therapy by Adriana V. F. Massicano PhD, Bernadette V. Marquez-Nostra PhD, Suzanne E. Lapi PhD

“…This review presents the most recent advances in HER2 targeting in nuclear medicine focusing on preclinical and clinical studies.…”
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The Effects of Dipeptidyl Peptidase-4 Inhibitors on Cardiovascular Disease Risks in Type 2 Diabetes Mellitus by Pegah Yousefzadeh, Xiangbing Wang

“…The majority of the recent clinical studies have demonstrated that DPP-4 inhibitors have beneficial effects on cardiovascular (CV) system. …”
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Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication by Jide Tian, Hoa Dang, Angela Hu, Willem Xu, Daniel L. Kaufman

“…Lesogaberan may be a promising drug candidate for clinical studies of diabetes intervention and islet transplantation.…”
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FROM ONCOLOGIST TO SURGEON - GENETICS IN COLORECTAL METASTASIS FOR SURGEONS by Marília Polo Mingueti e SILVA, Jorge SABBAGA, Henry Luiz NAJMAN, Carlos David Carvalho NASCIMENTO, Ricardo Lemos COTTA-PEREIRA, João Eduardo Leal NICOLUZZI, Maria Ignez BRAGHIROLI

“…With the development of treatments in metastatic disease and the use of targeted therapies and their biomarkers, it was possible to evaluate them within clinical studies both in the primary tumor and in the correspondence of metastases.…”
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Validation of Simultaneous Quantitative Method of HIV Protease Inhibitors Atazanavir, Darunavir and Ritonavir in Human Plasma by UPLC-MS/MS by Tulsidas Mishra, Pranav S. Shrivastav

“…The validated method can be useful in determining plasma concentration of these protease inhibitors for therapeutic drug monitoring and in high throughput clinical studies.…”
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The therapeutic potential of RNA m(6)A in lung cancer by Jingran Yu, Wei Sun, Xiangxuan Zhao, Yingying Chen

“…However, numerous basic and clinical studies have demonstrated that RNA m(6)A is deregulated in many human malignancies including LC. …”
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Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer’s disease in humans by Bryan J. Neth, Kevin Huynh, Corey Giles, Tingting Wang, Natalie A. Mellett, Thy Duong, Colette Blach, Leyla Schimmel, Thomas C. Register, Kaj Blennow, Henrik Zetterberg, Richa Batra, Annalise Schweickart, Amanda Hazel Dilmore, Cameron Martino, Matthias Arnold, Jan Krumsiek, Xianlin Han, Pieter C. Dorrestein, Rob Knight, Peter J. Meikle, Suzanne Craft, Rima Kaddurah-Daouk

“…We further validated our findings by leveraging our prior clinical studies into lipid related changeswith AD (n = 1912), and found that the lipidomic signature with MMKD was inversely associated with the lipidomic signature of prevalent and incident AD. …”
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Successful Strategy in Creating Low-FODMAP Wholegrain Bread—Simple and Global by Aleksandra M. Torbica, Vesna Vujasinović, Uroš Miljić, Goran Radivojević, Bojana Filipčev, Milorad Miljić, Miloš Radosavljević

“…Fermentable oligo-, di-, and monosaccharides as well as polyols (FODMAPs) came into focus following recent clinical studies confirming that they worsen the symptoms of several gastrointestinal disorders suffered by 40% of the general population. …”
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Immunotherapeutic Potential of Lactobacillus Species as Immune Checkpoint Inhibitors in Cancer Immunotherapy by Renukadevi J, Sam Helinto J, Prena D

“…Although the formulation of probiotic species in advanced drug delivery systems, such as niosomes and liposomes, may prove to be successful, regulatory guidelines need to be followed to support their nontoxic effects in preclinical trials followed by clinical studies. Although the concomitant administration of probiotics with ICIs remains a promising strategy, the underlying mechanisms need to be explored to support their systemic nontoxic effects.…”
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Trends in research on novel antidepressant treatments by Agnieszka Zelek-Molik, Ewa Litwa

“…Collectively, these symptoms underscore depression as a serious, long-term global health issue. In addition, clinical studies indicate a growing number of patients experiencing difficulties in responding to treatment, even in the long term. …”
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A proton therapy model using discrete difference equations with an example of treating hepatocellular carcinoma by Erin N. Bodine, K. Lars Monia

“…We demonstrate how to use data from in vitro and clinical studies to parameterize the model. Specifically, we use data from studies of Hepatocellular carcinoma, a common form of liver cancer. …”
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Assessment of the Effects of Albendazole-Loaded Sulfonated Graphene Oxide on Echinococcus granulosus Protoscoleces: An In Vitro Investigation by Mohammad Reza Lashkarizadeh, Mohammad Shafie’ei, Mahdiyeh Lashkarizadeh, Seyed Mohammad Mousavi, Ghazaleh Sheibani, Zahra Akbari, Haniyeh Daneshafruz, Ali Derakhshani, Faham Khamesipour

“…However, we recommend conducting in vivo and clinical studies to more accurately determine this nanocomplex’s potential and side effects.…”
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