Unveiling the Emerging Role of Xanthine Oxidase in Acute Pancreatitis: Beyond Reactive Oxygen Species by Chenxia Han, Yaling Wu, Juan Rong, Qing Xia, Dan Du

“…Considerable preclinical and clinical studies have been conducted over many decades to investigate the role of XO in the pathogenesis of AP and its potential targeting therapeutic value. …”
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Composition of food supplements containing melatonin available in Portugal by Beatriz Vieira Araújo, Fátima Rato, João Paulo Capela

“…Only 20% contained melatonin alone, while the majority included plant extracts and vitamins. The absence of clinical studies supporting the efficacy of melatonin combined with plant extracts in these formulations raises concerns about their evidence-based effectiveness. …”
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Prenatal Silicon Dioxide Nanoparticles Exposure Reduces Female Offspring Fertility Without Affecting Males by Min Lei, Zhenye Zhu, Chenlu Wei, Huihui Xie, Ruizhi Guo, Yanqing Zhao, Keer Wang, Mengchen Wang, Wenhui Chen, Xiqiao Xu, Xinxin Zeng, Yining Xu, Wandi Zhang, Yizhe Chu, Yingpu Sun, Qingling Yang

“…Further research, including clinical studies, is needed to confirm these findings in humans. …”
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Noninvasive Optical Imaging and In Vivo Cell Tracking of Indocyanine Green Labeled Human Stem Cells Transplanted at Superficial or In-Depth Tissue of SCID Mice by Vikram Sabapathy, Jyothsna Mentam, Paul Mazhuvanchary Jacob, Sanjay Kumar

“…Stem cell based therapies hold great promise for the treatment of human diseases; however results from several recent clinical studies have not shown a level of efficacy required for their use as a first-line therapy, because more often in these studies fate of the transplanted cells is unknown. …”
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An Assessment of the Intestinal Lumen as a Site for Intervention in Reducing Body Burdens of Organochlorine Compounds by Ronald J. Jandacek, Stephen J. Genuis

“…Non-absorbable dietary fats and fat absorption inhibitors, however, can reduce the re-absorption of OCs and other lipophiles involved in EHC and may enhance the secretion of these compounds into the large intestine—thereby hastening their elimination. Clinical studies are currently underway to determine the efficacy of using non-absorbable fats and inhibitors of fat absorption in facilitating the elimination of persistent body burdens of OCs and other lipophilic human contaminants.…”
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Magnetic Seizure Therapy for Unipolar and Bipolar Depression: A Systematic Review by Eric Cretaz, André R. Brunoni, Beny Lafer

“…OVID and MEDLINE databases were used to systematically search for clinical studies on MST. The terms “magnetic seizure therapy,” “depression,” and “bipolar” were employed. …”
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Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences by Gloria Ortiz-Guerrero, Diana Amador-Muñoz, Carlos Alberto Calderón-Ospina, Daniel López-Fuentes, Mauricio Orlando Nava Mesa

“…Dementia and AD are chronic neurodegenerative conditions with a complex physiopathology involving both genetic and environmental factors. Recent clinical studies have shown that proton pump inhibitors (PPIs) are associated with risk of dementia, including AD. …”
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Artificial Neural Network-Statistical Approach for PET Volume Analysis and Classification by Mhd Saeed Sharif, Maysam Abbod, Abbes Amira, Habib Zaidi

“…The system evaluation was carried out using experimental phantom studies (NEMA IEC image quality body phantom), simulated PET studies using the Zubal phantom, and clinical studies representative of nonsmall cell lung cancer and pharyngolaryngeal squamous cell carcinoma. …”
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Investigating Non-steroidal Anti-Inflammatory Drugs as Potential Cancer Adjuncts: A Novel Approach to Cancer Therapy by Sadaf Alam, Leena Anjum, Muhammad Haneef

“…However, further clinical studies are required to optimize their application and address potential risks, ensuring safe integration into oncological practice. …”
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Mesenchymal Stem Cell-Derived Extracellular Vesicles: Roles in Tumor Growth, Progression, and Drug Resistance by Xiaoyan Zhang, Huaijun Tu, Yazhi Yang, Lijun Fang, Qiong Wu, Jian Li

“…Due to their unique advantages, MSCs have been widely employed in clinical studies. Emerging evidences indicate that MSCs can also migrate to the tumor surrounding stroma and exert complex effects on tumor growth and progression. …”
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Optimizations of Placenta Extracellular Matrix‐Loaded Silk Fibroin/Alginate 3D‐Printed Scaffolds Structurally and Functionally for Bone Tissue Engineering by Zahra Bashiri, Zahra Khosrowpour, Ali Moghaddaszadeh, Davod Jafari, Sanaz Alizadeh, Hajar Nasiri, Houman Parsaei, Zahra Keshtkaran, Meghdad Abdollahpour‐Alitappeh, Farshad Bargrizaneh, Behzad Rezaei, Sara Simorgh, Mazaher Gholipourmalekabadi

“…Overall, these results proved that the placental ECM‐printed scaffolds could potentially construct biomimetic grafts to reconstruct significant bone defects and now promise to proceed with clinical studies.…”
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CathROB: A Highly Compact and Versatile Remote Catheter Navigation System by Laura Cercenelli, Barbara Bortolani, Emanuela Marcelli

“…Although further preclinical and clinical studies are required, the presented CathROB system seems to be a promising solution for an affordable and easy-to-use remote catheter navigation.…”
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Cell Therapy for Refractory Angina: A Reappraisal by Beatrice Bassetti, Patrizia Nigro, Valentina Catto, Laura Cavallotti, Stefano Righetti, Felice Achilli, Paolo Scacciatella, Corrado Carbucicchio, Giulio Pompilio

“…Although positive results in terms of surrogate endpoints have been suggested by early and phase II clinical studies as well as by meta-analyses, the more recent reports lacked the provision of definitive response in terms of hard clinical endpoints. …”
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A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges by Erica di Martino, Darren C. Tomlinson, Margaret A. Knowles

“…In vitro and in vivo studies have shown that FGFR inhibition has cytotoxic and/or cytostatic effects in FGFR-dependent bladder cancer cells and FGFR-targeted agents are currently being investigated in clinical studies for the treatment of UC. Urine-based tests detecting common FGFR3 mutations are also under development for surveillance of low-grade and -stage tumours and for general population screening. …”
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Application of a Plug-and-Play Immunogenicity Assay in Cynomolgus Monkey Serum for ADCs at Early Stages of Drug Development by Montserrat Carrasco-Triguero, Helen Davis, Yuda Zhu, Daniel Coleman, Denise Nazzal, Paul Vu, Surinder Kaur

“…It is rarely predictive for clinical studies and evidence for the presence of anti-drug antibodies (ADAs) may be inferred from the pharmacokinetic (PK) profile. …”
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PHOTODYNAMIC THERAPY OF CONDYLOMATA ACUMINATE by V. N. Galkin, A. V. Molochkov, V. A. Molochkov, S. V. Korenev, T. E. Sukhova, Zh. S. Kuntcevich, Yu. S. Romanko

“…It is necessary to conduct large-scale clinical studies on the effectiveness of photodynamic therapy of condylomata acuminatain order to standardize the treatment parameters.…”
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The Dual Diagnosis of Alcohol Use Disorder and Obsessive–Compulsive Disorder—How Do They Interact With Each Other? by Savitha Soman, Rajesh Nair

“…The prevalence rates in clinical studies are low as compared to epidemiological studies as the comorbidity is often missed during clinical evaluation due to a variety of reasons. …”
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Hepatobiliary organoid research: the progress and applications by Rui-Qi Zou, Rui-Qi Zou, Yu-Shi Dai, Yu-Shi Dai, Fei Liu, Fei Liu, Si-Qi Yang, Si-Qi Yang, Hai-Jie Hu, Hai-Jie Hu, Fu-Yu Li, Fu-Yu Li

“…Consequently, it is widely used in basic and clinical studies, becoming important preclinical models for studying diseases and developing therapies. …”
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Chronic coronary occlusions in patients after coronary artery bypass grafting. Morphological features and a review of possible interventions by S.М. Furkalo

“…Although precise mechanism of atherosclerosis in these patients unknown, several clinical studies reported that atherosclerotic progression occurs more rapidly in grafted arteries than in non-grafted arteries. …”
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The Use of Probiotics in Gastrointestinal Disease by Karen L Madsen

“…In addition, well planned and controlled clinical studies are necessary to delineate fully the potential for probiotic compounds.…”
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