Beta-adrenergic blocking agents in cutaneous and oral melanoma by Sivakamavalli Jeyachandran

“…This emerging research indicates beta-blockers' potential as adjunct therapy in melanoma treatment, necessitating comprehensive clinical studies to confirm their efficacy and safety. …”
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The Role of Complement System in Septic Shock by Jean Charchaflieh, Jiandong Wei, Georges Labaze, Yunfang Joan Hou, Benjamin Babarsh, Helen Stutz, Haekyung Lee, Samrat Worah, Ming Zhang

“…A better understanding of the underlying mechanisms is important to develop effective therapies. Basic and clinical studies suggest that activation of complements in the common cascade, for example, complement component 3 (C3) and C5, is involved in the development of septic shock. …”
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Investigating Non-steroidal Anti-Inflammatory Drugs as Potential Cancer Adjuncts: A Novel Approach to Cancer Therapy by Sadaf Alam, Leena Anjum, Muhammad Haneef

“…However, further clinical studies are required to optimize their application and address potential risks, ensuring safe integration into oncological practice. …”
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Metabolomics to Identify Unclassified Uremic Toxins: A Comprehensive Literature Review by Raymond Vanholder, Griet Glorieux, Angel Argiles, Stéphane Burtey, Gerald Cohen, Flore Duranton, Laetitia Koppe, Ziad A. Massy, Alberto Ortiz, Rosalinde Masereeuw, Dimitrios Stamatialis, Joachim Jankowski

“…For the selected molecules, the literature was screened for arguments regarding toxic (harmful), beneficial, or neutral effects in experimental or clinical studies. Findings were independently crosschecked. …”
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Eco-sustainable chromatographic method for the determination of favipiravir and nitazoxanide for COVID-19: application to human plasma by Amal B. Ahmed, Maha M. Abdelrahman, Fadwa H. Edrees

“…Despite the availability of various clinical studies on both FAV and NTZ, no existing analytical application for the simultaneous estimation of FAV and NTZ exists. …”
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Effectiveness of Onion Extract Gel on Surgical Scars in Asians by Kumutnart Chanprapaph, Somsak Tanrattanakorn, Penpun Wattanakrai, Pranee Wongkitisophon, Vasanop Vachiramon

“…Onion extracts have been shown in vitro to accelerate wound healing. Results from clinical studies on surgical scars in Caucasians were disappointing. …”
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Primary sclerosing cholangitis by Marina G Silveira, Keith D Lindor

“…No effective medical therapy is currently available, although clinical studies are in progress. Ursodeoxycholic acid at high doses (28 mg/kg/day to 30 mg/kg/day) is the most promising agent but is unproven so far. …”
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Tumor Necrosis Factor-α and Interleukin-6: Potential Interorgan Inflammatory Mediators Contributing to Destructive Periodontal Disease in Obesity or Metabolic Syndrome by Roozbeh Khosravi, Khady Ka, Ting Huang, Saeed Khalili, Bich Hong Nguyen, Belinda Nicolau, Simon D. Tran

“…Obesity is also part of a group of risk factors occurring together in an individual, which is referred to as metabolic syndrome. Clinical studies have shown higher risk for destructive periodontal disease in obesity and metabolic syndrome. …”
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Peptide Aptamer–Paclitaxel Conjugates for Tumor Targeted Therapy by Xinyang Shen, Yuan Ma, Hang Luo, Razack Abdullah, Yufei Pan, Yihao Zhang, Chuanxin Zhong, Baoting Zhang, Ge Zhang

“…However, further research and clinical studies are essential to fully unlock the therapeutic potential of these innovative conjugates and enhance patient outcomes.…”
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Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option? by Daniele Fanale, Giuseppe Bronte, Francesco Passiglia, Valentina Calò, Marta Castiglia, Florinda Di Piazza, Nadia Barraco, Antonina Cangemi, Maria Teresa Catarella, Lavinia Insalaco, Angela Listì, Rossella Maragliano, Daniela Massihnia, Alessandro Perez, Francesca Toia, Giuseppe Cicero, Viviana Bazan

“…Here we review several natural and synthetic microtubule-targeting agents, which showed antitumor activity and increased efficacy in comparison to traditional drugs in various preclinical and clinical studies. Cryptophycins, combretastatins, ombrabulin, soblidotin, D-24851, epothilones and discodermolide were used in clinical trials. …”
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Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 Patients by Bin Yi, Shaoyan Mo, Yumei Jiang, Dingwu Yi, Jinwen Luo, Xiang Chen, Jian Rong

“…Furthermore, sufficiently powered and randomized clinical studies are still needed in order to determine the role of nicorandil in preventing CIN after elective PCI.…”
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Who will carry out the tests that would be necessary for proper safety evaluation of food emulsifiers? by Katalin F. Csáki, Éva Sebestyén

“…We would like to draw the attention of the academic world to the need of specific in vivo and/or clinical studies for each emulsifier in order to help risk assessors make adequate evaluations and rule out with certainty that authorized food emulsifiers pose a safety concern to consumers’ health. …”
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Fabrication and characterisation of super‐paramagnetic responsive PLGA–gelatine–magnetite scaffolds with the unidirectional porous structure: a physicochemical, mechanical, and in... by Farnaz Ghorbani, Ali Zamanian, Alireza Shams, Atefeh Shamoosi, Amir Aidun

“…The evolution of rat bone marrow mesenchymal stem cells performance on the hybrid structure under a static magnetic field indicated the potential of super‐paramagnetic constructs for further pre‐clinical and clinical studies in the field of neural regeneration.…”
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Penile Rehabilitation after Pelvic Cancer Surgery by Fouad Aoun, Alexandre Peltier, Roland van Velthoven

“…The concept of early penile rehabilitation was developed in late nineties with a subsequent number of clinical studies supporting early pharmacologic penile rehabilitation. …”
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Rapid Stereology Based Quantitative Immunohistochemistry of Dendritic Cells in Lymph Nodes: A Methodological Study by Yvette van Hensbergen, Sylvia A. Luykx‐de Bakker, Daniëlle A. M. Heideman, Gerrit A. Meijer, Herbert M. Pinedo, Paul J. van Diest

“…This method will form the base for further clinical studies into the immunological response in lymph nodes of patients with locally advanced breast cancer.…”
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Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations by Mikołaj Kamiński, Karolina Skonieczna-Żydecka, Igor Łoniewski, Anastasios Koulaouzidis, Wojciech Marlicz

“…More CIC patient randomised clinical studies utilising well-defined strains, or combinations, are necessary.…”
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Fall in Vitamin D Levels during Hospitalization in Children by Devi Dayal, Suresh Kumar, Naresh Sachdeva, Rakesh Kumar, Meenu Singh, Sunit Singhi

“…In conclusion, vitamin D levels fall significantly and should be monitored during hospital stay in children. Large clinical studies are needed to prospectively evaluate the effect of vitamin D supplementation in vitamin D deficient hospitalized children on various disease outcome parameters.…”
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Pathogenesis of Functional Biliary Pain and Pharmacology of Trimebutin by E. L. Bueverova, O. Yu. Zolnikova, N. L. Dzhakhaya, A. V. Sedova, V. Т. Ivashkin

“…The agonist of peripheral receptors of the enkephalinergic system, trimebutine, in clinical studies led to the relief of biliary pain in more than 80 % of patients with functional biliary disorders, while a significant decrease in the severity of diarrhea, dyspeptic, and constipation syndromes was revealed.Conclusion. …”
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Markers of Inflammation Associated with Plaque Progression and Instability in Patients with Carotid Atherosclerosis by Enrico Ammirati, Francesco Moroni, Giuseppe Danilo Norata, Marco Magnoni, Paolo G. Camici

“…The large majority of clinical studies focused on the association between biomarkers and subclinical atherosclerosis, that is, carotid intima-media thickening (cIMT), which represents an earlier stage of the disease. …”
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Intrathecal Immunoglobulin A Synthesis in Multiple Sclerosis: From Biological Aspects to Clinical Relevance by Dariia Kliushnikova, Ferdinand Otto, Georg Pilz, Peter Wipfler, Andrea Harrer

“…In this review, we summarize current evidence on the occurrence and immunopathology of intrathecal IgA synthesis in MS, explore its biological implications, and address methodological challenges regarding the detection of IgA as a major limitation and possible source of inconsistencies in clinical studies. By synthesizing these diverse lines of evidence, we highlight the importance of further research and the need for standardized detection methods to clarify the role of IgA in MS pathogenesis, disease progression, and as potential biomarker.…”
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