Proton Pump Inhibitors and Fractures in Adults: A Critical Appraisal and Review of the Literature by Silvia Irina Briganti, Anda Mihaela Naciu, Gaia Tabacco, Roberto Cesareo, Nicola Napoli, Pierpaolo Trimboli, Marco Castellana, Silvia Manfrini, Andrea Palermo

“…The purpose of our narrative review is to gather and discuss results of clinical studies focusing on the interactions between PPIs and fracture risk. …”
Get full text

Biological Activity and Taxonomy of Persea americana Mill: A Systematic Review by Abdulrahman Mahmoud Dogara

“…The chemical compound that was mentioned the most frequently was polyphenol. Clinical studies involving humans are necessary to confirm and improve the effectiveness of avocado seed, peel, and leaf extracts in the treatment of diseases. …”
Get full text

Density functional theory and molecular dynamics simulation-based bioprospection of Agathosma betulina essential oil metabolites against protein tyrosine phosphatase 1B for interve... by Oluwaseye Adedirin, Rukayat A. Abdulsalam, Khadeejah O. Nasir-Naeem, Ayenitaju A. Oke, Akolade O. Jubril, Saheed Sabiu

“…Further validation through safety and clinical studies is recommended.…”
Get full text

The Molecular Imaging of Natural Killer Cells by Mariya Shapovalova, Sean R. Pyper MD, PhD, Branden S. Moriarity PhD, Aaron M. LeBeau PhD

“…In this review, we will provide an overview of the advances made in imaging NK cells in both preclinical and clinical studies.…”
Get full text

The Exposure to Osteoarthritic Synovial Fluid Enhances the Immunomodulatory Profile of Adipose Mesenchymal Stem Cell Secretome by Adriana Cifù, Rossana Domenis, Massimo Pozzi-Mucelli, Paolo Di Benedetto, Araldo Causero, Massimo Moretti, Marta Stevanato, Cinzia Pistis, Pier Camillo Parodi, Martina Fabris, Francesco Curcio

“…Objective. Several clinical studies have proposed the infusion of adipose mesenchymal stem cells (AMSCs) as an alternative therapy for joint diseases with inflammatory components, such as osteoarthritis. …”
Get full text

Diagnostic and therapeutic recommendations for chronic pancreatitis. Recommendations of the Working Group of the Polish Society of Gastroenterology and the Polish Pancreas Club by Roland Kadaj-Lipka, Michał Lipiński, Krystian Adrych, Marek Durlik, Anita Gąsiorowska, Mirosław Jarosz, Grażyna Jurkowska, Ewa Małecka-Panas, Grzegorz Oracz, Mariusz Rosołowski, Barbara Skrzydło-Radomańska, Renata Talar-Wojnarowska, Grażyna Rydzewska

“…In addition, the expert group assessed the value of clinical studies on which the statements are based, on a scale where A means high (based on meta‑analyses and randomised clinical trials), B means medium (based on clinical trials and observational studies), and C means low (based mainly on expert opinion).…”
Get full text

The State of the Art of the DSM-5 “with Mixed Features” Specifier by Norma Verdolini, Mark Agius, Laura Ferranti, Patrizia Moretti, Massimiliano Piselli, Roberto Quartesan

“…The new DSM-5 “with mixed features” specifier (MFS) has renewed the interest of the scientific community in mixed states, leading not only to new clinical studies but also to new criticisms of the current nosology. …”
Get full text

Basic Statistics for Radiologists: Part 1—Basic Data Interpretation and Inferential Statistics by Adarsh Anil Kumar, Jineesh Valakkada, Anoop Ayyappan, Santhosh Kannath

“…These tools are vital for evaluating the efficacy of imaging techniques and drawing valid conclusions from clinical studies. As radiology continues to push the boundaries of technology and therapeutic interventions, mastering these statistical principles will empower radiologists to critically assess literature, conduct rigorous research, and contribute to evidence-based practices. …”
Get full text

Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects by Henning Madry, Liang Gao, Hermann Eichler, Patrick Orth, Magali Cucchiarini

“…Implications of findings from both translational and clinical studies using BMA concentrate-enhanced marrow stimulation are discussed.…”
Get full text

Pharmacological Therapy in the Heart as an Alternative to Cellular Therapy: A Place for the Brain Natriuretic Peptide? by Nathalie Rosenblatt-Velin, Suzanne Badoux, Lucas Liaudet

“…The discovery that stem cells isolated from different organs have the ability to differentiate into mature beating cardiomyocytes has fostered considerable interest in developing cellular regenerative therapies to treat cardiac diseases associated with the loss of viable myocardium. Clinical studies evaluating the potential of stem cells (from heart, blood, bone marrow, skeletal muscle, and fat) to regenerate the myocardium and improve its functional status indicated that although the method appeared generally safe, its overall efficacy has remained modest. …”
Get full text

Post-kala-azar dermal leishmaniasis (PKDL) drug efficacy study landscape: A systematic scoping review of clinical trials and observational studies to assess the feasibility of esta... by Sauman Singh-Phulgenda, Rishikesh Kumar, Prabin Dahal, Abdalla Munir, Sumayyah Rashan, Rutuja Chhajed, Caitlin Naylor, Brittany J Maguire, Niyamat Ali Siddiqui, Eli Harriss, Manju Rahi, Fabiana Alves, Shyam Sundar, Kasia Stepniewska, Ahmed Musa, Philippe J Guerin, Krishna Pandey

“…We conducted a systematic scoping review to assess the characteristics of published PKDL clinical studies, understand the scope of research and explore the feasibility and value of developing a PKDL individual patient data (IPD) platform.…”
Get full text

Anatomical, functional, and blood-born predictors of severity of brachycephalic obstructive airway syndrome severity in French Bulldogs by Claudia Schmid, Claudia Schmid, Claudia Schmid, Aline R. Steiner, Léonie Spielhofer, Léonie Spielhofer, Meltem Galfetti, Meltem Galfetti, Nikki Rentsch, Nikolay Bogdanov, Johannes Vogel, Regina Hofmann-Lehmann, Regina Hofmann-Lehmann, Sonja Hartnack, Georgy Astakhov, Reinhard Furrer, Anna Bogdanova, Anna Bogdanova, Iris Margaret Reichler

Get full text

Comparison of Amino Acid Positron Emission Tomographic Radiotracers for Molecular Imaging of Primary and Metastatic Brain Tumors by Csaba Juhász, Shalini Dwivedi, David O. Kamson, Sharon K. Michelhaugh, Sandeep Mittal

“…First, we discuss and compare the mechanisms of tumoral transport and accumulation, the basis of differential performance of these radioligands in clinical studies. Then we summarize studies that provided direct comparisons among these amino acid tracers and to clinically used 2-deoxy-2[ 18 F]fluoro-D-glucose [FDG] PET imaging. …”
Get full text

Regulation of Glial Cell Functions by PPAR-𝜸 Natural and Synthetic Agonists by Antonietta Bernardo, Luisa Minghetti

“…PPAR-𝛾 agonists, which include naturally occurring compounds (such as long chain fatty acids and the cyclopentenone prostaglandin 15-deoxy Δ12,14 prostaglandin J2), and synthetic agonists (among which the thiazolidinediones and few nonsteroidal anti-inflammatory drugs) have shown anti-inflammatory and protective effects in several experimental models of Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, multiple sclerosis and stroke, as well as in few clinical studies. The pleiotropic effects of PPAR-𝛾 agonists are likely to be mediated by several mechanisms involving anti-inflammatory activities on peripheral immune cells (macrophages and lymphocytes), as well as direct effects on neural cells including cerebral vascular endothelial cells, neurons, and glia. …”
Get full text

Changing Management of Clinical Low-Stage Testicular Cancer by Timothy Gilligan

“…At this point in history, stage I patients have three treatment options following radical orchiectomy: adjuvant (sometimes called “primary”) chemotherapy (carboplatin for seminomas and the combined regimen of bleomycin, etoposide, and cisplatin for nonseminomas), surveillance, and either retroperitoneal lymph node dissection (for nonseminomas) or radiotherapy (for pure seminomas). Clinical studies have made it possible to identify subgroups of patients at high and low risk for relapse and this has made it possible to tailor treatment decisions to the individual patient's postorchiectomy relapse risk.…”
Get full text

Progress of the Target Selection and Localization of Repetitive Transcranial Magnetic Stimulation to Improve Upper Limb Function after Stroke by LIU Canhuan, SHEN Ying, DAI Wenjun, GUO Chuan, CHENG Yihui, ZHU Yi, WANG Tong

“…Currently, rehabilitation techniques for improving post-stroke upper limb motor function, both domestically and internationally, primarily involve motor function training.Repetitive transcranial magnetic stimulation (rTMS), because it can enhance upper limb motor function recovery by modulating cortical excitability and promoting neuroplasticity, has been increasingly used in stroke rehabilitation and has been included in the guideline as a grade A recommendation.However, there is still large heterogeneity in the relevant clinical studies, and the therapeutic effect is affected by factors such as different target selection and target localization accuracy. …”
Get full text

A Review on the Antimutagenic and Anticancer Effects of Cysteamine by Chun-Man Lee

“…In conclusion, regarding the high safety profile of cysteamine and the current literature data presented in this article, cysteamine might be considered as an interesting molecule for the prevention and the treatment of cancer. Further clinical studies should be performed to support these data in humans.…”
Get full text

Treatment of Postpartum Depression with Neurosteroids by Reda Stankevičiūtė, Robertas Strumila

“…Postpartum depression (PPD) is a form of depression which develops in women during the postnatal period. Clinical studies have been conducted, and the results indicate that Brexanolone (a water-soluble formulation of allopregnanolone) is effective in treating postpartum depression. …”
Get full text

Probiotics and functional nutrition products by Yu. О. Shulpekova

“…Fermented-milk product enriched by L. casei DN-114001 Imunitass, in controlled clinical studies demonstrated protective effect for the most of common infectious diseases. …”
Get full text

Assessing Health-Related Quality of Life in Asthma by Elizabeth F Juniper

“…Many clinicians now recognize the importance of incorporating an assessment of health-related quality of life (HRQL) into their clinical studies and practices. Conventional clinical measures provide valuable information about the status of the affected organ system but rarely capture the functional impairments (physical, emotional and social) that are important to patients in their everyday lives. …”
Get full text