Application of biomaterials in mesenchymal stem cell based endometrial reconstruction: current status and challenges by Ling He, Qianrong Li

“…This review discusses the use of various biomaterials in MSC-based therapies for endometrial reconstruction and summarizes evidence from preclinical and clinical studies, highlighting the efficacy and safety of these biomaterials. …”
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Probiotics, Prebiotics, and Synbiotics: Gut and Beyond by Usha Vyas, Natarajan Ranganathan

“…Restoration of the gut microbiota may be difficult to accomplish, but the use of probiotics has led to promising results in a large number of well-designed (clinical) studies. Microbiomics has spurred a dramatic increase in scientific, industrial, and public interest in probiotics and prebiotics as possible agents for gut microbiota management and control. …”
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Rheumatic Diseases and Obesity: Adipocytokines as Potential Comorbidity Biomarkers for Cardiovascular Diseases by Rossana Scrivo, Massimiliano Vasile, Ulf Müller-Ladner, Elena Neumann, Guido Valesini

“…In this review we summarize the current knowledge on experimental models and clinical studies in which adipocytokines were examined in obesity, RA, and OA and discuss the potential of adipocytokines as comorbidity biomarkers for cardiovascular risk.…”
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Status and Prospects of Robotic Gastrectomy for Gastric Cancer: Our Experience and a Review of the Literature by Sejin Lee, Taeil Son, Hyoung-Il Kim, Woo Jin Hyung

“…Robotic procedures have a significantly greater financial cost than laparoscopic gastrectomy, which is a major drawback. Recent clinical studies tried to demonstrate that the benefits of robotic surgery outweighed the cost, but the overall results were disappointing. …”
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Outcome measures in muscular dystrophy rehabilitation: an ICF content comparison approach to the most commonly used MD scales by Mihaela Taranu, Raquel Sebio-García, José C. Milisenda, Aida Alejaldre, Xavier Pastor, Sarah Laxe

“…Objective: To identify the outcome measurement instruments reported in clinical studies in muscular dystrophies (MDs) and provide an ICF content analysis. …”
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Therapeutic Options for the Management of the Cardiorenal Syndrome by Katerina Koniari, Marinos Nikolaou, Ioannis Paraskevaidis, John Parissis

“…On the other hand, ultrafiltration appears to be a more promising therapeutic procedure that will improve volume regulation, while preserving renal and cardiac function. Further clinical studies are required in order to determine their net effect on renal function and potential cardiovascular outcomes. …”
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Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density? by Kim Chau, Stephanie A. Atkinson, Valerie H. Taylor

“…Results. 2001 articles initially met the search criteria, and 35 studies were thoroughly reviewed for evidence of an association between SSRI use and BMD, and 8 clinical studies were detailed and summarized in this paper. …”
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Effects of (±) 3,4-Methylenedioxymethamphetamine (MDMA) on Sleep and Circadian Rhythms by Una D. McCann, George A. Ricaurte

“…This paper will review preclinical and clinical studies that have explored the effects of prior MDMA exposure on sleep, circadian activity, and the circadian pacemaker, and will highlight current gaps in knowledge and suggest areas for future research.…”
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A critical review on phytochemical profile and health promoting effects of mung bean (Vigna radiata) by Kumar Ganesan, Baojun Xu

“…All data of in vitro, in vivo and clinical studies of mung bean and its impact on human health were collected from a library database and electronic search. …”
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Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing Nonalcoholic Fatty Liver Disease in Diabetes Mellitus by Lung-Wen Tsai, Yi-Hsiang Lu, Rajni Dubey, Jeng-Fong Chiou

“…Based on these abovementioned approaches, we aimed to comprehensively analyze various preclinical and clinical studies from traditional to regenerative therapeutic approaches in managing concomitant NAFLD and T2DM.…”
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Neural Plasticity and Proliferation in the Generation of Antidepressant Effects: Hippocampal Implication by Fuencisla Pilar-Cuéllar, Rebeca Vidal, Alvaro Díaz, Elena Castro, Severiano dos Anjos, Jesús Pascual-Brazo, Raquel Linge, Veronica Vargas, Helena Blanco, Beatriz Martínez-Villayandre, Ángel Pazos, Elsa M. Valdizán

“…The neurotrophic/plasticity hypothesis of depression, proposed more than a decade ago, is now supported by multiple basic and clinical studies focused on the role of intracellular-signalling cascades that govern neural proliferation and plasticity. …”
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Mathematical modeling of continuous and intermittent androgen suppression for the treatment of advanced prostate cancer by Alacia M. Voth, John G. Alford, Edward W. Swim

“…Currently, many patients in the U.S. receive CAS therapy of ADT, but many undergo a relapse after several years and experience adverse side effects while receiving treatment. Some clinical studies have introduced various IAS regimens in order to delay the time to relapse, and/or to reduce the economic costs and adverse side effects. …”
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Intestinal organoids: The path towards clinical application by Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani

“…As the field develops and evolves, there is a need for standardized frameworks for generation, culture, storage, and analysis of intestinal organoids to ensure reproducibility, comparability, and interpretability of these preclinical and clinical studies to ultimately enable clinical translation.…”
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Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation by Emmanuel Kemmler, Julian Braun, Florent Fauchère, Sabine Dölle-Bierke, Kirsten Beyer, Robert Preissner, Margitta Worm, Priyanka Banerjee

“…The results obtained from this study will direct future experimental and clinical studies to understand the role of dietary lipids and PPAR-isoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.…”
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Using network pharmacology and molecular docking technology, proteomics and experiments were used to verify the effect of Yigu decoction (YGD) on the expression of key genes in ost... by Kun Yan, Rui-Kun Zhang, Jia-Xin Wang, Hai-Feng Chen, Yang Zhang, Feng Cheng, Yi Jiang, Min Wang, Ziqi Wu, Xiao-Gang Chen, Zhi-Neng Chen, Gui-Jin Li, Xin-Miao Yao

“…Background Yigu decoction (YGD) is a traditional Chinese medicine prescription for the treatment of osteoporosis, although many clinical studies have confirmed its anti-OP effect, but the specific mechanism is still not completely clear.Methods In this study, through the methods of network pharmacology and molecular docking, the material basis and action target of YGD in preventing and treating OP were analyzed, and the potential target and mechanism of YGD in preventing and treating OP were clarified by TMT quantitative protein and experiment.Results Network pharmacology and molecular docking revealed that the active components of YGD were mainly stigmasterol and flavonoids. …”
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Botanicals in human nutrition: focus on bioactive food-derived compounds on gut microbiota in gastrointestinal inflammatory diseases by Emanuele Rinninella, Giordana Galeazzi, Elisa Gianferrari, Sabrina Putzu, Pauline Raoul, Marco Cintoni, Francesca Bugli, Maria Cristina Mele, Maura Di Vito

“…We found preclinical and clinical studies confirming a striking potential role of these nutraceuticals in reducing gut inflammation in such conditions through gut eubiosis restoration. …”
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Infertility and Adenomyosis by Sebastiano Campo, Vincenzo Campo, Giuseppe Benagiano

“…In conclusion, sufficient indirect proof exists linking adenomyosis to infertility to warrant systematic clinical studies.…”
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Exploring the Role of Tranexamic Acid in Dermatology: A literature Review by Aleksandra Górska, Natalia Gniaź, Wiktor Grela, Jagoda Niewiadomska, Daria Furtak, Dawid Tulej, Natalia Marko, Alicja Dziedzic, Dominika Marciniuk, Paulina Głogowska

“…State of Knowledge An analysis of the existing literature highlights the growing interest in TXA’s dermatological applications. Clinical studies suggest that tranexamic acid effectively reduces hyperpigmentation and mitigates inflammation in rosacea cases. …”
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The Role of the New Anti-CD20 Monoclonal Antibodies in Active Relapsing – Remitting Multiple Sclerosis Treatment: Efficacy and Safety of ofatumumab by I. Jonušaitė, N. Giedraitienė, G. Kaubrys, R. Kizlaitienė

“…According to the newest clinical studies, anti-CD20 therapies have proven their effectiveness and safety in active relapsing multiple sclerosis treatment: since 2018, ocrelizumab, and, since 2023, ofatumumab have both been available as treatment options in Lithuania. …”
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Microbial Translocation in Chronic Liver Diseases by Marilia Rita Pinzone, Benedetto Maurizio Celesia, Michele Di Rosa, Bruno Cacopardo, Giuseppe Nunnari

“…In particular, probiotics may represent an attractive strategy, even though the promising results of experimental models and limited clinical studies need to be confirmed in larger randomized trials.…”
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