The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy by Felice Gragnano, Simona Sperlongano, Enrica Golia, Francesco Natale, Renatomaria Bianchi, Mario Crisci, Fabio Fimiani, Ivana Pariggiano, Vincenzo Diana, Andreina Carbone, Arturo Cesaro, Claudia Concilio, Giuseppe Limongelli, Mariagiovanna Russo, Paolo Calabrò

“…Results from animal models and clinical studies support the potent anti-inflammatory and antithrombotic effect of VWF antagonism, providing reassuring data on its safety profile. …”
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Factors Affecting Vagus Nerve Stimulation Outcomes in Epilepsy by Mehdi Abbasi, Atie Moghtadaie, Seyed Amir Miratashi Yazdi

“…Given the complexity and diversity of factors associated with response to VNS, more clinical studies are needed to establish better paradigm for selection of patients for VNS therapy.…”
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The Role of Mandibular Third Molars on Lower Anterior Teeth Crowding and Relapse after Orthodontic Treatment: A Systematic Review by Khalid H. Zawawi, Marcello Melis

“…Results. A total of 12 clinical studies were included in the review. A high risk of bias was found in most of the articles, either because the relative items assessed were inadequate or because they were unclearly described. …”
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Phaleria macrocarpa (Scheff.) Boerl. in Ethnopharmacology: Pharmacognosy, Safety, and Drug Development Perspectives by Anandarajagopal Kalusalingam, Kamaliah Kamal, Abdullah Khan, Bama Menon, Ching Siang Tan, Venkateshan Narayanan, Sattanathan Kumar, Khang Wen Goh, Kah Seng Lee, Jactty Chew, Long Chiau Ming

“…The review will be valuable for researchers involved in medicinal plant research and drug discovery, offering potential for use alongside modern therapeutic agents. However, clinical studies are essential to validate its therapeutic applications. …”
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Сryosurgery possibilities for nevus in intermarginal eyelid space by A.N. Steblyuk, V.E. Gunter, S.N. Sahnov, P.A. Khloponin, Е.V. Bykova, Zh.G. Litvinova

“…Material and methods. The clinical studies were conducted in 17 patients (17 eyes) with nevus in the eyelid intermarginal space, with conducting nevus cryodestruction using an autonomous cryoapplicator of porous-permeable titanium nickelide. …”
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JAK inhibitors: a new choice for diabetes mellitus? by Mengjun Zhou, Qi Shen, Bo Li

“…Recently, several clinical cases involving the reversal of type 1 diabetes mellitus (T1DM) during treatment with JAK inhibitors have been reported, and clinical studies have described the improvement of type 2 diabetes mellitus (T2DM) during treatment with JAK inhibitors. …”
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Novel gene manipulation approaches to unlock the existing bottlenecks of CAR-NK cell therapy by Fatemeh Dehghan, Yekta Metanat, Mandana Askarizadeh, Ehsan Ahmadi, Vahid Moradi

“…Although published results from preclinical and clinical studies with CAR-NK cells are promising, several bottlenecks must be unlocked to maximize the effectiveness of CAR-NK cell therapy. …”
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Irritable Bowel Syndrome in Terms of Changes in the Microbiota by Vladimir T. Ivashkin, Oxana Yu. Zolnikova

“…The results of experimental and clinical studies elucidating the mechanisms of action of probiotic cultures have been generalized. …”
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Desmoid-type fibromatosis of the breast: a case report and literature review by Zijun Zhao, Qingyao Shang, Chenxuan Yang, Jiaxiang Liu, Shanqing Liu, Xiaoqian Li, Xiyu Kang, Jiaxian Yue, Xin Wang, Xiang Wang

“…More effective drugs and larger sample clinical studies are encouraged for better management of refractory and progressive BDF.…”
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LC-MS/MS Quantification of Tramadol and Gabapentin Utilizing Solid Phase Extraction by Pappula Nagaraju, Balaji Kodali, Peda Varma Datla, Surya Prakasarao Kovvasu

“…The developed method can be ready to use by scientific community for quantification of analytes in plasma samples from various clinical studies of different dose strengths.…”
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Rehabilitation with Poststroke Motor Recovery: A Review with a Focus on Neural Plasticity by Naoyuki Takeuchi, Shin-Ichi Izumi

“…Various novel stroke rehabilitation techniques for motor recovery have been developed based on basic science and clinical studies of neural plasticity. However, the effectiveness of rehabilitative interventions among patients with stroke varies widely because the mechanisms underlying motor recovery are heterogeneous. …”
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Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration by José Carlos Viana Ribeiro, Rodrigo Silveira Vieira, Iracema Matos Melo, Vilana Maria Adriano Araújo, Vilma Lima

“…However, the absence of clinical studies in humans, the inadequate experimental designs, and the lack of information concerning chitosan’s characteristics limit the reproducibility and relevance of studies and the clinical applicability of chitosan.…”
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A Study of the Importance of Clonus Symptoms in Patients with Tramadol Poisoning by Fares Najari, Anahita Alizadeh-Ghamsari, Maryam Vahabzadeh, Bita Dadpour, Seyed Reza Mousavi, Ideh Baradaran Kayal

“…Objectives. Clinical studies to reduce the side effects of tramadol, such as seizure, are necessary. …”
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Long-Term Treatment with Romidepsin in Patients with Peripheral T-Cell Lymphoma by Claudius Irlé, Jonathan Weintraub

“…Angioimmunoblastic T-cell lymphoma (AITL) is a common subtype of PTCL, and patients with AITL typically have a poor prognosis with limited treatment options. Clinical studies have demonstrated the activity of romidepsin, a structurally unique, potent, bicyclic class 1 selective histone deacetylase inhibitor, in patients with relapsed or refractory AITL. …”
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Rotating antibiotics selects optimally against antibiotic resistance, in theory by Robert E. Beardmore, Rafael Peña-Miller

“…   Using mathematical models that do not explicitly incorporate the spatial dynamics of pathogen transmission within the ICU or hospital and assuming the antibiotics are from distinct functional groups, we use a control theoretic-approach to prove that one can relax the medical notion of what constitutes an antibiotic rotation and so obtain protocols that are arbitrarily close to the optimum.Finally, we show that theoretical feedback control measures that rotate between different antibiotics motivated directly by the outcome of clinical studies can be deployed to good effect to reduce the prevalence of antibiotic resistance below what can be achieved with random antibiotic use.…”
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Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and Bioavailability by Eleonora Truzzi, Giulia Vanti, Lucia Grifoni, Eleonora Maretti, Eliana Leo, Anna Rita Bilia

“…In addition, the resins or their fractions as enhancer penetration molecules can optimize the architecture and properties of nanovectors in their capacity to circumvent biological barriers. Although no clinical studies have been reported until now, nanovectors represent a huge platform for upgrading therapies and emerging new treatments of resins such as wound healing therapy.…”
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Research progress of non-drug therapy for post-stroke patients with cognitive impairment (脑卒中后认知障碍患者非药物治疗的研究进展) by SONG Wanchen (宋宛宸), DENG Ying (邓颖), HUANG Shan (黄山), LI Yang (李洋)

“…This paper aims to analyze the risk factors, evaluation and intervention measures of post-stroke cognitive impairment (PSCI) by collecting literature data in the past five years, summarize the clinical studies on non-drug treatment, further propose all-round extension, standard and high-quality non-drug treatment interventions, and provide clinical basis for standardizing non-drug treatment of PSCI patients. …”
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Non-thermal plasma as promising anti-cancer therapy against bladder cancer by inducing DNA damage and cell cycle arrest by Jojanneke Stoof, Zakaria Kalmoua, Ana Sobota, Ruud H. Brakenhoff, Marijke Stigter, Thang V. Pham, Sander R. Piersma, Alex Henneman, Tonny Lagerweij, Richard de Goeij-de Haas, R. Jeroen A. van Moorselaar, Connie R. Jimenez, Irene V. Bijnsdorp

“…Our findings demonstrate PAS’s mode of action and suggest its potential as a promising treatment for bladder cancer, warranting further clinical studies.…”
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GLP-1 Receptor Agonists’ Impact on Fertility - A Review by Joanna Wojda, Katarzyna Lesiczka-Fedoryj, Anna Walczak, Zuzanna Kościuszko, Adam Sobiński, Matylda Czerwonka, Katarzyna Kurza, Julianna Podolec, Silvia Ciraolo, Agnieszka Kulczycka-Rowicka

“… Purpose of Research: The aim of the research is to summarize the impact of GLP-1 analogs on fertility according to clinical studies, particularly in obese or overweight women with PCOS.  …”
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Abatacept in the Treatment of Juvenile Dermatomyositis-Associated Calcifications in a 16-Year-Old Girl by Sukesh Sukumaran, Vini Vijayan

“…Furthermore, large-scale clinical studies are needed to validate our findings and to evaluate the long-term outcomes.…”
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