Osteoarthritis synovium as a nidus for monosodium urate crystal deposition inducing severe gout studied by label‐free stimulated Raman scattering combined with synovial organoids by Ziyi Chen, Wenjuan Wang, Yaxin Chen, Minbiao Ji, Yinghui Hua

“…Osteoarthritis (OA), the most prevalent type of arthritis, is a progressive degenerative joint disease. Previous clinical studies have reported that gout frequently affects OA joints; however, the underlying mechanism remains unidentified. …”
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Identification and pharmacokinetics of saponins in Rhizoma Anemarrhenae after oral administration to rats by HPLC-Q-TOF/MS and HPLC-MS/MS by Wang Hai-Qiao, Lan Fen, Zhang Yi-Han, Xia Jin-Er, Gong Xiao-Mei, Liu Min

“…All these results provide support for further clinical studies.…”
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The Science of Disaster Medicine: From Response to Risk Reduction by Hüseyin Koçak, Kerem Kınık, Cüneyt Çalışkan, Kurtuluş Açıksarı

“…Disaster medicine is a global, mass, administrative, and doctrinal discipline that means beyond clinical studies. Particularly, the development and dissemination of disaster medicine education were emphasized for the first time with the Sendai Framework for Disaster Risk Reduction, which was determined globally in 2015. …”
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Increasing the concentration of plasma molecules improves the biological activity of platelet-rich plasma for tissue regeneration by Mikel Sánchez, Jon Mercader Ruiz, Daniel Marijuán Pinel, Pello Sánchez, Nicolás Fiz, Jorge Guadilla, Juan Azofra, Maider Beitia, Diego Delgado

“…In summary, although further preclinical and clinical studies are needed in order to determine the therapeutic potential of BPCP, this PRP with unique characteristics demonstrates encouraging in vitro results that could potentially enhance tissue regeneration capacity.…”
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Soft-tissue augmentation for increasing keratinized tissue around dental implants: A systematic review by Farjad Zafar, Maryam Riaz, Rafay Ahmed, Rahul Kumar

“…Results: The review includes 27 studies, comprising nine prospective clinical studies, 13 randomized controlled trials (RCTs), and 5 case series. …”
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Sulbactam–Durlobactam: A Novel Antibiotic Combination for the Treatment of Acinetobacter baumannii–Calcoaceticus Complex (ABC) Hospital-Acquired Bacterial Pneumonia and Ventilator-... by Wissam K. Kabbara, Elina Sadek, Hanine Mansour

“…Data were obtained from in vitro and preclinical studies as well as phase I, II, and III clinical studies published in English between 200t0 and January 2023. …”
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Cyclosporine and Herbal Supplement Interactions by D. Colombo, L. Lunardon, G. Bellia

“…Although findings from animal studies cannot be directly translated into humans, avoiding concomitant use of herbal extracts is prudent until human clinical studies have ruled out any possible interaction. …”
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Gut–brain axis and environmental factors in Parkinson’s disease: bidirectional link between disease onset and progression by Soo Jung Park, Kyung Won Kim, Eun Jeong Lee

“…In recent decades, however, accumulating research has revealed that Parkinson’s disease also involves the gut and uncovered an intimate and important bidirectional link between the brain and the gut, called the “gut–brain axis.” Numerous clinical studies demonstrate that gut dysfunction frequently precedes motor symptoms in Parkinson’s disease patients, with findings including impaired intestinal permeability, heightened inflammation, and distinct gut microbiome profiles and metabolites. …”
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Combined Dexamethasone Suppression-Corticotropin-Releasing Hormone Stimulation Test in Studies of Depression, Alcoholism, and Suicidal Behavior by Leo Sher

“…After CRH became available for clinical studies, the DST was combined with CRH administration. …”
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Is there a risk of esketamine misuse in clinical practice? by Carlos Roncero, Milton Merizalde-Torres, Néstor Szerman, Marta Torrens, Pablo Vega, Pilar Andres-Olivera, Francisco Javier Álvarez

“…Despite initial concerns, long-term clinical studies have not documented instances of abuse, misuse, addiction or withdrawal, and the same was found in case reports or subsamples of high-risk populations with comorbidities such as substance use disorder or alcohol use disorder. …”
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Evaluation Of Impulsivity Symptoms And Family Functioning In Adolescents Diagnosed With Obsessive Compulsive Disorder And Their Mothers by Gonca Ozyurt

“…Objective: In a variety of clinic studies, it has been shown that impulsivity is one of the core symptoms of Obsessive-compulsive disorder (OCD). …”
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An Investigation for Heavy Metals’ Contamination in Farmers’ Fingernails: Case Study in Libya by Aiman M. Bobaker, Intisar Alakili, Elrashied E. Elkhidir, Sukiman B. Sarmani, Zaher Mundher Yaseen

“…Thus, toxicological, epidemiological, and clinical studies for the Libyan farmers are strongly recommended.…”
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Appendicitis After Initiation of Tirzepatide by Chan G, Ansar M, Klein M

“…Appendicitis is not frequently reported as a GLP1/GIP receptor agonist side effect in clinical studies. There seems to be a temporal association between Tirzepatide and the onset of appendicitis. …”
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Febuxostat Improves Uric Acid Levels and Renal Function in Patients with Chronic Kidney Disease and Hyperuricemia: A Meta-Analysis by Yanqun Zheng, Jia Sun

“…However, large sample, multicenter, low risk of bias clinical studies, as well as basic medical research, are needed.…”
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Review of the Impact and Burden of Urinary Urgency on Adults with Overactive Bladder by Adrian Wagg, A. Lenore Ackerman, H. Henry Lai, Diane K. Newman

“…Reduction in UUI episodes is often a primary endpoint in clinical studies, with many studies requiring UUI—sometimes called OAB-wet—as an inclusion criterion, yet approximately two-thirds of those with OAB do not experience UUI. …”
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The Impact of Zinc Supplementation on the Course of Infections by Justyna Woźniak, Ewelina Kopczyńska, Piotr Kulej, Wiktor Biesiada, Justyna Weronika Kmieć, Anna-Mariia Chernysh, Aleksandra Dusińska, Jakub Waszczyński, Kamila Fuczyło, Karolina Stankevič

“…Furthermore, zinc supplementation improved gut microbiome composition, promoting beneficial bacteria and reducing pathogenic growth. Clinical studies confirmed its effectiveness in reducing respiratory infections, improving vaccine responses, and decreasing complications in vulnerable individuals. …”
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Perinatal Outcome of Fetal Echogenic Bowel: A Single-Center Retrospective Cohort Study by Hidayet Sal, Erhan Huseyin Comert, Yasin Semih Ekici, Turhan Aran

“…Conclusion: Isolated fetal echogenic bowel which can be considered as a soft marker for aneuploidy may be associated with lactose intolerance and celiac disease. Further clinical studies are warranted to evaluate this relationship. …”
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In Vitro Antimicrobial Activity of the Hydroalcoholic Extract of the Leaves of Myrcianthes hallii on Proteus spp by Abdel Bermúdez Sol, María José Goyes Baca, Diego Fernando Salazar Martínez

“…It is necessary to continue with clinical studies for its future use in medical formulations.…”
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Mesenchymal stem cells derived exosomes: a new era in cardiac regeneration by Hossein Rayat Pisheh, Mahsa Sani

“…We discuss the molecular mechanisms underlying their cardioprotective effects, summarize preclinical and clinical studies investigating their efficacy, and address the challenges and future perspectives of exosome-based therapies. …”
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G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth by Whitney K. Petrie, Megan K. Dennis, Chelin Hu, Donghai Dai, Jeffrey B. Arterburn, Harriet O. Smith, Helen J. Hathaway, Eric R. Prossnitz

“…Moreover, our findings shed light on the potential mechanisms of SERM/SERD side effects reported in many clinical studies. Finally, our results provide the first demonstration that pharmacological inhibition of GPER activity in vivo prevents estrogen-mediated tumor growth.…”
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