The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region by Toru Chikui, Makoto Obara, Arjan W. Simonetti, Masahiro Ohga, Shoichi Koga, Shintaro Kawano, Yoshio Matsuo, Takeshi Kamintani, Tomoko Shiraishi, Erina Kitamoto, Katsumasa Nakamura, Kazunori Yoshiura

“…The Toft and Kermode (TK) model is one of the most popular compartment models, which provide information about the influx forward volume transfer constant from plasma into the extravascular-extracellular space (EES) and the fractional volume of EES per unit volume of tissue is used in many clinical studies. This paper will introduce the method of pharmacokinetic analysis and also describe the clinical application of this technique in the head and neck region.…”
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Population Pharmacokinetics of Pegcetacoplan in Patients with Geographic Atrophy or Neovascular Age-related Macular Degeneration by Ryan L. Crass, PharmD, Komal Prem, MD, Francois Gauderault, PhD, Ramiro Ribeiro, MD, PhD, Caroline R. Baumal, MD, Brandon Smith, PhD, Daniel Epling, PhD, Sunny Chapel, PhD

“…Participants: Two hundred sixty-one patients with GA or nAMD enrolled in 4 clinical studies of pegcetacoplan. Methods: Serum concentration data were pooled from 4 clinical studies. …”
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Using Mathematical Modeling as a Resource in Clinical Trials by Evans K. Afenya

“…Areas of commonality between the model predictions and the clinical findings are investigated as a way of further validating the model predictions and also establishing mathematical foundations for the clinical studies. The model predictions are used to propose additional ways that treatment optimization could enhance the clinical processes. …”
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Assessing and visualizing fragility of clinical results with binary outcomes in R using the fragility package. by Lifeng Lin, Haitao Chu

“…The fragility index was proposed to quantify the robustness of statistical significance of clinical studies with binary outcomes. It is defined as the minimal event status modifications that can alter statistical significance. …”
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Mechanism of Respiratory Training in the Prevention and Treatment of Chronic Nonspecific Low Back Pain by Jianpeng ZOU, Tianwei LOU, Shijie HAO, Linlin LI, Wanhong WANG, Mengting XU, Hongyan BI

“…Here we analyze the pathological mechanism of chronic nonspecific low back pain, expounds the principle of prevention and treatment of this disease, and introduces relevant clinical studies from two aspects of modern rehabilitation medicine and traditional Chinese medicine to enrich its treatment system, so as to explore the intervention method of breathing training and improve treatment effects.…”
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Evaluation of serum concentration of cardiac troponin i in normal racing thoroughbred horses by Javad Tajik, Alireza Sazmand, Seyed Hossein Hekmatimoghaddam, Mohamad Reza Shirazi

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Latarjet Procedure for the Treatment of Anterior Glenohumeral Instability in the Athlete – Key Considerations for Rehabilitation by Helen Bradley, Lucca Lacheta, Brandon T. Goldenberg, Samuel I. Rosenberg, Matthew T. Provencher, Peter J. Millett

“…Biomechanical and clinical studies have shown excellent results and high rates of return to sports. …”
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Modified single rigid vacuum-formed indirect bonding trays for lingual bracket application: a case report by Nguyen Anh Viet, Nguyen Anh Thuy

“…Additionally, the close alignment between the planned orthodontic setup and the achieved treatment outcome highlights the reliability of the technique for predictable lingual orthodontic treatment. Further clinical studies with larger sample sizes are needed to confirm the effectiveness of this technique.…”
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Cardiovascular Risk Factors in the Antiphospholipid Syndrome by Felipe Freire da Silva, Roger Abramino Levy, Jozélio Freire de Carvalho

“…Experimental models and clinical studies show evidence of association between APS and premature formation of atherosclerotic plaques. …”
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Do Nonsteroidal Anti-Inflammatory Drugs Affect Bone Healing? A Critical Analysis by Ippokratis Pountos, Theodora Georgouli, Giorgio M. Calori, Peter V. Giannoudis

“…We have systematically reviewed the available literature, analyzing and presenting the available in vitro animal and clinical studies on this field. Our comprehensive review reveals the great diversity of the presented data in all groups of studies. …”
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Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease by Yu Yang, Hui Huang, Zheng Xu, Jun-kai Duan

“…Recently, emerging evidence from experimental and clinical studies has demonstrated that 5-HT is involved in the pathogenesis of diabetic vascular complications. …”
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The Role of Vitamin D in the Pathomechanism of Inflammatory Bowel Disease (IBD) and its Therapeutic Implications - a literature review by Wiktoria Maria Tomaszewska, Paweł Siudziński, Mateusz Łyko, Alicja Skoczylas, Jakub Kurasz, Wojciech Maj, Wiktoria Podlasiewicz, Katarzyna Pala, Piotr Dudziak, Anna Nowak, Maria Golińska

“…Aim: The purpose of this study was to analyze the mechanisms of action of vitamin D in the context of the pathogenesis of inflammatory bowel disease (IBD) and its potential therapeutic applications, with particular emphasis on clinical studies evaluating vitamin D supplementation. …”
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The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair by Shebin Tharakan, Michael Hadjiargyrou, Azhar Ilyas

“…These composite scaffolds can be engineered to mimic the biomechanical and biological properties of natural tissues, supporting the healing process and promoting regeneration. Various clinical studies examined the effectiveness of these composite scaffolds with collagen, ECM and synthetic polymers and provided outstanding results with remarkable improvements in range of motion (ROM), strength, and pain. …”
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Rebamipide during chronic gastritis: <i>H. pylori</i> eradication therapy and restoration of gastric mucosa barrier function by Т. L. Lapina, V. T. Ivashkin

“…Experimental and clinical studies have demonstrated that rebamipide increases concentration of prostaglandins (prostaglandin E2 and prostacyclin) and production of mucin, manages inflammation and oxidative stress, controls apoptosis and autophagy. …”
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Metabolic Syndrome and Triple-Negative Breast Cancer: A New Paradigm by Andrew A. Davis, Virginia G. Kaklamani

“…The evidence linking TNBC with the metabolic syndrome, which consists of central obesity, insulin resistance, impaired glucose tolerance, dyslipidemia, and hypertension, has emerged from clinical studies and experiments using cell lines and mouse models. …”
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Cerebral Cavernous Malformation: From Genetics to Pharmacotherapy by Zhuangzhuang Zhang, Jianwen Deng, Weiping Sun, Zhaoxia Wang

“…Recent preclinical and clinical studies have shown that various drugs can effectively reduce the burden of CCM lesions. …”
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Regulation and therapy: the role of ferroptosis in DLBCL by Yifan Wang, Yifan Wang, Zhengmei He, Zhengmei He, Xinyu Dong, Xinyu Dong, Yiming Yao, Yiming Yao, Qiuni Chen, Qiuni Chen, Yuye Shi, Yuye Shi, Yuan Deng, Yuan Deng, Quane Zhang, Quane Zhang, Liang Yu, Liang Yu, Liang Yu, Chunling Wang, Chunling Wang, Chunling Wang

“…This review highlights recent advances in ferroptosis-related genes (FRGs), including STAT3, Nrf2, and ZEB1, and focuses on the clinical potential of ferroptosis inducers such as IKE, α-KG, DMF, and APR-246, which are currently being explored in clinical studies for their therapeutic effects in DLBCL. …”
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Professor Larysa Iukhymivna Cherikchi: a founder of physiotherapy in ophthalmology of Ukraine by N.F. Bobrova, T.M. Serebrina

“…Filatov, and conducted multi-year versatile experimental and clinical studies for the development of effective physiotherapeutic techniques for the treatment of various eye diseases. …”
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Pleiotropic effects of niacin: Current possibilities for its clinical use by Zeman Miroslav, Vecka Marek, Perlík František, Staňková Barbora, Hromádka Robert, Tvrzická Eva, Širc Jakub, Hrib Jakub, Žák Aleš

“…Recent results published by the two large clinical studies, AIM-HIGH and HPS2-THRIVE, have led to the impugnation of niacin’s role in future clinical practice. …”
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Refractory IgD Multiple Myeloma Treated with Daratumumab: A Case Report and Literature Review by Muhammad Husnain, Sandra Kurtin, Nikki Barkett, Irbaz bin Riaz, Amit Agarwal

“…We report a case of 40-year-old man with immunoglobulin D (IgD) multiple myeloma whose disease was refractory to at least 5 different chemotherapy regimens including proteasome inhibitors and immunomodulatory drugs. The clinical studies assessing daratumumab did not include any patients with IgD myeloma which is a rare form of multiple myeloma and to our knowledge is the first study reporting use of daratumumab in IgD myeloma.…”
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