DIGITAL IMPRESSIONS VERSUS TRADITIONAL IMPRESSIONS: AN OVERVIEW by Marius Negucioiu, Smaranda Buduru, Diana Coman, Ana-Maria Condor, Antonela Berar, Daniela Condor, Rareș Buduru, Andreea Kui

“…Results Data from clinical studies indicated mixed conclusions regarding accuracy and impression parameters. …”
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Biomaterial-based regenerative therapeutic strategies for spinal cord injury by Keyi Chen, Wei Yu, Genjiang Zheng, Zeng Xu, Chen Yang, Yunhao Wang, Zhihao Yue, Weien Yuan, Bo Hu, Huajiang Chen

“…Finally, we discuss several biomaterial clinical studies. This review aims to provide a reference and new insights for the future exploration of spinal cord regeneration strategies.…”
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Monoclonal Antibodies for Non-Hodgkin's Lymphoma: State of the Art and Perspectives by Giulia Motta, Michele Cea, Eva Moran, Federico Carbone, Valeria Augusti, Franco Patrone, Alessio Nencioni

“…We will discuss these issues and present an overview of the most significant clinical studies with monoclonal antibodies for NHL treatment carried out to date.…”
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Stimulators and Activators of Soluble Guanylate Cyclase: Review and Potential Therapeutic Indications by Bobby Nossaman, Edward Pankey, Philip Kadowitz

“…In this report, we review current information on the pharmacology of heme-dependent stimulators and heme-independent activators of sGC in animal and in early clinical studies and the potential role these compounds may have in the management of cardiovascular disease.…”
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Simulation of clinical trials of oral treprostinil in pulmonary arterial hypertension using a virtual population by Andrew E. Stine, Jignesh Parmar, Amy K. Smith, Zachary Cummins, Narasimha Rao Pillalamarri, R. Joseph Bender

“…In this study, a quantitative systems pharmacology model of pulmonary arterial hypertension pathophysiology and pharmacology was used to predict changes in pulmonary vascular resistance and six-minute walk distance in the context of oral treprostinil clinical studies. We generated a virtual population that spanned the range of clinical observations and then calibrated virtual patient-specific weights to match clinical trials. …”
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The overview of modern approaches in treatment of triple negative breast cancer by A. A. Kharitonova, I. A. Smirnova, M. V. Kiseleva

“…On the basis of various clinical studies, the effectiveness of the use of anthracyclines, taxanes in the dose-dense regime, platinum preparations and other chemotherapy drugs for the treatment of triple-negative cancer has been shown. …”
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Recent Advances in Dipeptidyl-Peptidase-4 Inhibition Therapy: Lessons from the Bench and Clinical Trials by Jixin Zhong, Quan Gong, Aditya Goud, Srividya Srinivasamaharaj, Sanjay Rajagopalan

“…In this review, we will revisit the physiologic function of DPP4 and discuss its role in cardiometabolic disease based on recent experimental and clinical studies.…”
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Brain connectivity by single-photon emission computed tomography and graph theory: a mini-review by Carlos A. Sanchez-Catasus, Karla Batista-García-Ramó, Lester Melie-Garcia

“…We also include some clinical studies to illustrate the potential of this method to detect subtle changes in brain connectivity. …”
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Two ways to one goal: new strategy of antiviral therapy for chronic hepatitis C by S. N. Batskikh

“…To analyze data of the clinical studies on chronic hepatitis C (CHC) treatment with application of new modes of combined therapy, including selective inhibitor of viral protease.Key points. …”
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Statistical Inference of the Class of Nonparametric Tests for the Panel Count and Current Status Data from the Perspective of the Saddlepoint Approximation by Abd El-Raheem M. Abd El-Raheem, Mona Hosny, Ehab F. Abd-Elfattah

“…In this article, the saddlepoint approximation method is proposed as an alternative to the asymptotic normal approximation method to carry out statistical inference for a number of nonparametric tests for an important type of data that appears frequently in many clinical studies such as cancer and tumorigenicity studies. …”
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The Clinical Trials of Mesenchymal Stromal Cells Therapy by Mohammad Reza Kouchakian, Neda Baghban, Seyedeh Farzaneh Moniri, Mandana Baghban, Shabnam Bakhshalizadeh, Vahid Najafzadeh, Zahra Safaei, Safoura Izanlou, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Amin Tamadon

“…Considering the importance of clinical trials to develop this type of therapy as a new treatment, the current paper is aimed at describing characteristics of MSCs and reviewing relevant clinical studies registered on the NIH database during 2016-2020 to discuss recent advances on MSC-based therapeutic approaches being used in different diseases.…”
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Nouvelle économie du développement et essais cliniques randomisés : une mise en perspective d’un outil de preuve et de gouvernement by Agnès Labrousse

“…This technology transfer from clinical studies makes a decisive contribution to mainstream development economics by instilling a welcome concreteness into the core of the analysis, far away from the late Washington consensus. …”
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Peripheral T-Cell Lymphoma: Review and Updates of Current Management Strategies by Tiffany Tang, Kevin Tay, Richard Quek, Miriam Tao, Soo Yong Tan, Leonard Tan, Soon Thye Lim

“…More work, however, needs to be done, and international collaboration will be pertinent to deriving meaningful results from future clinical studies.…”
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Focus on Adoptive T Cell Transfer Trials in Melanoma by Liat Hershkovitz, Jacob Schachter, Avraham J. Treves, Michal J. Besser

“…Various TIL-ACT trials, which differ in their TIL generation procedures and patient preconditioning, have been reported. In the latest clinical studies, genetically engineered peripheral T cells were utilized instead of TIL. …”
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Translating Research into Clinical Scale Manufacturing of Mesenchymal Stromal Cells by Karen Bieback, Sven Kinzebach, Marianna Karagianni

“…This paper will focus on the definition of mesenchymal stromal cells (MSCs), and challenges and achievements in the manufacturing process enabling their use in clinical studies. It will allude to different cellular sources, special capacities of MSCs, but also to current regulations, with a special focus on accessory material of human or animal origin, like media supplements. …”
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Taba Binary, Multinomial, and Ordinal Regression Models: New Machine Learning Methods for Classification by Mohammad Tabatabai, Derek Wilus, Chau-Kuang Chen, Karan P. Singh, Tim L. Wallace

“…To evaluate the performance of Taba regression, liver cirrhosis data obtained from a Mayo Clinic study were analyzed. The results were then compared with an artificial neural network (ANN), random forest (RF), logistic regression (LR), and probit analysis (PA). …”
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THERAPEUTIC GENE EDITING FOR HEMOGLOBINOPATHIES by Ugo Testa, Giuseppe Leone, Maria Domenica Cappellini

“… In the last ten years, a consistent number of clinical studies have evaluated different gene approaches for the treatment of patients with sickle cell disease (SCD) and transfusion-dependent b-thalassemia (TDT). …”
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Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice by Xiao-Tang Yin, Tammie L. Keadle, Jessicah Hard, John Herndon, Chloe A. Potter, Chelsea R. Del Rosso, Thomas A. Ferguson, Patrick M. Stuart

“…Herpes simplex virus-1 (HSV-1) infection of the cornea leads to a potentially blinding condition termed herpetic stromal keratitis (HSK). Clinical studies have indicated that disease is primarily associated with recurrent HSK following reactivation of a latent viral infection of the trigeminal ganglia. …”
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Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune Uveitis by Kailei Guo, Xiaomin Zhang

“…The association between pathogenic Th17 cells and the development of uveitis has been confirmed in experimental and clinical studies. Several cytokines affect the initiation and stabilization of the differentiation of Th17 cells. …”
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Existing problems and new advice on stage criteria of natural history for chronic hepatitis B by Tongjing Xing

“…However, further clinical studies with large samples are needed to confirm these suggestions.…”
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