Lepidium meyenii biological activity and future perspectives by Zoya Dzhakova, Diana Karcheva-Bahchevanska, Stanislava Ivanova

“…The purpose of this review is to summarize the data of some in vitro, in vivo and clinical studies on the biological activity of Maca and to analyze the future perspectives for the inclusion of Maca into novel herbal medicines…”
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Navigating the landscape of neoadjuvant immunotherapy for NSCLC: progress and controversies by Yuzhu Chen, Fei Qi, Chenhao Sun, Peng Jiang, Xiangyu Xue, Xiaomei Yang, Xiaomi Li, Xin He, Yishuo Wang, Tongmei Zhang

“…Recently, attention has increasingly centered on non-small-cell lung cancer (NSCLC) with immune checkpoint inhibitors application. Numerous clinical studies have underscored the potential of immunotherapy in treating resectable NSCLC, highlighting its role in improving patient outcomes. …”
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CAR-T Therapy Beyond B-Cell Hematological Malignancies by Martina Canichella, Paolo de Fabritiis

“…Despite the advances of CAR-T cells in certain hematological malignancies, mostly from B-cell derivations such as non-Hodgkin lymphomas, acute lymphoblastic leukemia and multiple myeloma, a significant portion of other hematological and non-hematological pathologies can benefit from this innovative treatment, as the results of clinical studies are demonstrating. The clinical application of CAR-T in the setting of acute T-lymphoid leukemia, acute myeloid leukemia, solid tumors, autoimmune diseases and infections has encountered limitations that are different from those of hematological B-cell diseases. …”
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Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials by Sathish Muthu, Sathish Muthu, Sathish Muthu, Vibhu Krishnan Viswanathan, Vibhu Krishnan Viswanathan, Prakash Gangadaran, Prakash Gangadaran, Prakash Gangadaran

“…Animal or in vitro studies, clinical studies without a comparator group, and retrospective or non-randomised clinical studies were excluded. …”
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Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression by Danbi Seo, Dain Kim, Wanyeon Kim

“…In this review, we focus on the oncogenic role of linc00152 in tumorigenesis and provided an overview of recent clinical studies on the effects of linc00152 expression in human cancers.…”
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Efficacy of Monoclonal Antibodies Against Calcitonin Gene-Related Peptide for Medication Overuse Headache in Migraine Patients: Literature Review by A. Kairytė, P. Lukoševičius, G. Žemgulytė

“…This review article discusses the epidemiology and risk factors of MOH as well as the latest clinical studies investigating the efficacy of monoclonal antibodies against CGRP in treating MOH in patients suffering from migraine. …”
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The Fruit Malus prunifolia (Malus micromalus Mak.): A Minireview of Current Knowledge of Fruit Composition and Health Benefits by Xiaolong Ji, Chunyan Hou, Xudan Guo

“…A stronger focus on clinical studies and phytochemical characterization of the fruit will be essential for future research efforts. …”
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Advances in 3D printed hydroxyapatite-collagen scaffolds in bone regeneration by CHENG Ziyang, HAN Xiaoyan, MAO Keming, LIU Laikui, LIANG Weiwei

“…Collagen/hydroxyapatite(CHA) composite scaffolds made by combining the two have been shown to have excellent biocompatibility and bone-enhancing potential in various in vitro, in vivo, and clinical studies. With the development of three-dimensional(3D) printing technology in the field of tissue engineering, bone scaffolds constructed using 3D printing methods have been shown to possess superior clinical potential. …”
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Bacteria in Cancer Therapy: Renaissance of an Old Concept by Sebastian Felgner, Dino Kocijancic, Michael Frahm, Siegfried Weiss

“…This review summarizes and compares the results of the past 150 years in bacteria mediated tumor therapy from preclinical to clinical studies. Lessons we have learned from the past provide a solid foundation on which to base future efforts. …”
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Computerized Tomography Technique for the Investigation of the Maxillary First Molar Mesiobuccal Root by Stefano Corbella, Massimo Del Fabbro, Igor Tsesis, Silvio Taschieri

“…In fact, it was observed that the frequency of second mesiobuccal canal detection is similar to those presented by clinical studies or micro-CT evaluations.…”
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Life-Threatening Hypertriglyceridemia in a Patient on Ruxolitinib and Sirolimus for Chronic Graft-versus-Host Disease by Allison P. Watson, Claudio G. Brunstein, Shernan G. Holtan

“…In preclinical and retrospective clinical studies, use of ruxolitinib was shown to reduce graft-versus-host-disease (GVHD) in allograft recipients with moderate/severe corticosteroid-dependent or refractory chronic GVHD. …”
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RAA System and Exercise Relationship by Sadettin Ünsal, Suleyman Patlar

“…From this point of view, an analysis of the experimental and clinical studies on this subject has been made. Physical exercise leads to a number of changes in the plasma levels of renin, angiotensin, and aldosterone, which represent the adaptation of the human body to a new biological environment. …”
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Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions by Wang-Soo Lee, Jaetaek Kim

“…However, substantial differences exist in the therapeutic or adverse effects of specific drug candidates, and clinical studies have yielded inconsistent data on their cardioprotective effects. …”
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Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications by E. Russo, M. Caprnda, P. Kruzliak, P. G. Conaldi, C. V. Borlongan, G. La Rocca

“…In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.…”
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Ceftobiprole medocaril: clinical and pharmacological characteristics and possibilities of clinical use by Rachina S.A., Fedina L.V., Stafeev A.N., Kremneva A.O., Dekhnich A.V.

“…The purpose of this review is to consider the mechanism of action and safety profile of ceftobiprole, as well as to summarize the results of clinical studies of the drug. Possible areas of clinical use of ceftobiprole for infections of the skin and soft tissues, complicated staphylococcal bacteremia, infective endocarditis, as well as communityacquired and nosocomial pneumonia are given. …”
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STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes by Zoe King, Sudhamsh Reddy Desai, David A. Frank, Aditi Shastri

“…By integrating findings from recent preclinical and clinical studies, this review provides insights into the evolving landscape of STAT-targeted therapies, highlighting the promise of these approaches in enhancing treatment efficacy and improving patient outcomes in high-risk hematologic malignancies.…”
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Non-diffuse Large B-cell Lymphoma. Case Presentation by Miguel Ángel Serra Valdés, Yasniel Borrego Moreno, Marleny Viera García

“…The case of a 64-year-old patient is presented, with a pathological history of arterial hypertension, ex-smoker, who was admitted because for 3 months she had increased volume of the left lateral region of the neck. Clinical studies, imaging, aspiration cytology, medullogram and spinal biopsy and lymph node biopsy allowed diagnosis and staging to begin treatment with cyclophosphamide, doxorubicin, vincristine and prednisone plus the monoclonal antibody rituximab according to the protocol for these tumors. …”
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Is There a Role for Probiotics in Liver Disease? by Robert S. Lo, Andrew S. Austin, Jan G. Freeman

“…Probiotic therapy has also not been shown to prevent primary or secondary spontaneous bacterial peritonitis. Larger clinical studies are required before probiotics can be recommended as a treatment modality in liver diseases.…”
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The Safety and Efficacy of Dietary Epigallocatechin Gallate Supplementation for the Management of Obesity and Non-Alcoholic Fatty Liver Disease: Recent Updates by Ruike Yan, Yanli Cao

“…Current increases in obesity and non-alcoholic fatty liver disease (NAFLD) rates represent a persistent and burdensome threat to global public health. While many clinical studies have demonstrated that EGCG is associated with positive effects on various health parameters, including metabolic biomarkers, waist circumference, and body weight when consumed by individuals affected by obesity and NAFLD, there are also some reports suggesting that it may entail some degree of hepatotoxicity. …”
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Inflammation and Oxidative Stress in Diabetic Nephropathy: New Insights on Its Inhibition as New Therapeutic Targets by Akira Mima

“…Although anti-inflammatory or antioxidant drugs can show benefits in rodent models of DN, negative evidence from large clinical studies indicates that more effective anti-inflammatory and antioxidant drugs need to be studied to clear this question. …”
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