Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment by Tianning Huang, Fan Li, Yiming Wang, Jian Gu, Ling Lu, Peifang Wei

“…In this review, we summarize novel therapeutic approaches targeting both the metabolic pathways and hallmarks of TI-Tregs in preclinical and clinical studies. Although the phenotypic and functional diversity of TI-Tregs remains unclear, our review provides new insights into TI-Treg-based therapies and facilitates precision medicine for tumor treatment.…”
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Virotherapy in Head and Neck Cancer by Zhan Wang

“…Notably, oncolytic virotherapy, viral vector-based vaccines, and viral vector-based gene therapy are key branches of virotherapeutic interventions that have demonstrated potential in preclinical and clinical studies.…”
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Preparedness of European pediatric oncologists to integrate AI in the clinical routine by Alberto E. Tozzi, Diana Ferro, Ileana Croci, Francesco Fabozzi, Angela Mastronuzzi

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Publication Rates of Oculoplastic Surgery and Orbit Abstracts Presented at Turkish Ophthalmological Association National Congresses: 10-Year Analysis by Yusuf İkbal Erdoğdu, Nilay Yüksel

“…Case abstracts had a publication rate of 6.3%, while clinical studies had a higher rate of 21.8% (p<0.05). Publication time was negatively correlated with journal impact factor (r=-0.211, p=0.039). …”
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Informing the development of diagnostic criteria for differential diagnosis of alcohol-related cognitive impairment (ARCI) among heavy drinkers: A systematic scoping review. by Lisa Jones, Lynn Owens, Andrew Thompson, Ian Gilmore, Paul Richardson

“…<h4>Methods</h4>We searched Medline, PsycINFO, Cinahl and the Web of Science, screened reference lists and carried out forward and backwards citation searching to identify clinical studies about screening, diagnosis or assessment of patients with suspected ARCI.…”
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Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment by Fabian Flores-Borja, Sheeba Irshad, Peter Gordon, Felix Wong, Ibrahim Sheriff, Andrew Tutt, Tony Ng

“…However, recent evidence from experimental models and clinical studies has demonstrated that ILC contribute to the mechanisms that generate suppressive or tolerant environments that allow tumor regression or progression. …”
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The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy by Suxia Han, Guihua Jin, Lijuan Wang, Meng Li, Chenchen He, Xijing Guo, Qing Zhu

“…Several different radiolabeled immunodiagnostic and immunotherapeutic agents of PAM4 have been developed and some are being evaluated in preclinical and/or clinical studies. The review will focus on PAM4 and its potential utility for the diagnosis, radioimmunodetection, and radioimmunotherapy of pancreatic cancer.…”
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Relationship between Periodontitis and Ischemic Cerebrovascular Disease by Magda Pinilla Pérez, Elisa DBeche Riambau, Miriam Castro Ortega

“…Periodontitis is an immunoinflammatory disorder of microbial etiology caused by unique germs in the oral cavity that can spread through the bloodstream, activate the host's inflammatory response and promote the formation, maturation and exacerbation of atheromatous plaque. Several clinical studies have investigated the possible relationship between periodontal disease and diseases resulting from atherosclerosis such as ischemic heart disease and ischemic cerebrovascular disease. …”
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The Use of Natural Health Products Especially Papaya Leaf Extract and Dandelion Root Extract in Previously Untreated Chronic Myelomonocytic Leukemia by Leena T. Rahmat, Lloyd E. Damon

“…Natural health products such as papaya leaf extract and dandelion root extract have been shown to demonstrate anticancer activity in preclinical and clinical studies, respectively. We present a case study of a 76-year-old male with previously untreated CMML, whose hematological parameters remained stable and whose bone marrow blast counts vastly improved while taking papaya leaf extract and dandelion root extract.…”
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The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma by Gillian R. Naro, Nicholas Noverati, Timothy Craig

“…Though data exist concerning the role of bradykinin in GB, no clinical studies using C1INH have been done in humans with GB.…”
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Diagnosis and Pharmacological Management of Small Intestinal Bacterial Overgrowth in Children with Intestinal Failure by Bushra A Malik, Yuan Y Xie, Eytan Wine, Hien Q Huynh

“…Although treatment trials can be challenging in such a vulnerable population, more investigative clinical studies examining early diagnosis, more effective control of recurrence and the prevention of associated complications must be conducted.…”
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Modern possibilities for treating acute rhinosinusitis using herbal medications by Valery M. Svistushkin, Liliya V. Selezneva, Mikhail V. Svistushkin, Gaya V. Lebedeva, Igor A. Zinchenko

“…This review assessed the quality of the evidence for the use of herbal medicine for acute rhinosinusitis to determine its position among other treatments and future directions for research. Clinical studies of the effectiveness of the drug Sinupret extract are presented, the use of which promotes the outflow of exudate from the paranasal sinuses and upper respiratory tract, preventing the development of complications.…”
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NEW TECHNOLOGIES IN CRYOSURGERY ENDOSCOPIC TREATMENT OF TUMORS OF THE RESPIRATORY TRACT by V. V. Sokolov, D. V. Sokolov, L. V. Telegina, A. L. Nikolaev, A. P. Kirukhin, Yu. L. Kudryavtseva

“…Preliminary results of clinical studies show that, in comparison with cryosurgery on older devices, cryorecanalization using the latest generation of m edical eq uipment and a new cryosondond model is an effective method of recanalization to restore airway patency, which can be used in combination with electrodestruction, argon-plasma And laser coagulation.…”
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Diagnostic and therapeutic recommendations in pancreatic ductal adenocarcinoma. Recommendations of the Working Group of the Polish Pancreatic Club by Katarzyna Winter, Renata Talar-Wojnarowska, Andrzej Dąbrowski, Małgorzata Degowska, Marek Durlik, Anita Gąsiorowska, Stanisław Głuszek, Grażyna Jurkowska, Aleksandra Kaczka, Paweł Lampe, Tomasz Marek, Anna Nasierowska-Guttmejer, Ewa Nowakowska-Duława, Grażyna Rydzewska, Janusz Strzelczyk, Zbigniew Śledziński, Ewa Małecka-Panas

“…A vast majority of the statements are based on data obtained in clinical studies and experts’ recommendations on PDAC management, including the following guidelines: International Association of Pancreatology/European Pancreatic Club (IAP/EPC), American Society of Clinical Oncology (ASCO), European Society for Medical Oncology (ESMO), National Comprehensive Cancer Network (NCCN) and Polish Society of Gastroenterology (PSG) and The National Institute for Health and Care Excellence (NICE). …”
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Real-world studies of crizotinib in patients with ROS1-positive non-small-cell lung cancer: experience from China by Hua Zhong, Jun Lu, Mengzhao Wang, Baohui Han

“…However, due to the paucity of solid data from randomized, controlled phase III clinical studies, clinicians often require more systematic, real-world data-based guidance for its optimal clinical use. …”

Acute Renal Failure and Volume Overload Syndrome Secondary to a Femorofemoral Arteriovenous Fistula Angioplasty in a Kidney Transplant Recipient by Dominique Bertrand, Geoffroy Desbuissons, Nicolas Pallet, Albane Sartorius, Christophe Legendre, Marie-France Mamzer, Rebecca Sberro Soussan

“…Experimental and clinical studies analyzing the impact of AVF on cardiovascular and renal parameters, as well as outcomes, in kidney transplant recipients are lacking. …”
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Current status of bicompartmental arthroplasty by Yingjian Gao, Bing Yue, Weiwei Xin

“…While BCA is evolving towards a more exciting future, more clinical studies are warranted to exploit its potential and validate its efficacy, eventually improving outcomes and patient satisfaction.…”
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Capsule endoscopy: New Technology That is Here to Stay by Robert Enns

“…Food and Drug Administration approval was based on two clinical studies (1,2). The first (1) compared CE with push enteroscopy (PE) (the previous gold standard) in dogs who had nine to 13 beads (3 mm to 6 mm each) sewn into the small intestine. …”
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FDA-approved kinase inhibitors: a promising therapeutic avenue for traumatic brain injury by Dezhu Gao, Yu Shi, Zhiliang Wang, Weiming Liu

“…There are fewer randomized clinical studies that evaluate efficacy. We search the kinase inhibitors approved by the FDA and traumatic brain injury as keywords on websites and analyze associated research. …”
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Homogeneity Test of Response Rate Functions in Bilateral Correlated Data under Dallal’s Model by Hengyi Zhao, Xiaojuan Wang, Jingwen Bian, Shenglong Chen, Zhiming Li

“…In clinical studies, paired binary metadata are often encountered during collecting information from paired organs or parts. …”
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