Effect of glucagon-like peptide-1 receptor agonists in osteoarthritis: A systematic review of pre-clinical and human studies by Jacinta Cheng, Tia Solomon, Mahnuma Estee, Flavia M. Cicuttini, Yuan Z. Lim

“…Results: This systematic review included 11 (7 pre-clinical; 4 human studies) studies. In pre-clinical studies, GLP-1A was assessed for its effect on structural (n ​= ​6); immunomodulation (n ​= ​7); analgesia (n ​= ​1) and molecular pathways in osteoarthritis (n ​= ​5). …”
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Parenteral Nutrition in Liver Resection by Carlo Chiarla, Ivo Giovannini, Felice Giuliante, Francesco Ardito, Maria Vellone, Agostino Maria De Rose, Gennaro Nuzzo

“…Albeit a very large number of experiments have assessed the impact of various substrates on liver regeneration after partial hepatectomy, a limited number of clinical studies have evaluated artificial nutrition in liver resection patients. …”
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Effect of ranolazine on the course of ischemic heart disease after percutaneous coronary intervention by О.А. Yepanchintseva, O.J. Zharinov, І.V. Shklianka

“…The results of many clinical studies have proven the antiischemic effect and safety of ranolazine after coronary artery stenting. …”
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Vascular Effects of Dietary Advanced Glycation End Products by Alin Stirban, Diethelm Tschöpe

“…This review summarizes the evidence from clinical studies regarding effects of dietary AGEs on the vascular system, highlighting also the different aspects of vascular tests. …”
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The role of peroxisome proliferator-activated receptor in the treatment of non-alcoholic fatty liver disease by Sun Xin, Zhang Yan, Xie Meilin

“…Many therapeutic targets have been found and used in clinical studies. Peroxisome proliferator-activated receptors (PPARs) are among the potential targets and have been demonstrated to exert a pivotal role in modulation of NAFLD. …”
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Cognitive Impairment in Genetic Parkinson’s Disease by A. Planas-Ballvé, D. Vilas

“…In this review, we summarize data regarding cognitive function on clinical studies, neuroimaging, and biological markers of cognitive decline in autosomal dominant PD linked to mutations in LRRK2 and SNCA, autosomal recessive PD linked to Parkin and PINK1, and also PD linked to GBA mutations.…”
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A structured exercise regimen enhances autonomic function compared to unstructured physical activities in geriatric horses by Kanokpan Sanigavatee, Chanoknun Poochipakorn, Onjira Huangsaksri, Sipaporn Vichitkraivin, Sireetorn Pakdeelikhit, Wanlapa Chotiyothin, Sirapatch Wongkosoljit, Thita Wonghanchao, Metha Chanda

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Echocardiographic Assessment of Preload Responsiveness in Critically Ill Patients by Alexander Levitov, Paul E. Marik

“…Fluid challenges are considered the cornerstone of resuscitation in critically ill patients. However, clinical studies have demonstrated that only about 50% of hemodynamically unstable patients are volume responsive. …”
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The Impact of the Myeloid Response to Radiation Therapy by Michael J. Gough, Kristina Young, Marka Crittenden

“…Radiation therapy is showing potential as a partner for immunotherapies in preclinical cancer models and early clinical studies. As has been discussed elsewhere, radiation provides debulking, antigen and adjuvant release, and inflammatory targeting of effector cells to the treatment site, thereby assisting multiple critical checkpoints in antitumor adaptive immunity. …”
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Inflammation in Retinal Vein Occlusion by Avnish Deobhakta, Louis K. Chang

“…A number of more recent laboratory and clinical studies have begun to elucidate the role inflammation may play in the molecular pathways responsible for the vision-impairing consequences of retinal vein occlusion, such as macular edema. …”
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Biological Strategies to Enhance Healing of the Avascular Area of the Meniscus by Umile Giuseppe Longo, Stefano Campi, Giovanni Romeo, Filippo Spiezia, Nicola Maffulli, Vincenzo Denaro

“…Although most preclinical and clinical studies are very promising, they are still at an experimental stage. …”
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Multivitamin Supplementation and Fertility Outcome: A Retrospective Single-Center Cohort Study and the Clinical and Medicolegal Value of Nutritional Counseling by Giuseppe Gullo, Simona Zaami, Adriana Vita Streva, Sofia Burgio, Valentina Billone, Yulia Kotlik, Elena Chitoran, Silvia Ganduscio, Giovanni Baglio, Antonio Perino, Gaspare Cucinella

“…Resveratrol can beneficially affect growth and follicle development and lead to improved sperm function parameters in pre-clinical studies, while information from clinical studies is still inconclusive. …”
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Underlying Anticancer Mechanisms and Synergistic Combinations of Phytochemicals with Cancer Chemotherapeutics: Potential Benefits and Risks by Muhammad Ayaz, Asif Nawaz, Sajjad Ahmad, Osama F. Mosa, Alashary Adam Eisa Hamdoon, Modawy Alnour Khalifa, Abdul Sadiq, Farhat Ullah, Abdul Wadood, Atul Kabra, H. C. Ananda Murthy

“…Various preclinical and clinical studies revealed that natural products and their combinations with chemotherapeutics mediate their anticancer effects via modulation of various signaling pathways implicated in promoting apoptosis, inhibiting excessive cellular proliferation, and mobilizing the immune system. …”
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A literature review of recent advances in gastric cancer treatment: exploring the cross-talk between targeted therapies by Reza Panahizadeh, Padideh Panahi, Vahid Asghariazar, Shima Makaremi, Ghasem Noorkhajavi, Elham Safarzadeh

“…Abstract Background Gastric cancer (GC) ranks fourth in global mortality rates and fifth in prevalence, making it one of the most common cancers worldwide. Recent clinical studies have highlighted the potential of immunotherapies as a promising approach to treating GC. …”
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Robotic surgery in gastrointestinal surgery: History, current status, and challenges by Yu Liu, Qingyang Feng, Jianmin Xu

“…The publication of high-quality clinical studies gradually confirms the advantages of robotic surgery in gastrointestinal surgery. …”
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Macrolides in Chronic Inflammatory Skin Disorders by Abdullateef A. Alzolibani, Khaled Zedan

“…This paper summarizes a collection of clinical studies and case reports dealing with the potential benefits of macrolides antibiotics in the treatment of selected dermatoses which have primarily been classified as noninfectious and demonstrating their potential for being disease-modifying agents.…”
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Tryptophan Kynurenine Pathway-Based Imaging Agents for Brain Disorders and Oncology—From Bench to Bedside by Erik Stauff, Wenqi Xu, Heidi H. Kecskemethy, Sigrid A. Langhans, Vinay V. R. Kandula, Lauren W. Averill, Xuyi Yue

“…The newly developed amino acid-based tracers have been demonstrated to have favorable radiochemical and imaging characteristics in pre-clinical studies. However, many barriers still exist in the clinical translation of KYN pathway-specific radiotracers.…”
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Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources by Xiaolong Ji, Jianhang Guo, Tengzheng Cao, Tingting Zhang, Yanqi Liu, Yizhe Yan

“…This review could provide a comprehensive perspective for better understanding on development and mechanism of natural polysaccharides against diabetes mellitus, which have been required by clinical studies yet.…”
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Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review by Francesco M Marincola, Alessandra Cesano, Yana G Najjar, Davide Bedognetti, Marco Ruella, Sarah Warren, Christine Spencer, Elad Ziv, Tomas Kirchhoff, Jennifer McQuade, Tullia C Bruno, Jakob Nikolas Kather, Allison Betof Warner, Christian Hammer, Alberto Carturan, Ryan Augustin, Rhine Shen, Winson S Ho, Rongze O Lu, Luigi Barrea, Violena Pietrobon, Laura Soldati

“…Though CIR is multifactorial, fundamental concepts are emerging that should be considered for the design of novel therapeutic strategies and related clinical studies. Recent advancements as well as novel approaches to address the limitations of current treatments are discussed here, with a specific focus on ICI and ACT.…”
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Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy by Jianjing Lin, Jingtao Huang, Zilu Jiao, Mengyuan Nian, Canfeng Li, Yali Dai, Shicheng Jia, Xintao Zhang

“…Mesenchymal stem cells from various tissues are the most studied cell type and have been used in preclinical and clinical studies of OA, because they are more widely available, have a greater capacity for in vitro expansion, and have anti‐inflammatory and immunomodulatory properties compared to autologous chondrocytes. …”
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