Artificial intelligence-enabled non-invasive ubiquitous anemia screening: The HEMO-AI pilot study on pediatric population by Daniel Gordon, Jason Hoffman, Keren Gamrasni, Yotam Barlev, Alex Levine, Tamar Landau, Ronen Shpiegel, Avishai Lahad, Ariel Koren, Carina Levin, Osnat Naor, Hannah Lee, Xin Liu, Shwetak Patel, Gilad Chayen, Michael Brandwein

“…Methods HEMO-AI (Hemoglobin Easy Measurement by Optical Artificial Intelligence), a clinical study carried out from December 2020 to February 2023, recruited patients from the Pediatric Emergency Department, Pediatric Inpatient Department and Pediatric Hematology Unit of the Haemek Medical Center, Afula, Israel. …”
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The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy... by Ahmet Serhat Genç, Ali Kerim Yılmaz, Berna Anıl, Esra Korkmaz Salkılıç, Enes Akdemir, Berna Güzel, Ahmet Mor, Hacı Ahmet Yarar, Nizamettin Güzel, Lokman Kehribar

“…Methods This randomized, double-blind, placebo-controlled clinical study included 32 patients (collagen = 17 and placebo = 15) with meniscopathy. …”
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Synchronized autologous T-cell immunotherapy with hyperthermia to previously heavy treated advanced renal cell carcinoma by Jun Ren, Congcong Li, Dazhao Xu, Kun Wan, Chuxiong Zeng, Lina Hu, Xianzhi Guo, Feifei Huo, Xiumei Rong, Xinna Zhou, Tiecheng Wu, Xiaoli Wang, Bo Sun, JingJing Lou, Amy Hobeika, Michael A. Morse, Herbert Kim Lyerly

“…The safety and clinical response with a three-year follow-up were filed.Materials and methods This was N-of-1 clinical study describing such mRCC case with ECOG 3-4 score was treated by SHAPE-T. …”
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Meta-analysis of Therapeutic Effect of Warm Acupuncture and Moxibustion on Knee Osteoarthritis of Yang Deficiency and Cold Coagulation and Research on Regularity of Acupoint Select... by Zeling HUANG, Shanni SHI, Junjun HE, Hongjian GAO, Haiya GE, Zhenqiang HONG

“…However, the further research needs to carry out a multi-center, large-sample, high-quality randomized controlled clinical study to provide more reliable evidence for warm acupuncture and moxibustion in the treatment of KOA of Yang deficiency and cold coagulation.…”
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A Comprehensive Analysis of <i>Echinococcus granulosus</i> Infections in Children and Adolescents: Results of a 7-Year Retrospective Study and Literature Review by Cristina Maria Mihai, Ancuta Lupu, Tatiana Chisnoiu, Adriana Luminita Balasa, Ginel Baciu, Vasile Valeriu Lupu, Violeta Popovici, Felicia Suciu, Florin-Daniel Enache, Simona Claudia Cambrea, Ramona Mihaela Stoicescu

“…A 7-year retrospective clinical study on pediatric patients with CE from Southeast Romania was performed, and 39 children and adolescents were included, aged 2–15 years old. …”
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Diagnostic Accuracy of Non-Invasive Diagnostic Tests for Nonalcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis by Sun Y, Hu D, Yu M, Liang SB, Zheng Y, Wang X, Tong G

“…Yuxin Sun,1,&ast; Die Hu,1,&ast; Mingkun Yu,2 Shi-Bing Liang,3– 5 Youyou Zheng,6 Xin Wang,7 Guangdong Tong1,8 1Shenzhen Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Shenzhen, People’s Republic of China; 2Department of Oncology, Binzhou Hospital of Traditional Chinese Medicine, Binzhou, People’s Republic of China; 3Clinical Study Center, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 4Centre for Evidence-Based Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 5Postdoctoral Research Station, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 6Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 7Department of Traditional Chinese Medicine, Sanbo Brian Hospital of Capital Medical University, Beijing, People’s Republic of China; 8Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Guangdong Tong, Shenzhen Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Shenzhen, People’s Republic of China, Email tgd755@163.comPurpose: In recent decades, numerous non-invasive tests (NITs) for diagnosing nonalcoholic fatty liver disease (NAFLD) have been developed, however, a comprehensive comparison of their relative diagnostic accuracies is lacking. …”
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The proportion of clinically relevant alarms decreases as patient clinical severity decreases in intensive care units: a pilot study by Ryota Inokuchi, Kent Doi, Kazuaki Shinohara, Kensuke Nakamura, Takehiro Matsubara, Susumu Nakajima, Hajime Sato, Masataka Gunshin, Takahiro Hiruma, Takeshi Ishii, Yoichi Kitsuta, Naoki Yahagi, Yuko Nanjo, Masahiro Echigo, Aoi Tanaka, Mitsuo Umezu

“…Objectives To determine (1) the proportion and number of clinically relevant alarms based on the type of monitoring device; (2) whether patient clinical severity, based on the sequential organ failure assessment (SOFA) score, affects the proportion of clinically relevant alarms and to suggest; (3) methods for reducing clinically irrelevant alarms in an intensive care unit (ICU).Design A prospective, observational clinical study.Setting A medical ICU at the University of Tokyo Hospital in Tokyo, Japan.Participants All patients who were admitted directly to the ICU, aged ≥18 years, and not refused active treatment were registered between January and February 2012.Methods The alarms, alarm settings, alarm messages, waveforms and video recordings were acquired in real time and saved continuously. …”
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Hypofractionated radiotherapy combined with a PD-1 inhibitor, granulocyte macrophage-colony stimulating factor, and thymosin-α1 in advanced metastatic solid tumors: a multicenter P... by Jiamin Yu, Li Yin, Wenjie Guo, Qiang Wang, Juying Liu, Lansheng Zhang, Hongxun Ye, Jianhong Xia, Youyou Xia, Jianfeng Wu, Wanwei Wang, Yanguang Yang, Dan Zong, Xia He, Lijun Wang, Hong Jiang

“…Abstract Purpose This multicenter Phase II clinical study assessed the efficacy and safety of hypofractionated radiotherapy (HFRT) in combination with a PD-1 inhibitor, granulocyte macrophage-colony stimulating factor (GM-CSF), and thymosin-α1 in patients with heavily treated metastatic solid tumors. …”
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Clinical experience with heparin-containing eye ointment for dry eye by D.M. Safonova, A.O. Root, V.D. Yartsev, M.N. Narbut

“…<br> Patients and Methods: non-controlled prospective clinical study included 21 patients (41 eyes) with moderate scleral conjunctival xerosis. …”
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Survey of Legionella Species Found in Thai Soil by Tatiana C. Travis, Ellen W. Brown, Leonard F. Peruski, Duangkamon Siludjai, Possawat Jorakate, Prasert Salika, Genyan Yang, Natalia A. Kozak, Maja Kodani, Agnes K. Warner, Claressa E. Lucas, Kathleen A. Thurman, Jonas M. Winchell, Somsak Thamthitiwat, Barry S. Fields

“…As a followup to a prior clinical study of legionellosis in rural Thailand, indigenous soil samples were collected proximal to cases’ homes and workplaces and tested for the presence of legionellae by culture. …”
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Treatment of chronic hepatitis C by cepeginterferon alpha-2b in combination to ribavirin by M. V. Mayevskaya, O. O. Znoyko, Ye. A. Klimova, S. L. Maximov, S. N. Kizhlo, N. A. Petrochenkova, F. I. Nagimova, Yu. N. Linkova

“…In open randomized «noninferiority» clinical study of II–III phase 150 previously untreated by interferon adult CHC patients (genotypes 1, 2, 3) were randomized in three medical groups: Algeron 1,5 mkg/kg, Algeron 2,0 mkg/kg and active control group — PegIntron 1,5 mkg/kg. …”
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Baseline Serum Cholesterol Is Associated with a Response to Pegylated Interferon Alfa-2b and Ribavirin Therapy for Chronic Hepatitis C Genotype 2 by Naota Taura, Tatsuki Ichikawa, Hisamitsu Miyaaki, Yoshiko Kadokawa, Takuya Tsutsumi, Shotaro Tsuruta, Yuji Kato, Osami Inoue, Noboru Kinoshita, Kazuo Ohba, Hiroyuki Kato, Kazuyuki Ohata, Junichi Masuda, Keisuke Hamasaki, Hiroshi Yatsuhashi, Kazuhiko Nakao

“…Thus, we performed a multi-institutional clinical study to evaluate the impact of lipid profiles on SVR rates in patients with HCV genotype 2. …”
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Titin gene mutations enhance radiotherapy efficacy via modulation of tumour immune microenvironment in rectum adenocarcinoma by Hengchang Liu, Jialiang Liu, Xu Guan, Zhixun Zhao, Pu Cheng, Haipeng Chen, Zheng Jiang, Xishan Wang

“…Observations from the clinical study showed a substantial decline in ANKRD1 expression levels alongside a notable surge in the counts of CD4+ and CD8+ T cells after undergoing radiotherapy. …”
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Relationship between vaginal and gut microbiome and pregnancy outcomes in eastern Ethiopia: a protocol for a longitudinal maternal-infant cohort study (the EthiOMICS study) by Piet Cools, Alemseged Abdissa, Abera Kenay Tura, Nega Assefa, Merga Dheresa, Kedir Teji Roba, Tara Wilfong, Tesfaye Assebe Yadeta, Fitsum Weldegebreal, Desalegn Admassu Ayana, Akewok Sime Negesa, Yohannes Mulugeta Demmu, Tewodros Tesfa, Tegbaru Nibrat Alemu, Tadesse Gure Eticha, Abraham Geremew, Abel Abera Negash

“…Results will be published in international peer-reviewed journals, and summaries will be provided to the study funders. Clinical study data will be submitted to Data Compass (https://datacompass.lshtm.ac.uk/), and molecular profiles of the microbiome and whole-genome sequences will be submitted to the European Nucleotide Archive (https://www. ebi.ac.uk/ena). …”
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Probiotics in the Management of Chronic Bacterial Prostatitis Patients: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom Re... by Cristina Vocca, Diana Marisol Abrego-Guandique, Erika Cione, Vincenzo Rania, Gianmarco Marcianò, Caterina Palleria, Luca Catarisano, Manuela Colosimo, Gregorio La Cava, Italo Michele Palumbo, Giovambattista De Sarro, Tommaso Ceccato, Simone Botti, Tommaso Cai, Alessandro Palmieri, Luca Gallelli

“…In this randomized, placebo-controlled clinical study, we evaluated the efficacy and safety of consumption of probiotics containing human <i>Lactobacillus casei</i> DG^® as an add-on treatment in patients with clinical recurrences of CBP, through gut microbiota modification analysis. …”
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Selected results of a post-registration observational study on the clinical efficacy and tolerability of Bimicombi Antiglau ECO and Brim Antiglau ECO in different stages of primary... by A.V. Kuroyedov, M.V. Kosakovskaya, O.V. Gapon’ko, V.V. Gorodnichiy, D.N. Lovpache, I.A. Bulakh

“…</p> <p> <b>Patients and Methods: </b>data from 1036 patients were included in the final protocol of the multicenter combined scientific and clinical study. All patients were diagnosed with POAG or were glaucoma suspects (GS) with ocular hypertension (OHT). …”
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Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

“…Objectives To assess the beneficial and harmful effects of duloxetine versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder.Design Systematic review with meta-analysis and trial sequential analysis of randomised trials.Data sources Cochrane Central Register of Controlled Trials, MEDLINE, Embase, PsycINFO and other relevant databases up until January 2023. We requested clinical study reports from 36 competent authorities.Eligibility criteria for selecting studies All randomised clinical trials comparing duloxetine versus placebo, ‘active placebo’ or no intervention, irrespective of publication type, publication status, publication year and language for treatment of major depressive disorder in adults.Data extraction and synthesis Five authors in pairs extracted data using a standardised data extraction sheet. …”
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The Comparison of Cost-Effectiveness Between Magnetic Resonance Spectroscopy and Provocative Discography in the Identification of Chronic Low Back Pain Surgery Candidates by Wilson L, Beall DP, Eastlack RK, Berven S, Lotz JC

“…A non-invasive alternative using Magnetic Resonance Spectroscopy (MRS) offers a potential solution.Context/Purpose: We assess cost-effectiveness of MRS with NOCISCAN diagnostic algorithm compared to PD for identifying lumbar discs requiring surgical intervention.Study Design/Setting: We conducted cost-effectiveness analysis using modelling.Patient Sample: We used data from a clinical study of 139 CLBP patients who met criteria for and received PD of lumbar spine and presented with an ODI score ≥ 40; comparing PD and MRS-based diagnostics.Outcome Measures: We considered diagnostic costs, adverse events, surgical costs and outcomes based on a 15-point improvement on the Oswestry Disability Index.Methods: Incremental cost-effectiveness ratios (ICERS) and probabilistic sensitivity analyses were determined. …”
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Alleviating effect of intranasal zinc on symptoms of allergic rhinitis by Huadong Xu, PhD, Keming Tong, BS, Naruhito Iwasaki, MD, PhD, Nobutaka Ohgami, PhD, Akira Tazaki, PhD, Takumi Kagawa, MMSc, Yanjun Gao, MMSc, Delgama A.S.M. Nishadhi, MMSc, Akihito Harusato, MD, PhD, Masafumi Sakashita, MD, PhD, Kazuhiro Ogi, MD, PhD, Shigeharu Fujieda, MD, PhD, Shogo Sumiya, MD, Shinichi Iwasaki, MD, PhD, Masashi Kato, MD, PhD

“…The clinical implications and kinetics of Zn levels in ELF and serum were further investigated in model mice with JCP. Results: This clinical study showed that the Zn level in nasal ELF from patients with JCP was increased after pollen exposure and became significantly higher than that in nasal ELF from controls in the JCP season. …”
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Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…Carcinoembryonic antigen (CEA) is an attractive target due to its high expression in many tumors, particularly gastrointestinal cancers, while limited expression in normal adult tissues. In our previous clinical study, we reported a 70% disease control rate with no severe side effects using a humanized CEA-targeting CAR-T cell. …”
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