Effect of PCSK9 inhibitor on early neurological deterioration in acute ischemic stroke patients with a history of coronary heart disease: a study protocol for a randomized controll... by Xing Gong, Xinting Yu, Lanlan Pu, Yang Jiao, Lin Liu, Hua Cao, Xiaofei Ji

“…Methods This is a prospective, randomized, parallel-group, blinded-endpoint, single-center clinical study. A total of 156 AIS patients with a history of CHD and within 24 h from symptom onset will be recruited and randomized in a 1:1 allocation to either the PCSK9 inhibitor combined with statin treatment group (PI group) or the statin monotherapy group (AT group). …”
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Predictive model for determining the indications for automated 3D ultrasound for screening patients at low risk of developing breast tumors by A. E. Garanina, A. V. Kholin

“…A retro-prospective clinical study has been conducted from February 2019 to May 2023. …”
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Spontaneous pneumothorax: intubated or non-intubated surgery? by V.V. Tkalich, Yu.V. Nedilia, V.I. Borysova, O.V. Galiiev, S.I. Savoliuk

“…The aim of our clinical study was to justify and implement non-intubated video assisted thoracic surgery as a part of enhanced recovery after surgery pathway in treatment of spontaneous pneumothorax. …”
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Efficacy and Safety of Murivenna Anal Infiltration Compared to Diltiazem Topical Application in Chronic Anal Fissure: Protocol for a Prospective, Randomized, Open-Label Clinical Tr... by Pratap Shankar KM, Indu Puthan Purayil, Palengara Binitha, Amit Kumar Rai, Sophia Jameela, Azeem Ahmad, Chandra Sekhara Rao Bhogavalli, Narayanam Srikanth, Rabinarayan Acharya

“…Ayurvedic treatments have shown potential for the therapeutic management of anal fissure. ObjectiveThis clinical study aims to analyze the efficacy and safety of murivenna anal infiltration compared to diltiazem topical application in chronic anal fissure. …”
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Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascend... by Annette Janus, Daniël Dumas, Juliette Le Douce, Sébastien Marie, Giuseppe Pasculli, Pauline Bambury, Sighild Lemarchant, Philip Kremer, Yann Godfrin

“…NX210c demonstrated a good safety profile in a single ascending dose phase 1a clinical study. The present multiple ascending dose phase 1b study was performed to evaluate the tolerability and pharmacological effects of repeated doses of NX210c in healthy elderly (age: > 55 years) volunteers. …”
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Pulse oximetry at two sensor placement sites in conscious foals by Heini Sofia Rossi, Anna Kristina Mykkänen, Jouni Juho Tapio Junnila, Heli Katariina Hyytiäinen

“…The aim of this prospective clinical study was to evaluate the usability, validity, and reliability of pulse oximetry at two measuring sites (lip and caudal abdominal skin fold) for blood oxygen saturation measurement in conscious foals with and without respiratory compromise. …”
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Prevention of sufentanil-induced cough during induction of general anesthesia by low-dose esketamine by Xueyue Zhou, Chaoping Guo, Boyu Liu, Yongqing Guan, Shengxiang Wang, Jun Ji

“…Methods This randomised, double-blind, placebo-controlled clinical study was conducted at the Air Force Medical Center between September 2023 and May 2024. …”
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Safety and efficacy of the amino acid-crosslinked hyaluronic acid in the treatment of temple hollowing by Yanping Guo, Puzhen Li, Wuhan Wei, Qiang Li, Caiqi Shen, Xiaoying Zhuo, Yujie Luo, Jie Liu, Peisheng Jin, Xueyang Li

“…Objective: The authors conduct a clinical study to investigate the safety and effectiveness of the amino acid crosslinked hyaluronic acid (ACHA) for the treatment of temple hollowing. …”
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Optimizing hypoglycaemia prediction in type 1 diabetes with Ensemble Machine Learning modeling by Daphne N. Katsarou, Eleni I. Georga, Maria A. Christou, Panagiota A. Christou, Stelios Tigas, Costas Papaloukas, Dimitrios I. Fotiadis

“…The dataset comprises 29 individuals with T1D, who were monitored for 2 to 4 weeks during the GlucoseML prospective observational clinical study. Results Among six different basis models (i.e., linear regression (LR), automatic relevance determination (ARD), support vector regression (SVR), Gaussian process regression (GPR), eXtreme gradient boosting (XGBoost), and long short-term memory (LSTM)), XGBoost and SVR showed a dominant performance in the hypoglycaemic region and were selected as the constituent basis models of the ensemble model. …”
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PI3Kδ inhibitor linperlisib combined with gemcitabine and oxaliplatin for relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm phase Ib/II trial by Peng Sun, Hong Cen, Haiyan Yang, Rui Huang, Zhen Cai, Xuekui Gu, Hanying Bao, Zusheng Xu, Zuhong Xu, Zhi-Ming Li

“…Methods This was a multicenter, phase Ib/II clinical study conducted across six sites in China, enrolling 39 individuals with histologically confirmed R/R DLBCL. …”
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Anatomy-Informed Multimodal Learning for Myocardial Infarction Prediction by Ivan-Daniel Sievering, Ortal Senouf, Thabo Mahendiran, David Nanchen, Stephane Fournier, Olivier Muller, Pascal Frossard, Emmanuel Abbe, Dorina Thanou

“…<italic>Results:</italic> The results of our framework on a clinical study of 445 patients admitted with acute coronary syndromes confirms that multimodal learning increases the predictive power and achieves good performance (AUC: <inline-formula><tex-math notation="LaTeX">$0.67\pm 0.04$</tex-math></inline-formula> &amp; F1-Score: <inline-formula><tex-math notation="LaTeX">$0.36\pm 0.12$</tex-math></inline-formula>), which outperforms the prediction obtained by each modality independently as well as that of interventional cardiologists (AUC: 0.54 &amp; F1-Score: 0.18). …”
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Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients by Wanqing Huang, Jiuxu Bai, Yanping Zhang, Dongxia Qiu, Lin Wei, Chen Zhao, Zhuo Ren, Qian Wang, Kaiming Ren, Ning Cao

“…The purpose of this study was to determine the relationship between the use of low-flux or high-flux membranes and all-cause and cardiovascular mortality in elderly hemodialysis patients.Methods This was a retrospective clinical study involving maintenance hemodialysis patients which were categorized into low-flux and high-flux groups according to the dialyzer they were using. …”
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Safety and Feasibility of Repeated Intrathecal Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells in Patients with Neurological Diseases by Kuang Pan, Lingna Deng, Peiying Chen, Qingxia Peng, Jingrui Pan, Yanfeng Wu, Yidong Wang

“…In this study, we evaluate the safety and feasibility of intrathecal allogeneic bone marrow-derived MSCs (BM-MSCs) in patients with neurological diseases. This open-label clinical study included 37 patients (14 diseases). Eligible patients underwent a baseline assessment and were intrathecally injected with allogeneic BM-MSCs (1×106 cells/kg, 4 consecutive treatments at 1-week intervals). …”
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Comparative effects of methamphetamine, cannabis, and polysubstance use on oral health by Osman Hasan Tahsin Kılıç, Duygu Kürklü Arpaçay, Onur Çağdaş Gezen, Zehra Nur Bayram, Aysel Başer

“…IntroductionThis study aimed to compare the clinical oral health status of individuals with Methamphetamine (MA), Cannabis (THC), and Polysubstance (PS) use disorders to healthy controls, and assess the impact of substance type, usage duration, quantity, and oral health behaviors on dental health outcomes through comprehensive oral examinations.MethodsThis cross-sectional clinical study was conducted at İzmir Democracy University Buca Seyfi Demirsoy Education and Research Hospital between April 2024 and August 2024. …”
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SUCCESSFUL REGISTRATION OF DOMESTIC BIOANALOGUE OF BEVACIZUMAB – NEW OPPORTUNITIES FOR EFFECTIVE TREA TMENT OF PATIENTS WITH NON-SQUAMOUS CELL NON-SMALL CELL LUNG CANCER by S. V. Orlov, S. N. Fogt, M. S. Shustova

“…Based on the results of the clinical study the first biosimilar of bevacizumab — drug "Avegra®" was successfully registered in Russian Federation in November 2015 and can be recommended for use in clinical practice.…”
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Qualitative evaluation of the implementation and national roll-out of the NHS App in England by Claire Reidy, Chrysanthi Papoutsi, Sukriti KC, Bernard Gudgin, Anthony A. Laverty, Felix Greaves, John Powell

“…Conclusions As the NHS App remains a complex innovation in a shifting landscape, it is clear ongoing work is needed to ensure its potential can be sustained to meet patient, service and policy needs. Clinical study registration ISRCTN72729780.…”
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Expert Consensus on Clinical Application of Lower Limb Rehabilitation Robots by ZHANG Lixin, BAI Dingqun, BAI Yulong, CHEN Wenhua, CHEN Yan, DU Qing, FAN Maohua, HE Hongchen, HUANG Liping, JIA Jie, LI Jianhua, LI Lei, PAN Yu, SU Min, WANG Hongtu, YIN Yong, ZHANG Bi

“…However, determining whether its training effect is superior to conventional rehabilitation therapy requires further clinical study (high-level evidence). Studies have also shown that lower limb rehabilitation robot training can improve walking function (medium to high-level evidence), cardiopulmonary function (low to medium-level evidence), lower urinary tract function (low-level evidence), and balance function (low to medium-level evidence) in paraplegic patients. …”
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The disinfectant effects of portable ultraviolet light devices and their application to dentures by Kae Harada, Reiya Horinouchi, Mamoru Murakami, Masakazu Isii, Yuji Kamashita, Naohiro Shimotahira, Fumio Suehiro, Yasuhiro Nishi, Hiroshi Murata, Masahiro Nishimura

“…Device A was tested on denture-wearing patients in a clinical study, with samples collected from mucosal surfaces before and after irradiation to assess microbial CFUs (colony forming units). …”
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Single-staged Surgical Correction of Kyphotic Deformity due to Dorsal Spinal Tuberculosis in Pediatric Patients: Outcome Analysis by Mageswaran Shanmugavelu, Makesh Ram Sriraghavan, Prabhu Aloy, Poornima Kumararaja, Sai Vinay Bharadwaj Namala

“…Conclusion: This study aimed to evaluate the clinical study efficacy and feasibility of one-stage posterior-only surgical treatment for thoracic spinal TB in adolescents. …”
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Machine learning validation of the AVAS classification compared to ultrasound mapping in a multicentre study by Katerina Lawrie, Petr Waldauf, Peter Balaz, Radoslav Bortel, Ricardo Lacerda, Emma Aitken, Krzysztof Letachowicz, Mario D’Oria, Vittorio Di Maso, Pavel Stasko, Antonio Gomes, Joana Fontainhas, Matej Pekar, Alena Srdelic, VAVASC Study Group, Stephen O’Neill

“…It’s been previously validated in a clinical study. Here, AVAS performance was tested against multiple ultrasound mapping measurements using machine learning. …”
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