Differential Cannabinoid Receptor Expression during Reactive Gliosis: a Possible Implication for a Nonpsychotropic Neuroprotection by Daniele De Filippis, Antonio Steardo, Alessandra D'Amico, Caterina Scuderi, Mariateresa Cipriano, Giuseppe Esposito, Teresa Iuvone

“…In the search for new neuroprotective compounds, interest has turned to marijuana derivatives, since in several in vitro, in vivo, and clinical studies, they have shown a great ability to control neuroinflammation.…”
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Bioactive Ingredients in Traditional Fermented Food Condiments: Emerging Products for Prevention and Treatment of Obesity and Type 2 Diabetes by Alphonse Laya, Honoré Wangso, Iva Fernandes, Raphaël Djakba, Joana Oliveira, Eugenia Carvalho

“…Nevertheless, further investigation is required in more clinical studies of TFC to support the formulation of functional fermented condiments and nutraceutical and pharmaceutical applications.…”
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Human Serum Eye Drops in Eye Alterations: An Insight and a Critical Analysis by Maria Rosaria De Pascale, Michele Lanza, Linda Sommese, Claudio Napoli

“…Besides, reported ongoing clinical studies confirmed the open debate regarding the use of biologic tools for cornea regeneration. …”
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Biological factors controlling starch digestibility in human digestive system by Cheng Li, Yiming Hu, Songnan Li, Xueer Yi, Shuaibo Shao, Wenwen Yu, Enpeng Li

“…This is due to the inherent complexity of human GIT anatomy, motility and biochemical conditions, as well as ethical, financial and technical issues in conducting clinical studies. Much technological and scientific efforts from both clinical studies and in vitro simulation models are required for a better understanding of in vivo starch digestion behaviors.…”
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Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative Medicine by Francesca Veronesi, Melania Maglio, Deyanira Contartese, Lucia Martini, Aurelio Muttini, Milena Fini

“…Forty-eight preclinical and clinical studies, performed in the last 10 years, were identified. …”
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Organic Alternatives to Quantum Dots for Intraoperative Near-Infrared Fluorescent Sentinel Lymph Node Mapping by Shunsuke Ohnishi, Stephen J. Lomnes, Rita G. Laurence, Andrew Gogbashian, Giuliano Mariani, John V. Frangioni

“…This preclinical study, performed on large animals approaching the size of humans, should serve as a foundation for future clinical studies.…”
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Hypofractionated External-Beam Radiotherapy for Prostate Cancer by L. Chinsoo Cho, Robert Timmerman, Brian Kavanagh

“…The preliminary results from clinical studies indicate that abbreviated fractionation programs can result in successful treatment of localized prostate cancer without escalation of late toxicity.…”
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MUC5AC mucin release from human airways in vitro: Effects of indomethacin and Bay X1005 by Patricia Roger, Jean-Pierre Gascard, Jacques Bara, Vincent Thomas de Montpreville, Charles Brink

“…While the current pharmacological approach to reducing mucus and sputum production in patients is limited, clinical studies have suggested that drugs which inhibit the cyclooxygenase and/or 5-lipoxygenase enzymatic pathways may reduce secretory activity in patients with airway disease.…”
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Evidence Graph Analysis of Postoperative Pain Sensitization Induced by Perioperative Sleep Deprivation by XUE Jianjun, WANG Caihong, GUO Lingling, LI Xiuxia, ZHANG Jie, XU Ziqing, HOU Huaijing, YANG Kehu

“…More high-quality, large-sample and standardized clinical studies should be carried out in the future to provide better scientific basis for clinical work.…”
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Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy by Izabela Zdolińska-Malinowska, Dariusz Boruczkowski, Dominika Hołowaty, Paweł Krajewski, Emilian Snarski

“…In humans, the efficacy and safety of CB administration were reported in a few early clinical studies which confirmed the feasibility and safety of this intervention for up to 10 years. …”
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Absence of mTOR Inhibitor Effect on Hepatic Cyst Growth: A Case Report of a Kidney Transplant Recipient with Autosomal Dominant Polycystic Kidney Disease by L. Friedrich, F. Barbey, M. Pascual, J.-P. Venetz

“…However, the results of clinical studies are conflicting and the role of mTOR inhibitors is still uncertain. …”
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Effects of Virtual Reality Immersion and Audiovisual Distraction Techniques for Patients with Pruritus by Vera Leibovici, Florella Magora, Sarale Cohen, Arieh Ingber

“…Resemblance between anatomical and neuroendocrine pathways of pain and pruritus may prove VRI to be a suitable adjunct for basic and clinical studies of the complex aspects of pruritus.…”
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Single-Stage Craniectomy and Cranioplasty for Multilobular Osteochondrosarcoma Managed with a Custom Additive Manufactured Titanium Plate in a Dog by Galina M. Hayes, Elena A. Demeter, Eunju Choi, Michelle Oblak

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Systematic Review and Meta-Analysis on Human African Trypanocide Resistance by Keneth Iceland, Kasozi, Ewan Thomas, MacLeod, Susan Christina, Welburn

“…Methods: Electronic searches of 12 databases and 3 Google search websites for human African trypanocide resistance were performed using a keyword search criterion applied to both laboratory and clinical studies. Fifty-one publications were identified and included in this study using the PRISMA checklist. …”
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Astaxanthin as a potential therapeutic agent for knee osteoarthritis: A review of mechanisms and clinical evidence by Sidra Sabir, AHM Mahmudur Rahman, Abdul Haseeb Bhutta

“…Results: The review identified several key mechanisms by which astaxanthin exerts its therapeutic effects, including reducing oxidative stress, attenuating inflammation, and preserving cartilage integrity. Clinical studies also provided promising evidence of its efficacy in alleviating symptoms and improving joint function in patients with KOA. …”
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Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review by Laya Jalilian-Khave, Razi Kitaneh, Binah Baht Ysrayl, Anna Borelli, Melissa C. Funaro, Marc N. Potenza, Gustavo A. Angarita

“…This scoping review (OSF registered as 67yhb) examines preclinical and clinical studies exploring relationships between vitamin D in impulse control disorders, behavioral addictions, and substance use disorders. …”
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Study of the passage of low-frequency ultrasonic vibrations through heterogeneous biological media during ultrasonic sanitation of urological catheters by A. A. Novikov, A. R. Putintseva, A. Yu. Tsukanov, D. S. Akhmedov

“…To achieve the goal, a mathematical model for the propagation of ultrasonic vibrations in heterogeneous media has been developed, and clinical studies have been carried out. It is shown that the proposed calculation method can be used to evaluate the passage of ultrasonic vibrations through inhomogeneous biological media. …”
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Prolonged Relief of Chronic Pain from Local Anaesthetic Blocks by Ellen N Thompson

“…In a fascinating essay on the future of local anesthetic agents, Wall (1) cited a 1990 paper from the Karolinska Institute in Stockholm, Sweden, entitled 'Prolonged relief of neuralgia after regional anesthetic blocks: A call for further experimental and systematic clinical studies' (2). The Swedish researchers had found that two-thirds of 38 patients with neuralgia experienced prolonged (up to six days) relief of pain after blocking of the injured nerve.…”
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Targeted gut microbiome therapy: Applications and prospects of probiotics, fecal microbiota transplantation and natural products in the management of type 2 diabetes by Luqi Qin, Bei Fan, Yixia Zhou, Jiahuan Zheng, Rao Diao, Fengzhong Wang, Jiameng Liu

“…Based on these current studies, future research should be focused on large-scale, long-term clinical studies and further investigation on the potential role of the gut virome in T2DM. …”
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Interleukin-17: Potential Target for Chronic Wounds by Yasmin Hadian, Michelle D. Bagood, Sara E. Dahle, Apra Sood, R. Rivkah Isseroff

“…Interleukin-17 family signaling is reviewed in the context of tissue repair, and preclinical and clinical studies examining its role in the skin and other organ systems are critically reviewed. …”
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