A Novel Model Using ML Techniques for Clinical Trial Design and Expedited Patient Onboarding Process by Iyer A, Narayanaswami S

“…As ML technology continues to evolve, its integration into clinical research could drive innovation and improve patient care.Keywords: clinical trials, site selection, machine learning, patient onboarding, feature engineering, feature encoding…”
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Evaluation of health care providers’ ability to identify patient-ventilator triggering asynchrony in intensive care unit: a translational observational study in China by Shengjun Liu, Zhangyi Zhao, Xiangyu Chen, Yi Chi, Siyi Yuan, Fuhong Cai, Zhangwei Song, Yue Ma, Huaiwu He, Longxiang Su, Yun Long

“…Conclusions Receiving training in mechanical ventilation and conducting critical respiratory clinical research may increase healthcare providers’ ability to identify patient-ventilator asynchrony by using waveform analysis. …”
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A Nomogram Model for Predicting Recurrent Coronary Thrombosis in Kawasaki Disease Patients by Zhou X, Peng Y, Yi Q

“…Xue Zhou,1– 4 Yue Peng,1– 4,* Qijian Yi1– 4,* 1Department of Cardiovascular Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2National Clinical Research Center for Child Health and Disorders, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 3Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 4Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical University, Chongqing,People’s Republic of China*These authors contributed equally to this workCorrespondence: Qijian Yi, Email qjyi@hospital.cqmu.edu.cnBackground: Coronary thrombosis is a serious cardiovascular complication of Kawasaki disease (KD), and recurrence of coronary thrombosis increases the short-term risk of myocardial infarction and the long-term risk of coronary artery disease. …”
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Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial by Liu Y, Li X, Zhang M, Men Y, Wang Y, Zhu X, Zheng L

“…Yixian Liu,1,2,* Xiaoyu Li,1,2,* Mengyu Zhang,1,2 Yuchun Men,1,2 Ying Wang,1,2 Xiaohong Zhu,1,2 Li Zheng1,2 1Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Clinical Trial Center, NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Zheng, Cancer Center, West China Hospital, Sichuan University, No. 5 Telecom Road, Wuhou District, Chengdu, 610041, People’s Republic of China, Email zhengli@wchscu.cnPurpose: HA121-28, a novel multi-targeting tyrosine kinase inhibitor, has dual efficacy against tumor growth and neovascularization. …”
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Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost by Bo Zhang, Youyi Fong, Lauren Dang, Jonathan Fintzi, Shiyu Chen, Jing Wang, Nadine G. Rouphael, Angela R. Branche, David J. Diemert, Ann R. Falsey, Daniel S. Graciaa, Lindsey R. Baden, Sharon E. Frey, Jennifer A. Whitaker, Susan J. Little, Satoshi Kamidani, Emmanuel B. Walter, Richard M. Novak, Richard Rupp, Lisa A. Jackson, Chenchen Yu, Craig A. Magaret, Cindy Molitor, Bhavesh Borate, Sydney Busch, David Benkeser, Antonia Netzl, Derek J. Smith, Tara M. Babu, Angelica C. Kottkamp, Anne F. Luetkemeyer, Lilly C. Immergluck, Rachel M. Presti, Martín Bäcker, Patricia L. Winokur, Siham M. Mahgoub, Paul A. Goepfert, Dahlene N. Fusco, Robert L. Atmar, Christine M. Posavad, Jinjian Mu, Mat Makowski, Mamodikoe K. Makhene, Seema U. Nayak, Paul C. Roberts, Peter B. Gilbert, Dean Follmann, Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…“Exploitation in Clinical Research,” in The Oxford Textbook of Clinical Research Ethics, ed. …”
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The Application of Traditional Chinese Medicine-Derived Formulations in Cancer Immunotherapy: A Review by Li Y, Li C, Fan J, Liu Y, Xu Y, Pang G

“…As cancer immunotherapy evolves, the integration of TCM into conventional treatment regimens may offer enhanced therapeutic efficacy, reduced side effects, and improved overall outcomes for cancer patients. Further clinical research is needed to fully elucidate the therapeutic potential and safety of TCM-based immunotherapeutic strategies in cancer care.Keywords: traditional Chinese medicine, TCM, cancer, nanocarriers, immune ability, anti-tumor therapy, tumor microenvironment, drug delivery systems…”
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Association of C-Reactive Protein with Short-Term Outcomes in Spontaneous Intracerebral Hemorrhage Patients with or without Infection: From a Large-Scale Nationwide Longitudinal Re... by Du Y, Liu L, Kang K, Lin Y, Gu H, Bian L, Li Z, Zhao X

“…Yang Du,1,2 Lijun Liu,1,2 Kaijiang Kang,1,2 Yijun Lin,1,2 Hongqiu Gu,1,2 Liheng Bian,1,2 Zixiao Li,1,2 Xingquan Zhao1– 4 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, People’s Republic of China; 3Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 4Center of Stroke, Beijing Institute for Brain Disorders, Beijing, People’s Republic of ChinaCorrespondence: Xingquan Zhao; Zixiao Li, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119 West Road, South 4th Ring, Fengtai District, Beijing, People’s Republic of China, 100070, Tel +86-10-59975835, Email lizixiao2008@hotmail.com; zxq@vip.163.comAim: To study the relationship between elevated C-reactive protein (CRP) levels, infection, and spontaneous intracerebral hemorrhage (ICH) outcomes.Methods: Patients were classified into four groups (Q1–Q4). …”
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Percutaneous nephroscopy versus flexible ureteroscopy in the treatment of calyceal diverticulum calculi: a meta-analysis by Conglei Hu, Rui Ma, Yongxiang Shao, Zilong Liang, Meng Cheng, Haofeng Pang, Liping Yao, Fei Liu

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The effect of emotional intelligence on nurses’ job performance: the mediating role of moral intelligence and occupational stress by Rozita Cheraghi, Naser Parizad, Vahid Alinejad, Mehri Piran, Laleh Almasi

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Association of abstinence time with semen quality in men who undergoing fertility evaluation: a cross-sectional study from 3052 participants by Guanying Yao, Qinglin Qi, Xianchao Dou, Wen Zhou, Shun Bai, Xi Zhang, Xi Zhang

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The effectiveness of Transcranial Photobiomodulation therapy (tPBM) on reducing anxiety, depression, and opioid craving in patients undergoing methadone maintenance treatment: a do... by Helya Helali, Nastaran Samani, Faraj Tabeie, Shiva Eiliaei, Ali Kheradmand

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Prone versus Supine Position Ventilation in Adult Patients with Acute Respiratory Distress Syndrome: A Meta-Analysis of Randomized Controlled Trials by Zanfeng Cao, Zhanzheng Yang, Zijing Liang, Qingyan Cen, Zuopeng Zhang, Hengrui Liang, Rong Liu, Liangbo Zeng, Yubao Xie, Youping Wang

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Additive impact of metabolic syndrome and sarcopenia on all-cause and cause-specific mortality: an analysis of NHANES by Meng Zhang, Qing-Yue Zeng, Linli Zhuang

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Analysis of syphilis epidemiological characteristics among the resident population in Ruian City, 2014‒2023 by HONG Wansheng, CHEN Jiangmin, ZHOU Limin, HU Yunlei, CHEN Chunnan, CHEN Liangchai, LI Jun, HUANG Jieru, ZHOU Zumu

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Comprehensive bioinformatics analysis identifies metabolic and immune-related diagnostic biomarkers shared between diabetes and COPD using multi-omics and machine learning by Qianqian Liang, Yide Wang, Zheng Li, Zheng Li, Zheng Li, Zheng Li

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Genome-Wide Expression Difference of MicroRNAs in Basal Cell Carcinoma by Hai-Peng Wei, Song Zhan, Qing-An Zhu, Zhen-Juan Chen, Xian Feng, Jun-Yuan Chen, Qi-Lin Zhang, Jingjie Zhao, Lingzhang Meng

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Description and characterization of pneumococcal community acquired pneumonia (CAP) among radiologically confirmed CAP in outpatients by Josselin Le Bel, Juliette Pinot, Toni Alfaiate, Marie Ecollan, Fanny Cussac, Raphaël Pecqueur, Marie-Pierre Revel, Cyrille Vartanian, Emmanuelle Varon, Christian Theilacker, Xavier Duval, Henri Partouche, Cédric Laouénan, Serge Gilberg

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Health-related Quality of Life and hospital costs of Finnish melanoma patients participating in the second Multicenter Selective Lymphadenectomy Trial (MSLT-II) by Pia J. Heino, Jukka Pappinen, John F. Thompson, Micaela Hernberg, Tiina A. Jahkola, Mark B. Faries

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Epidemiological Changes in Hospitalized Bronchiolitis in Children Under 2 Years of Age in Hangzhou Before and After COVID-19 Restriction Easing by Xu X, Chen X, He J, Su L, Tong X, Sun Y, Huang S, Bai G, Chen Z

“…Xuchen Xu,1,* Xiya Chen,1,* Jing He,1,* Lin Su,1 Xudong Tong,2 Ying Sun,1 Shumin Huang,1 Guannan Bai,1 Zhimin Chen1 1Department of Pulmonology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health., Hangzhou, Zhejiang, People’s Republic of China; 2Department of Paediatrics, Cixi Maternity and Child Health Care Hospital, Ningbo, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhimin Chen; Guannan Bai, Email zmchen@zju.edu.cn; guannanbai@zju.edu.cnBackground: Bronchiolitis is a common cause of hospitalization in infants under 2 years of age. …”
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