Risk of Coronary Heart Disease among HIV-Infected Patients: A Multicenter Study in Brazil by Sandra C. Fuchs, Paulo R. Alencastro, Maria Letícia R. Ikeda, Nêmora T. Barcellos, Fernando H. Wolff, Ajácio B. M. Brandão, Ricardo A. A. Ximenes, Demócrito de B. Miranda-Filho, Heloísa Ramos Lacerda, Maria de Fátima P. M. de Albuquerque, Ulisses Ramos Montarroyos, Max W. Nery, Marilia D. Turchi

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Advances in the Drugs Treatment of Psoriatic Arthritis by LU Chaofan, LENG Xiaomei

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Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model by Kathryn M. Buller, Julie A. Wixey, Hanna E. Reinebrant

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Primary Biliary Cholangitis Associated with Ulcerative Colitis: Case Series and Literature Review by Qi Li, Ye Zong

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Association between fresh fruit intake and cardiovascular disease risk in patients with diabetes: A prospective cohort study by Xin Fang, Xingyi Zhang, Ze Yang, Yefa Zhang, Shaofeng Huang, Tiehui Chen, Ling Yu, Wenling Zhong, Peifang Wei

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Is PPAR𝛾 a Prospective Player in HIV-1-Associated Bone Disease? by Eoin J. Cotter, Patrick W. Mallon, Peter P. Doran

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Interferon-Gamma Release Assays for Screening of Health Care Workers in Low Tuberculosis Incidence Settings: Dynamic Patterns and Interpretational Challenges by Madhukar Pai, Kevin Elwood

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ESTRO guidelines for developing questionnaires in survey-based radiation oncology research by Amanda Webster, Lotte S. Fog, Emma Hall, Peter S.N. van Rossum, Daan Nevens, Pierre Montay-Gruel, Pierfrancesco Franco, Elizabeth Joyce, Nuria Jornet, Catharine H. Clark, Jenny Bertholet

“…Dissemination strategies are highlighted to maximize response rates and enhance data completeness across diverse clinical, research and industrial settings. Rigorous analysis techniques are discussed to uncover insights that optimize operational efficiencies and inform evidence-based practices. …”
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Canadian Association of Gastroenterology Policy on the Application for, and Implementation of, Clinical Practice Guidelines by Harminder Singh, Grigorios I Leontiadis, Lawrence Hookey, Robert Enns, Lana Bistritz, Louis-Charles Rioux, Louise Hope, Paul Sinclair

“…The benefits of timely, high-quality and evidenced-based recommendations include: Enhancing the professional development of clinical members through education and dissemination of synthesized clinical research;Improving patient care provided by members by providing focus on quality and evidence;Creating legislative environments that favour effective clinical practice;Enhancing the clinical care provided to patients with digestive disease by nongastroenterologists; andIdentifying areas that require further information or research to improve clinical care.The present document provides the foundation required to ensure that clinical practice guidelines produced by the CAG are necessary, appropriate, credible and applicable. …”
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Mener la recherche avec les sujets concernés : comment et pour quels résultats ? by Gilles Monceau, Marguerite Soulière

“…The goal is not to produce recommendations for a better way to do research but an analytical framework applicable to the action research, intervention research, collaborative research, participatory research, socio-clinical research and other approaches that involve the subjects concerned by the research object.…”
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Multiphoton Laser Microscopy and Fluorescence Lifetime Imaging for the Evaluation of the Skin by Stefania Seidenari, Federica Arginelli, Sara Bassoli, Jennifer Cautela, Paul M. W. French, Mario Guanti, Davide Guardoli, Karsten König, Clifford Talbot, Chris Dunsby

“…Although still limited to the clinical research field, the development of multiphoton laser microscopy is thought to become suitable for a practical application in the next few years: in this paper, we performed an accurate review of the studies published so far, considering the possible fields of application of this imaging method and providing high quality images acquired in the Department of Dermatology of the University of Modena.…”
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Alveolar Ridge Preservation Using Leukocyte and Platelet-Rich Fibrin: A Report of a Case by Mogammad Thabit Peck, Johan Marnewick, Lawrence Stephen

“…Leukocyte and platelet-rich fibrin (L-PRF) is a newly developed platelet concentrate that is prepared from the patient's own blood. Clinical research has indicated that it improves wound healing and stimulates bone formation. …”
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Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation by Marcia L. Moss, Dmitry Minond

“…The field of ADAM metalloproteinases is at a crossroad with many of the new potential therapeutic agents for ADAM17 advancing into the clinic. Researchers have now developed potential drugs for ADAM17 that are selective and do not have the side effects which were seen in earlier chemical entities that targeted this enzyme. …”
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Building Application-Related Patient Identifiers: What Solution for a European Country? by Catherine Quantin, François-André Allaert, Paul Avillach, Maniane Fassa, Benoît Riandey, Gilles Trouessin, Olivier Cohen

“…Hashing the social security number will make it possible to link the information in the personal medical file to other national health information sources with the aim of completing or validating the personal medical record or conducting epidemiological and clinical research. This data linkage would meet the anonymous data requirements of the European directive on data protection.…”
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A Novel Partial Sequence Alignment Tool for Finding Large Deletions by Taner Aruk, Duran Ustek, Olcay Kursun

“…Finding large deletions in genome sequences has become increasingly more useful in bioinformatics, such as in clinical research and diagnosis. Although there are a number of publically available next generation sequencing mapping and sequence alignment programs, these software packages do not correctly align fragments containing deletions larger than one kb. …”
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Exploring the impacts of senescence on implantation and early embryonic development using totipotent cell-derived blastoids by Yuxin Luo, Chenrui An, Ke Zhong, Ping Zhou, Dan Li, Hui Liu, Qing Guo, Wei Wei, Hen Pan, Zheying Min, Rong Li, Yang Yu, Yong Fan

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Clinical Utility of Combined Tissue and Plasma Next-Generation Sequencing in Patients With Advanced, Treatment-Naïve NSCLC by Helena Bote-de Cabo, MD, Marco Siringo, MD, Esther Conde, MD, PhD, Susana Hernández, PhD, Fernando López-Ríos, MD, PhD, Alicia Castelo-Loureiro, MD, Esther García-Lorenzo, MD, Javier Baena, MD-PhD, Mercedes Herrera, MD, Ana Belén Enguita, MD, Yolanda Ruano, PhD, Jon Zugazagoitia, MD, PhD, Luis Paz-Ares, MD, PhD

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Voice EHR: introducing multimodal audio data for health by James Anibal, James Anibal, Hannah Huth, Ming Li, Lindsey Hazen, Veronica Daoud, Dominique Ebedes, Yen Minh Lam, Hang Nguyen, Phuc Vo Hong, Michael Kleinman, Shelley Ost, Christopher Jackson, Laura Sprabery, Cheran Elangovan, Balaji Krishnaiah, Lee Akst, Lee Akst, Ioan Lina, Iqbal Elyazar, Lenny Ekawati, Stefan Jansen, Richard Nduwayezu, Charisse Garcia, Jeffrey Plum, Jacqueline Brenner, Miranda Song, Emily Ricotta, Emily Ricotta, David Clifton, C. Louise Thwaites, Yael Bensoussan, Bradford Wood

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Elucidating the synergistic roles of CD4+ T and dendritic cells in antitumor immunity by Xiubao Ren

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The e-STROKE Study: The Design of a Prospective Observational Multicentral Study by Kateřina Dvorníková, Veronika Kunešová, Svatopluk Ostrý, Robert Mikulík, Michal Bar

“…<b>Methods:</b> This multicenter observational study involves patients with suspected acute ischemic stroke and a premorbid mRS ≤ 4, who are treated with endovascular thrombectomy (EVT), intravenous thrombolysis (IVT), or managed conservatively in stroke centers within the Czech Stroke Research Network (STROCZECH), which is part of the Czech Clinical Research Infrastructure Network (CZECRIN). Data collection includes demographic, clinical, and imaging data variables such as age, sex, ethnicity, risk factors, treatment times (OTT, DNT, and OGT), TICI scores, post-treatment hemorrhage (ECAS II), mRS outcome, stroke etiology, e-ASPECTS, acute ischemic volume (AIV), thrombus length on NCCT, CTA collateral score and collateral vessel density, location of large vessel occlusion, ischemic core, hypoperfusion volume, mismatch ratio and volume, final infarct volume, hemorrhage volume, and MRI in case of negative follow-up NCCT. …”
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