卒中：回眸2024 Highlights in Stroke in 2024 by 熊云云1，2，3，4，李光硕1，马宇洁1，李祉馨1，沈柯佳1，马瑛1，孙大鹏1，孙溢阳1，王拥军1，2，3，5，6，7（XIONG Yunyun1,2,3,4, LI Guangshuo1, MA Yujie1, LI Zhixin1, SHEN Kejia1, MA Ying1, SUN Dapeng1, SUN Yiyang1, WANG Yongjun1,2,3,5,6,7 ）

“…Abstract: In 2024, significant advancements were made in clinical research on cerebrovascular diseases. Stroke researchers worldwide have actively contributed their expertise, and further refined the diagnosis, treatment, and management strategies for cerebrovascular diseases. …”
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Size-controllable synthesis of hydroxyapatite nanorods via fluorine modulation: applications in dental adhesives for enhanced enamel remineralization by Linzhi Meng, Mengmeng Shu, Peng Mei, Yakun Liang, Lunguo Xia

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Hypervirulent Klebsiella pneumoniae have better clinical outcomes than classical Klebsiella pneumoniae for lower respiratory tract infection patients by Xianxia Zhuo, Zichen Lei, Danni Pu, Yongli Wu, Jiankang Zhao, Bin Cao

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A Study on the Inflammatory Response of the Brain in Neurosyphilis by Qiyu Zhang, Jie Ma, Jia Zhou, Hanlin Zhang, Mansheng Li, Huizi Gong, Yujie Wang, Heyi Zheng, Jun Li, Ling Leng

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Dual-positive gastric cancer: an extremely malignant subtype of gastric cancer with high serum alpha-fetoprotein and carcinoembryonic antigen concentrations by Weixun Xie, Chengyu Hu, Hongming Liu, Zelai Wu, Bixian Luo, Xiaoying Wu, Xiaoying Wu, Chuanlei Tuo, Ziyin Deng, Han Liang, Yong Liu, Weihua Gong, Weihua Gong

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Regulation of viral replication by host restriction factors by Ying Lin, Ying Lin, Ying Lin, Yun Zhu, Yun Zhu, Ling Jing, Ling Jing, Ling Jing, Xiaobo Lei, Xiaobo Lei, Zhengde Xie, Zhengde Xie

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Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy by Wen-Ying Yu, Wen-Ying Yu, Jing Liu, Jing Liu, Ze-Hao Lin, Ze-Hao Lin, Hong Liu, Hong Liu, Liang-Zhi Zhang, Liang-Zhi Zhang, Xiang-Long Feng, Xiang-Long Feng, Zhong-Biao Xiu, Zhong-Biao Xiu, Zhong-Biao Xiu

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Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb) by Hiroaki Tanaka, Yasuhiro Tanaka, Yoichi Aoki, Masayuki Endo, Tomoaki Ikeda, Shintaro Maki, Masafumi Nii, Kayo Tanaka, Satoshi Tamaru, Toru Ogura, Yuki Nishimura, Tomomi Kotani, Akihiko Sekizawa, Masahiko Nakata, Koji Nakamura, Kenji Nagao, Ichiro Yasuhi, Hiroshi Kawamura, Sho Takakura, Mayumi Kotera, Takafumi Ushida, Norihiko Kikuchi, Tadatsugu Kinjo, Mayumi Takano, Sachie Suga, Michi Kasai, Osamu Yasui, Yuka Maegawa, Shigeru Aoki, Yoshio Yoshida

“…The investigator will evaluate fetal baseline conditions at enrolment and decide the timing of delivery based on this indication.Ethics and dissemination This study has been approved by Mie University Hospital Clinical Research Review Board on 22 July 2019 (S2018-007). …”
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Research Progress on Tumor Treatment Strategies Targeting TGF-β by Jian ZHANG, Binyue LYU, Xiao ZHAO

“…New combination therapies, such as CAR-T therapy modified with TGF-βRII, are also emerging in clinical research. This article systematically reviews the therapeutic strategies targeting TGF-β to provide research basis and ideas for the development of drugs targeting the TGF-β pathway.…”
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Current Status of Diagnosis and Treatment of High-risk Resistant and Recurrent Gestational Trophoblastic Neoplasia by MAO Mingyi, JIANG Fang, XIANG Yang

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Author Correction: Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia by Kevin C. Kobylinski, Tri B. T. Satoto, Wisnu Nurcahyo, Yudi Ratna Nugraheni, Vincentius A. Testamenti, I Putu B. A. Winata, Yosua L. Pono, Diana Timoria, Piyanan Assawasuwannakit, Mary Chambers, J. Kevin Baird, Joel Tarning, Lorenz von Seidlein, Claus Bøgh

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PPAR-Alpha Agonist Fenofibrate Combined with Octreotide Acetate in the Treatment of Acute Hyperlipidemia Pancreatitis by Wen Bao, Rui Kong, Nan Wang, Wei Han, Jie Lu

“…Therefore, through clinical research and analysis, we reported for the first time that fenofibrate combined with octreotide acetate has a more excellent effect in the treatment of patients with acute hypertriglyceridemia pancreatitis, and from the perspective of signal pathways, we revealed that the combination of the two drugs has an effect on NF-κB P65. …”
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Sex/gender analysis in systematic reviews. Critical review and recommendations by Raúl Aguilera Eguía, Olga Patricia López Soto, Ángel Roco Videla, Brenda Herrera Serna, Héctor Fuentes Barria, Lorena Gerli Candia

“…Although historically underestimated, these variables are vital in clinical research to consolidate evidence in health, technological assessments and public policies. …”
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Observational research in epidemic settings: a roadmap to reform by Marc Lipsitch, Nicholas Evans, Alexandra L Phelan, Stephany N Duda, Annette Rid, Colin J Carlson, Jennifer B Rosen, Natalie E Dean, John Barugahare, Maya B Mathur, Emily E Ricotta, Fausto A Bustos Carrillo, Samuel Angelli-Nichols, Adia Benton, Emma Chang-Rabley, Lisa Federer, Mary-Margaret A Fill, Elizabeth C LeRoy, Natalie M Linton, Lauren Sauer, Sheena G Sullivan, Mackenzie Zendt

“…Observational studies are critical tools in clinical research and public health response, but challenges arise in ensuring the data produced by these studies are scientifically robust and socially valuable. …”
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PPARs: Protectors or Opponents of Myocardial Function? by Christine J. Pol, Melissa Lieu, Konstantinos Drosatos

“…This review article aims to summarize the current basic and clinical research findings of the beneficial or detrimental effects of PPAR biology on myocardial function.…”
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Treatment of HIV-1 Infection with Combination Therapy: Antiretroviral Agents and Biological Response Modifiers by Steven M Schnittman

“…Other promising approaches include antiretroviral therapy with interleukin (IL) -2, and IFN-α wilh IL-2. The clinical research pertaining to these combinations of antiretrovirals and biological response modifiers is reviewed.…”
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The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients by Yangjie Dang, Xingxing Shi, William Xu, Mingzhang Zuo

“…Anesthesia is an effective way to control the stress response, and recent basic and clinical research has shown that anesthesia and related drugs can directly or indirectly affect the immune system of colorectal cancer patients during the perioperative period. …”
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Autologous Bone Marrow Mononuclear Cells in Ischemic Cerebrovascular Accident Paves Way for Neurorestoration: A Case Report by Alok Sharma, Hemangi Sane, Anjana Nagrajan, Nandini Gokulchandran, Prerna Badhe, Amruta Paranjape, Hema Biju

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Classification of peripheral vitreoretinal interface lesions using spectral-domain optical coherence tomography with guidance of ultrawide field imaging by Weiwei Zheng, Ying Huang, Ying Huang, Shanshan Qian, Bing Lin, Bing Lin, Shenghai Huang, Shenghai Huang

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Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study by Hang Zhang, Jing-jing Zuo, Si-si Dong, Yuan Lan, Chen-wei Wu, Guang-yun Mao, Chao Zheng

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